Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 119 (03 Jul 2019)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter

Gene

SLC35D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling.2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=8 µM for UDP-N-acetylglucosamine1 Publication
  2. KM=2.1 µM for UDP-glucose1 Publication
  3. KM=0.14 µM for GDP-mannose1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processSugar transport, Transport

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-2022854 Keratan sulfate biosynthesis
    R-HSA-2022928 HS-GAG biosynthesis
    R-HSA-727802 Transport of nucleotide sugars

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.7.15.1 the drug/metabolite transporter (dmt) superfamily

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
    Alternative name(s):
    Homolog of Fringe connection protein 1
    Short name:
    HFRC1
    SQV7-like protein
    Short name:
    SQV7L
    Solute carrier family 35 member D2
    UDP-galactose transporter-related protein 8
    Short name:
    UGTrel8
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC35D2
    Synonyms:HFRC, UGTREL8
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:20799 SLC35D2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    609182 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q76EJ3

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
    Topological domaini49 – 53ExtracellularSequence analysis5
    Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
    Topological domaini75 – 146CytoplasmicSequence analysisAdd BLAST72
    Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
    Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
    Topological domaini189 – 201CytoplasmicSequence analysisAdd BLAST13
    Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
    Topological domaini223 – 237ExtracellularSequence analysisAdd BLAST15
    Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
    Topological domaini259 – 265CytoplasmicSequence analysis7
    Transmembranei266 – 288HelicalSequence analysisAdd BLAST23
    Topological domaini289 – 292ExtracellularSequence analysis4
    Transmembranei293 – 315HelicalSequence analysisAdd BLAST23
    Topological domaini316 – 337CytoplasmicSequence analysisAdd BLAST22

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    11046

    Open Targets

    More...
    OpenTargetsi
    ENSG00000130958

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134909604

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC35D2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74749832

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003130801 – 337UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporterAdd BLAST337

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q76EJ3

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q76EJ3

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q76EJ3

    PeptideAtlas

    More...
    PeptideAtlasi
    Q76EJ3

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q76EJ3

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    68663
    68664 [Q76EJ3-2]

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000130958 Expressed in 219 organ(s), highest expression level in mucosa of transverse colon

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q76EJ3 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q76EJ3 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA064047

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    116234, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000253270

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1444 Eukaryota
    COG5070 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000160237

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000038339

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q76EJ3

    KEGG Orthology (KO)

    More...
    KOi
    K15281

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    SHYNSAL

    Database of Orthologous Groups

    More...
    OrthoDBi
    1093260at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q76EJ3

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313307

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR004853 Sugar_P_trans_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03151 TPT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q76EJ3-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MTAGGQAEAE GAGGEPGAAR LPSRVARLLS ALFYGTCSFL IVLVNKALLT
    60 70 80 90 100
    TYGFPSPIFL GIGQMAATIM ILYVSKLNKI IHFPDFDKKI PVKLFPLPLL
    110 120 130 140 150
    YVGNHISGLS STSKLSLPMF TVLRKFTIPL TLLLETIILG KQYSLNIILS
    160 170 180 190 200
    VFAIILGAFI AAGSDLAFNL EGYIFVFLND IFTAANGVYT KQKMDPKELG
    210 220 230 240 250
    KYGVLFYNAC FMIIPTLIIS VSTGDLQQAT EFNQWKNVVF ILQFLLSCFL
    260 270 280 290 300
    GFLLMYSTVL CSYYNSALTT AVVGAIKNVS VAYIGILIGG DYIFSLLNFV
    310 320 330
    GLNICMAGGL RYSFLTLSSQ LKPKPVGEEN ICLDLKS
    Length:337
    Mass (Da):36,673
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7895A9153A82BE5A
    GO
    Isoform 2 (identifier: Q76EJ3-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         164-251: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:249
    Mass (Da):26,702
    Checksum:i6A7E4EDF143D3609
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    Q5VZJ2Q5VZJ2_HUMAN
    UDP-N-acetylglucosamine/UDP-glucose...
    SLC35D2
    163Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3IU97A0A3B3IU97_HUMAN
    UDP-N-acetylglucosamine/UDP-glucose...
    SLC35D2
    193Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3ITR5A0A3B3ITR5_HUMAN
    UDP-N-acetylglucosamine/UDP-glucose...
    SLC35D2
    62Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037653184A → S2 PublicationsCorresponds to variant dbSNP:rs1051763Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030006164 – 251Missing in isoform 2. 1 PublicationAdd BLAST88

