UniProtKB - Q76KF5 (Q76KF5_ENTHI)
Protein
Submitted name:
D 3 phosphoglycerate dehydrogenase putative
Gene
EhPGDH
Organism
Entamoeba histolytica
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 241 | NADCombined sources | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 142 – 143 | NADCombined sources | 2 | |
Nucleotide bindingi | 162 – 164 | NADCombined sources | 3 | |
Nucleotide bindingi | 215 – 217 | NADCombined sources | 3 | |
Nucleotide bindingi | 263 – 266 | NADCombined sources | 4 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- NAD binding Source: InterPro
- phosphoglycerate dehydrogenase activity Source: GO_Central
GO - Biological processi
- cellular amino acid metabolic process Source: GO_Central
Keywordsi
Molecular function | OxidoreductaseUniRule annotationImported |
Ligand | NADCombined sources, Nucleotide-bindingCombined sources |
Enzyme and pathway databases
BRENDAi | 1.1.1.95 2080 |
Names & Taxonomyi
Protein namesi | Submitted name: D 3 phosphoglycerate dehydrogenase putativeImportedSubmitted name: D-3-phosphoglycerate dehydrogenase, putativeImported (EC:1.1.1.95Imported)Submitted name: D-phosphoglycerate dehydrogenaseImported |
Gene namesi | Name:EhPGDHImported ORF Names:CL6EHI_060860Imported, EHI_060860Imported |
Organismi | Entamoeba histolyticaImported |
Taxonomic identifieri | 5759 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Archamoebae › Entamoebidae › Entamoeba |
Proteomesi |
|
Organism-specific databases
EuPathDBi | AmoebaDB:EHI_060860 |
Interactioni
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
MINTi | Q76KF5 |
STRINGi | 5759.rna_EHI_060860-1 |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4NFY | X-ray | 2.45 | A/B | 1-299 | [»] | |
4NJM | X-ray | 1.79 | A/B | 1-299 | [»] | |
4NJO | X-ray | 2.22 | A/B | 1-299 | [»] | |
SMRi | Q76KF5 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 297 | 2-Hacid_dhInterPro annotationAdd BLAST | 279 | |
Domaini | 124 – 247 | 2-Hacid_dh_CInterPro annotationAdd BLAST | 124 |
Sequence similaritiesi
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG0068 Eukaryota COG0111 LUCA |
KOi | K00058 |
OMAi | MICNTAR |
OrthoDBi | 911009at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR006139 D-isomer_2_OHA_DH_cat_dom IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
Q76KF5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIVVITEKP FAENAVKGIR EILEKAGHEV VMIEKYKKKE DVIERIKDAD
60 70 80 90 100
GVIVRSDKID EEIIKAGEKV KIIVRAGAGY DNIDIEACNQ GKIVVMNTPG
110 120 130 140 150
QNRNGVAELC IGMMIFGFRK GFKEGKGREL KDKTLGICGC GYVGKRVKEI
160 170 180 190 200
AEGIGMKIKV YDPFITTENQ VKKIEELFEE CQVISLHLPL TKETKGKIGY
210 220 230 240 250
ELIKKLPYGG MICNTARKEI IDEEGLIRIM REREDLIYIT DVAPTSKVFN
260 270 280 290
NEFKGRFFAT PIKIGAETEE SNINAGMAAA SQICDFFTNG TVKFQVNKF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB091512 Genomic DNA Translation: BAD00050.1 AK420447 mRNA Translation: BAN39060.1 DS571413 Genomic DNA Translation: EAL46754.1 BDEQ01000001 Genomic DNA Translation: GAT98393.1 |
RefSeqi | XP_652140.1, XM_647048.1 |
Genome annotation databases
EnsemblProtistsi | GAT98393; GAT98393; CL6EHI_060860 rna_EHI_060860-1; rna_EHI_060860-1; EHI_060860 |
GeneIDi | 3406457 |
KEGGi | ehi:EHI_060860 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB091512 Genomic DNA Translation: BAD00050.1 AK420447 mRNA Translation: BAN39060.1 DS571413 Genomic DNA Translation: EAL46754.1 BDEQ01000001 Genomic DNA Translation: GAT98393.1 |
RefSeqi | XP_652140.1, XM_647048.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4NFY | X-ray | 2.45 | A/B | 1-299 | [»] | |
4NJM | X-ray | 1.79 | A/B | 1-299 | [»] | |
4NJO | X-ray | 2.22 | A/B | 1-299 | [»] | |
SMRi | Q76KF5 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
MINTi | Q76KF5 |
STRINGi | 5759.rna_EHI_060860-1 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
EnsemblProtistsi | GAT98393; GAT98393; CL6EHI_060860 rna_EHI_060860-1; rna_EHI_060860-1; EHI_060860 |
GeneIDi | 3406457 |
KEGGi | ehi:EHI_060860 |
Organism-specific databases
EuPathDBi | AmoebaDB:EHI_060860 |
Phylogenomic databases
eggNOGi | KOG0068 Eukaryota COG0111 LUCA |
KOi | K00058 |
OMAi | MICNTAR |
OrthoDBi | 911009at2759 |
Enzyme and pathway databases
BRENDAi | 1.1.1.95 2080 |
Family and domain databases
InterProi | View protein in InterPro IPR006139 D-isomer_2_OHA_DH_cat_dom IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | Q76KF5_ENTHI | |
Accessioni | Q76KF5Primary (citable) accession number: Q76KF5 Secondary accession number(s): A0A175JYE6, C4M9N0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 13, 2019 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |