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Protein

Coiled-coil domain-containing protein 80

Gene

CCDC80

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes cell adhesion and matrix assembly.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 80
Alternative name(s):
Down-regulated by oncogenes protein 1
Up-regulated in BRS-3 deficient mouse homolog
Gene namesi
Name:CCDC80
Synonyms:DRO1, URB
ORF Names:HBE245
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000091986.15
HGNCiHGNC:30649 CCDC80
MIMi608298 gene
neXtProtiNX_Q76M96

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi151887
OpenTargetsiENSG00000091986
PharmGKBiPA144596470

Polymorphism and mutation databases

DMDMi74712933

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000028241822 – 950Coiled-coil domain-containing protein 80Add BLAST929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki545Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki548Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ76M96
MaxQBiQ76M96
PaxDbiQ76M96
PeptideAtlasiQ76M96
PRIDEiQ76M96
ProteomicsDBi68685
68686 [Q76M96-2]
68687 [Q76M96-3]

PTM databases

GlyConnecti1124
iPTMnetiQ76M96
PhosphoSitePlusiQ76M96

Expressioni

Tissue specificityi

Expressed in dermal papilla and dermal fibroblasts (at protein level). Expressed in heart, thymus, placenta, pancreas, colon, epithelium, spleen and osteoblasts.3 Publications

Inductioni

Down-regulated in cancer and after osteoblastic differentiation. Up-regulated by dihydrotestosterone (DHT).2 Publications

Gene expression databases

BgeeiENSG00000091986 Expressed in 187 organ(s), highest expression level in parietal pleura
CleanExiHS_CCDC80
ExpressionAtlasiQ76M96 baseline and differential
GenevisibleiQ76M96 HS

Organism-specific databases

HPAiHPA002266

Interactioni

Subunit structurei

Binds to various extracellular matrix proteins.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127410, 3 interactors
IntActiQ76M96, 4 interactors
STRINGi9606.ENSP00000206423

Structurei

3D structure databases

ProteinModelPortaliQ76M96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili560 – 587Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi347 – 404Thr-richAdd BLAST58
Compositional biasi486 – 610Lys-richAdd BLAST125

Sequence similaritiesi

Belongs to the CCDC80 family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IJS1 Eukaryota
ENOG410XSSN LUCA
GeneTreeiENSGT00910000144117
HOVERGENiHBG104210
InParanoidiQ76M96
OMAiSPMWSMA
OrthoDBiEOG091G045R
PhylomeDBiQ76M96
TreeFamiTF332926

Family and domain databases

InterProiView protein in InterPro
IPR025232 DUF4174
PfamiView protein in Pfam
PF13778 DUF4174, 3 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q76M96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTWRMGPRFT MLLAMWLVCG SEPHPHATIR GSHGGRKVPL VSPDSSRPAR
60 70 80 90 100
FLRHTGRSRG IERSTLEEPN LQPLQRRRSV PVLRLARPTE PPARSDINGA
110 120 130 140 150
AVRPEQRPAA RGSPREMIRD EGSSARSRML RFPSGSSSPN ILASFAGKNR
160 170 180 190 200
VWVISAPHAS EGYYRLMMSL LKDDVYCELA ERHIQQIVLF HQAGEEGGKV
210 220 230 240 250
RRITSEGQIL EQPLDPSLIP KLMSFLKLEK GKFGMVLLKK TLQVEERYPY
260 270 280 290 300
PVRLEAMYEV IDQGPIRRIE KIRQKGFVQK CKASGVEGQV VAEGNDGGGG
310 320 330 340 350
AGRPSLGSEK KKEDPRRAQV PPTRESRVKV LRKLAATAPA LPQPPSTPRA
360 370 380 390 400
TTLPPAPATT VTRSTSRAVT VAARPMTTTA FPTTQRPWTP SPSHRPPTTT
410 420 430 440 450
EVITARRPSV SENLYPPSRK DQHRERPQTT RRPSKATSLE SFTNAPPTTI
460 470 480 490 500
SEPSTRAAGP GRFRDNRMDR REHGHRDPNV VPGPPKPAKE KPPKKKAQDK
510 520 530 540 550
ILSNEYEEKY DLSRPTASQL EDELQVGNVP LKKAKESKKH EKLEKPEKEK
560 570 580 590 600
KKKMKNENAD KLLKSEKQMK KSEKKSKQEK EKSKKKKGGK TEQDGYQKPT
610 620 630 640 650
NKHFTQSPKK SVADLLGSFE GKRRLLLITA PKAENNMYVQ QRDEYLESFC
660 670 680 690 700
KMATRKISVI TIFGPVNNST MKIDHFQLDN EKPMRVVDDE DLVDQRLISE
710 720 730 740 750
LRKEYGMTYN DFFMVLTDVD LRVKQYYEVP ITMKSVFDLI DTFQSRIKDM
760 770 780 790 800
EKQKKEGIVC KEDKKQSLEN FLSRFRWRRR LLVISAPNDE DWAYSQQLSA
810 820 830 840 850
LSGQACNFGL RHITILKLLG VGEEVGGVLE LFPINGSSVV EREDVPAHLV
860 870 880 890 900
KDIRNYFQVS PEYFSMLLVG KDGNVKSWYP SPMWSMVIVY DLIDSMQLRR
910 920 930 940 950
QEMAIQQSLG MRCPEDEYAG YGYHSYHQGY QDGYQDDYRH HESYHHGYPY
Length:950
Mass (Da):108,174
Last modified:July 5, 2004 - v1
Checksum:i67A1D4A7DD907AA0
GO
Isoform 2 (identifier: Q76M96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTSVHRKVDYTM

Show »
Length:961
Mass (Da):109,492
Checksum:i9EAE839A541AADF3
GO
Isoform 3 (identifier: Q76M96-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-865: Missing.

