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Protein

Linoleate 9S-lipoxygenase 1

Gene

Os03g0699700

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. This lipoxygenase introduces molecular oxygen exclusively into the C-9 position of linoleic and linolenic.1 Publication

Catalytic activityi

Linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.

Cofactori

Fe cationPROSITE-ProRule annotationNote: Binds 1 Fe cation per subunit. Iron is tightly bound.PROSITE-ProRule annotation

Pathwayi: oxylipin biosynthesis

This protein is involved in the pathway oxylipin biosynthesis, which is part of Lipid metabolism.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway oxylipin biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi518Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi523Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi709Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi713Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi863Iron; via carboxylate; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-12733
BRENDAi1.13.11.58 4460
ReactomeiR-OSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-OSA-2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
R-OSA-2142700 Synthesis of Lipoxins (LX)
R-OSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives
R-OSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives
R-OSA-6798695 Neutrophil degranulation
R-OSA-9018676 Biosynthesis of D-series resolvins
R-OSA-9018677 Biosynthesis of DHA-derived SPMs
R-OSA-9018681 Biosynthesis of protectins
R-OSA-9018682 Biosynthesis of maresins
R-OSA-9018896 Biosynthesis of E-series 18(S)-resolvins
R-OSA-9020265 Biosynthesis of aspirin-triggered D-series resolvins
R-OSA-9023661 Biosynthesis of E-series 18(R)-resolvins
R-OSA-9025106 Biosynthesis of DPAn-6 SPMs
R-OSA-9026286 Biosynthesis of DPAn-3-derived protectins and resolvins
R-OSA-9026290 Biosynthesis of DPAn-3-derived maresins
R-OSA-9026403 Biosynthesis of DPAn-3-derived 13-series resolvins
R-OSA-9027604 Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives
UniPathwayi
UPA00382

Names & Taxonomyi

Protein namesi
Recommended name:
Linoleate 9S-lipoxygenase 1 (EC:1.13.11.58)
Alternative name(s):
9-lipoxygenase
Lipoxygenase 1
r9-LOX1
Gene namesi
Ordered Locus Names:Os03g0699700, LOC_Os03g49260
ORF Names:OSJNBb0017F17.10
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002207071 – 863Linoleate 9S-lipoxygenase 1Add BLAST863

Proteomic databases

PaxDbiQ76I22
PRIDEiQ76I22

Expressioni

Developmental stagei

Expressed in the embryo 1 day after inbibition, and at low levels in developing seeds between 3 and 20 days after flowering.1 Publication

Gene expression databases

ExpressionAtlasiQ76I22 differential
GenevisibleiQ76I22 OS

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os03g49260.1

Structurei

3D structure databases

ProteinModelPortaliQ76I22
SMRiQ76I22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 158PLATPROSITE-ProRule annotationAdd BLAST127
Domaini161 – 863LipoxygenasePROSITE-ProRule annotationAdd BLAST703

Sequence similaritiesi

Belongs to the lipoxygenase family.Curated

Phylogenomic databases

eggNOGiENOG410IY05 Eukaryota
ENOG410XT0Q LUCA
HOGENOMiHOG000230469
InParanoidiQ76I22
KOiK15718
OMAiKFFIRTI
OrthoDBiEOG093601GX

