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Entry version 149 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Nucleolar protein 8

Gene

NOL8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processrRNA processing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q76FK4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar protein 8
Alternative name(s):
Nucleolar protein Nop132
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOL8Imported
Synonyms:C9orf34, NOP132
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23387, NOL8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611534, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q76FK4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000198000.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55035

Open Targets

More...
OpenTargetsi
ENSG00000198000

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134918056

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q76FK4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NOL8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74758950

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002394431 – 1167Nucleolar protein 8Add BLAST1167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki225Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei268PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei302PhosphothreonineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Cross-linki314Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei331PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei376PhosphotyrosineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei381PhosphothreonineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei723PhosphoserineCombined sources1
Modified residuei795PhosphothreonineBy similarity1
Modified residuei801PhosphoserineBy similarity1
Modified residuei837PhosphoserineCombined sources1
Modified residuei838PhosphoserineCombined sources1
Modified residuei843PhosphoserineCombined sources1
Modified residuei845PhosphoserineCombined sources1
Modified residuei888PhosphothreonineCombined sources1
Modified residuei890PhosphoserineCombined sources1
Modified residuei1036PhosphoserineCombined sources1
Cross-linki1057Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1082PhosphoserineCombined sources1
Modified residuei1083PhosphoserineCombined sources1
Modified residuei1084PhosphoserineCombined sources1
Modified residuei1099PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q76FK4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q76FK4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q76FK4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q76FK4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q76FK4

PeptideAtlas

More...
PeptideAtlasi
Q76FK4

PRoteomics IDEntifications database

More...
PRIDEi
Q76FK4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68665 [Q76FK4-1]
68666 [Q76FK4-2]
68668 [Q76FK4-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q76FK4, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q76FK4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q76FK4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in diffuse-type gastric cancers.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198000, Expressed in calcaneal tendon and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q76FK4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q76FK4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000198000, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the GTP form of RRAGA, RRAGC and RRAGD.

Interacts with NIP7.

Interacts with DDX18; the interaction is RNA-dependent.

Interacts with DDX47; the interaction is RNA-dependent.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120364, 61 interactors

Protein interaction database and analysis system

More...
IntActi
Q76FK4, 30 interactors

Molecular INTeraction database

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MINTi
Q76FK4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000441140

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q76FK4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q76FK4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 89RRMPROSITE-ProRule annotationAdd BLAST82

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili753 – 779Sequence analysisAdd BLAST27
Coiled coili886 – 924Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1113 – 1116Poly-PheSequence analysis4

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4365, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004860

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008415_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q76FK4

Identification of Orthologs from Complete Genome Data

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OMAi
KHKDARR

Database of Orthologous Groups

More...
OrthoDBi
442365at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q76FK4

TreeFam database of animal gene trees

More...
TreeFami
TF323283

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12226, RRM_NOL8, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034138, NOP8_RRM
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076, RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360, RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 12 Publications (identifier: Q76FK4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVNRETKRL YVGGLSQDIS EADLQNQFSR FGEVSDVEII TRKDDQGNPQ
60 70 80 90 100
KVFAYINISV AEADLKKCMS VLNKTKWKGG TLQIQLAKES FLHRLAQERE
110 120 130 140 150
AAKAKKEEST TGNANLLEKT GGVDFHMKAV PGTEVPGHKN WVVSKFGRVL
160 170 180 190 200
PVLHLKNQHK RKIIKYDPSK YCHNLKKIGE DFSNTIPISS LTWELEGGND
210 220 230 240 250
PMSKKRRGEF SDFHGPPKKI IKVQKDESST GSLAMSTRPR RVIERPPLTQ
260 270 280 290 300
QQAAQKRTCD SITPSKSSPV PVSDTQKLKN LPFKTSGLET AKKRNSISDD
310 320 330 340 350
DTDSEDELRM MIAKEENLQR TTQPSINESE SDPFEVVRDD FKSGVHKLHS
360 370 380 390 400
LIGLGIKNRV SCHDSDDDIM RNDREYDSGD TDEIIAMKKN VAKVKNSTEF
410 420 430 440 450
SQMEKSTKKT SFKNRENCEL SDHCIKLQKR KSNVESALSH GLKSLNRKSP
460 470 480 490 500
SHSSSSEDAD SASELADSEG GEEYNAMMKN CLRVNLTLAD LEQLAGSDLK
510 520 530 540 550
VPNEDTKSDG PETTTQCKFD RGSKSPKTPT GLRRGRQCIR PAEIVASLLE
560 570 580 590 600
GEENTCGKQK PKENNLKPKF QAFKGVGCLY EKESMKKSLK DSVASNNKDQ
610 620 630 640 650
NSMKHEDPSI ISMEDGSPYV NGSLGEVTPC QHAKKANGPN YIQPQKRQTT
660 670 680 690 700
FESQDRKAVS PSSSEKRSKN PISRPLEGKK SLSLSAKTHN IGFDKDSCHS
710 720 730 740 750
TTKTEASQEE RSDSSGLTSL KKSPKVSSKD TREIKTDFSL SISNSSDVSA
760 770 780 790 800
KDKHAEDNEK RLAALEARQK AKEVQKKLVH NALANLDGHP EDKPTHIIFG
810 820 830 840 850
SDSECETEET STQEQSHPGE EWVKESMGKT SGKLFDSSDD DESDSEDDSN
860 870 880 890 900
RFKIKPQFEG RAGQKLMDLQ SHFGTDDRFR MDSRFLETDS EEEQEEVNEK
910 920 930 940 950
KTAEEEELAE EKKKALNVVQ SVLQINLSNS TNRGSVAAKK FKDIIHYDPT
960 970 980 990 1000
KQDHATYERK RDDKPKESKA KRKKKREEAE KLPEVSKEMY YNIAMDLKEI
1010 1020 1030 1040 1050
FQTTKYTSEK EEGTPWNEDC GKEKPEEIQD PAALTSDAEQ PSGFTFSFFD
1060 1070 1080 1090 1100
SDTKDIKEET YRVETVKPGK IVWQEDPRLQ DSSSEEEDVT EETDHRNSSP
1110 1120 1130 1140 1150
GEASLLEKET TRFFFFSKND ERLQGSDLFW RGVGSNMSRN SWEARTTNLR
1160
MDCRKKHKDA KRKMKPK
Length:1,167
Mass (Da):131,616
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E64780D6F0E7415
GO
Isoform 21 Publication (identifier: Q76FK4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Show »
Length:1,099
Mass (Da):123,927
Checksum:iBED9401AC2D5ABE8
GO
Isoform 41 Publication (identifier: Q76FK4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     787-824: Missing.

