Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 91 (26 Feb 2020)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

ESF1 homolog

Gene

Esf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ESF1 homolog
Alternative name(s):
ABT1-associated protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Esf1
Synonyms:Abtap
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...
RGDi
1306067 Esf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002331672 – 842ESF1 homologAdd BLAST841

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei75PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei135PhosphoserineBy similarity1
Modified residuei155PhosphoserineBy similarity1
Modified residuei180PhosphoserineCombined sources1
Modified residuei198PhosphoserineBy similarity1
Modified residuei288PhosphoserineBy similarity1
Modified residuei290PhosphoserineBy similarity1
Modified residuei303PhosphothreonineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei305PhosphoserineCombined sources1
Modified residuei605PhosphoserineBy similarity1
Modified residuei648PhosphoserineCombined sources1
Modified residuei654PhosphoserineCombined sources1
Modified residuei686PhosphoserineCombined sources1
Modified residuei726PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q76MT4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q76MT4

PRoteomics IDEntifications database

More...
PRIDEi
Q76MT4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q76MT4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q76MT4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000004777 Expressed in lung and 8 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q76MT4 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ABT1.

Forms a complex with ABT1 and suppresses the ABT1-induced activation of polymerase II-directed transcription in mammalian cells. Disrupts the interaction between ABT1 and TATA-binding protein (TBP), and suppresses the ABT1-induced activation of polymerase II-directed basal transcription in vitro.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000037915

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q76MT4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili772 – 804Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi87 – 210Lys-richAdd BLAST124
Compositional biasi226 – 327Glu-richAdd BLAST102
Compositional biasi558 – 737Lys-richAdd BLAST180

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ESF1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2318 Eukaryota
COG5638 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004881

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010564_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q76MT4

Identification of Orthologs from Complete Genome Data

More...
OMAi
LTWDETA

Database of Orthologous Groups

More...
OrthoDBi
1300279at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q76MT4

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039754 Esf1
IPR012580 NUC153

The PANTHER Classification System

More...
PANTHERi
PTHR12202 PTHR12202, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08159 NUC153, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q76MT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKQEIMDD QRFRRVSKDP RFWEMPEKDR KVKIDKRFRA MFHDKKFKLN
60 70 80 90 100
YAVDKRGRPI SHSTTEDLKR FYDLSDSDSD LSDEESKVLD EKRVKEKKKQ
110 120 130 140 150
TKKETKSKTP IEEKKKETKK TDQKDSINKN DLNNSERIQK MKNSHKSPKI
160 170 180 190 200
DSEVSPKDSE ESLQSRKKKR DTTDLSVEAS PKGKLRTKDP STSAMVKSST
210 220 230 240 250
VSGSKAKREK QAVIMAKDNA GRMLHEEAPE EDSDSASELG RDEESEGEIT
260 270 280 290 300
SDDRASADDD ENEDEEEEED GEEEEEEEEE EDESDDESDS GPDLARGKGN
310 320 330 340 350
VETSSEDEDD LADLFPEEPG FEHAWRELDK DAPRADEITR RLAVCNMDWD
360 370 380 390 400
RLKAKDLLAL FNSFKPKGGV VFSVKIYPSE FGKQRMKEEQ IQGPVELLSI
410 420 430 440 450
PEDAPEKDWA SREKLRDYQF KRLKYYYAVV ECDSPETASK IYEDCDGLEF
460 470 480 490 500
ESSCSFIDLR FIPDDITFDD EPKDAASEVD LTAYKPKYFT SAAMGTSTVE
510 520 530 540 550
ITWDETDHER ITTLNRKFKK DELLDMDFEA YLASSSEDEE EVEEAPEGED
560 570 580 590 600
GVSIEDGKTK KSQKDDEEQI AKYRQLLQVI QEKEKKGKEN DMEMEIKWVP
610 620 630 640 650
GLKESAEEMV KNKLEGKDKL TPWEQFLEKK KEKKRLKKKQ KALAEEASED
660 670 680 690 700
EIPSDVDLND PYFAEEVKKI GIKKKSMKSA KDGATSEEET ELEKQKAEMA
710 720 730 740 750
LLVMDEEEDS KKHFNYDKIV EHQNLSKKKK KQLMKKKELL EDDFEVNVSD
760 770 780 790 800
ARFQAMYTSH LFNLDPSDPN FKKTKAMEKI LEEKARHREQ KEERLIQAVE
810 820 830 840
RAQQDTGKPA QKQPMDPALS MLIKSVKNKT EQFQARKKQR IK
Length:842
Mass (Da):97,534
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i590CF5618ABF1C10
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB038233 mRNA Translation: BAD10946.1

NCBI Reference Sequences

More...
RefSeqi
NP_001094241.1, NM_001100771.1
XP_006235167.1, XM_006235105.3
XP_006235168.1, XM_006235106.2
XP_017447439.1, XM_017591950.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000034487; ENSRNOP00000037915; ENSRNOG00000004777

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
366203

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:366203

UCSC genome browser

More...
UCSCi
RGD:1306067 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038233 mRNA Translation: BAD10946.1
RefSeqiNP_001094241.1, NM_001100771.1
XP_006235167.1, XM_006235105.3
XP_006235168.1, XM_006235106.2
XP_017447439.1, XM_017591950.1

3D structure databases

SMRiQ76MT4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037915

PTM databases

iPTMnetiQ76MT4
PhosphoSitePlusiQ76MT4

Proteomic databases

jPOSTiQ76MT4
PaxDbiQ76MT4
PRIDEiQ76MT4

Genome annotation databases

EnsembliENSRNOT00000034487; ENSRNOP00000037915; ENSRNOG00000004777
GeneIDi366203
KEGGirno:366203
UCSCiRGD:1306067 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51575
RGDi1306067 Esf1

Phylogenomic databases

eggNOGiKOG2318 Eukaryota
COG5638 LUCA
GeneTreeiENSGT00390000004881
HOGENOMiCLU_010564_2_1_1
InParanoidiQ76MT4
OMAiLTWDETA
OrthoDBi1300279at2759
PhylomeDBiQ76MT4

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q76MT4

Gene expression databases

BgeeiENSRNOG00000004777 Expressed in lung and 8 other tissues
GenevisibleiQ76MT4 RN

Family and domain databases

InterProiView protein in InterPro
IPR039754 Esf1
IPR012580 NUC153
PANTHERiPTHR12202 PTHR12202, 2 hits
PfamiView protein in Pfam
PF08159 NUC153, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESF1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q76MT4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: February 26, 2020
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again