Family and domain databases

Gene3Di4.10.372.10, 1 hit
InterProiView protein in InterPro
IPR000907 LipOase
IPR013819 LipOase_C
IPR036226 LipOase_C_sf
IPR020834 LipOase_CS
IPR020833 LipOase_Fe_BS
IPR001246 LipOase_plant
IPR027433 Lipoxygenase_dom_3
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
PANTHERiPTHR11771 PTHR11771, 1 hit
PfamiView protein in Pfam
PF00305 Lipoxygenase, 1 hit
PF01477 PLAT, 1 hit
PRINTSiPR00087 LIPOXYGENASE
PR00468 PLTLPOXGNASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF48484 SSF48484, 1 hit
SSF49723 SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS00711 LIPOXYGENASE_1, 1 hit
PS00081 LIPOXYGENASE_2, 1 hit
PS51393 LIPOXYGENASE_3, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q76I22-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGGLKDKLT GKNGNKIKGL AVLMSRKLLD PRDFTASLLD NVHEVFGNSI
60 70 80 90 100
TCQLVSATVA DQNNEGRGIV GSEANLEQGL TDLPSVSQGE SKLTVRFNWE
110 120 130 140 150
MDKHGVPGAI IIKNHHSTKF FLKTITLHDV PGCDTIVFVA NSWIYPVGKY
160 170 180 190 200
HYNRIFFANN SYLPSQMPEA LRPYREDELR YLRGEDRQGP YQEHDRIYRY
210 220 230 240 250
DVYNDLGEPD RDNPRPVLGG SQKHPYPRRG RTGRIPTKKD PNSESRLSLL
260 270 280 290 300
EQIYVPSDER FAHLKMSDFA GYSIKAIVQG ILPAIRTYVD LTPGEFDSFE
310 320 330 340 350
DILKLYRGGL KLPSIPALEE LRKSFPVQLI KDLLPVGGSY LLKFPKPDII
360 370 380 390 400
KENEVAWRTD EEFAREILAG LNPMVIRRLT EFPPKSTLDP SKYGDQTSTI
410 420 430 440 450
TPAHIEKNLE GLSVQQALDS NRLYILDHHD HFMPFLIDIN SLDGIFTYAT
460 470 480 490 500
RTLLFLRDDD TLKPLAIELS LPHIEGNLTS AKSKVHTPAS SGIESWVWQL
510 520 530 540 550
AKAYVAVNDS GWHQLISHWL NTHAVMEPFV IATNRQLSVT HPVYKLLQPH
560 570 580 590 600
YRDTMTINAL ARQTLINGGG IFEQTVFPGK HALAMSSAVY KNWNFTEQGL
610 620 630 640 650
PDDLIKRGIA IKDPSSPSKV KLLIKDYPYA TDGLAIWQAI EQWVTEYCAI
660 670 680 690 700
YYPNDGVLQG DVELQAWWKE VREVGHGDLK DADWWPKMQS LPELTKACTT
710 720 730 740 750
IIWIASALHA AVNFGQYPYA GYLPNRPTIS RRPMPEPGSK EYTELDENPE
760 770 780 790 800
KFFIRTITSQ FQTILGVSLI EILSKHSADE IYLGQRDTPE WTSDPKALEA
810 820 830 840 850
FKRFSRQLVE IESKVLNMNK DPLLKNRVGP ANFPYTLMFP NTSDNKGAAE
860
GITARGIPNS ISI
Length:863
Mass (Da):97,499
Last modified:August 30, 2005 - v2
Checksum:iAA8309F3DBCEC2F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160N → I in BAD02945 (PubMed:14634153).Curated1
Sequence conflicti163L → P in BAD02945 (PubMed:14634153).Curated1
Sequence conflicti513H → R in BAD02945 (PubMed:14634153).Curated1
Sequence conflicti527E → K in BAD02945 (PubMed:14634153).Curated1
Sequence conflicti596T → A in BAD02945 (PubMed:14634153).Curated1
Sequence conflicti663E → A in BAD02945 (PubMed:14634153).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB099850 mRNA Translation: BAD02945.1
AC093017 Genomic DNA Translation: AAX95631.1
AC097368 Genomic DNA Translation: AAO38440.1
DP000009 Genomic DNA Translation: ABF98382.1
AP008209 Genomic DNA Translation: BAF12904.1
AP014959 Genomic DNA Translation: BAS85907.1
AK103565 mRNA Translation: BAG96145.1
RefSeqiXP_015632769.1, XM_015777283.1
UniGeneiOs.18598