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB106537 mRNA Translation: BAD14396.1
    AB122077 mRNA Translation: BAC99016.1
    AL160269 Genomic DNA No translation available.
    CH471174 Genomic DNA Translation: EAW92646.1
    BC009413 mRNA Translation: AAH09413.1
    BC100278 mRNA Translation: AAI00279.1
    BC113579 mRNA Translation: AAI13580.1
    AJ005866 mRNA Translation: CAA06743.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS6717.1 [Q76EJ3-1]
    CCDS69625.1 [Q76EJ3-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001273919.1, NM_001286990.1 [Q76EJ3-2]
    NP_008932.2, NM_007001.2 [Q76EJ3-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000253270; ENSP00000253270; ENSG00000130958 [Q76EJ3-1]
    ENST00000375259; ENSP00000364408; ENSG00000130958 [Q76EJ3-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    11046

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:11046

    UCSC genome browser

    More...
    UCSCi
    uc004awc.4 human [Q76EJ3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB106537 mRNA Translation: BAD14396.1
    AB122077 mRNA Translation: BAC99016.1
    AL160269 Genomic DNA No translation available.
    CH471174 Genomic DNA Translation: EAW92646.1
    BC009413 mRNA Translation: AAH09413.1
    BC100278 mRNA Translation: AAI00279.1
    BC113579 mRNA Translation: AAI13580.1
    AJ005866 mRNA Translation: CAA06743.1
    CCDSiCCDS6717.1 [Q76EJ3-1]
    CCDS69625.1 [Q76EJ3-2]
    RefSeqiNP_001273919.1, NM_001286990.1 [Q76EJ3-2]
    NP_008932.2, NM_007001.2 [Q76EJ3-1]

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi116234, 1 interactor
    STRINGi9606.ENSP00000253270

    Protein family/group databases

    TCDBi2.A.7.15.1 the drug/metabolite transporter (dmt) superfamily

    Polymorphism and mutation databases

    BioMutaiSLC35D2
    DMDMi74749832

    Proteomic databases

    jPOSTiQ76EJ3
    MaxQBiQ76EJ3
    PaxDbiQ76EJ3
    PeptideAtlasiQ76EJ3
    PRIDEiQ76EJ3
    ProteomicsDBi68663
    68664 [Q76EJ3-2]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000253270; ENSP00000253270; ENSG00000130958 [Q76EJ3-1]
    ENST00000375259; ENSP00000364408; ENSG00000130958 [Q76EJ3-2]
    GeneIDi11046
    KEGGihsa:11046
    UCSCiuc004awc.4 human [Q76EJ3-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    11046
    DisGeNETi11046

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC35D2
    HGNCiHGNC:20799 SLC35D2
    HPAiHPA064047
    MIMi609182 gene
    neXtProtiNX_Q76EJ3
    OpenTargetsiENSG00000130958
    PharmGKBiPA134909604

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1444 Eukaryota
    COG5070 LUCA
    GeneTreeiENSGT00940000160237
    HOGENOMiHOG000038339
    InParanoidiQ76EJ3
    KOiK15281
    OMAiSHYNSAL
    OrthoDBi1093260at2759
    PhylomeDBiQ76EJ3
    TreeFamiTF313307

    Enzyme and pathway databases

    ReactomeiR-HSA-2022854 Keratan sulfate biosynthesis
    R-HSA-2022928 HS-GAG biosynthesis
    R-HSA-727802 Transport of nucleotide sugars

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLC35D2 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    11046

    Protein Ontology

    More...
    PROi
    PR:Q76EJ3

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000130958 Expressed in 219 organ(s), highest expression level in mucosa of transverse colon
    ExpressionAtlasiQ76EJ3 baseline and differential
    GenevisibleiQ76EJ3 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR004853 Sugar_P_trans_dom
    PfamiView protein in Pfam
    PF03151 TPT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS35D2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q76EJ3
    Secondary accession number(s): O95454
    , Q498C1, Q75W21, Q7Z5X5
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 5, 2004
    Last modified: July 3, 2019
    This is version 119 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again