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UniProtKB - Q76I76 (SSH2_HUMAN)

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Protein

Protein phosphatase Slingshot homolog 2

Gene

SSH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.1 Publication

Miscellaneous

Tyrosine phosphatase activity has not been demonstrated for this protein to date.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei392Phosphocysteine intermediatePROSITE-ProRule annotation1 Publication1

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • phosphoprotein phosphatase activity Source: UniProtKB
  • protein tyrosine/serine/threonine phosphatase activity Source: InterPro
  • protein tyrosine phosphatase activity Source: UniProtKB-EC
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • protein dephosphorylation Source: UniProtKB
  • regulation of actin polymerization or depolymerization Source: GO_Central
  • regulation of axonogenesis Source: GO_Central
  • regulation of lamellipodium assembly Source: GO_Central
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActin-binding, Hydrolase, Protein phosphatase

Enzyme and pathway databases

SIGNORiQ76I76

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase Slingshot homolog 2 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
SSH-like protein 2
Short name:
SSH-2L
Short name:
hSSH-2L
Gene namesi
Name:SSH2
Synonyms:KIAA1725, SSH2L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141298.17
HGNCiHGNC:30580 SSH2
MIMi606779 gene
neXtProtiNX_Q76I76

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi392C → S: Abrogates phosphatase activity. 1 Publication1

Organism-specific databases

DisGeNETi85464
OpenTargetsiENSG00000141298
PharmGKBiPA134861867

Chemistry databases

ChEMBLiCHEMBL3351198

Polymorphism and mutation databases

BioMutaiSSH2
DMDMi74749833

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948431 – 1423Protein phosphatase Slingshot homolog 2Add BLAST1423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1
Modified residuei36PhosphoserineCombined sources1
Modified residuei461PhosphoserineBy similarity1
Modified residuei487PhosphoserineCombined sources1
Modified residuei534PhosphoserineBy similarity1
Modified residuei631PhosphoserineBy similarity1
Modified residuei633PhosphoserineBy similarity1
Modified residuei1217PhosphoserineCombined sources1
Modified residuei1422PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ76I76
MaxQBiQ76I76
PaxDbiQ76I76
PeptideAtlasiQ76I76
PRIDEiQ76I76
ProteomicsDBi68671
68672 [Q76I76-2]
68673 [Q76I76-3]
68674 [Q76I76-4]

PTM databases

DEPODiQ76I76
iPTMnetiQ76I76
PhosphoSitePlusiQ76I76

Expressioni

Gene expression databases

BgeeiENSG00000141298
CleanExiHS_SSH2
ExpressionAtlasiQ76I76 baseline and differential
GenevisibleiQ76I76 HS

Organism-specific databases

HPAiCAB017189
HPA057099

Interactioni

Subunit structurei

Interacts with filamentous actin.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi124548, 30 interactors
IntActiQ76I76, 19 interactors
STRINGi9606.ENSP00000269033

Structurei

Secondary structure

11423
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi309 – 312Combined sources4
Beta strandi315 – 318Combined sources4
Helixi320 – 323Combined sources4
Helixi326 – 331Combined sources6
Beta strandi334 – 339Combined sources6
Beta strandi342 – 344Combined sources3
Beta strandi352 – 356Combined sources5
Helixi368 – 370Combined sources3
Helixi371 – 383Combined sources13
Beta strandi387 – 391Combined sources5
Beta strandi393 – 397Combined sources5
Helixi398 – 411Combined sources14
Helixi415 – 425Combined sources11
Helixi433 – 447Combined sources15

3D structure databases

ProteinModelPortaliQ76I76
SMRiQ76I76
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ76I76

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini307 – 447Tyrosine-protein phosphataseAdd BLAST141

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family.Curated

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118902
HOVERGENiHBG094002
InParanoidiQ76I76
KOiK05766
PhylomeDBiQ76I76
TreeFamiTF319444

