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UniProtKB - Q76L82 (Q76L82_HUMAN)
Protein
Submitted name:
Additional sex combs like 1 (Drosophila), isoform CRA_d
Gene
ASXL1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | RepressorARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Additional sex combs like 1 (Drosophila), isoform CRA_dImportedSubmitted name: Polycomb group proteinImportedSubmitted name: Polycomb group protein ASXL1Imported |
Gene namesi | ORF Names:hCG_38816Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18318, ASXL1 |
VEuPathDBi | HostDB:ENSG00000171456 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000171456, Expressed in stomach and 237 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 81 | HTH HARE-typeInterPro annotationAdd BLAST | 75 | |
Domaini | 250 – 359 | DEUBADInterPro annotationAdd BLAST | 110 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 89 – 164 | DisorderedSequence analysisAdd BLAST | 76 | |
Regioni | 188 – 207 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 388 – 541 | DisorderedSequence analysisAdd BLAST | 154 | |
Regioni | 632 – 714 | DisorderedSequence analysisAdd BLAST | 83 | |
Regioni | 770 – 878 | DisorderedSequence analysisAdd BLAST | 109 | |
Regioni | 897 – 946 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 984 – 1039 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 1120 – 1140 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1190 – 1299 | DisorderedSequence analysisAdd BLAST | 110 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 105 – 158 | Polar residuesSequence analysisAdd BLAST | 54 | |
Compositional biasi | 192 – 207 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 393 – 429 | Basic and acidic residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 834 – 853 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 904 – 920 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 996 – 1027 | Basic and acidic residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 1220 – 1243 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1244 – 1298 | Polar residuesSequence analysisAdd BLAST | 55 |
Sequence similaritiesi
Belongs to the Asx family.ARBA annotation
Keywords - Domaini
Zinc-fingerARBA annotationPhylogenomic databases
GeneTreei | ENSGT00520000055578 |
Family and domain databases
InterProi | View protein in InterPro IPR026905, ASX-like_PHD IPR024811, ASX/ASX-like IPR028020, ASX_DEUBAD_dom IPR024815, ASXL1 IPR007759, Asxl_HARE-HTH IPR044867, DEUBAD_dom |
PANTHERi | PTHR13578, PTHR13578, 1 hit PTHR13578:SF19, PTHR13578:SF19, 1 hit |
Pfami | View protein in Pfam PF13919, ASXH, 1 hit PF05066, HARE-HTH, 1 hit PF13922, PHD_3, 1 hit |
PROSITEi | View protein in PROSITE PS51916, DEUBAD, 1 hit PS51913, HTH_HARE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
Q76L82-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVVNFVFRA SEDLQVLENY SDAPMTPKQI LQVIEAEGLK EMSGTSPLAC
60 70 80 90 100
LNAMLHSNSR GGEGLFYKLP GRISLFTLKK DALQWSRHPA TVEGEEPEDT
110 120 130 140 150
ADVESCGSNE ASTVSGENDV SLDETSSNAS CSTESQSRPL SNPRDSYRAS
160 170 180 190 200
SQANKQKKKT GVMLPRVVLT PLKVNGAHVE SASGFSGCHA DGESGSPSSS
210 220 230 240 250
SSGSLALGSA AIRGQAEVTQ DPAPLLRGFR KPATGQMKRN RGEEIDFETP
260 270 280 290 300
GSILVNTNLR ALINSRTFHA LPSHFQQQLL FLLPEVDRQV GTDGLLRLSS
310 320 330 340 350
SALNNEFFTH AAQSWRERLA DGEFTHEMQV RIRQEMEKEK KVEQWKEKFF
360 370 380 390 400
EDYYGQKLGL TKEESLQQNV GQEEAEIKSG LCVPGESVRI QRGPATRQRD
410 420 430 440 450
GHFKKRSRPD LRTRARRNLY KKQESEQAGV AKDAKSVASD VPLYKDGEAK
460 470 480 490 500
TDPAGLSSPH LPGTSSAAPD LEGPEFPVES VASRIQAEPD NLARASASPD
510 520 530 540 550
RIPSLPQETV DQEPKDQKRK SFEQAASASF PEKKPRLEDR QSFRNTIESV
560 570 580 590 600
HTEKPQPTKE EPKVPPIRIQ LSRIKPPWVV KGQPTYQICP RIIPTTESSC
610 620 630 640 650
RGWTGARTLA DIKARALQVR GARGHHCHRE AATTAIGGGG GPGGGGGGAT
660 670 680 690 700
DEGGGRGSSS GDGGEACGHP EPRGGPSTPG KCTSDLQRTQ LLPPYPLNGE
710 720 730 740 750
HTQAGTAMSR ARREDLPSLR KEESCLLQRA TVGLTDGLGD ASQLPVAPTG
760 770 780 790 800
DQPCQALPLL SSQTSVAERL VEQPQLHPDV RTECESGTTS WESDDEEQGP
810 820 830 840 850
TVPADNGPIP SLVGDDTLEK GTGQALDSHP TMKDPVNVTP SSTPESSPTD
