BRINP3

Functionⁱ

Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.1 Publication

GO - Biological processⁱ

cell cycle arrest Source: UniProtKB-KW
cellular response to retinoic acid Source: UniProtKB
negative regulation of mitotic cell cycle Source: UniProtKB
positive regulation of neuron differentiation Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Growth arrest

Biological process

Cell cycle, Growth arrest

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: BMP/retinoic acid-inducible neural-specific protein 3 Alternative name(s): DBCCR1-like protein 1
Gene namesⁱ	Name:BRINP3 Synonyms:DBCCR1L, DBCCR1L1, FAM5C
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162670.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:22393 BRINP3
neXtProtⁱ	NX_Q76B58

Keywords - Cellular componentⁱ

Mitochondrion, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	339479
Open Targets More...OpenTargetsⁱ	ENSG00000162670
PharmGKBⁱ	PA142671896

Polymorphism and mutation databases

BioMutaⁱ	FAM5C
DMDMⁱ	74749831

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 33	Sequence analysisAdd BLAST		33
ChainⁱPRO_0000045774	34 – 766	BMP/retinoic acid-inducible neural-specific protein 3Add BLAST		733

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	168	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	337	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	456	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	562	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	609	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	641	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q76B58
PaxDbⁱ	Q76B58
PeptideAtlas More...PeptideAtlasⁱ	Q76B58
PRIDEⁱ	Q76B58
ProteomicsDBⁱ	68662

PTM databases

iPTMnetⁱ	Q76B58
PhosphoSitePlusⁱ	Q76B58

Expressionⁱ

Tissue specificityⁱ

Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells. Overexpressed in gonadotropinomas compared to normal pituitarie tissues.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000162670 Expressed in 116 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_FAM5C
ExpressionAtlasⁱ	Q76B58 baseline and differential
Genevisibleⁱ	Q76B58 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA054693

HPAⁱ

HPA054693

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	130891, 20 interactors
STRINGⁱ	9606.ENSP00000356432

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q76B58
SMRⁱ	Q76B58
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	74 – 264	MACPFAdd BLAST		191

Sequence similaritiesⁱ

Belongs to the BRINP family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IF4X Eukaryota ENOG410XQ74 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008571
HOGENOMⁱ	HOG000049122
HOVERGENⁱ	HBG081412
InParanoidⁱ	Q76B58
OMAⁱ	DTTKLCS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02AS
PhylomeDBⁱ	Q76B58
TreeFamⁱ	TF331600

Family and domain databases

InterProⁱ	View protein in InterPro IPR033237 BRINP IPR009030 Growth_fac_rcpt_cys_sf IPR020864 MACPF
PANTHERⁱ	PTHR15564 PTHR15564, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01823 MACPF, 1 hit
SMARTⁱ	View protein in SMART SM00457 MACPF, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q76B58-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIWRSRAGAE LFSLMALWEW IALSLHCWVL AVAAVSDQHA TSPFDWLLSD 
        60         70         80         90        100
KGPFHRSQEY TDFVDRSRQG FSTRYKIYRE FGRWKVNNLA VERRNFLGSP 
       110        120        130        140        150
LPLAPEFFRN IRLLGRRPTL QQITENLIKK YGTHFLLSAT LGGEESLTIF 
       160        170        180        190        200
VDKRKLSKRA EGSDSTTNSS SVTLETLHQL AASYFIDRDS TLRRLHHIQI 
       210        220        230        240        250
ASTAIKVTET RTGPLGCSNY DNLDSVSSVL VQSPENKIQL QGLQVLLPDY 
       260        270        280        290        300
LQERFVQAAL SYIACNSEGE FICKENDCWC HCGPKFPECN CPSMDIQAME 
       310        320        330        340        350
ENLLRITETW KAYNSDFEES DEFKLFMKRL PMNYFLNTST IMHLWTMDSN 
       360        370        380        390        400
FQRRYEQLEN SMKQLFLKAQ KIVHKLFSLS KRCHKQPLIS LPRQRTSTYW 
       410        420        430        440        450
LTRIQSFLYC NENGLLGSFS EETHSCTCPN DQVVCTAFLP CTVGDASACL 
       460        470        480        490        500
TCAPDNRTRC GTCNTGYMLS QGLCKPEVAE STDHYIGFET DLQDLEMKYL 
       510        520        530        540        550
LQKTDRRIEV HAIFISNDMR LNSWFDPSWR KRMLLTLKSN KYKSSLVHMI 
       560        570        580        590        600
LGLSLQICLT KNSTLEPVLA VYVNPFGGSH SESWFMPVNE NSFPDWERTK 
       610        620        630        640        650
LDLPLQCYNW TLTLGNKWKT FFETVHIYLR SRIKSNGPNG NESIYYEPLE 
       660        670        680        690        700
FIDPSRNLGY MKINNIQVFG YSMHFDPEAI RDLILQLDYP YTQGSQDSAL 
       710        720        730        740        750
LQLLEIRDRV NKLSPPGQRR LDLFSCLLRH RLKLSTSEVV RIQSALQAFN 
       760 
AKLPNTMDYD TTKLCS

Length:766

Mass (Da):88,445

Last modified:July 5, 2004 - v1

Checksum:ⁱD325EB7E9F416FB3

GO

Isoform 2 (identifier: Q76B58-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-40: MIWRSRAGAE...AVAAVSDQHA → MPQAPSTGSS...RDLAQDTRYT
41-142: Missing.

« Hide

        10         20         30         40         50
MPQAPSTGSS LIRDPSIAHR NTQILWTEAG RDLAQDTRYT GEESLTIFVD 
        60         70         80         90        100
KRKLSKRAEG SDSTTNSSSV TLETLHQLAA SYFIDRDSTL RRLHHIQIAS 
       110        120        130        140        150
TAIKVTETRT GPLGCSNYDN LDSVSSVLVQ SPENKIQLQG LQVLLPDYLQ 
       160        170        180        190        200
ERFVQAALSY IACNSEGEFI CKENDCWCHC GPKFPECNCP SMDIQAMEEN 
       210        220        230        240        250
LLRITETWKA YNSDFEESDE FKLFMKRLPM NYFLNTSTIM HLWTMDSNFQ 
       260        270        280        290        300
RRYEQLENSM KQLFLKAQKI VHKLFSLSKR CHKQPLISLP RQRTSTYWLT 
       310        320        330        340        350
RIQSFLYCNE NGLLGSFSEE THSCTCPNDQ VVCTAFLPCT VGDASACLTC 
       360        370        380        390        400
APDNRTRCGT CNTGYMLSQG LCKPEVAEST DHYIGFETDL QDLEMKYLLQ 
       410        420        430        440        450
KTDRRIEVHA IFISNDMRLN SWFDPSWRKR MLLTLKSNKY KSSLVHMILG 
       460        470        480        490        500
LSLQICLTKN STLEPVLAVY VNPFGGSHSE SWFMPVNENS FPDWERTKLD 
       510        520        530        540        550
LPLQCYNWTL TLGNKWKTFF ETVHIYLRSR IKSNGPNGNE SIYYEPLEFI 
       560        570        580        590        600
DPSRNLGYMK INNIQVFGYS MHFDPEAIRD LILQLDYPYT QGSQDSALLQ 
       610        620        630        640        650
LLEIRDRVNK LSPPGQRRLD LFSCLLRHRL KLSTSEVVRI QSALQAFNAK 
       660 
LPNTMDYDTT KLCS

Note: No experimental confirmation available.

Show »

Length:664

Mass (Da):76,299

Checksum:ⁱ2A9FC9B061911025

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	A0A0J9YVN8	A0A0J9YVN8_HUMAN		BMP/retinoic acid-inducible neural-... BMP/retinoic acid-inducible neural-specific protein 3	BRINP3	158	Annotation score:
	B1AMP1	B1AMP1_HUMAN		BMP/retinoic acid-inducible neural-... BMP/retinoic acid-inducible neural-specific protein 3	BRINP3	28	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	422	E → K in AAD09521 (PubMed:16710414).Curated		1
Sequence conflictⁱ	534	L → F in AAD09521 (PubMed:16710414).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055545	1 – 40	MIWRS…SDQHA → MPQAPSTGSSLIRDPSIAHR NTQILWTEAGRDLAQDTRYT in isoform 2. 1 PublicationAdd BLAST		40
Alternative sequenceⁱVSP_055546	41 – 142	Missing in isoform 2. 1 PublicationAdd BLAST		102

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB111893 mRNA Translation: BAD04066.1 AK123024 mRNA Translation: BAG53853.1 AK294365 mRNA Translation: BAH11746.1 AL354771 Genomic DNA No translation available. AL365402 Genomic DNA No translation available. AL391645 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91222.1 BC105052 mRNA Translation: AAI05053.1 BC105054 mRNA Translation: AAI05055.1 U67037 mRNA Translation: AAD09521.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1373.1 [Q76B58-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001304117.1, NM_001317188.1 [Q76B58-2] NP_950252.1, NM_199051.2 [Q76B58-1] XP_011507778.1, XM_011509476.2 [Q76B58-2] XP_016856614.1, XM_017001125.1 [Q76B58-1] XP_016856615.1, XM_017001126.1 [Q76B58-1] XP_016856618.1, XM_017001129.1 [Q76B58-2] XP_016856619.1, XM_017001130.1 [Q76B58-2]
UniGeneⁱ	Hs.65765

Genome annotation databases

Ensemblⁱ	ENST00000367462; ENSP00000356432; ENSG00000162670 [Q76B58-1]
GeneIDⁱ	339479
KEGGⁱ	hsa:339479
UCSC genome browser More...UCSCⁱ	uc001gse.2 human [Q76B58-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q76B58	BMP/retinoic acid-inducible neural-specific protein 3 (Fragment)		HUMAN		158	UniRef100_Q76B58
BRINP3 isoform 3 (Fragment)		PANTR		158
Uncharacterized protein		MACMU		28
BMP/retinoic acid-inducible neural-specific protein 3 (Fragment)		HUMAN		28
UPI000512304A		HUMAN		473
+1

Protein	Similar proteins		Species	Score	Length	Source
Q76B58	BMP/retinoic acid-inducible neural-specific protein 3		MOUSE		766	UniRef90_Q499E0
BMP/retinoic acid-inducible neural-specific protein 3		RAT		766
BMP/retinoic acid-inducible neural-specific protein 3 (Fragment)		HUMAN		158
BRINP3 isoform 3 (Fragment)		PANTR		158
Uncharacterized protein		MACMU		28
+138
Q76B58-2	BMP/retinoic acid inducible neural specific 3		MACNE		736	UniRef90_Q76B58-2
BMP/retinoic acid inducible neural specific 3		RHIRO		735
BMP/retinoic acid-inducible neural-specific protein 3 isoform X2		TURTR		664
BMP/retinoic acid-inducible neural-specific protein 3 isoform X2		Florida manatee		664
BMP/retinoic acid-inducible neural-specific protein 3 isoform X2		ODORO		664
+29

Protein	Similar proteins		Species	Score	Length	Source
Q76B58	BMP/retinoic acid-inducible neural-specific protein 3		MOUSE		766	UniRef50_Q499E0
BMP/retinoic acid-inducible neural-specific protein 3		RAT		766
BMP/retinoic acid inducible neural specific 3		CANLF		766
BMP/retinoic acid inducible neural specific 3		FICAL		766
Protein FAM5C		CALJA		766
+250
Q76B58-2	BMP/retinoic acid-inducible neural-specific protein 2		MOUSE		783	UniRef50_Q6DFY8
BMP/retinoic acid-inducible neural-specific protein 2		RAT		783
BMP/retinoic acid-inducible neural-specific protein 2		HUMAN		783
BMP/retinoic acid-inducible neural-specific protein 2		PONAB		783
BMP/retinoic acid inducible neural specific 2		SHEEP		790
+536

Entry informationⁱ

Entry nameⁱ	BRNP3_HUMAN
Accessionⁱ	Q76B58Primary (citable) accession number: Q76B58 Secondary accession number(s): B3KVP1 , B7Z260, O95726, Q2M330
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
	Last sequence update:	July 5, 2004
	Last modified:	September 12, 2018
	This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q76B58 (BRNP3_HUMAN)

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BMP/retinoic acid-inducible neural-specific protein 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