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Entry version 108 (05 Jun 2019)
Sequence version 1 (05 Jul 2004)
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Protein

FH1/FH2 domain-containing protein 3

Gene

Fhod3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in actin filament polymerization in cardiomyocytes (By similarity). Actin-organizing protein that may cause stress fiber formation together with cell elongation.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FH1/FH2 domain-containing protein 3
Alternative name(s):
Formin homolog overexpressed in spleen 2
Short name:
mFHOS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fhod3
Synonyms:Fhos2, Kiaa1695
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1925847 Fhod3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002837921 – 1578FH1/FH2 domain-containing protein 3Add BLAST1578

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei345PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei413PhosphothreonineCombined sources1
Modified residuei921PhosphoserineCombined sources1
Modified residuei933PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q76LL6

PRoteomics IDEntifications database

More...
PRIDEi
Q76LL6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q76LL6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q76LL6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the heart, including left ventricle, kidney, brain and skeletal muscle, including soleus and tibialis anterior (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034295 Expressed in 281 organ(s), highest expression level in primary oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q76LL6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with nestin/NES-based interfilament (IF).

Interacts with SQSTM1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q76LL6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000041361

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q76LL6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 405GBD/FH3PROSITE-ProRule annotationAdd BLAST388
Domaini985 – 1016FH1Add BLAST32
Domaini1039 – 1435FH2PROSITE-ProRule annotationAdd BLAST397
Domaini1515 – 1547DADPROSITE-ProRule annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili597 – 645Sequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi553 – 596Ser-richAdd BLAST44
Compositional biasi784 – 793Poly-Ser10
Compositional biasi985 – 1016Pro-richAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the formin homology family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1925 Eukaryota
ENOG410XRBZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154807

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015130

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q76LL6

Identification of Orthologs from Complete Genome Data

More...
OMAi
FNIYEVA

Database of Orthologous Groups

More...
OrthoDBi
148001at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q76LL6

TreeFam database of animal gene trees

More...
TreeFami
TF316268

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.2220, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014767 DAD_dom
IPR015425 FH2_Formin
IPR042201 FH2_Formin_sf
IPR041387 FHOD1_GBD_N
IPR027651 FHOD3
IPR014768 GBD/FH3_dom

The PANTHER Classification System

More...
PANTHERi
PTHR45920:SF3 PTHR45920:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02181 FH2, 1 hit
PF18382 Formin_GBD_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00498 FH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51231 DAD, 1 hit
PS51444 FH2, 1 hit
PS51232 GBD_FH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Named isoforms=3.
Isoform 1 (identifier: Q76LL6-1) [UniParc]FASTAAdd to basket
Also known as: FHOS2L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATLACRVQF LDDTDPFNST NFPEPSRPPL FTFREDLALG TQLAGVHRLL
60 70 80 90 100
RAPHKLDDCT LQLSHNGAYL DLEATLAEQR DELEGFQDDT GRGKKNSIIL
110 120 130 140 150
RTQLSVRVHA CIEKLYNSSG RDLRRALFSL KQIFQDDKDL VHEFVIAEGL
160 170 180 190 200
TCLIKVGAEA DQNYQNYILR ALGQIMLYVD GMNGVINHSE TIQWLYTLVG
210 220 230 240 250
SKFRLVVKTA LKLLLVFVEY SESNAPLLIQ AVSAVDTKRG VKPWSNIMEI
260 270 280 290 300
LEEKDGVDTE LLVYAMTLVN KTLAGLPDQD TFYDVVDCLE ELGIAAVSQR
310 320 330 340 350
HLNKKGTDLD LLEQFNIYEV ALRHEDGDET AEPPPSGHRD RRRASMCSGG
360 370 380 390 400
TVGEQQGLDR RRSRRHSIQN IKSPLSAPTS PCSPSVPAFK PSQVRDLCEK
410 420 430 440 450
DEEEEEEEEQ PITEPNSEEE REDDAQCQGK DSKASSASGQ SSPGKDAAPE
460 470 480 490 500
SSALHTTSSP TSQGRWLSAS TAARSPVLGG TSGPEASRPA ARLLPPSPGL
510 520 530 540 550
ATRPSTAPKV SPTIDKLPYV PHSPFHLFSY DFEDSPLLTK DKGGDSQTEN
560 570 580 590 600
RYSNFSSNSF QSSRPSPGPS GSPSYASSFS SPQDTRSSPS GLLTSSFRQH
610 620 630 640 650
QESLAAERER RRQEREERLQ RIEREERNKF NREYLDKREE QRQARGERYK
660 670 680 690 700
YLEQLAAETQ EKEPRSQSVS RGRADLSLDL SLPAAPAPPS PSSQSPSADS
710 720 730 740 750
QEALPVPSSP PTLQCPQVSG KDHEPELEAE AGQGADEASQ DIASAHRGAE
760 770 780 790 800
SQEEPVLELE PEERASLSEK ERQNEEVNER DNCSASSISS SSSTLEREEK
810 820 830 840 850
EDKLSEDRAT GLWSTSLQDV GVNGQCGDIL TSKRFMLDML YAHNRKSTED
860 870 880 890 900
EEKDDGEPGR SAQEVEAVAS LATRISTLQA NSQAPEESIK RVDIGCLDNR
910 920 930 940 950
GSVKAFAEKF NSGEVGRGAI SPDVESQDKV PDTPPAQLKT ESDYIWDQLM
960 970 980 990 1000
ANPRELRIQD MDFTDLGEED DIDVLDVDLG HREAPGPPPP PPPTFLGLPP
1010 1020 1030 1040 1050
PPPPPLLDSV PPPPVPGNLL ASPVFNTPQG LGWSQVPRGQ PAFTKKKKTI
1060 1070 1080 1090 1100
RLFWNEVRPF EWPSKNNRRC REFLWSKLEP IKVDTSRLEH LFESKSKELS
1110 1120 1130 1140 1150
VTKKTAADGK RQEIIVLDSK RSNAINIGLT VLPPPRTIKI AILNFDEYAL
1160 1170 1180 1190 1200
NKEGIEKILT MIPTEEEKQK IQEAQLANPE VPLGSAEQFL LTLSSISELS
1210 1220 1230 1240 1250
ARLHLWAFKM DYETTEKEVA EPLLDLKEGI DQLENNKTLG FILSTLLAIG
1260 1270 1280 1290 1300
NFLNGTNAKA FELSYLEKVP EVKDTVHKQS LLHHVCTMVV ENFPDSSDLY
1310 1320 1330 1340 1350
SEIGAITRSA KVDFDQLQDN LCQMERRCKA SWDHLKAIAK HEMKPVLKQR
1360 1370 1380 1390 1400
MSEFLKDCAE RIIILKIVHR RIINRFHSFL LFMGHPPYAI REVNINKFCR
1410 1420 1430 1440 1450
IISEFALEYR TTRERVLQQK QKRANHRERN KTRGKMITDS GKFSGSSPAA
1460 1470 1480 1490 1500
PSQPQGLSYA EDAAEHENMK AVLKTSSPAL EDATPVLGVR TRSRASRGST
1510 1520 1530 1540 1550
SSWTMGTEES PSVTDDAADE IMDRIVKSAT QVPSQRVVPR ERKRSRANRK
1560 1570
SLRRTLKSGL TPEEARALGL VGTSELQL
Note: Major form in heart.
Length:1,578
Mass (Da):175,655
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9EE9B7354D51A70
GO
Isoform 2 (identifier: Q76LL6-2) [UniParc]FASTAAdd to basket
Also known as: FHOS2S

The sequence of this isoform differs from the canonical sequence as follows:
     401-551: Missing.

Note: Major form in kidney and brain.
Show »
Length:1,427
Mass (Da):159,682
Checksum:iE088AEDD88BA61E8
GO
Isoform 3 (identifier: Q76LL6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     401-551: Missing.
     992-1005: Missing.

