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Entry version 125 (05 Jun 2019)
Sequence version 2 (23 Oct 2007)
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Protein

Kinase non-catalytic C-lobe domain-containing protein 1

Gene

KNDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Ras guanyl-nucleotide exchange factor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinase non-catalytic C-lobe domain-containing protein 1Imported
Short name:
KIND domain-containing protein 11 Publication
Alternative name(s):
Cerebral protein 91 Publication
Protein very KINDBy similarity
Short name:
v-KINDBy similarity
Ras-GEF domain-containing family member 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KNDC1Imported
Synonyms:C10orf23, KIAA1768, RASGEF2, VKINDBy similarity
ORF Names:hucep-91 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29374 KNDC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616237 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q76NI1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000171798

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134983621

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KNDC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160013711

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003071411 – 1749Kinase non-catalytic C-lobe domain-containing protein 1Add BLAST1749

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei964PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q76NI1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q76NI1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q76NI1

PeptideAtlas

More...
PeptideAtlasi
Q76NI1

PRoteomics IDEntifications database

More...
PRIDEi
Q76NI1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68693
68694 [Q76NI1-2]
68695 [Q76NI1-3]
68696 [Q76NI1-4]
68697 [Q76NI1-5]
68698 [Q76NI1-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q76NI1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q76NI1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed specifically in the cerebral cortex.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171798 Expressed in 130 organ(s), highest expression level in adenohypophysis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q76NI1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039624

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via KIND2) with MAP2; the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124529, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q76NI1, 6 interactors

Molecular INTeraction database

More...
MINTi
Q76NI1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000304437

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 217KIND 1PROSITE-ProRule annotationAdd BLAST181
Domaini444 – 608KIND 2PROSITE-ProRule annotationAdd BLAST165
Domaini1246 – 1371N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST126
Domaini1468 – 1719Ras-GEFPROSITE-ProRule annotationAdd BLAST252

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1133 – 1190Sequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi724 – 885Pro-richAdd BLAST162

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II5U Eukaryota
ENOG410XQ1A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011408

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q76NI1

Identification of Orthologs from Complete Genome Data

More...
OMAi
FCLLQAW

Database of Orthologous Groups

More...
OrthoDBi
78094at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q76NI1

TreeFam database of animal gene trees

More...
TreeFami
TF336009

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06224 REM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.840.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR011019 KIND_dom
IPR029899 KNDC1
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21560 PTHR21560, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16474 KIND, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00750 KIND, 2 hits
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48366 SSF48366, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51377 KIND, 2 hits
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q76NI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQAMDPAAAD LYEEDGKDLD FYDFEPLPTL PEDEENVSLA DILSLRDRGL
60 70 80 90 100
SEQEAWAVCL ECSLSMRSVA HAAIFQSLCI TPDTLAFNTS GNVCFMEQLS
110 120 130 140 150
DDPEGAFVPP EFDVTGNTFE AHIYSLGATL KAALEYVAEP TLEPRLSQDL
160 170 180 190 200
EALLSRMQAE DPGDRPDLES IIALCEEKLQ LTSSCRVCRS LSAVGRRVLS
210 220 230 240 250
IESFGALQDV SESSWRERPA PGNAGPRRPP GDPSTDPEVL PTPEGPESET
260 270 280 290 300
SRGPRASPTK ALLSTPVRNG ESHSREGLAG LVLDAERTLG ELDRDALRRS
310 320 330 340 350
RLRKVQTFPR LLSDSPEATL CLPLTRGKSQ LPISELFSPD PRKAFLDRKN
360 370 380 390 400
GLSSFQAQPK CRLWPEQEPE HQLGRVPCAG RSTDRGPGVP GSPGQPETSH
410 420 430 440 450
PSQGPAEAPA DPRDASGEAQ TPRDDERIPE GARQLESAAA EQWVSLQDLL
460 470 480 490 500
SQLGRPFREY ELWALCLACL RALQTRPEHP AYLCLDSVLV AEDGAVLFQP
510 520 530 540 550
PPANGSYDSF FLAPELAEER LVTEKASVYC VAAVLWTAAK FSVPRNHKLA
560 570 580 590 600
LPRRLKTLLL DMARRSAPER PSAAEAIKVC GSYLLQRGMD SRKILAHLRA
610 620 630 640 650
SICQVYQEEE TISLQNAFSV VELKPSVAPA PEPSPGFLPV NSDTGLVAVP
660 670 680 690 700
GPVPGQHPCG EEATQLPAAF TSEATHFKPI VLAQNASVAR DQPALAQEES
710 720 730 740 750
EERGGQREGE GEEKLSLEAH AGSPSLKTPD GPVPGPGPQG AAPEPLGASV
760 770 780 790 800
QRDSAQGRPC PPPQAPANQP EGASSAAPGS PVPAPPTKAS ALPVEQGPAE
810 820 830 840 850
PIPPGVASGG LRPDALGPTT AHHGPRHPPK PPRSKATERP GQEPEGPGAT
860 870 880 890 900
PAGERDDQSP DSVPERPRPA DRRLCLPCVD ASPLPGRTAC PSLQEATRLI
910 920 930 940 950
QEEFAFDGYL DNGLEALIMG EYIFALKDLT FATFCGAISE KFCDLYWDEK
960 970 980 990 1000
LLQNLFKVVN GQASPSPSTA EEAGSQLEGS QSPRSPSSKR PSLHRLGKEK
1010 1020 1030 1040 1050
PAMARTSSRA PCSPTSVSDV DSDALSRGNF EVGFRPQRSV KAERAQQPEA
1060 1070 1080 1090 1100
GEDRRPAGGA SDVEAVTRLA RSKGVGPALS PGPAGFQSCS PGWCSAFYEA
1110 1120 1130 1140 1150
DCFGADVHNY VKDLGRQQAD GALPDAQSPE LEQQLMMEKR NYRKTLKFYQ
1160 1170 1180 1190 1200
KLLQKEKRNK GSDVKTMLSK LKGQLEEMKS RVQFLSLVKK YLQVMYAERW
1210 1220 1230 1240 1250
GLEPCTLPVI VNIAAAPCDT LDFSPLDESS SLIFYNVNKH PGGRQKARIL
1260 1270 1280 1290 1300
QAGTPLGLMA YLYSSDAFLE GYVQQFLYTF RYFCTPHDFL HFLLDRINST
1310 1320 1330 1340 1350
LTRAHQDPTS TFTKIYRRSL CVLQAWVEDC YAVDFPRNSG LLGKLEDFIS
1360 1370 1380 1390 1400
SKILPLDGSA KHLLGLLEVG MDRRAEGNPR GTDLENPREA EEDARPFNAL
1410 1420 1430 1440 1450
CKRLSEDGIS RKSFPWRLPR GNGLVLPPHK ERPYTIAAAL PKPCFLEDFY
1460 1470 1480 1490 1500
GPCAKTSEKG PYFLTEYSTH QLFSQLTLLQ QELFQKCHPV HFLNSRALGV
1510 1520 1530 1540 1550
MDKSTAIPKA SSSESLSAKT CSLFLPNYVQ DKYLLQLLRN ADDVSTWVAA
1560 1570 1580 1590 1600
EIVTSHTSKL QVNLLSKFLL IAKSCYEQRN FATAMQILSG LEHLAVRQSP
1610 1620 1630 1640 1650
AWRILPAKIA EVMEELKAVE VFLKSDSLCL MEGRRFRAQP TLPSAHLLAM
1660 1670 1680 1690 1700
HIQQLETGGF TMTNGAHRWS KLRNIAKVVS QVHAFQENPY TFSPDPKLQS
1710 1720 1730 1740
YLKQRIARFS GADISTLAAD SRANFHQVSS EKHSRKIQDK LRRMKATFQ
Length:1,749
Mass (Da):191,397
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB5F6C6692BBCB06
GO
Isoform 2 (identifier: Q76NI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
     1194-1206: VMYAERWGLEPCT → ASGLRAPLCPVRQ
     1207-1749: Missing.

Show »
Length:1,141
Mass (Da):122,639
Checksum:i631124F7586C846F
GO
Isoform 3 (identifier: Q76NI1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Show »
Length:1,684
Mass (Da):184,133
Checksum:i2FE7062F7447A263
GO
Isoform 4 (identifier: Q76NI1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1130-1396: ELEQQLMMEK...PREAEEDARP → VSPRPWHCRV...LSCRLLACTL
     1397-1749: Missing.

Show »
Length:1,397
Mass (Da):148,552
Checksum:i898CFE93F843B2E5
GO
Isoform 5 (identifier: Q76NI1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1258: Missing.

Show »
Length:491
Mass (Da):55,823
Checksum:iA8F9C33FB112DCA3
GO
Isoform 6 (identifier: Q76NI1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1584: Missing.

