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UniProtKB - Q76CU2 (PDR1_TOBAC)

Entry version 74 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Pleiotropic drug resistance protein 1

Gene

PDR1

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a general defense protein.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi194 – 201ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi882 – 889ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleiotropic drug resistance protein 1
Alternative name(s):
NtPDR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNicotiana tabacum (Common tobacco)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4097 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › lamiids › Solanales › Solanaceae › Nicotianoideae › Nicotianeae › Nicotiana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000084051 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei530 – 550HelicalSequence analysisAdd BLAST21
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21
Transmembranei618 – 638HelicalSequence analysisAdd BLAST21
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21
Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
Transmembranei702 – 722HelicalSequence analysisAdd BLAST21
Transmembranei760 – 780HelicalSequence analysisAdd BLAST21
Transmembranei1181 – 1201HelicalSequence analysisAdd BLAST21
Transmembranei1221 – 1241HelicalSequence analysisAdd BLAST21
Transmembranei1269 – 1289HelicalSequence analysisAdd BLAST21
Transmembranei1296 – 1316HelicalSequence analysisAdd BLAST21
Transmembranei1326 – 1346HelicalSequence analysisAdd BLAST21
Transmembranei1357 – 1377HelicalSequence analysisAdd BLAST21
Transmembranei1406 – 1426HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002346551 – 1434Pleiotropic drug resistance protein 1Add BLAST1434

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By the phytohormone methyl jasmonate (MeJA), defense elicitors (INF1 elicitin of P.infestans, flagellin of P.syringae and yeast extract), and protein phosphatase inhibitor (cantharidin). Repressed by protein kinase inhibitor (K252a) and cycloheximide.1 Publication

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini161 – 434ABC transporter 1PROSITE-ProRule annotationAdd BLAST274
Domaini512 – 725ABC transmembrane type-2 1Add BLAST214
Domaini837 – 1089ABC transporter 2PROSITE-ProRule annotationAdd BLAST253
Domaini1162 – 1376ABC transmembrane type-2 2Add BLAST215

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		ACGYFVQ

Database of Orthologous Groups

More...OrthoDBi		324553at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd03233, ABCG_PDR_domain1, 1 hit
cd03232, ABCG_PDR_domain2, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR029481, ABC_trans_N
IPR003439, ABC_transporter-like
IPR043926, ABCG_dom
IPR034001, ABCG_PDR_1
IPR034003, ABCG_PDR_2
IPR027417, P-loop_NTPase
IPR013581, PDR_assoc

