UniProtKB - Q76LC6 (RBM24_DANRE)
RNA-binding protein 24
rbm24
Functioni
Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. Plays a role in the regulation of mRNA stability and mRNA translation to which it is bound. Involved in myogenic differentiation by regulating myog levels. Binds to a huge amount of mRNAs (By similarity).
Required for embryonic heart development, sarcomer and M-band formation in striated muscles (PubMed:22345307).
By similarity1 PublicationGO - Molecular functioni
- mRNA 3'-UTR AU-rich region binding Source: UniProtKB
- mRNA 3'-UTR binding Source: UniProtKB
- mRNA CDS binding Source: UniProtKB
- pre-mRNA intronic binding Source: UniProtKB
- sequence-specific mRNA binding Source: UniProtKB
GO - Biological processi
- 3'-UTR-mediated mRNA destabilization Source: UniProtKB
- atrial cardiac muscle tissue development Source: ZFIN
- cell differentiation Source: UniProtKB-KW
- cellular response to DNA damage stimulus Source: UniProtKB
- circulatory system development Source: ZFIN
- embryonic neurocranium morphogenesis Source: ZFIN
- heart looping Source: ZFIN
- mRNA destabilization Source: UniProtKB
- mRNA processing Source: ZFIN
- mRNA stabilization Source: UniProtKB
- negative regulation of cytoplasmic translation Source: UniProtKB
- positive regulation of 3'-UTR-mediated mRNA stabilization Source: UniProtKB
- positive regulation of myoblast differentiation Source: UniProtKB
- positive regulation of myotube differentiation Source: UniProtKB
- positive regulation of sarcomere organization Source: UniProtKB
- positive regulation of skeletal muscle fiber differentiation Source: UniProtKB
- positive regulation of stem cell differentiation Source: UniProtKB
- regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
- regulation of mRNA stability Source: UniProtKB
- regulation of myotube differentiation Source: UniProtKB
- regulation of sarcomere organization Source: ZFIN
- RNA splicing Source: UniProtKB-KW
- skeletal muscle tissue development Source: ZFIN
- somitogenesis Source: ZFIN
Keywordsi
Molecular function | RNA-binding |
Biological process | Differentiation, mRNA processing, mRNA splicing, Translation regulation |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein 24CuratedAlternative name(s): RNA-binding motif protein 24By similarity RNA-binding protein SEB-4By similarity |
Gene namesi | Name:rbm24 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040628-1, rbm24a |
Pathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000273372 | 1 – 230 | RNA-binding protein 24Add BLAST | 230 |
Proteomic databases
PaxDbi | Q76LC6 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | ENSDARG00000102995, Expressed in somite and 49 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 88 | RRMPROSITE-ProRule annotationAdd BLAST | 78 |
Domaini
Phylogenomic databases
eggNOGi | KOG0149, Eukaryota |
GeneTreei | ENSGT00940000156245 |
HOGENOMi | CLU_065652_0_1_1 |
InParanoidi | Q76LC6 |
OrthoDBi | 1579773at2759 |
PhylomeDBi | Q76LC6 |
TreeFami | TF314235 |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MHTTQKDTTY TKIFVGGLPY HTTDSSLRKY FEVFGEIEEA VVITDRQTGK
60 70 80 90 100
SRGYGFVTMA DRSAADRACK DPNPIIDGRK ANVNLAYLGA KPRVMQPGFT
110 120 130 140 150
FGVPQIHPAF IQRPYGIPTH YVYPQAFMQP SVVIPHIQPT ATSATASSPY
160 170 180 190 200
IDYTGAAYAQ YASAATAAAA AAYEQYPYAA SPAATGYVAA AGYGYAMQQP
210 220 230
LATAAPGSAA AAAAAFGQYQ PQQLQAERMQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4ICY2 | A0A0R4ICY2_DANRE | RNA-binding motif protein 24a | rbm24a | 116 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB080735 mRNA Translation: BAD12194.1 |
RefSeqi | NP_998030.1, NM_212865.1 |
Genome annotation databases
Ensembli | ENSDART00000161826; ENSDARP00000135480; ENSDARG00000102995 |
GeneIDi | 405801 |
KEGGi | dre:405801 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB080735 mRNA Translation: BAD12194.1 |
RefSeqi | NP_998030.1, NM_212865.1 |
3D structure databases
AlphaFoldDBi | Q76LC6 |
SMRi | Q76LC6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000100853 |
Proteomic databases
PaxDbi | Q76LC6 |
Genome annotation databases
Ensembli | ENSDART00000161826; ENSDARP00000135480; ENSDARG00000102995 |
GeneIDi | 405801 |
KEGGi | dre:405801 |
Organism-specific databases
CTDi | 405801 |
ZFINi | ZDB-GENE-040628-1, rbm24a |
Phylogenomic databases
eggNOGi | KOG0149, Eukaryota |
GeneTreei | ENSGT00940000156245 |
HOGENOMi | CLU_065652_0_1_1 |
InParanoidi | Q76LC6 |
OrthoDBi | 1579773at2759 |
PhylomeDBi | Q76LC6 |
TreeFami | TF314235 |
Miscellaneous databases
PROi | PR:Q76LC6 |
Gene expression databases
Bgeei | ENSDARG00000102995, Expressed in somite and 49 other tissues |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RBM24_DANRE | |
Accessioni | Q76LC6Primary (citable) accession number: Q76LC6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |