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Entry version 119 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Semaphorin-6D

Gene

Sema6d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-416700 Other semaphorin interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Semaphorin-6D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sema6d
Synonyms:Kiaa1479
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2387661 Sema6d

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 662ExtracellularSequence analysisAdd BLAST642
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei663 – 683HelicalSequence analysisAdd BLAST21
Topological domaini684 – 1073CytoplasmicSequence analysisAdd BLAST390

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004461621 – 1073Semaphorin-6DAdd BLAST1053

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi108 ↔ 118PROSITE-ProRule annotation
Disulfide bondi136 ↔ 145PROSITE-ProRule annotation
Disulfide bondi259 ↔ 370PROSITE-ProRule annotation
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi284 ↔ 329PROSITE-ProRule annotation
Glycosylationi435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi477 ↔ 506PROSITE-ProRule annotation
Disulfide bondi515 ↔ 533PROSITE-ProRule annotation
Disulfide bondi521 ↔ 568PROSITE-ProRule annotation
Disulfide bondi525 ↔ 541PROSITE-ProRule annotation
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei723PhosphoserineCombined sources1
Modified residuei734PhosphoserineCombined sources1
Modified residuei744PhosphoserineBy similarity1
Modified residuei773PhosphothreonineBy similarity1
Modified residuei931PhosphoserineBy similarity1
Modified residuei957PhosphoserineBy similarity1
Modified residuei983PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q76KF0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q76KF0

PRoteomics IDEntifications database

More...
PRIDEi
Q76KF0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q76KF0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q76KF0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027200 Expressed in 270 organ(s), highest expression level in brain blood vessel

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q76KF0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q76KF0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
229581, 8 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099529

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q76KF0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q76KF0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 512SemaPROSITE-ProRule annotationAdd BLAST486
Domaini514 – 569PSIAdd BLAST56

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3611 Eukaryota
ENOG410XQZC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159303

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q76KF0

KEGG Orthology (KO)

More...
KOi
K06842

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCKKACI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q76KF0

TreeFam database of animal gene trees

More...
TreeFami
TF316102

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002165 Plexin_repeat
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11036 PTHR11036, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00630 Sema, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912 SSF101912, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51004 SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 4 (identifier: Q76KF0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGFLLLWFCV LFLLVSRLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG
60 70 80 90 100
NESQHRLDFQ LMLKIRDTLY IAGRDQVYTV NLNEIPQTEV IPSKKLTWRS
110 120 130 140 150
RQQDRENCAM KGKHKDECHN FIKVFVPRND EMVFVCGTNA FNPMCRYYRL
160 170 180 190 200
RTLEYDGEEI SGLARCPFDA RQTNVALFAD GKLYSATVAD FLASDAVIYR
210 220 230 240 250
SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI AVEHNNLGKA
260 270 280 290 300
VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI
310 320 330 340 350
TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF KGRFKEQKTP
360 370 380 390 400
DSVWTAVPED KVPKPRPGCC AKHGLAEAYK TSIDFPDDTL AFIKSHPLMD
410 420 430 440 450
SAVPPIADEP WFTKTRVRYR LTAIEVDRSA GPYQNYTVIF VGSEAGVVLK
460 470 480 490 500
VLAKTSPFSL NDSVLLEEIE AYNPAKCSAE SEEDRKVVSL QLDKDHHALY
510 520 530 540 550
VAFSSCVVRI PLSRCERYGS CKKSCIASRD PYCGWLSQGV CERVTLGMLP
560 570 580 590 600
GGYEQDTEYG NTAHLGDCHE SLPPSTTPDY KIFGGPTSDM EVSSSSVTTV
610 620 630 640 650
ASSPEITSKV IDTWRPKLTS SRKFVVQDDP NTSDFTDTIS GIPKGVRWEV
660 670 680 690 700
QSGESNQMVH MNVLITCVFA AFVLGAFIAG VAVYCYRDMF VRKNRKIHKD
710 720 730 740 750
AESAQSCTDS SGSFAKLNGL FDSPVKEYQQ NIDSPKLYSN LLTSRKELPP
760 770 780 790 800
NTDTKSMAVD HRGQPPELAA LPTPESTPVL HQKTLQAMKS HSEKAHSHGA
810 820 830 840 850
SRKEHPQFFP SSPPPHSPLS HGHIPSAIVL PNATHDYNTS FSNSNAHKAE
860 870 880 890 900
KKLQSMDHPL TKSSSKREHR RSVDSRNTLN DLLKHLNDPN SNPKAILGEI
910 920 930 940 950
HMAHQTLMLD PVGPMAEVPP KVPNREASLY SPPSTLPRNS PTKRVDVPTT
960 970 980 990 1000
PGVPMTSLER QRGYHKNSSQ RHSISAVPKN LNSPNGVLLS RQPSMNRGGY
1010 1020 1030 1040 1050
MPTPTGAKVD YIQGTPVSVH LQPSLSRQSS YTSNGTLPRT GLKRTPSLKP
1060 1070
DVPPKPSFVP QTTSVRPLNK YTY
Length:1,073
Mass (Da):119,815
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD985053A2D37DA2A
GO
Isoform 1 (identifier: Q76KF0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     549-549: L → LLLTEDFFAFHNHS
     570-644: Missing.

