We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q76CU2 (PDR1_TOBAC)
Protein
Pleiotropic drug resistance protein 1
Gene
PDR1
Organism
Nicotiana tabacum (Common tobacco)
Status
Functioni
May be a general defense protein.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 194 – 201 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 882 – 889 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type transporter activity Source: InterPro
- ATP binding Source: UniProtKB-KW
Keywordsi
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Pleiotropic drug resistance protein 1Alternative name(s): NtPDR1 |
Gene namesi | Name:PDR1 |
Organismi | Nicotiana tabacum (Common tobacco) |
Taxonomic identifieri | 4097 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › lamiids › Solanales › Solanaceae › Nicotianoideae › Nicotianeae › Nicotiana |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 530 – 550 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 563 – 583 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 618 – 638 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 649 – 669 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 675 – 695 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 702 – 722 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 760 – 780 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1181 – 1201 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1221 – 1241 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1269 – 1289 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1296 – 1316 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1326 – 1346 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1357 – 1377 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1406 – 1426 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000234655 | 1 – 1434 | Pleiotropic drug resistance protein 1Add BLAST | 1434 |
Expressioni
Inductioni
By the phytohormone methyl jasmonate (MeJA), defense elicitors (INF1 elicitin of P.infestans, flagellin of P.syringae and yeast extract), and protein phosphatase inhibitor (cantharidin). Repressed by protein kinase inhibitor (K252a) and cycloheximide.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 161 – 434 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 274 | |
Domaini | 512 – 725 | ABC transmembrane type-2 1Add BLAST | 214 | |
Domaini | 837 – 1089 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 253 | |
Domaini | 1162 – 1376 | ABC transmembrane type-2 2Add BLAST | 215 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 793 – 824 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 801 – 824 | Polar residuesSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
OMAi | SMSMFFR |
OrthoDBi | 324553at2759 |
PhylomeDBi | Q76CU2 |
Family and domain databases
CDDi | cd03233, ABCG_PDR_domain1, 1 hit cd03232, ABCG_PDR_domain2, 1 hit |
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR013525, ABC_2_trans IPR029481, ABC_trans_N IPR003439, ABC_transporter-like_ATP-bd IPR043926, ABCG_dom IPR034001, ABCG_PDR_1 IPR034003, ABCG_PDR_2 IPR027417, P-loop_NTPase IPR013581, PDR_assoc |
Pfami | View protein in Pfam PF01061, ABC2_membrane, 2 hits PF19055, ABC2_membrane_7, 1 hit PF00005, ABC_tran, 2 hits PF14510, ABC_trans_N, 1 hit PF08370, PDR_assoc, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS50893, ABC_TRANSPORTER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q76CU2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPANLSNLR GSSLRGSTRG SLRANSNSIW RNNGVEIFSR SSRDEDDEEA
60 70 80 90 100
LKWAALEKLP TFDRLRKGLL FGSQGAAAEV DINDLGFQER KNLLERLVKV
110 120 130 140 150
ADEDNEKFLL KLKNRIDRVG IDLPTIEVRY EHLNIDADAY VGSRSLPTFM
160 170 180 190 200
NFMTNFVETL LNSLHILSSR KRQLTILKDI SGIIKPCRMT LLLGPPSSGK
210 220 230 240 250
TTLLLALAGK LDPALKVTGK VSYNGHELHE FVPQRTAAYI SQHDLHIGEM
260 270 280 290 300
TVRETLEFSA RCQGVGSRFE MLAELSRREK AANIKPDADI DIYMKAAATE
310 320 330 340 350
GQEANVVTDY VLKILGLDIC ADTMVGDDMI RGISGGQKKR VTTGEMLVGP
360 370 380 390 400
SKALFMDEIS TGLDSSTTYS IVNSLRQSVQ ILKGTAVISL LQPAPETYNL
410 420 430 440 450
FDDIILLSDG YIVYQGPRDD VLEFFESMGF KCPQRKGVAD FLQEVTSKKD
460 470 480 490 500
QQQYWSKRNE PYRFITSKEF AEAYQSFHVG RKLGDELATP FDKTKCHPAA
510 520 530 540 550
LTNEKYGIGK KELLKVCTER ELLLMKRNSF VYMFKFSQLT IMALITMTLF
560 570 580 590 600
FRTEMPRDTT DDGGIYAGAL FFVVIMIMFN GMSELAMTIF KLPVFYKQRD
610 620 630 640 650
LLFFPSWAYA IPSWILKIPV TLVEVGLWVI LTYYVIGFDP NITRFLKQFL
660 670 680 690 700
LLIVVNQMAS GMFRFIGAVG RTMGVASTFG SFALLLQFAL GGFVLSRDDV
710 720 730 740 750
KSWWIWGYWI SPMMYSVNSI LVNEFDGKKW NHIVPGGNET LGSTVVKSRG
760 770 780 790 800
FFPEAYWYWI GVGALVGFTV VFNFCYSLAL AYLNPFDKPQ AVLPEDGENA
810 820 830 840 850
ENGEVSSQIT STDGGDSISE SQNNKKGMVL PFEPHSITFD DVVYSVDMPQ
860 870 880 890 900
EMKEQGAGED RLVLLKGVSG AFRPGVLTAL MGVSGAGKTT LMDVLAGRKT
910 920 930 940 950
GGYIDGEIKI SGYPKKQETF ARISGYCEQN DIHSPYVTVY ESLVYSAWLR
960 970 980 990 1000
LPQDVDEKTR KMFVDEVMEL VELGPLRSAL VGLPGVNGLS TEQRKRLTIA
1010 1020 1030 1040 1050
VELVANPSII FMDEPTSGLD ARAAAIVMRT VRNTVDTGRT VVCTIHQPSI
1060 1070 1080 1090 1100
DIFEAFDELF LMKRGGQEIY VGPLGRHSCH LIKYFESNPG VAKIKEGYNP
1110 1120 1130 1140 1150
ATWMLEVTAS AQEMMLGIDF TEVYKNSDLY RRNKALISEL GVPRPGSKDL
1160 1170 1180 1190 1200
HFETQYSQSF WTQCVACLWK QHWSYWRNPA YTAVRFIFTT FIALIFGTMF
1210 1220 1230 1240 1250
WDLGTKVSKS QDLLNAMGSM YAAVLFLGVQ NASSVQPVVA IERTVFYRER
1260 1270 1280 1290 1300
AAGMYSAIPY AFGQVSIEIP YIFVQSVFYG IIVYAMIGFE WDVGKFFWYL
1310 1320 1330 1340 1350
FIMFFTLLYF TFYGMMGVAV TPNQNVASIV AAFFYGVWNL FSGFIIPRPR
1360 1370 1380 1390 1400
MPVWWRWYYW ANPVAWTLYG LVASQFGDIQ TKLSDNETVE QFLRRYFGFK
1410 1420 1430
HDFLGVVAAV LTAYVFMFAF TFAFAIKAFN FQRR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 810 | T → P in BAB92011 (PubMed:11997039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB075550 mRNA Translation: BAB92011.1 AB109388 Genomic DNA Translation: BAD07483.1 |
RefSeqi | NP_001312599.1, NM_001325670.1 XP_016478140.1, XM_016622654.1 |
Genome annotation databases
GeneIDi | 107799533 |
KEGGi | nta:107799533 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB075550 mRNA Translation: BAB92011.1 AB109388 Genomic DNA Translation: BAD07483.1 |
RefSeqi | NP_001312599.1, NM_001325670.1 XP_016478140.1, XM_016622654.1 |
3D structure databases
SMRi | Q76CU2 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 107799533 |
KEGGi | nta:107799533 |
Phylogenomic databases
OMAi | SMSMFFR |
OrthoDBi | 324553at2759 |
PhylomeDBi | Q76CU2 |
Family and domain databases
CDDi | cd03233, ABCG_PDR_domain1, 1 hit cd03232, ABCG_PDR_domain2, 1 hit |
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR013525, ABC_2_trans IPR029481, ABC_trans_N IPR003439, ABC_transporter-like_ATP-bd IPR043926, ABCG_dom IPR034001, ABCG_PDR_1 IPR034003, ABCG_PDR_2 IPR027417, P-loop_NTPase IPR013581, PDR_assoc |
Pfami | View protein in Pfam PF01061, ABC2_membrane, 2 hits PF19055, ABC2_membrane_7, 1 hit PF00005, ABC_tran, 2 hits PF14510, ABC_trans_N, 1 hit PF08370, PDR_assoc, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS50893, ABC_TRANSPORTER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PDR1_TOBAC | |
Accessioni | Q76CU2Primary (citable) accession number: Q76CU2 Secondary accession number(s): Q8LP45 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families