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Protein

BMP/retinoic acid-inducible neural-specific protein 3

Gene

BRINP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.1 Publication

GO - Biological processi

Keywordsi

Biological processCell cycle, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
BMP/retinoic acid-inducible neural-specific protein 3
Alternative name(s):
DBCCR1-like protein 1
Gene namesi
Name:BRINP3
Synonyms:DBCCR1L, DBCCR1L1, FAM5C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162670.10
HGNCiHGNC:22393 BRINP3
neXtProtiNX_Q76B58

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi339479
OpenTargetsiENSG00000162670
PharmGKBiPA142671896

Polymorphism and mutation databases

BioMutaiFAM5C
DMDMi74749831

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000004577434 – 766BMP/retinoic acid-inducible neural-specific protein 3Add BLAST733

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi562N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi609N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi641N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ76B58
PaxDbiQ76B58
PeptideAtlasiQ76B58
PRIDEiQ76B58
ProteomicsDBi68662

PTM databases

iPTMnetiQ76B58
PhosphoSitePlusiQ76B58

Expressioni

Tissue specificityi

Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells. Overexpressed in gonadotropinomas compared to normal pituitarie tissues.3 Publications

Gene expression databases

BgeeiENSG00000162670 Expressed in 116 organ(s), highest expression level in corpus callosum
CleanExiHS_FAM5C
ExpressionAtlasiQ76B58 baseline and differential
GenevisibleiQ76B58 HS

Organism-specific databases

HPAiHPA054693

Interactioni

Protein-protein interaction databases

BioGridi130891, 20 interactors
STRINGi9606.ENSP00000356432

Structurei

3D structure databases

ProteinModelPortaliQ76B58
SMRiQ76B58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 264MACPFAdd BLAST191

Sequence similaritiesi

Belongs to the BRINP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF4X Eukaryota
ENOG410XQ74 LUCA
GeneTreeiENSGT00390000008571
HOGENOMiHOG000049122
HOVERGENiHBG081412
InParanoidiQ76B58
OMAiDTTKLCS
OrthoDBiEOG091G02AS
PhylomeDBiQ76B58
TreeFamiTF331600

Family and domain databases

InterProiView protein in InterPro
IPR033237 BRINP
IPR009030 Growth_fac_rcpt_cys_sf
IPR020864 MACPF
PANTHERiPTHR15564 PTHR15564, 1 hit
PfamiView protein in Pfam
PF01823 MACPF, 1 hit
SMARTiView protein in SMART
SM00457 MACPF, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q76B58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIWRSRAGAE LFSLMALWEW IALSLHCWVL AVAAVSDQHA TSPFDWLLSD
60 70 80 90 100
KGPFHRSQEY TDFVDRSRQG FSTRYKIYRE FGRWKVNNLA VERRNFLGSP
110 120 130 140 150
LPLAPEFFRN IRLLGRRPTL QQITENLIKK YGTHFLLSAT LGGEESLTIF
160 170 180 190 200
VDKRKLSKRA EGSDSTTNSS SVTLETLHQL AASYFIDRDS TLRRLHHIQI
210 220 230 240 250
ASTAIKVTET RTGPLGCSNY DNLDSVSSVL VQSPENKIQL QGLQVLLPDY
260 270 280 290 300
LQERFVQAAL SYIACNSEGE FICKENDCWC HCGPKFPECN CPSMDIQAME
310 320 330 340 350
ENLLRITETW KAYNSDFEES DEFKLFMKRL PMNYFLNTST IMHLWTMDSN
360 370 380 390 400
FQRRYEQLEN SMKQLFLKAQ KIVHKLFSLS KRCHKQPLIS LPRQRTSTYW
410 420 430 440 450
LTRIQSFLYC NENGLLGSFS EETHSCTCPN DQVVCTAFLP CTVGDASACL
460 470 480 490 500
TCAPDNRTRC GTCNTGYMLS QGLCKPEVAE STDHYIGFET DLQDLEMKYL
510 520 530 540 550
LQKTDRRIEV HAIFISNDMR LNSWFDPSWR KRMLLTLKSN KYKSSLVHMI
560 570 580 590 600
LGLSLQICLT KNSTLEPVLA VYVNPFGGSH SESWFMPVNE NSFPDWERTK
610 620 630 640 650
LDLPLQCYNW TLTLGNKWKT FFETVHIYLR SRIKSNGPNG NESIYYEPLE
660 670 680 690 700
FIDPSRNLGY MKINNIQVFG YSMHFDPEAI RDLILQLDYP YTQGSQDSAL
710 720 730 740 750
LQLLEIRDRV NKLSPPGQRR LDLFSCLLRH RLKLSTSEVV RIQSALQAFN
760
AKLPNTMDYD TTKLCS
Length:766
Mass (Da):88,445
Last modified:July 5, 2004 - v1
Checksum:iD325EB7E9F416FB3
GO
Isoform 2 (identifier: Q76B58-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MIWRSRAGAE...AVAAVSDQHA → MPQAPSTGSS...RDLAQDTRYT
     41-142: Missing.

Note: No experimental confirmation available.
Show »
Length:664
Mass (Da):76,299
Checksum:i2A9FC9B061911025
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YVN8A0A0J9YVN8_HUMAN
BMP/retinoic acid-inducible neural-...
BRINP3
158Annotation score:
B1AMP1B1AMP1_HUMAN
BMP/retinoic acid-inducible neural-...
BRINP3
28Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti422E → K in AAD09521 (PubMed:16710414).Curated1
Sequence conflicti534L → F in AAD09521 (PubMed:16710414).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555451 – 40MIWRS…SDQHA → MPQAPSTGSSLIRDPSIAHR NTQILWTEAGRDLAQDTRYT in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_05554641 – 142Missing in isoform 2. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB111893 mRNA Translation: BAD04066.1
AK123024 mRNA Translation: BAG53853.1
AK294365 mRNA Translation: BAH11746.1
AL354771 Genomic DNA No translation available.
AL365402 Genomic DNA No translation available.
AL391645 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91222.1
BC105052 mRNA Translation: AAI05053.1
BC105054 mRNA Translation: AAI05055.1
U67037 mRNA Translation: AAD09521.1
CCDSiCCDS1373.1 [Q76B58-1]
RefSeqiNP_001304117.1, NM_001317188.1 [Q76B58-2]
NP_950252.1, NM_199051.2 [Q76B58-1]
XP_011507778.1, XM_011509476.2 [Q76B58-2]
XP_016856614.1, XM_017001125.1 [Q76B58-1]
XP_016856615.1, XM_017001126.1 [Q76B58-1]
XP_016856618.1, XM_017001129.1 [Q76B58-2]
XP_016856619.1, XM_017001130.1 [Q76B58-2]
UniGeneiHs.65765

Genome annotation databases

EnsembliENST00000367462; ENSP00000356432; ENSG00000162670 [Q76B58-1]
GeneIDi339479
KEGGihsa:339479
UCSCiuc001gse.2 human [Q76B58-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBRNP3_HUMAN
AccessioniPrimary (citable) accession number: Q76B58
Secondary accession number(s): B3KVP1
, B7Z260, O95726, Q2M330
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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