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR014876 DEK_C
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF08766 DEK_C, 1 hit
PF00782 DSPc, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q76I76-1) [UniParc]FASTAAdd to basket
Also known as: L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALVTVQRSP TPSTTSSPCA SEADSGEEEC RSQPRSISES FLTVKGAALF 
        60         70         80         90        100
LPRGNGSSTP RISHRRNKHA GDLQQHLQAM FILLRPEDNI RLAVRLESTY 
       110        120        130        140        150
QNRTRYMVVV STNGRQDTEE SIVLGMDFSS NDSSTCTMGL VLPLWSDTLI 
       160        170        180        190        200
HLDGDGGFSV STDNRVHIFK PVSVQAMWSA LQSLHKACEV ARAHNYYPGS 
       210        220        230        240        250
LFLTWVSYYE SHINSDQSSV NEWNAMQDVQ SHRPDSPALF TDIPTERERT 
       260        270        280        290        300
ERLIKTKLRE IMMQKDLENI TSKEIRTELE MQMVCNLREF KEFIDNEMIV 
       310        320        330        340        350
ILGQMDSPTQ IFEHVFLGSE WNASNLEDLQ NRGVRYILNV TREIDNFFPG 
       360        370        380        390        400
VFEYHNIRVY DEEATDLLAY WNDTYKFISK AKKHGSKCLV HCKMGVSRSA 
       410        420        430        440        450
STVIAYAMKE YGWNLDRAYD YVKERRTVTK PNPSFMRQLE EYQGILLASK 
       460        470        480        490        500
QRHNKLWRSH SDSDLSDHHE PICKPGLELN KKDITTSADQ IAEVKTMESH 
       510        520        530        540        550
PPIPPVFVEH MVPQDANQKG LCTKERMICL EFTSREFHAG QIEDELNLND 
       560        570        580        590        600
INGCSSGCCL NESKFPLDNC HASKALIQPG HVPEMANKFP DLTVEDLETD 
       610        620        630        640        650
ALKADMNVHL LPMEELTSPL KDPPMSPDPE SPSPQPSCQT EISDFSTDRI 
       660        670        680        690        700
DFFSALEKFV ELSQETRSRS FSHSRMEELG GGRNESCRLS VVEVAPSKVT 
       710        720        730        740        750
ADDQRSSSLS NTPHASEESS MDEEQSKAIS ELVSPDIFMQ SHSENAISVK 
       760        770        780        790        800
EIVTEIESIS QGVGQIQLKG DILPNPCHTP KKNSIHELLL ERAQTPENKP 
       810        820        830        840        850
GHMEQDEDSC TAQPELAKDS GMCNPEGCLT THSSIADLEE GEPAEGEQEL 
       860        870        880        890        900
QGSGMHPGAK WYPGSVRRAT LEFEERLRQE QEHHGAAPTC TSLSTRKNSK 
       910        920        930        940        950
NDSSVADLAP KGKSDEAPPE HSFVLKEPEM SKGKGKYSGS EAGSLSHSEQ 
       960        970        980        990       1000
NATVPAPRVL EFDHLPDPQE GPGSDTGTQQ EGVLKDLRTV IPYQESETQA 
      1010       1020       1030       1040       1050
VPLPLPKRVE IIEYTHIVTS PNHTGPGSEI ATSEKSGEQG LRKVNMEKSV 
      1060       1070       1080       1090       1100
TVLCTLDENL NRTLDPNQVS LHPQVLPLPH SSSPEHNRPT DHPTSILSSP 
      1110       1120       1130       1140       1150
EDRGSSLSTA LETAAPFVSH TTHLLSASLD YLHPQTMVHL EGFTEQSSTT 
      1160       1170       1180       1190       1200
DEPSAEQVSW EESQESPLSS GSEVPYKDSQ LSSADLSLIS KLGDNTGELQ 
      1210       1220       1230       1240       1250
EKMDPLPVAC RLPHSSSSEN IKSLSHSPGV VKERAKEIES RVVFQAGLTK 
      1260       1270       1280       1290       1300
PSQMRRSASL AKLGYLDLCK DCLPEREPAS CESPHLKLLQ PFLRTDSGMH 
      1310       1320       1330       1340       1350
AMEDQESLEN PGAPHNPEPT KSFVEQLTTT ECIVQSKPVE RPLVQYAKEF 
      1360       1370       1380       1390       1400
GSSQQYLLPR AGLELTSSEG GLPVLQTQGL QCACPAPGLA VAPRQQHGRT 
      1410       1420 
HPLRRLKKAN DKKRTTNPFY NTM
Length:1,423
Mass (Da):158,216
Last modified:July 5, 2004 - v1
Checksum:i23D0B59C97D6BE38
GO
Isoform 2 (identifier: Q76I76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MALVTVQRSP...EEECRSQPRS → MTLSTLARKR...VISQNAINQL
     179-195: SALQSLHKACEVARAHN → VDRDSRNKHCYVLLVEE
     196-1423: Missing.