Show »
Length:1,129
Mass (Da):127,337
Checksum:iCF4642596A282A1A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WE42F8WE42_HUMAN
Nucleolar protein 8
NOL8
969Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWN9F5GWN9_HUMAN
Nucleolar protein 8
NOL8
413Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H101F5H101_HUMAN
Nucleolar protein 8
NOL8
1,085Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSJ1A0A0A0MSJ1_HUMAN
Nucleolar protein 8
NOL8
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0I5F5H0I5_HUMAN
Nucleolar protein 8
NOL8
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H8B8F5H8B8_HUMAN
Nucleolar protein 8
NOL8
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H532F5H532_HUMAN
Nucleolar protein 8
NOL8
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXV1F5GXV1_HUMAN
Nucleolar protein 8
NOL8
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7D5F5H7D5_HUMAN
Nucleolar protein 8
NOL8
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H797F5H797_HUMAN
Nucleolar protein 8
NOL8
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91356 differs from that shown. Reason: Frameshift.Curated
The sequence BAA91356 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14229 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15003 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69M → I in BAC99315 (PubMed:14660641).Curated1
Sequence conflicti69M → I in BAA91479 (PubMed:14702039).Curated1
Sequence conflicti454S → G in BAB14857 (PubMed:14702039).Curated1
Sequence conflicti479K → E in BAB14857 (PubMed:14702039).Curated1
Sequence conflicti630C → W in BAC99315 (PubMed:14660641).Curated1
Sequence conflicti630C → W in BAA91356 (PubMed:14702039).Curated1
Sequence conflicti733E → G in BAB14857 (PubMed:14702039).Curated1
Sequence conflicti749S → G in BAB14857 (PubMed:14702039).Curated1
Sequence conflicti945I → L in BAC99315 (PubMed:14660641).Curated1
Sequence conflicti945I → L in BAA91356 (PubMed:14702039).Curated1
Sequence conflicti966K → R in BAC99315 (PubMed:14660641).Curated1
Sequence conflicti966K → R in BAA91356 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061830470G → E. Corresponds to variant dbSNP:rs58545014Ensembl.1
Natural variantiVAR_052211748V → L. Corresponds to variant dbSNP:rs2236344Ensembl.1
Natural variantiVAR_052212841D → E. Corresponds to variant dbSNP:rs15717Ensembl.1
Natural variantiVAR_052213988E → D. Corresponds to variant dbSNP:rs34224798Ensembl.1
Natural variantiVAR_0522141021G → S. Corresponds to variant dbSNP:rs921122Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0520551 – 68Missing in isoform 2. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_052056787 – 824Missing in isoform 4. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB105104 mRNA Translation: BAD12268.1
AB109030 mRNA Translation: BAC99315.1
AK000743 mRNA Translation: BAA91356.1 Sequence problems.
AK001049 mRNA Translation: BAA91479.1
AK022755 mRNA Translation: BAB14229.1 Different initiation.
AK024245 mRNA Translation: BAB14857.1
AK024786 mRNA Translation: BAB15003.1 Different initiation.
AL136097 Genomic DNA No translation available.
BC013788 mRNA Translation: AAH13788.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47993.1 [Q76FK4-1]
CCDS59135.1 [Q76FK4-2]
CCDS83384.1 [Q76FK4-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001243323.1, NM_001256394.1 [Q76FK4-2]
NP_001317651.1, NM_001330722.1 [Q76FK4-4]
NP_060418.4, NM_017948.5 [Q76FK4-1]
XP_006717229.1, XM_006717166.3 [Q76FK4-1]
XP_006717230.1, XM_006717167.3 [Q76FK4-1]
XP_006717232.1, XM_006717169.3 [Q76FK4-2]
XP_006717233.1, XM_006717170.3 [Q76FK4-2]
XP_011517126.1, XM_011518824.2 [Q76FK4-2]
XP_016870365.1, XM_017014876.1 [Q76FK4-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358855; ENSP00000351723; ENSG00000198000 [Q76FK4-2]
ENST00000442668; ENSP00000401177; ENSG00000198000 [Q76FK4-1]
ENST00000535387; ENSP00000441300; ENSG00000198000 [Q76FK4-4]
ENST00000542053; ENSP00000440709; ENSG00000198000 [Q76FK4-2]
ENST00000545558; ENSP00000441140; ENSG00000198000 [Q76FK4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55035