Note: No experimental confirmation available.
Show »
Length:1,413
Mass (Da):158,276
Checksum:i6321BBA9B36FD3C2
GO
Isoform 4 (identifier: Q76LL6-4) [UniParc]FASTAAdd to basket
Also known as: FHOS2M

The sequence of this isoform differs from the canonical sequence as follows:
     400-432: KDEEEEEEEEQPITEPNSEEEREDDAQCQGKDS → N

Show »
Length:1,546
Mass (Da):171,905
Checksum:i76E2D19AC522F045
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti575Y → S in BAD90459 (Ref. 3) Curated1
Sequence conflicti690S → P in BAD90459 (Ref. 3) Curated1
Sequence conflicti856G → S in BAD90459 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024399400 – 432KDEEE…QGKDS → N in isoform 4. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_024400401 – 551Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST151
Alternative sequenceiVSP_024401992 – 1005Missing in isoform 3. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB078608 mRNA Translation: BAC98302.1
AB078609 mRNA Translation: BAC98303.1
AB100088 mRNA Translation: BAC98348.1
BC138046 mRNA Translation: AAI38047.1
AK220413 mRNA Translation: BAD90459.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29104.1 [Q76LL6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001276583.1, NM_001289654.1 [Q76LL6-2]
NP_001276584.1, NM_001289655.1 [Q76LL6-4]
NP_780485.2, NM_175276.4 [Q76LL6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000037097; ENSMUSP00000041361; ENSMUSG00000034295 [Q76LL6-1]
ENSMUST00000234526; ENSMUSP00000157193; ENSMUSG00000034295 [Q76LL6-4]
ENSMUST00000234834; ENSMUSP00000157226; ENSMUSG00000034295 [Q76LL6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
225288

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:225288

UCSC genome browser

More...
UCSCi
uc008ehb.2 mouse [Q76LL6-1]
uc008ehc.2 mouse [Q76LL6-2]
uc012bak.2 mouse [Q76LL6-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078608 mRNA Translation: BAC98302.1
AB078609 mRNA Translation: BAC98303.1
AB100088 mRNA Translation: BAC98348.1
BC138046 mRNA Translation: AAI38047.1
AK220413 mRNA Translation: BAD90459.1
CCDSiCCDS29104.1 [Q76LL6-1]
RefSeqiNP_001276583.1, NM_001289654.1 [Q76LL6-2]
NP_001276584.1, NM_001289655.1 [Q76LL6-4]
NP_780485.2, NM_175276.4 [Q76LL6-1]

3D structure databases

SMRiQ76LL6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ76LL6, 1 interactor
STRINGi10090.ENSMUSP00000041361

PTM databases

iPTMnetiQ76LL6
PhosphoSitePlusiQ76LL6

Proteomic databases

PaxDbiQ76LL6
PRIDEiQ76LL6

Genome annotation databases

EnsembliENSMUST00000037097; ENSMUSP00000041361; ENSMUSG00000034295 [Q76LL6-1]
ENSMUST00000234526; ENSMUSP00000157193; ENSMUSG00000034295 [Q76LL6-4]
ENSMUST00000234834; ENSMUSP00000157226; ENSMUSG00000034295 [Q76LL6-2]
GeneIDi225288
KEGGimmu:225288
UCSCiuc008ehb.2 mouse [Q76LL6-1]
uc008ehc.2 mouse [Q76LL6-2]
uc012bak.2 mouse [Q76LL6-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80206
MGIiMGI:1925847 Fhod3

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG1925 Eukaryota
ENOG410XRBZ LUCA
GeneTreeiENSGT00940000154807
HOGENOMiHOG000015130
InParanoidiQ76LL6
OMAiFNIYEVA
OrthoDBi148001at2759
PhylomeDBiQ76LL6
TreeFamiTF316268

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Fhod3 mouse

Protein Ontology

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PROi
PR:Q76LL6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000034295 Expressed in 281 organ(s), highest expression level in primary oocyte
GenevisibleiQ76LL6 MM

Family and domain databases

Gene3Di1.20.58.2220, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014767 DAD_dom
IPR015425 FH2_Formin
IPR042201 FH2_Formin_sf
IPR041387 FHOD1_GBD_N
IPR027651 FHOD3
IPR014768 GBD/FH3_dom
PANTHERiPTHR45920:SF3 PTHR45920:SF3, 1 hit
PfamiView protein in Pfam
PF02181 FH2, 1 hit
PF18382 Formin_GBD_N, 1 hit
SMARTiView protein in SMART
SM00498 FH2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51231 DAD, 1 hit
PS51444 FH2, 1 hit
PS51232 GBD_FH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFHOD3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q76LL6
Secondary accession number(s): B2RQR3
, Q5DTV7, Q76HP7, Q76LL5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 5, 2004
Last modified: June 5, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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