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Protein

Membrane-associated protein VP24

Gene

VP24

Organism
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Interferon antiviral system evasion

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated protein VP24
Gene namesi
Name:VP24
ORF Names:REBOVgp6
OrganismiReston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
Taxonomic identifieri386032 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000138664 Componenti: Genome
  • UP000007207 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002450681 – 251Membrane-associated protein VP24Add BLAST251

Interactioni

Subunit structurei

Binds to host importin alpha-1/KPNA1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ77DB4
SMRiQ77DB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000KL

Family and domain databases

InterProiView protein in InterPro
IPR009433 Filo_VP24
PfamiView protein in Pfam
PF06389 Filo_VP24, 1 hit
PIRSFiPIRSF011355 VP24, 1 hit

Sequencei

Sequence statusi: Complete.

Q77DB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKATGRYNL VPPKKDMEKG VIFSDLCNFL ITQTLQGWKV YWAGIEFDVS
60 70 80 90 100
QKGMALLTRL KTNDFAPAWA MTRNLFPHLF QNPNSVIQSP IWALRVILAA
110 120 130 140 150
GLQDQLLDHS LVEPLTGALG LISDWLLTTT STHFNLRTRS VKDQLSLRML
160 170 180 190 200
SLIRSNILQF INKLDALHVV NYNGLLSSIE IGTSTHTIII TRTNMGFLVE
210 220 230 240 250
VQEPDKSAMN SKRPGPVKFS LLHESAFKPF TRVPQSGMQS LIMEFNSLLA

I
Length:251
Mass (Da):28,169
Last modified:February 21, 2006 - v1
Checksum:iDB8F144CA8FB2509
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522874 Genomic RNA Translation: AAN04453.1
AY769362 Genomic RNA Translation: AAV48580.1
RefSeqiNP_690586.1, NC_004161.1

Genome annotation databases

GeneIDi955193
KEGGivg:955193

Similar proteinsi

Entry informationi

Entry nameiVP24_EBORR
AccessioniPrimary (citable) accession number: Q77DB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: February 21, 2006
Last modified: June 20, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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