Show »
Length:1,011
Mass (Da):113,327
Checksum:i33AA586827B5E05F
GO
Isoform 2 (identifier: Q76KF0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     570-644: Missing.

Show »
Length:998
Mass (Da):111,767
Checksum:iF1D2265365C13D1E
GO
Isoform 3 (identifier: Q76KF0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     589-644: Missing.

Show »
Length:1,017
Mass (Da):113,743
Checksum:iCA765719599CABDE
GO
Isoform 5 (identifier: Q76KF0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     549-549: L → LLLTEDFFAFHNHS
     589-644: Missing.

Show »
Length:1,030
Mass (Da):115,303
Checksum:i27705EDF0464989A
GO
Isoform 6 (identifier: Q76KF0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     570-588: Missing.

Show »
Length:1,054
Mass (Da):117,839
Checksum:iC059C768C186ABD5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AW73A2AW73_MOUSE
Semaphorin-6D
Sema6d
1,069Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC65797 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016568549L → LLLTEDFFAFHNHS in isoform 1 and isoform 5. 1 Publication1
Alternative sequenceiVSP_016569570 – 644Missing in isoform 1 and isoform 2. 3 PublicationsAdd BLAST75
Alternative sequenceiVSP_016570570 – 588Missing in isoform 6. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_016571589 – 644Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB091532 mRNA Translation: BAD05168.1
AB091533 mRNA Translation: BAD05169.1
AB091534 mRNA Translation: BAD05170.1
AB091535 mRNA Translation: BAD05171.1
AB091536 mRNA Translation: BAD05172.1
AK122515 mRNA Translation: BAC65797.1 Different initiation.
AL935323 Genomic DNA No translation available.
BC060680 mRNA Translation: AAH60680.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16670.1 [Q76KF0-2]
CCDS16671.1 [Q76KF0-3]
CCDS16672.1 [Q76KF0-6]
CCDS16673.1 [Q76KF0-1]
CCDS38225.1 [Q76KF0-5]

NCBI Reference Sequences

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RefSeqi
NP_001277926.1, NM_001290997.1 [Q76KF0-3]
NP_001277929.1, NM_001291000.1
NP_766125.2, NM_172537.4 [Q76KF0-2]
NP_954708.1, NM_199238.3 [Q76KF0-3]
NP_954709.1, NM_199239.3 [Q76KF0-5]
NP_954710.1, NM_199240.3 [Q76KF0-6]
NP_954711.1, NM_199241.3 [Q76KF0-1]
XP_011237729.1, XM_011239427.2 [Q76KF0-6]
XP_017172490.1, XM_017317001.1 [Q76KF0-1]
XP_017172501.1, XM_017317012.1 [Q76KF0-6]
XP_017172508.1, XM_017317019.1 [Q76KF0-5]
XP_017172510.1, XM_017317021.1 [Q76KF0-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000051419; ENSMUSP00000061123; ENSMUSG00000027200 [Q76KF0-2]
ENSMUST00000076335; ENSMUSP00000075674; ENSMUSG00000027200 [Q76KF0-3]
ENSMUST00000077847; ENSMUSP00000077014; ENSMUSG00000027200 [Q76KF0-6]
ENSMUST00000078621; ENSMUSP00000077691; ENSMUSG00000027200 [Q76KF0-5]
ENSMUST00000103238; ENSMUSP00000099528; ENSMUSG00000027200 [Q76KF0-6]
ENSMUST00000103239; ENSMUSP00000099529; ENSMUSG00000027200 [Q76KF0-1]
ENSMUST00000103241; ENSMUSP00000099531; ENSMUSG00000027200 [Q76KF0-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
214968