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55035

UCSC genome browser

More...
UCSCi
uc064uhl.1, human [Q76FK4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB105104 mRNA Translation: BAD12268.1
AB109030 mRNA Translation: BAC99315.1
AK000743 mRNA Translation: BAA91356.1 Sequence problems.
AK001049 mRNA Translation: BAA91479.1
AK022755 mRNA Translation: BAB14229.1 Different initiation.
AK024245 mRNA Translation: BAB14857.1
AK024786 mRNA Translation: BAB15003.1 Different initiation.
AL136097 Genomic DNA No translation available.
BC013788 mRNA Translation: AAH13788.2
CCDSiCCDS47993.1 [Q76FK4-1]
CCDS59135.1 [Q76FK4-2]
CCDS83384.1 [Q76FK4-4]
RefSeqiNP_001243323.1, NM_001256394.1 [Q76FK4-2]
NP_001317651.1, NM_001330722.1 [Q76FK4-4]
NP_060418.4, NM_017948.5 [Q76FK4-1]
XP_006717229.1, XM_006717166.3 [Q76FK4-1]
XP_006717230.1, XM_006717167.3 [Q76FK4-1]
XP_006717232.1, XM_006717169.3 [Q76FK4-2]
XP_006717233.1, XM_006717170.3 [Q76FK4-2]
XP_011517126.1, XM_011518824.2 [Q76FK4-2]
XP_016870365.1, XM_017014876.1 [Q76FK4-4]

3D structure databases

SMRiQ76FK4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120364, 61 interactors
IntActiQ76FK4, 30 interactors
MINTiQ76FK4
STRINGi9606.ENSP00000441140

PTM databases

GlyGeniQ76FK4, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ76FK4
PhosphoSitePlusiQ76FK4

Genetic variation databases

BioMutaiNOL8
DMDMi74758950

Proteomic databases

EPDiQ76FK4
jPOSTiQ76FK4
MassIVEiQ76FK4
MaxQBiQ76FK4
PaxDbiQ76FK4
PeptideAtlasiQ76FK4
PRIDEiQ76FK4
ProteomicsDBi68665 [Q76FK4-1]
68666 [Q76FK4-2]
68668 [Q76FK4-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
43737, 106 antibodies

Genome annotation databases

EnsembliENST00000358855; ENSP00000351723; ENSG00000198000 [Q76FK4-2]
ENST00000442668; ENSP00000401177; ENSG00000198000 [Q76FK4-1]
ENST00000535387; ENSP00000441300; ENSG00000198000 [Q76FK4-4]
ENST00000542053; ENSP00000440709; ENSG00000198000 [Q76FK4-2]
ENST00000545558; ENSP00000441140; ENSG00000198000 [Q76FK4-1]
GeneIDi55035
KEGGihsa:55035
UCSCiuc064uhl.1, human [Q76FK4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55035
DisGeNETi55035

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NOL8
HGNCiHGNC:23387, NOL8
HPAiENSG00000198000, Low tissue specificity
MIMi611534, gene
neXtProtiNX_Q76FK4
OpenTargetsiENSG00000198000
PharmGKBiPA134918056
VEuPathDBiHostDB:ENSG00000198000.11

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4365, Eukaryota
GeneTreeiENSGT00390000004860
HOGENOMiCLU_008415_0_0_1
InParanoidiQ76FK4
OMAiKHKDARR
OrthoDBi442365at2759
PhylomeDBiQ76FK4
TreeFamiTF323283

Enzyme and pathway databases

PathwayCommonsiQ76FK4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55035, 581 hits in 1002 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NOL8, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NOL8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55035
PharosiQ76FK4, Tbio

Protein Ontology

More...
PROi
PR:Q76FK4
RNActiQ76FK4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198000, Expressed in calcaneal tendon and 227 other tissues
ExpressionAtlasiQ76FK4, baseline and differential
GenevisibleiQ76FK4, HS

Family and domain databases

CDDicd12226, RRM_NOL8, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR034138, NOP8_RRM
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
PfamiView protein in Pfam
PF00076, RRM_1, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOL8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q76FK4
Secondary accession number(s): Q5TCC7
, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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