Show »
Length:202
Mass (Da):22,470
Checksum:i027BBBE4C2D6FE7B
GO
Isoform 3 (identifier: Q76I76-3) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     179-195: SALQSLHKACEVARAHN → VDRDSRNKHCYVLLVEE
     196-1423: Missing.

Show »
Length:195
Mass (Da):21,685
Checksum:i21EB60284CB3E961
GO
Isoform 4 (identifier: Q76I76-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     449-449: S → R
     450-1423: Missing.

Note: No experimental confirmation available.
Show »
Length:449
Mass (Da):51,492
Checksum:iAFD156098A92A04D
GO

Sequence cautioni

The sequence AAH11636 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL92027 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051758743S → L. Corresponds to variant dbSNP:rs2289629Ensembl.1
Natural variantiVAR_051759763V → A. Corresponds to variant dbSNP:rs6505140Ensembl.1
Natural variantiVAR_0517601300H → Q. Corresponds to variant dbSNP:rs8080046Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0163211 – 36MALVT…SQPRS → MTLSTLARKRKAPLACTCSL GGPDMIPYFSANAVISQNAI NQL in isoform 2. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_016322179 – 195SALQS…ARAHN → VDRDSRNKHCYVLLVEE in isoform 2 and isoform 3. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_016323196 – 1423Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST1228
Alternative sequenceiVSP_016324449S → R in isoform 4. 1 Publication1
Alternative sequenceiVSP_016325450 – 1423Missing in isoform 4. 1 PublicationAdd BLAST974

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072358 mRNA Translation: BAB84117.1
AB072359 mRNA Translation: BAB84118.1
AB099290 mRNA Translation: BAC97813.1
BC008941 mRNA Translation: AAH08941.1
BC011636 mRNA Translation: AAH11636.2 Different initiation.
BC068223 mRNA Translation: AAH68223.1
AF484838 mRNA Translation: AAL92027.1 Different initiation.
AB051512 mRNA Translation: BAB21816.1
CCDSiCCDS11253.1 [Q76I76-1]
RefSeqiNP_001269058.1, NM_001282129.1
NP_001269059.1, NM_001282130.1
NP_001269060.1, NM_001282131.1
NP_203747.2, NM_033389.3 [Q76I76-1]
UniGeneiHs.654754
Hs.659026

Genome annotation databases

EnsembliENST00000269033; ENSP00000269033; ENSG00000141298 [Q76I76-1]
GeneIDi85464
KEGGihsa:85464
UCSCiuc002heo.3 human [Q76I76-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSSH2_HUMAN
AccessioniPrimary (citable) accession number: Q76I76
Secondary accession number(s): Q8TDB5
, Q8WYL1, Q8WYL2, Q96F40, Q96H36, Q9C0D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2004
Last modified: July 18, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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