860 870 880 890 900
CLQNRAFDDE LGLGGSCPPM RESDTRQENL KTKALVSNSS LHWIPIPSND
910 920 930 940 950
EVVKQPKPES REHIPSVEPQ VGEEWEKAAP TPPALPGDLT AEEGLDPLDS
960 970 980 990 1000
LTSLWTVPSR GGSDSNGSYC QQVDIEKLKI NGDSEALSPH GESTDTASDF
1010 1020 1030 1040 1050
EGHLTEDSSE ADTREAAVTK GSSVDKDEKP NWNQSAPLSK VNGDMRLVTR
1060 1070 1080 1090 1100
TDGMVAPQSW VSRVCAVRQK IPDSLLLAST EYQPRAVCLS MPGSSVEATN
1110 1120 1130 1140 1150
PLVMQLLQGS LPLEKVLPPA HDDSMSESPQ VPLTKDQSHG SLRMGSLHGL
1160 1170 1180 1190 1200
GKNSGMVDGS SPSSLRALKE PLLPDSCETG TGLARIEATQ APGAPQKNCK
1210 1220 1230 1240 1250
AVPSFDSLHP VTNPITSSRK LEEMDSKEQF SSFSCEDQKE VRAMSQDSNS
1260 1270 1280 1290 1300
NAAPGKSPGD LTTSRTPRFS SPNVISFGPE QTGRALGDQS NVTGQGKKLF
1310 1320 1330 1340 1350
GSGNVAATLQ RPRPADPMPL PAEIPPVFPS GKLGPSTNSM SGGVQTPRED
1360 1370 1380 1390 1400
WAPKPHAFVG SVKNEKTFVG GPLKANAENR KATGHSPLEL VGHLEGMPFV
1410 1420 1430 1440 1450
MDLPFWKLPR EPGKGLSEPL EPSSLPSQLS IKQAFYGKLS KLQLSSTSFN
1460 1470 1480 1490 1500
YSSSSPTFPK GLAGSVVQLS HKANFGASHS ASLSLQMFTD SSTVESISLQ
1510 1520 1530
CACSLKAMIM CQGCGAFCHD DCIGPSKLCV LCLVVR
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8IXJ9 | ASXL1_HUMAN | Polycomb group protein ASXL1 | ASXL1 KIAA0978 | 1,541 | Annotation score: | ||
A0A2R8Y5U1 | A0A2R8Y5U1_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 1,480 | Annotation score: | ||
A0A494C1R1 | A0A494C1R1_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 625 | Annotation score: | ||
A0A2R8Y627 | A0A2R8Y627_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 135 | Annotation score: | ||
Q498B9 | Q498B9_HUMAN | ASXL1 protein | ASXL1 | 85 | Annotation score: | ||
Q5JWS8 | Q5JWS8_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 81 | Annotation score: | ||
H0YJC9 | H0YJC9_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 75 | Annotation score: | ||
A0A2R8Y6V0 | A0A2R8Y6V0_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 78 | Annotation score: | ||
A0A2R8Y4U9 | A0A2R8Y4U9_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 85 | Annotation score: | ||
A0A2R8Y6F0 | A0A2R8Y6F0_HUMAN | Polycomb group protein ASXL1 | ASXL1 | 75 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL034550 Genomic DNA No translation available. AL121583 Genomic DNA No translation available. KF495689 Genomic DNA No translation available. AB084280 mRNA Translation: BAD00087.1 CH471077 Genomic DNA Translation: EAW76380.1 |
Genome annotation databases
Ensembli | ENST00000306058; ENSP00000305119; ENSG00000171456 |
UCSCi | uc061wen.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL034550 Genomic DNA No translation available. AL121583 Genomic DNA No translation available. KF495689 Genomic DNA No translation available. AB084280 mRNA Translation: BAD00087.1 CH471077 Genomic DNA Translation: EAW76380.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 1299 |
Protocols and materials databases
Antibodypediai | 10384, 111 antibodies from 25 providers |
Genome annotation databases
Ensembli | ENST00000306058; ENSP00000305119; ENSG00000171456 |
UCSCi | uc061wen.1, human |
Organism-specific databases
HGNCi | HGNC:18318, ASXL1 |
OpenTargetsi | ENSG00000171456 |
VEuPathDBi | HostDB:ENSG00000171456 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00520000055578 |
Miscellaneous databases
ChiTaRSi | ASXL1, human |
Gene expression databases
Bgeei | ENSG00000171456, Expressed in stomach and 237 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR026905, ASX-like_PHD IPR024811, ASX/ASX-like IPR028020, ASX_DEUBAD_dom IPR024815, ASXL1 IPR007759, Asxl_HARE-HTH IPR044867, DEUBAD_dom |
PANTHERi | PTHR13578, PTHR13578, 1 hit PTHR13578:SF19, PTHR13578:SF19, 1 hit |
Pfami | View protein in Pfam PF13919, ASXH, 1 hit PF05066, HARE-HTH, 1 hit PF13922, PHD_3, 1 hit |
PROSITEi | View protein in PROSITE PS51916, DEUBAD, 1 hit PS51913, HTH_HARE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q76L82_HUMAN | |
Accessioni | Q76L82Primary (citable) accession number: Q76L82 Secondary accession number(s): A6NIZ6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | January 19, 2022 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |