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Entry version 61 (05 Jun 2019)
Sequence version 1 (15 May 2007)
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Protein
Submitted name:

G protein-coupled receptor

Gene

ORF74

Organism
Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
G protein-coupled receptorImported
Submitted name:
IL-8 receptor-like G protein coupled receptor homologImported
Submitted name:
ORF74Imported
Submitted name:
Putative G-protein coupled receptorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ORF74Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri37296 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000155579 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000141755 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei51 – 72HelicalSequence analysisAdd BLAST22
Transmembranei84 – 113HelicalSequence analysisAdd BLAST30
Transmembranei125 – 147HelicalSequence analysisAdd BLAST23
Transmembranei159 – 177HelicalSequence analysisAdd BLAST19
Transmembranei216 – 237HelicalSequence analysisAdd BLAST22
Transmembranei249 – 270HelicalSequence analysisAdd BLAST22
Transmembranei290 – 317HelicalSequence analysisAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2321625

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q76SF8, 8 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 314G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST251

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K21667

Database of Orthologous Groups

More...
OrthoDBi
22198at10239

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q76SF8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEDFLTIF LDDDESWNET LNMSGYDYSG NFSLEVSVCE MTTVVPYTWN
60 70 80 90 100
VGILSLIFLI NVLGNGLVTY IFCKHRSRAG AIDILLLGIC LNSLCLSISL
110 120 130 140 150
LAEVLMFLFP NIISTGLCRL EIFFYYLYVY LDIFSVVCVS LVRYLLVAYS
160 170 180 190 200
TRSWPKKQSL GWVLTSAALL IALVLSGDAC RHRSRVVDPV SKQAMCYENA
210 220 230 240 250
GNMTADWRLH VRTVSVTAGF LLPLALLILF YALTWCVVRR TKLQARRKVR
260 270 280 290 300
GVIVAVVLLF FVFCFPYHVL NLLDTLLRRR WIRDSCYTRG LINVGLAVTS
310 320 330 340
LLQALYSAVV PLIYSCLGSL FRQRMYGLFQ SLRQSFMSGA TT
Length:342
Mass (Da):38,669
Last modified:May 15, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i41E4B33CA2D9F069
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U71368 Genomic DNA Translation: AAC34949.1
AF179929 Genomic DNA Translation: AAD56656.1
AF179930 Genomic DNA Translation: AAD56657.1
AF179931 Genomic DNA Translation: AAD56658.1
AF367765 mRNA Translation: AAK53416.1
AF367766 mRNA Translation: AAK53418.1
AF367767 mRNA Translation: AAK53419.1
GQ994935 Genomic DNA Translation: ACY00479.1
KF588566 Genomic DNA Translation: AKE33117.1
KT271453 Genomic DNA Translation: ALH44235.1
KT271454 Genomic DNA Translation: ALH44323.1
KT271455 Genomic DNA Translation: ALH44411.1
KT271456 Genomic DNA Translation: ALH44499.1
KT271457 Genomic DNA Translation: ALH44586.1
KT271458 Genomic DNA Translation: ALH44674.1
KT271459 Genomic DNA Translation: ALH44762.1
KT271460 Genomic DNA Translation: ALH44850.1
KT271461 Genomic DNA Translation: ALH44938.1
KT271462 Genomic DNA Translation: ALH45026.1
KT271463 Genomic DNA Translation: ALH45112.1
KT271464 Genomic DNA Translation: ALH45200.1
KT271465 Genomic DNA Translation: ALH45288.1
KT271466 Genomic DNA Translation: ALH45376.1
KT271467 Genomic DNA Translation: ALH45462.1
KT271468 Genomic DNA Translation: ALH45550.1
AP017458 Genomic DNA Translation: BAV17933.1
LC200586 Genomic DNA Translation: BBA90926.1
LC200587 Genomic DNA Translation: BBA91014.1
LC200588 Genomic DNA Translation: BBA91102.1
LC200589 Genomic DNA Translation: BBA91190.1
MK143395 Genomic DNA Translation: QAX88146.1

NCBI Reference Sequences

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RefSeqi
YP_001129433.1, NC_009333.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
4961465

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:4961460

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71368 Genomic DNA Translation: AAC34949.1
AF179929 Genomic DNA Translation: AAD56656.1
AF179930 Genomic DNA Translation: AAD56657.1
AF179931 Genomic DNA Translation: AAD56658.1
AF367765 mRNA Translation: AAK53416.1
AF367766 mRNA Translation: AAK53418.1
AF367767 mRNA Translation: AAK53419.1
GQ994935 Genomic DNA Translation: ACY00479.1
KF588566 Genomic DNA Translation: AKE33117.1
KT271453 Genomic DNA Translation: ALH44235.1
KT271454 Genomic DNA Translation: ALH44323.1
KT271455 Genomic DNA Translation: ALH44411.1
KT271456 Genomic DNA Translation: ALH44499.1
KT271457 Genomic DNA Translation: ALH44586.1
KT271458 Genomic DNA Translation: ALH44674.1
KT271459 Genomic DNA Translation: ALH44762.1
KT271460 Genomic DNA Translation: ALH44850.1
KT271461 Genomic DNA Translation: ALH44938.1
KT271462 Genomic DNA Translation: ALH45026.1
KT271463 Genomic DNA Translation: ALH45112.1
KT271464 Genomic DNA Translation: ALH45200.1
KT271465 Genomic DNA Translation: ALH45288.1
KT271466 Genomic DNA Translation: ALH45376.1
KT271467 Genomic DNA Translation: ALH45462.1
KT271468 Genomic DNA Translation: ALH45550.1
AP017458 Genomic DNA Translation: BAV17933.1
LC200586 Genomic DNA Translation: BBA90926.1
LC200587 Genomic DNA Translation: BBA91014.1
LC200588 Genomic DNA Translation: BBA91102.1
LC200589 Genomic DNA Translation: BBA91190.1
MK143395 Genomic DNA Translation: QAX88146.1
RefSeqiYP_001129433.1, NC_009333.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ76SF8, 8 interactors

Chemistry databases

ChEMBLiCHEMBL2321625

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4961465
KEGGivg:4961460

Phylogenomic databases

KOiK21667
OrthoDBi22198at10239

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ76SF8_HHV8
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q76SF8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: June 5, 2019
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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