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Entry version 105 (31 Jul 2019)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Falcilysin

Gene

PF3D7_1360800

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi129Zinc; via tele nitrogenCombined sources1
Metal bindingi133Zinc; via tele nitrogenCombined sources1
Metal bindingi243ZincCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported
LigandMetal-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PLASMO:PF13_0322-MONOMER

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M16.011

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FalcilysinImported (EC:3.4.24.-Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_1360800Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_1360800

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

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PRIDEi
Q76NL8

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q76NL8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q76NL8, 4 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q76NL8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini584 – 901M16C_associatedInterPro annotationAdd BLAST318

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni376 – 404DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili583 – 619Sequence analysisAdd BLAST37
Coiled coili895 – 922Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000281714

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q76NL8

KEGG Orthology (KO)

More...
KOi
K06972

Identification of Orthologs from Complete Genome Data

More...
OMAi
TFYPFAT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q76NL8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR007863 Peptidase_M16_C
IPR013578 Peptidase_M16C_assoc

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08367 M16C_assoc, 2 hits
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01264 M16C_associated, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63411 SSF63411, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q76NL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLTKLMKVI GYINIITNCV QSFTNRADKK RYNVFAKSFI NTINTNLYTF
60 70 80 90 100
KAVMSKTPEW IHEKSPKHNS YDIIEKRYNE EFKMTYTVYQ HKKAKTQVIS
110 120 130 140 150
LGTNDPLDVE QAFAFYVKTL THSGKGIPHI LEHSVLSGSK NYNYKNSIGL
160 170 180 190 200
LEKGTLHTHL NAYTFNDRTV YMAGSMNNKD FFNIMGVYMD SVFQPNVLEN
210 220 230 240 250
KYIFETEGWT YEVEKLKEDE KGKAEIPQMK DYKVSFNGIV YNEMKGALSS
260 270 280 290 300
PLEDLYHEEM KYMFPDNVHS NNSGGDPKEI TNLTYEEFKE FYYKNYNPKK
310 320 330 340 350
VKVFFFSKNN PTELLNFVDQ YLGQLDYSKY RDDAVESVEY QTYKKGPFYI
360 370 380 390 400
KKKYGDHSEE KENLVSVAWL LNPKVDKTNN HNNNHSNNQS SENNGYSNGS
410 420 430 440 450
HSSDLSLENP TDYFVLLIIN NLLIHTPESV LYKALTDCGL GNNVIDRGLN
460 470 480 490 500
DSLVQYIFSI GLKGIKRNNE KIKNFDKVHY EVEDVIMNAL KKVVKEGFNK
510 520 530 540 550
SAVEASINNI EFILKEANLK TSKSIDFVFE MTSKLNYNRD PLLIFEFEKY
560 570 580 590 600
LNIVKNKIKN EPMYLEKFVE KHFINNAHRS VILLEGDENY AQEQENLEKQ
610 620 630 640 650
ELKKRIENFN EQEKEQVIKN FEELSKYKNA EESPEHLNKF PIISISDLNK
660 670 680 690 700
KTLEVPVNVY FTNINENNNI METYNKLKTN EHMLKDNMDV FLKKYVLKND
710 720 730 740 750
KHNTNNNNNN NNNMDYSFTE TKYEGNVPIL VYEMPTTGIV YLQFVFSLDH
760 770 780 790 800
LTVDELAYLN LFKTLILENK TNKRSSEDFV ILREKNIGSM SANVALYSKD
810 820 830 840 850
DHLNVTDKYN AQALFNLEMH VLSHKCNDAL NIALEAVKES DFSNKKKVID
860 870 880 890 900
ILKRKINGMK TTFSEKGYAI LMKYVKAHLN SKHYAHNIIY GYENYLKLQE
910 920 930 940 950
QLELAENDFK TLENILVRIR NKIFNKKNLM VSVTSDYGAL KHLFVNSNES
960 970 980 990 1000
LKNLVSYFEE NDKYINDMQN KVNDPTVMGW NEEIKSKKLF DEEKVKKEFF
1010 1020 1030 1040 1050
VLPTFVNSVS MSGILFKPGE YLDPSFTVIV AALKNSYLWD TVRGLNGAYG
1060 1070 1080 1090 1100
VFADIEYDGS VVFLSARDPN LEKTLATFRE SAKGLRKMAD TMTENDLLRY
1110 1120 1130 1140 1150
IINTIGTIDK PRRGIELSKL SFLRLISNES EQDRVEFRKR IMNTKKEDFY
1160 1170 1180 1190
KFADLLESKV NEFEKNIVII TTKEKANEYI ANVDGEFKKV LIE
Length:1,193
Mass (Da):138,863
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBA1FC548ED5056A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL844509 Genomic DNA Translation: CAD52728.1

NCBI Reference Sequences

More...
RefSeqi
XP_001350319.1, XM_001350283.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAD52728; CAD52728; PF3D7_1360800

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_1360800.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
814283

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_1360800

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA Translation: CAD52728.1
RefSeqiXP_001350319.1, XM_001350283.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S5HX-ray1.60A1-1193[»]
3S5IX-ray1.74A1-1193[»]
3S5KX-ray3.20A1-1193[»]
3S5MX-ray1.55A1-1193[»]
SMRiQ76NL8
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ76NL8, 4 interactors

Protein family/group databases

MEROPSiM16.011

PTM databases

SwissPalmiQ76NL8

Proteomic databases

PRIDEiQ76NL8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAD52728; CAD52728; PF3D7_1360800
GeneDBiPF3D7_1360800.1:pep
GeneIDi814283
KEGGipfa:PF3D7_1360800

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1360800

Phylogenomic databases

HOGENOMiHOG000281714
InParanoidiQ76NL8
KOiK06972
OMAiTFYPFAT
PhylomeDBiQ76NL8

Enzyme and pathway databases

BioCyciPLASMO:PF13_0322-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR007863 Peptidase_M16_C
IPR013578 Peptidase_M16C_assoc
PfamiView protein in Pfam
PF08367 M16C_assoc, 2 hits
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
SMARTiView protein in SMART
SM01264 M16C_associated, 1 hit
SUPFAMiSSF63411 SSF63411, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ76NL8_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q76NL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 31, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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