Show »
Length:165
Mass (Da):18,783
Checksum:iEC85325473AD06D2
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB21859 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti346L → P in BAD12625 (Ref. 1) Curated1
Sequence conflicti806V → D in BAD12625 (Ref. 1) Curated1
Sequence conflicti925A → G in BAD12625 (Ref. 1) Curated1
Sequence conflicti971E → G in BAD12625 (Ref. 1) Curated1
Sequence conflicti1072S → P in BAD12625 (Ref. 1) Curated1
Sequence conflicti1084A → V in BAD12625 (Ref. 1) Curated1
Sequence conflicti1260A → T in BAD12625 (Ref. 1) Curated1
Sequence conflicti1315I → T in BAD12625 (Ref. 1) Curated1
Sequence conflicti1468S → G in BAD12625 (Ref. 1) Curated1
Sequence conflicti1624K → R in BAD12625 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035358436E → G1 PublicationCorresponds to variant dbSNP:rs3810964Ensembl.1
Natural variantiVAR_035359581G → S. Corresponds to variant dbSNP:rs35152544Ensembl.1
Natural variantiVAR_035360717L → P1 PublicationCorresponds to variant dbSNP:rs2998139Ensembl.1
Natural variantiVAR_0617861038R → W. Corresponds to variant dbSNP:rs35604376Ensembl.1
Natural variantiVAR_0519021332A → T. Corresponds to variant dbSNP:rs11101642Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0285921 – 1584Missing in isoform 6. 1 PublicationAdd BLAST1584
Alternative sequenceiVSP_0285931 – 1258Missing in isoform 5. 1 PublicationAdd BLAST1258
Alternative sequenceiVSP_0285941 – 65Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST65
Alternative sequenceiVSP_0285951130 – 1396ELEQQ…EDARP → VSPRPWHCRVGQGVSFQQSF LVTAGDRWHRVPRAPNRVTL VLVPPPRGCQDGQGPLPGLS STSRDRLVCTGAPGGSTSED REGLFSHGRPGDGFTGGPSM LVTRLRSVVFSVGQAQPPGP WAASLCSERKHQKRLPSKSR LGLVAAAWSGLSGQQCHPGS GAAATPPWPAGRGGLRPGSP GCRRGLQSSGRKVGPVTHSP DLGCILESPGTPGWMTGGAQ WPSAPGTSPTTVCLELSHRG KPPPASGHRSPSWGSSLLLS CRLLACTL in isoform 4. 1 PublicationAdd BLAST267
Alternative sequenceiVSP_0285961194 – 1206VMYAE…LEPCT → ASGLRAPLCPVRQ in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0285971207 – 1749Missing in isoform 2. 1 PublicationAdd BLAST543
Alternative sequenceiVSP_0285981397 – 1749Missing in isoform 4. 1 PublicationAdd BLAST353

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB000781 mRNA Translation: BAD12625.1
AB051555 mRNA Translation: BAB21859.1 Different initiation.
AK057756 mRNA Translation: BAB71561.1
AK131205 mRNA Translation: BAD18397.1
AL445199 Genomic DNA No translation available.
AK074179 mRNA Translation: BAB85005.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7674.1 [Q76NI1-1]

NCBI Reference Sequences

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RefSeqi
NP_689856.6, NM_152643.7 [Q76NI1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000304613; ENSP00000304437; ENSG00000171798 [Q76NI1-1]
ENST00000368571; ENSP00000357560; ENSG00000171798 [Q76NI1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
85442

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:85442

UCSC genome browser

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UCSCi
uc001llz.2 human [Q76NI1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000781 mRNA Translation: BAD12625.1
AB051555 mRNA Translation: BAB21859.1 Different initiation.
AK057756 mRNA Translation: BAB71561.1
AK131205 mRNA Translation: BAD18397.1
AL445199 Genomic DNA No translation available.
AK074179 mRNA Translation: BAB85005.1
CCDSiCCDS7674.1 [Q76NI1-1]
RefSeqiNP_689856.6, NM_152643.7 [Q76NI1-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124529, 4 interactors
IntActiQ76NI1, 6 interactors
MINTiQ76NI1
STRINGi9606.ENSP00000304437

PTM databases

iPTMnetiQ76NI1
PhosphoSitePlusiQ76NI1

Polymorphism and mutation databases

BioMutaiKNDC1
DMDMi160013711

Proteomic databases

EPDiQ76NI1
jPOSTiQ76NI1
PaxDbiQ76NI1
PeptideAtlasiQ76NI1
PRIDEiQ76NI1
ProteomicsDBi68693
68694 [Q76NI1-2]
68695 [Q76NI1-3]
68696 [Q76NI1-4]
68697 [Q76NI1-5]
68698 [Q76NI1-6]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
85442
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304613; ENSP00000304437; ENSG00000171798 [Q76NI1-1]
ENST00000368571; ENSP00000357560; ENSG00000171798 [Q76NI1-2]
GeneIDi85442
KEGGihsa:85442
UCSCiuc001llz.2 human [Q76NI1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
85442

GeneCards: human genes, protein and diseases

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GeneCardsi
KNDC1
HGNCiHGNC:29374 KNDC1
HPAiHPA039624
MIMi616237 gene
neXtProtiNX_Q76NI1
OpenTargetsiENSG00000171798
PharmGKBiPA134983621

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II5U Eukaryota
ENOG410XQ1A LUCA
GeneTreeiENSGT00390000011408
InParanoidiQ76NI1
OMAiFCLLQAW
OrthoDBi78094at2759
PhylomeDBiQ76NI1
TreeFamiTF336009

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KNDC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
85442

Protein Ontology

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PROi
PR:Q76NI1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171798 Expressed in 130 organ(s), highest expression level in adenohypophysis
GenevisibleiQ76NI1 HS

Family and domain databases

CDDicd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR011019 KIND_dom
IPR029899 KNDC1
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
PANTHERiPTHR21560 PTHR21560, 1 hit
PfamiView protein in Pfam
PF16474 KIND, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00750 KIND, 2 hits
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51377 KIND, 2 hits
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKNDC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q76NI1
Secondary accession number(s): B0QZC5
, Q5T233, Q6ZNH8, Q8TEE5, Q96LV7, Q9C095
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 5, 2019
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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