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01061, ABC2_membrane, 2 hits
PF19055, ABC2_membrane_7, 1 hit
PF00005, ABC_tran, 2 hits
PF14510, ABC_trans_N, 1 hit
PF08370, PDR_assoc, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q76CU2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPANLSNLR GSSLRGSTRG SLRANSNSIW RNNGVEIFSR SSRDEDDEEA 
        60         70         80         90        100
LKWAALEKLP TFDRLRKGLL FGSQGAAAEV DINDLGFQER KNLLERLVKV 
       110        120        130        140        150
ADEDNEKFLL KLKNRIDRVG IDLPTIEVRY EHLNIDADAY VGSRSLPTFM 
       160        170        180        190        200
NFMTNFVETL LNSLHILSSR KRQLTILKDI SGIIKPCRMT LLLGPPSSGK 
       210        220        230        240        250
TTLLLALAGK LDPALKVTGK VSYNGHELHE FVPQRTAAYI SQHDLHIGEM 
       260        270        280        290        300
TVRETLEFSA RCQGVGSRFE MLAELSRREK AANIKPDADI DIYMKAAATE 
       310        320        330        340        350
GQEANVVTDY VLKILGLDIC ADTMVGDDMI RGISGGQKKR VTTGEMLVGP 
       360        370        380        390        400
SKALFMDEIS TGLDSSTTYS IVNSLRQSVQ ILKGTAVISL LQPAPETYNL 
       410        420        430        440        450
FDDIILLSDG YIVYQGPRDD VLEFFESMGF KCPQRKGVAD FLQEVTSKKD 
       460        470        480        490        500
QQQYWSKRNE PYRFITSKEF AEAYQSFHVG RKLGDELATP FDKTKCHPAA 
       510        520        530        540        550
LTNEKYGIGK KELLKVCTER ELLLMKRNSF VYMFKFSQLT IMALITMTLF 
       560        570        580        590        600
FRTEMPRDTT DDGGIYAGAL FFVVIMIMFN GMSELAMTIF KLPVFYKQRD 
       610        620        630        640        650
LLFFPSWAYA IPSWILKIPV TLVEVGLWVI LTYYVIGFDP NITRFLKQFL 
       660        670        680        690        700
LLIVVNQMAS GMFRFIGAVG RTMGVASTFG SFALLLQFAL GGFVLSRDDV 
       710        720        730        740        750
KSWWIWGYWI SPMMYSVNSI LVNEFDGKKW NHIVPGGNET LGSTVVKSRG 
       760        770        780        790        800
FFPEAYWYWI GVGALVGFTV VFNFCYSLAL AYLNPFDKPQ AVLPEDGENA 
       810        820        830        840        850
ENGEVSSQIT STDGGDSISE SQNNKKGMVL PFEPHSITFD DVVYSVDMPQ 
       860        870        880        890        900
EMKEQGAGED RLVLLKGVSG AFRPGVLTAL MGVSGAGKTT LMDVLAGRKT 
       910        920        930        940        950
GGYIDGEIKI SGYPKKQETF ARISGYCEQN DIHSPYVTVY ESLVYSAWLR 
       960        970        980        990       1000
LPQDVDEKTR KMFVDEVMEL VELGPLRSAL VGLPGVNGLS TEQRKRLTIA 
      1010       1020       1030       1040       1050
VELVANPSII FMDEPTSGLD ARAAAIVMRT VRNTVDTGRT VVCTIHQPSI 
      1060       1070       1080       1090       1100
DIFEAFDELF LMKRGGQEIY VGPLGRHSCH LIKYFESNPG VAKIKEGYNP 
      1110       1120       1130       1140       1150
ATWMLEVTAS AQEMMLGIDF TEVYKNSDLY RRNKALISEL GVPRPGSKDL 
      1160       1170       1180       1190       1200
HFETQYSQSF WTQCVACLWK QHWSYWRNPA YTAVRFIFTT FIALIFGTMF 
      1210       1220       1230       1240       1250
WDLGTKVSKS QDLLNAMGSM YAAVLFLGVQ NASSVQPVVA IERTVFYRER 
      1260       1270       1280       1290       1300
AAGMYSAIPY AFGQVSIEIP YIFVQSVFYG IIVYAMIGFE WDVGKFFWYL 
      1310       1320       1330       1340       1350
FIMFFTLLYF TFYGMMGVAV TPNQNVASIV AAFFYGVWNL FSGFIIPRPR 
      1360       1370       1380       1390       1400
MPVWWRWYYW ANPVAWTLYG LVASQFGDIQ TKLSDNETVE QFLRRYFGFK 
      1410       1420       1430 
HDFLGVVAAV LTAYVFMFAF TFAFAIKAFN FQRR
Length:1,434
Mass (Da):161,683
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i041F2DCDD4D3239A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti810T → P in BAB92011 (PubMed:11997039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB075550 mRNA Translation: BAB92011.1
AB109388 Genomic DNA Translation: BAD07483.1

NCBI Reference Sequences

More...RefSeqi		NP_001312599.1, NM_001325670.1
XP_016478140.1, XM_016622654.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		107799533

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		nta:107799533

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075550 mRNA Translation: BAB92011.1
AB109388 Genomic DNA Translation: BAD07483.1
RefSeqiNP_001312599.1, NM_001325670.1
XP_016478140.1, XM_016622654.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi107799533
KEGGinta:107799533

Phylogenomic databases

OMAiACGYFVQ
OrthoDBi324553at2759

Family and domain databases

CDDicd03233, ABCG_PDR_domain1, 1 hit
cd03232, ABCG_PDR_domain2, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR029481, ABC_trans_N
IPR003439, ABC_transporter-like
IPR043926, ABCG_dom
IPR034001, ABCG_PDR_1
IPR034003, ABCG_PDR_2
IPR027417, P-loop_NTPase
IPR013581, PDR_assoc
PfamiView protein in Pfam
PF01061, ABC2_membrane, 2 hits
PF19055, ABC2_membrane_7, 1 hit
PF00005, ABC_tran, 2 hits
PF14510, ABC_trans_N, 1 hit
PF08370, PDR_assoc, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDR1_TOBAC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q76CU2
Secondary accession number(s): Q8LP45
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 5, 2004
Last modified: December 2, 2020
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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