Show »
Length:85
Mass (Da):10,174
Checksum:iF43811D3541675A0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J8I6C9J8I6_HUMAN
Coiled-coil domain-containing prote...
CCDC80
212Annotation score:
H7C5K4H7C5K4_HUMAN
Coiled-coil domain-containing prote...
CCDC80
261Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti411S → L in BAC11475 (PubMed:14702039).Curated1
Sequence conflicti549E → K in AAH86876 (PubMed:15489334).Curated1
Sequence conflicti551K → E in AAH86876 (PubMed:15489334).Curated1
Sequence conflicti837S → G in AAH73164 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0241351 – 865Missing in isoform 3. 1 PublicationAdd BLAST865
Alternative sequenceiVSP_0241361M → MTSVHRKVDYTM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY333429 mRNA Translation: AAQ96742.1
AY548106 mRNA Translation: AAS66643.1
AY548107 mRNA Translation: AAS66644.1
AY526612 mRNA Translation: AAS92235.1
AB052098 mRNA Translation: BAD05134.1
AF506819 mRNA Translation: AAM33633.1
BX647817 mRNA Translation: CAH56167.1
BX647117 mRNA Translation: CAH56178.1
AL833034 mRNA Translation: CAH56325.1
CH471052 Genomic DNA Translation: EAW79663.1
CH471052 Genomic DNA Translation: EAW79665.1
BC042105 mRNA Translation: AAH42105.1
BC073164 mRNA Translation: AAH73164.1
BC086876 mRNA Translation: AAH86876.1
BC110842 mRNA Translation: AAI10843.1
BC116178 mRNA Translation: AAI16179.1
AK075210 mRNA Translation: BAC11475.1
CCDSiCCDS2968.1 [Q76M96-1]
RefSeqiNP_955805.1, NM_199511.2 [Q76M96-1]
NP_955806.1, NM_199512.2 [Q76M96-1]
UniGeneiHs.477128

Genome annotation databases

EnsembliENST00000206423; ENSP00000206423; ENSG00000091986 [Q76M96-1]
ENST00000439685; ENSP00000411814; ENSG00000091986 [Q76M96-1]
GeneIDi151887
KEGGihsa:151887
UCSCiuc003dzf.5 human [Q76M96-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY333429 mRNA Translation: AAQ96742.1
AY548106 mRNA Translation: AAS66643.1
AY548107 mRNA Translation: AAS66644.1
AY526612 mRNA Translation: AAS92235.1
AB052098 mRNA Translation: BAD05134.1
AF506819 mRNA Translation: AAM33633.1
BX647817 mRNA Translation: CAH56167.1
BX647117 mRNA Translation: CAH56178.1
AL833034 mRNA Translation: CAH56325.1
CH471052 Genomic DNA Translation: EAW79663.1
CH471052 Genomic DNA Translation: EAW79665.1
BC042105 mRNA Translation: AAH42105.1
BC073164 mRNA Translation: AAH73164.1
BC086876 mRNA Translation: AAH86876.1
BC110842 mRNA Translation: AAI10843.1
BC116178 mRNA Translation: AAI16179.1
AK075210 mRNA Translation: BAC11475.1
CCDSiCCDS2968.1 [Q76M96-1]
RefSeqiNP_955805.1, NM_199511.2 [Q76M96-1]
NP_955806.1, NM_199512.2 [Q76M96-1]
UniGeneiHs.477128

3D structure databases

ProteinModelPortaliQ76M96
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127410, 3 interactors
IntActiQ76M96, 4 interactors
STRINGi9606.ENSP00000206423

PTM databases

GlyConnecti1124
iPTMnetiQ76M96
PhosphoSitePlusiQ76M96

Polymorphism and mutation databases

DMDMi74712933

Proteomic databases

EPDiQ76M96
MaxQBiQ76M96
PaxDbiQ76M96
PeptideAtlasiQ76M96
PRIDEiQ76M96
ProteomicsDBi68685
68686 [Q76M96-2]
68687 [Q76M96-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000206423; ENSP00000206423; ENSG00000091986 [Q76M96-1]
ENST00000439685; ENSP00000411814; ENSG00000091986 [Q76M96-1]
GeneIDi151887
KEGGihsa:151887
UCSCiuc003dzf.5 human [Q76M96-1]

Organism-specific databases

CTDi151887
DisGeNETi151887
EuPathDBiHostDB:ENSG00000091986.15
GeneCardsiCCDC80
H-InvDBiHIX0003550
HGNCiHGNC:30649 CCDC80
HPAiHPA002266
MIMi608298 gene
neXtProtiNX_Q76M96
OpenTargetsiENSG00000091986
PharmGKBiPA144596470
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJS1 Eukaryota
ENOG410XSSN LUCA
GeneTreeiENSGT00910000144117
HOVERGENiHBG104210
InParanoidiQ76M96
OMAiSPMWSMA
OrthoDBiEOG091G045R
PhylomeDBiQ76M96
TreeFamiTF332926

Miscellaneous databases

ChiTaRSiCCDC80 human
GeneWikiiCCDC80
GenomeRNAii151887
PROiPR:Q76M96
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091986 Expressed in 187 organ(s), highest expression level in parietal pleura
CleanExiHS_CCDC80
ExpressionAtlasiQ76M96 baseline and differential
GenevisibleiQ76M96 HS

Family and domain databases

InterProiView protein in InterPro
IPR025232 DUF4174
PfamiView protein in Pfam
PF13778 DUF4174, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCCD80_HUMAN
AccessioniPrimary (citable) accession number: Q76M96
Secondary accession number(s): D3DN67
, Q5PR20, Q6GPG9, Q8IVT6, Q8NBV1, Q8NHY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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