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:214968

UCSC genome browser

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UCSCi
uc008mbk.2 mouse [Q76KF0-3]
uc008mbo.2 mouse [Q76KF0-2]
uc056zpa.1 mouse [Q76KF0-5]
uc056zpb.1 mouse [Q76KF0-1]
uc056zpc.1 mouse [Q76KF0-6]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB091532 mRNA Translation: BAD05168.1
AB091533 mRNA Translation: BAD05169.1
AB091534 mRNA Translation: BAD05170.1
AB091535 mRNA Translation: BAD05171.1
AB091536 mRNA Translation: BAD05172.1
AK122515 mRNA Translation: BAC65797.1 Different initiation.
AL935323 Genomic DNA No translation available.
BC060680 mRNA Translation: AAH60680.1
CCDSiCCDS16670.1 [Q76KF0-2]
CCDS16671.1 [Q76KF0-3]
CCDS16672.1 [Q76KF0-6]
CCDS16673.1 [Q76KF0-1]
CCDS38225.1 [Q76KF0-5]
RefSeqiNP_001277926.1, NM_001290997.1 [Q76KF0-3]
NP_001277929.1, NM_001291000.1
NP_766125.2, NM_172537.4 [Q76KF0-2]
NP_954708.1, NM_199238.3 [Q76KF0-3]
NP_954709.1, NM_199239.3 [Q76KF0-5]
NP_954710.1, NM_199240.3 [Q76KF0-6]
NP_954711.1, NM_199241.3 [Q76KF0-1]
XP_011237729.1, XM_011239427.2 [Q76KF0-6]
XP_017172490.1, XM_017317001.1 [Q76KF0-1]
XP_017172501.1, XM_017317012.1 [Q76KF0-6]
XP_017172508.1, XM_017317019.1 [Q76KF0-5]
XP_017172510.1, XM_017317021.1 [Q76KF0-4]

3D structure databases

SMRiQ76KF0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi229581, 8 interactors
STRINGi10090.ENSMUSP00000099529

PTM databases

iPTMnetiQ76KF0
PhosphoSitePlusiQ76KF0

Proteomic databases

jPOSTiQ76KF0
PaxDbiQ76KF0
PRIDEiQ76KF0

Genome annotation databases

EnsembliENSMUST00000051419; ENSMUSP00000061123; ENSMUSG00000027200 [Q76KF0-2]
ENSMUST00000076335; ENSMUSP00000075674; ENSMUSG00000027200 [Q76KF0-3]
ENSMUST00000077847; ENSMUSP00000077014; ENSMUSG00000027200 [Q76KF0-6]
ENSMUST00000078621; ENSMUSP00000077691; ENSMUSG00000027200 [Q76KF0-5]
ENSMUST00000103238; ENSMUSP00000099528; ENSMUSG00000027200 [Q76KF0-6]
ENSMUST00000103239; ENSMUSP00000099529; ENSMUSG00000027200 [Q76KF0-1]
ENSMUST00000103241; ENSMUSP00000099531; ENSMUSG00000027200 [Q76KF0-3]
GeneIDi214968
KEGGimmu:214968
UCSCiuc008mbk.2 mouse [Q76KF0-3]
uc008mbo.2 mouse [Q76KF0-2]
uc056zpa.1 mouse [Q76KF0-5]
uc056zpb.1 mouse [Q76KF0-1]
uc056zpc.1 mouse [Q76KF0-6]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80031
MGIiMGI:2387661 Sema6d

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00940000159303
InParanoidiQ76KF0
KOiK06842
OMAiSCKKACI
PhylomeDBiQ76KF0
TreeFamiTF316102

Enzyme and pathway databases

ReactomeiR-MMU-416700 Other semaphorin interactions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Sema6d mouse

Protein Ontology

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PROi
PR:Q76KF0
RNActiQ76KF0 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000027200 Expressed in 270 organ(s), highest expression level in brain blood vessel
ExpressionAtlasiQ76KF0 baseline and differential
GenevisibleiQ76KF0 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEM6D_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q76KF0
Secondary accession number(s): A2AW72
, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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