Genome annotation databases

EnsemblPlantsiOs03t0699700-01; Os03t0699700-01; Os03g0699700
GeneIDi4333818
GrameneiOs03t0699700-01; Os03t0699700-01; Os03g0699700
KEGGiosa:4333818

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB099850 mRNA Translation: BAD02945.1
AC093017 Genomic DNA Translation: AAX95631.1
AC097368 Genomic DNA Translation: AAO38440.1
DP000009 Genomic DNA Translation: ABF98382.1
AP008209 Genomic DNA Translation: BAF12904.1
AP014959 Genomic DNA Translation: BAS85907.1
AK103565 mRNA Translation: BAG96145.1
RefSeqiXP_015632769.1, XM_015777283.1
UniGeneiOs.18598

3D structure databases

ProteinModelPortaliQ76I22
SMRiQ76I22
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os03g49260.1

Proteomic databases

PaxDbiQ76I22
PRIDEiQ76I22

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOs03t0699700-01; Os03t0699700-01; Os03g0699700
GeneIDi4333818
GrameneiOs03t0699700-01; Os03t0699700-01; Os03g0699700
KEGGiosa:4333818

Phylogenomic databases

eggNOGiENOG410IY05 Eukaryota
ENOG410XT0Q LUCA
HOGENOMiHOG000230469
InParanoidiQ76I22
KOiK15718
OMAiKFFIRTI
OrthoDBiEOG093601GX

Enzyme and pathway databases

UniPathwayi
UPA00382

BioCyciMetaCyc:MONOMER-12733
BRENDAi1.13.11.58 4460
ReactomeiR-OSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-OSA-2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
R-OSA-2142700 Synthesis of Lipoxins (LX)
R-OSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives
R-OSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives
R-OSA-6798695 Neutrophil degranulation
R-OSA-9018676 Biosynthesis of D-series resolvins
R-OSA-9018677 Biosynthesis of DHA-derived SPMs
R-OSA-9018681 Biosynthesis of protectins
R-OSA-9018682 Biosynthesis of maresins
R-OSA-9018896 Biosynthesis of E-series 18(S)-resolvins
R-OSA-9020265 Biosynthesis of aspirin-triggered D-series resolvins
R-OSA-9023661 Biosynthesis of E-series 18(R)-resolvins
R-OSA-9025106 Biosynthesis of DPAn-6 SPMs
R-OSA-9026286 Biosynthesis of DPAn-3-derived protectins and resolvins
R-OSA-9026290 Biosynthesis of DPAn-3-derived maresins
R-OSA-9026403 Biosynthesis of DPAn-3-derived 13-series resolvins
R-OSA-9027604 Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives

Gene expression databases

ExpressionAtlasiQ76I22 differential
GenevisibleiQ76I22 OS

Family and domain databases

Gene3Di4.10.372.10, 1 hit
InterProiView protein in InterPro
IPR000907 LipOase
IPR013819 LipOase_C
IPR036226 LipOase_C_sf
IPR020834 LipOase_CS
IPR020833 LipOase_Fe_BS
IPR001246 LipOase_plant
IPR027433 Lipoxygenase_dom_3
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
PANTHERiPTHR11771 PTHR11771, 1 hit
PfamiView protein in Pfam
PF00305 Lipoxygenase, 1 hit
PF01477 PLAT, 1 hit
PRINTSiPR00087 LIPOXYGENASE
PR00468 PLTLPOXGNASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF48484 SSF48484, 1 hit
SSF49723 SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS00711 LIPOXYGENASE_1, 1 hit
PS00081 LIPOXYGENASE_2, 1 hit
PS51393 LIPOXYGENASE_3, 1 hit
PS50095 PLAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLOX1_ORYSJ
AccessioniPrimary (citable) accession number: Q76I22
Secondary accession number(s): Q10EI8, Q7G786
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: May 23, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
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