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Protein

Non-structural protein 1

Gene

NS

Organism
Influenza C virus (strain C/Yamagata/1964)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Prevents the establishment of the cellular antiviral state initiated by host DDX58, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Participates also in the upregulation of the splicing of viral mRNAs.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host RIG-I by virus, Inhibition of host RLR pathway by virus, Interferon antiviral system evasion, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 1UniRule annotation
Short name:
NS1UniRule annotation
Alternative name(s):
NS1AUniRule annotation
Gene namesi
Name:NSUniRule annotation
OrganismiInfluenza C virus (strain C/Yamagata/1964)
Taxonomic identifieri217166 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeGammainfluenzavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

  • Host cytoplasm UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002236261 – 246Non-structural protein 1Add BLAST246

Family & Domainsi

Sequence similaritiesi

Belongs to the influenza C viruses NS1 family.UniRule annotation

Family and domain databases

HAMAPiMF_04066 INFV_NS1, 1 hit
InterProiView protein in InterPro
IPR005187 Flu_C_NS1
IPR005188 Flu_C_NS2
IPR004208 NS1
PfamiView protein in Pfam
PF03506 Flu_C_NS1, 1 hit
PF03555 Flu_C_NS2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform NS1 (identifier: Q784P6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDKTVKSTN LMAFVATKML ERQEDLDTCT EMQVEKMKTS TKARLRTESS
60 70 80 90 100
FAPRTWEDAI KDGELLFNGT ILQAESPTMT PASVEMKGKK FPIDFAPSNI
110 120 130 140 150
APIGQNPIYL SPCIPNFDGN VWEATMYHHR GATLTKTMNC NCFQRTIWCH
160 170 180 190 200
PNPSRMRLSY AFVLYCRNTK KICGYLIAKQ VAGIETGIRK CFRCIKSGFV
210 220 230 240
MATDEISLTI LQSIKSGAQL DPYWGNETPD IDKTEAYMLS LREAGP
Length:246
Mass (Da):27,695
Last modified:March 21, 2006 - v1
Checksum:iC1625ABA89A3672A
GO
Isoform NEP (identifier: Q9ENZ3-1) [UniParc]FASTAAdd to basket
Also known as: NS2
The sequence of this isoform can be found in the external entry Q9ENZ3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:182
Mass (Da):20,795
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034155 Genomic RNA Translation: BAB12049.1

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNS1_INCY6
AccessioniPrimary (citable) accession number: Q784P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: April 25, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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