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Protein

Elongation factor P

Gene

efp

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).By similarity

Pathwayi: polypeptide chain elongation

This protein is involved in the pathway polypeptide chain elongation, which is part of Protein biosynthesis.
View all proteins of this organism that are known to be involved in the pathway polypeptide chain elongation and in Protein biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-1131-MONOMER
UniPathwayiUPA00345

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor P
Short name:
EF-P
Gene namesi
Name:efp
Ordered Locus Names:TTHA1125
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000943571 – 184Elongation factor PAdd BLAST184

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1125

Structurei

Secondary structure

1184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Beta strandi12 – 15Combined sources4
Beta strandi18 – 30Combined sources13
Beta strandi36 – 47Combined sources12
Beta strandi49 – 55Combined sources7
Beta strandi59 – 62Combined sources4
Beta strandi65 – 76Combined sources12
Beta strandi79 – 84Combined sources6
Turni85 – 87Combined sources3
Beta strandi90 – 94Combined sources5
Helixi95 – 97Combined sources3
Helixi101 – 103Combined sources3
Beta strandi109 – 115Combined sources7
Beta strandi118 – 123Combined sources6
Beta strandi126 – 134Combined sources9
Beta strandi137 – 139Combined sources3
Beta strandi142 – 145Combined sources4
Beta strandi147 – 153Combined sources7
Beta strandi158 – 162Combined sources5
Beta strandi170 – 174Combined sources5
Turni175 – 178Combined sources4
Beta strandi179 – 183Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UEBX-ray1.65A/B1-184[»]
4V6AX-ray3.10AV/CV1-184[»]
ProteinModelPortaliQ76G20
SMRiQ76G20
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ76G20

Family & Domainsi

Sequence similaritiesi

Belongs to the elongation factor P family.Curated

Phylogenomic databases

eggNOGiENOG4105DRH Bacteria
COG0231 LUCA
HOGENOMiHOG000010047
KOiK02356
OMAiNTFSAGH
PhylomeDBiQ76G20

Family and domain databases

CDDicd04470 S1_EF-P_repeat_1, 1 hit
cd05794 S1_EF-P_repeat_2, 1 hit
Gene3Di2.30.30.30, 1 hit
HAMAPiMF_00141 EF_P, 1 hit
InterProiView protein in InterPro
IPR015365 Elong-fact-P_C
IPR012340 NA-bd_OB-fold
IPR014722 Rib_L2_dom2
IPR020599 Transl_elong_fac_P/YeiP
IPR013185 Transl_elong_KOW-like
IPR001059 Transl_elong_P/YeiP_cen
IPR013852 Transl_elong_P/YeiP_CS
IPR011768 Transl_elongation_fac_P
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR30053 PTHR30053, 1 hit
PfamiView protein in Pfam
PF01132 EFP, 1 hit
PF08207 EFP_N, 1 hit
PF09285 Elong-fact-P_C, 1 hit
PIRSFiPIRSF005901 EF-P, 1 hit
SMARTiView protein in SMART
SM01185 EFP, 1 hit
SM00841 Elong-fact-P_C, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 2 hits
TIGRFAMsiTIGR00038 efp, 1 hit
PROSITEiView protein in PROSITE
PS01275 EFP, 1 hit

Sequencei

Sequence statusi: Complete.

Q76G20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISVTDLRPG TKVKMDGGLW ECVEYQHQKL GRGGAKVVAK FKNLETGATV
60 70 80 90 100
ERTFNSGEKL EDIYVETREL QYLYPEGEEM VFMDLETYEQ FAVPRSRVVG
110 120 130 140 150
AEFFKEGMTA LGDMYEGQPI KVTPPTVVEL KVVDTPPGVR GDTVSGGSKP
160 170 180
ATLETGAVVQ VPLFVEPGEV IKVDTRTGEY VGRA
Length:184
Mass (Da):20,225
Last modified:July 5, 2004 - v1
Checksum:i962699782753CB30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB103477 Genomic DNA Translation: BAD14383.1
AP008226 Genomic DNA Translation: BAD70948.1
RefSeqiWP_011173195.1, NC_006461.1
YP_144391.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD70948; BAD70948; BAD70948
GeneIDi3169027
KEGGittj:TTHA1125
PATRICifig|300852.9.peg.1104

Similar proteinsi

Entry informationi

Entry nameiEFP_THET8
AccessioniPrimary (citable) accession number: Q76G20
Secondary accession number(s): Q5SJ89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health