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Entry version 97 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Kinetochore protein NDC80 homolog

Gene

NDC80

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12829748). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores to spindle microtubules (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-GGA-2467813 Separation of Sister Chromatids
R-GGA-2500257 Resolution of Sister Chromatid Cohesion
R-GGA-5663220 RHO GTPases Activate Formins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinetochore protein NDC80 homolog
Alternative name(s):
Kinetochore protein Hec1
Kinetochore-associated protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDC80
Synonyms:HEC1, KNTC2
ORF Names:RCJMB04_4o15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002495531 – 640Kinetochore protein NDC80 homologAdd BLAST640

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q76I89

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000014801 Expressed in 6 organ(s), highest expression level in female gonad

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NDC80 complex, which is composed of at least NDC80/HEC1 and CDCA1.

Interacts with CENPH.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
675431, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q76I89, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000023851

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q76I89

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili265 – 427Sequence analysisAdd BLAST163
Coiled coili464 – 573Sequence analysisAdd BLAST110

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NDC80/HEC1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0995 Eukaryota
COG5185 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018386

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000012981

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q76I89

KEGG Orthology (KO)

More...
KOi
K11547

Identification of Orthologs from Complete Genome Data

More...
OMAi
YRDWLAM

Database of Orthologous Groups

More...
OrthoDBi
925552at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q76I89

TreeFam database of animal gene trees

More...
TreeFami
TF101177

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040967 DUF5595
IPR005550 Kinetochore_Ndc80
IPR038273 Ndc80_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10643 PTHR10643, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18077 DUF5595, 1 hit
PF03801 Ndc80_HEC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q76I89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRSSTTSGS SGRQSTMVLR VQDSNKMGLQ TPQTKDRGTF GKLSMSKTTS
60 70 80 90 100
ATSERKVSFF GKRASGAGGS RNSQYGMFGT EKIKDPRPLH DKAFIQQCIK
110 120 130 140 150
QLCEFLVENG YAHNVTIKSL QSPSVKDFIK IFTFIYGFLC PSYELPDSKF
160 170 180 190 200
EEEIPRVFKE LGYPFPLSKS SMYTVGAPHT WPQIVAALIW LTDCFKLYAA
210 220 230 240 250
MRENPSSFDD GQNWGGETDD GIVHNKLFMD YVVKCYEHFM KGGDTYEELD
260 270 280 290 300
AEVQSKLKDL FNVDEFKIEG LAAENKRLHE EIARLEKERE SEPDRLVSLR
310 320 330 340 350
KLRSSFQADV QKYQAYLANL ESHTTILDQK MKSVNEEVET TEMEVEAMKQ
360 370 380 390 400
ENARLQHIFD NQKYSVADIE RINHERNELQ QTINKLTKEL EAEEHQLWNE
410 420 430 440 450
ELKYARNKEA IETQLAEYHK LARKLKLIPI SAENSKGHDF EIHFNPEAGP
460 470 480 490 500
NCLVKYRTQI KAPLMEIVNQ TEEEIRKATQ RKMSLEDTLE QVNAMVAEKK
510 520 530 540 550
SSVKTLKEEA EKLDDLYHQK LKEAEEEEQK CANELELLEK HKQLLESGVN
560 570 580 590 600
EGLSEATNEL HDIQRQYQIV MQTTTEESRK AGDNLNRLLE VITTHVVSIE
610 620 630 640
KYLDEQNSKI DRDYEEFMSE DLLSTLTGIL DSYKKKAESI
Length:640
Mass (Da):73,741
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFACFED7A0857F71B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti93A → T in CAG31305 (PubMed:15642098).Curated1
Sequence conflicti487D → N in CAG31305 (PubMed:15642098).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB098622 mRNA Translation: BAC81642.1
AJ719646 mRNA Translation: CAG31305.1

NCBI Reference Sequences

More...
RefSeqi
NP_989808.2, NM_204477.2
XP_015133419.1, XM_015277933.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000023897; ENSGALP00000023851; ENSGALG00000014801

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
395134

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:395134

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098622 mRNA Translation: BAC81642.1
AJ719646 mRNA Translation: CAG31305.1
RefSeqiNP_989808.2, NM_204477.2
XP_015133419.1, XM_015277933.1

3D structure databases

SMRiQ76I89
ModBaseiSearch...

Protein-protein interaction databases

BioGridi675431, 2 interactors
IntActiQ76I89, 2 interactors
STRINGi9031.ENSGALP00000023851

Proteomic databases

PaxDbiQ76I89

Genome annotation databases

EnsembliENSGALT00000023897; ENSGALP00000023851; ENSGALG00000014801
GeneIDi395134
KEGGigga:395134

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10403

Phylogenomic databases

eggNOGiKOG0995 Eukaryota
COG5185 LUCA
GeneTreeiENSGT00390000018386
HOGENOMiHOG000012981
InParanoidiQ76I89
KOiK11547
OMAiYRDWLAM
OrthoDBi925552at2759
PhylomeDBiQ76I89
TreeFamiTF101177

Enzyme and pathway databases

ReactomeiR-GGA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-GGA-2467813 Separation of Sister Chromatids
R-GGA-2500257 Resolution of Sister Chromatid Cohesion
R-GGA-5663220 RHO GTPases Activate Formins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q76I89

Gene expression databases

BgeeiENSGALG00000014801 Expressed in 6 organ(s), highest expression level in female gonad

Family and domain databases

Gene3Di1.10.418.30, 1 hit
InterProiView protein in InterPro
IPR040967 DUF5595
IPR005550 Kinetochore_Ndc80
IPR038273 Ndc80_sf
PANTHERiPTHR10643 PTHR10643, 1 hit
PfamiView protein in Pfam
PF18077 DUF5595, 1 hit
PF03801 Ndc80_HEC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDC80_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q76I89
Secondary accession number(s): Q5ZLT8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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