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Protein
Submitted name:

Exo-beta-D-glucosaminidase

Gene

Tk-Glm

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • beta-galactosidase activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:MONOMER-16777
TKOD69014:G1G2A-1761-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.2.1.165 5246

Protein family/group databases

Carbohydrate-Active enZymes

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CAZyi
GH35 Glycoside Hydrolase Family 35

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Exo-beta-D-glucosaminidaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tk-GlmImported
Ordered Locus Names:TK1754Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri69014 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000536 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
69014.TK1754

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GSMX-ray1.27A/B1-786[»]

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 415Glyco_hydro_42InterPro annotationAdd BLAST391

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
arCOG05856 Archaea
COG1874 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000114804

KEGG Orthology (KO)

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KOi
K12308

Identification of Orthologs from Complete Genome Data

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OMAi
WMINEYV

Database of Orthologous Groups

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OrthoDBi
2265at2157

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.880, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029062 Class_I_gatase-like
IPR013529 Glyco_hydro_42_N
IPR001944 Glycoside_Hdrlase_35
IPR017853 Glycoside_hydrolase_SF

The PANTHER Classification System

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PANTHERi
PTHR23421 PTHR23421, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02449 Glyco_hydro_42, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00742 GLHYDRLASE35

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445 SSF51445, 1 hit
SSF52317 SSF52317, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q76HN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKVEFSGKR YVIDGEPVTI AGGTLQFFRV PADAWKDRLL KMREAGLNTV
60 70 80 90 100
DTYVAWNWHE PEKGSFDFKG ETHPQRNLVG FLELADELGF YVIIRPGPYI
110 120 130 140 150
CGEWRNGGIP DWLIDEHPEI LAKGPNGPLP RDIYYPPITY LHPTYLEAVG
160 170 180 190 200
EWYNAVFPVI RKYLYTNGGP IISVSIDDEP SYWETIFQPF LTDYNEIITK
210 220 230 240 250
PGGLWEKWLE QNYTLEDLRR RYKGDFKDYS EIKVPTSFSE PLPKLIDWHH
260 270 280 290 300
FKLWMINEYV RWIYERMARE FDVPISILDP YLLQVAWRHF FTYMREHNLK
310 320 330 340 350
IHVWTEFWYS FYRSSDFKED KLGHIYYKTG IYRYHVRKAG TPPLSIETQS
360 370 380 390 400
SLAHTIDPTE AELLYSILPP LGIPNINYYL FVGGENPEGY ESHNGITWDV
410 420 430 440 450
YSPVGLDGSE RPHFGVIKAL SETMTSAEGL ADAELRPKVA VGLYEPYEAL
460 470 480 490 500
NLWGYEGLEE STDLNEYLLG ERGLFTLLAM SNTPFDAVDL EDVTLDELLS
510 520 530 540 550
YDQLWVYSLD FMSREVQDKL VEFVARGGNL VILPMLPRYD ENLEPYSSLK
560 570 580 590 600
DFLGVEVERE KARRNPRLIQ FLSVSAEGID RMLVRNTVRG VRGGEPIAFL
610 620 630 640 650
GEKPVGAFVR KGGGSAVVLG FRLQYYTSHH DLHRKFVWKL KELQGVREDF
660 670 680 690 700
EVTNPDMIVL PMEGKGYAYL AVTNPRGHPI KGRISYRGLE VPVLLDGIEL
710 720 730 740 750
KRRGTLYLPF GVRKGDVEVA YATATLVMWE GDVLTFRNHL SGHSEIALKG
760 770 780
VESVKVSGGK IVDGSDGEVL RIVIEHPGEY FEVELL
Length:786
Mass (Da):90,232
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74F024EE06C0BD18
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB100422 Genomic DNA Translation: BAC82164.1
AP006878 Genomic DNA Translation: BAD85943.1

NCBI Reference Sequences

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RefSeqi
WP_011250705.1, NC_006624.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

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EnsemblBacteriai
BAD85943; BAD85943; TK1754

Database of genes from NCBI RefSeq genomes

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GeneIDi
3235173

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
tko:TK1754

Pathosystems Resource Integration Center (PATRIC)

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PATRICi
fig|69014.16.peg.1710

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100422 Genomic DNA Translation: BAC82164.1
AP006878 Genomic DNA Translation: BAD85943.1
RefSeqiWP_011250705.1, NC_006624.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GSMX-ray1.27A/B1-786[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi69014.TK1754

Protein family/group databases

CAZyiGH35 Glycoside Hydrolase Family 35

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD85943; BAD85943; TK1754
GeneIDi3235173
KEGGitko:TK1754
PATRICifig|69014.16.peg.1710

Phylogenomic databases

eggNOGiarCOG05856 Archaea
COG1874 LUCA
HOGENOMiHOG000114804
KOiK12308
OMAiWMINEYV
OrthoDBi2265at2157

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16777
TKOD69014:G1G2A-1761-MONOMER
BRENDAi3.2.1.165 5246

Family and domain databases

Gene3Di3.40.50.880, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR013529 Glyco_hydro_42_N
IPR001944 Glycoside_Hdrlase_35
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR23421 PTHR23421, 1 hit
PfamiView protein in Pfam
PF02449 Glyco_hydro_42, 1 hit
PRINTSiPR00742 GLHYDRLASE35
SUPFAMiSSF51445 SSF51445, 1 hit
SSF52317 SSF52317, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ76HN4_THEKO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q76HN4
Secondary accession number(s): Q5JDU4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 16, 2019
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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