UniProtKB - Q76B58 (BRNP3_HUMAN)
Protein
BMP/retinoic acid-inducible neural-specific protein 3
Gene
BRINP3
Organism
Homo sapiens (Human)
Status
Functioni
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.1 Publication
GO - Biological processi
- cell cycle arrest Source: UniProtKB-KW
- cellular response to retinoic acid Source: UniProtKB
- negative regulation of mitotic cell cycle Source: UniProtKB
- positive regulation of neuron differentiation Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Growth arrest |
Enzyme and pathway databases
PathwayCommonsi | Q76B58 |
Names & Taxonomyi
Protein namesi | Recommended name: BMP/retinoic acid-inducible neural-specific protein 3Alternative name(s): DBCCR1-like protein 1 |
Gene namesi | Name:BRINP3 Synonyms:DBCCR1L, DBCCR1L1, FAM5C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000162670.10 |
HGNCi | HGNC:22393, BRINP3 |
MIMi | 618390, gene |
neXtProti | NX_Q76B58 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Mitochondrion
- Mitochondrion By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Other locations
- dendrite Source: GO_Central
- neuronal cell body Source: GO_Central
Keywords - Cellular componenti
Mitochondrion, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 339479 |
OpenTargetsi | ENSG00000162670 |
PharmGKBi | PA142671896 |
Miscellaneous databases
Pharosi | Q76B58, Tbio |
Polymorphism and mutation databases
BioMutai | BRINP3 |
DMDMi | 74749831 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | Sequence analysisAdd BLAST | 33 | |
ChainiPRO_0000045774 | 34 – 766 | BMP/retinoic acid-inducible neural-specific protein 3Add BLAST | 733 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 168 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 337 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 456 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 562 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 609 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 641 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q76B58 |
MassIVEi | Q76B58 |
MaxQBi | Q76B58 |
PaxDbi | Q76B58 |
PeptideAtlasi | Q76B58 |
PRIDEi | Q76B58 |
ProteomicsDBi | 6410 68662 [Q76B58-1] |
PTM databases
GlyGeni | Q76B58, 6 sites |
iPTMneti | Q76B58 |
PhosphoSitePlusi | Q76B58 |
Expressioni
Tissue specificityi
Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells. Overexpressed in gonadotropinomas compared to normal pituitarie tissues.3 Publications
Gene expression databases
Bgeei | ENSG00000162670, Expressed in corpus callosum and 137 other tissues |
ExpressionAtlasi | Q76B58, baseline and differential |
Genevisiblei | Q76B58, HS |
Organism-specific databases
HPAi | ENSG00000162670, Tissue enhanced (brain, intestine) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 130891, 20 interactors |
IntActi | Q76B58, 16 interactors |
STRINGi | 9606.ENSP00000356432 |
Miscellaneous databases
RNActi | Q76B58, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 74 – 264 | MACPFAdd BLAST | 191 |
Sequence similaritiesi
Belongs to the BRINP family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QQZS, Eukaryota |
GeneTreei | ENSGT00940000156099 |
HOGENOMi | CLU_018347_0_0_1 |
InParanoidi | Q76B58 |
OMAi | EKNRQGF |
OrthoDBi | 157712at2759 |
PhylomeDBi | Q76B58 |
TreeFami | TF331600 |
Family and domain databases
InterProi | View protein in InterPro IPR033237, BRINP IPR009030, Growth_fac_rcpt_cys_sf IPR020864, MACPF |
PANTHERi | PTHR15564, PTHR15564, 1 hit |
Pfami | View protein in Pfam PF19052, BRINP, 1 hit PF01823, MACPF, 1 hit |
SMARTi | View protein in SMART SM00457, MACPF, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q76B58-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIWRSRAGAE LFSLMALWEW IALSLHCWVL AVAAVSDQHA TSPFDWLLSD
60 70 80 90 100
KGPFHRSQEY TDFVDRSRQG FSTRYKIYRE FGRWKVNNLA VERRNFLGSP
110 120 130 140 150
LPLAPEFFRN IRLLGRRPTL QQITENLIKK YGTHFLLSAT LGGEESLTIF
160 170 180 190 200
VDKRKLSKRA EGSDSTTNSS SVTLETLHQL AASYFIDRDS TLRRLHHIQI
210 220 230 240 250
ASTAIKVTET RTGPLGCSNY DNLDSVSSVL VQSPENKIQL QGLQVLLPDY
260 270 280 290 300
LQERFVQAAL SYIACNSEGE FICKENDCWC HCGPKFPECN CPSMDIQAME
310 320 330 340 350
ENLLRITETW KAYNSDFEES DEFKLFMKRL PMNYFLNTST IMHLWTMDSN
360 370 380 390 400
FQRRYEQLEN SMKQLFLKAQ KIVHKLFSLS KRCHKQPLIS LPRQRTSTYW
410 420 430 440 450
LTRIQSFLYC NENGLLGSFS EETHSCTCPN DQVVCTAFLP CTVGDASACL
460 470 480 490 500
TCAPDNRTRC GTCNTGYMLS QGLCKPEVAE STDHYIGFET DLQDLEMKYL
510 520 530 540 550
LQKTDRRIEV HAIFISNDMR LNSWFDPSWR KRMLLTLKSN KYKSSLVHMI
560 570 580 590 600
LGLSLQICLT KNSTLEPVLA VYVNPFGGSH SESWFMPVNE NSFPDWERTK
610 620 630 640 650
LDLPLQCYNW TLTLGNKWKT FFETVHIYLR SRIKSNGPNG NESIYYEPLE
660 670 680 690 700
FIDPSRNLGY MKINNIQVFG YSMHFDPEAI RDLILQLDYP YTQGSQDSAL
710 720 730 740 750
LQLLEIRDRV NKLSPPGQRR LDLFSCLLRH RLKLSTSEVV RIQSALQAFN
760
AKLPNTMDYD TTKLCS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0J9YVN8 | A0A0J9YVN8_HUMAN | BMP/retinoic acid-inducible neural-... | BRINP3 | 158 | Annotation score: | ||
B1AMP1 | B1AMP1_HUMAN | BMP/retinoic acid-inducible neural-... | BRINP3 | 28 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 422 | E → K in AAD09521 (PubMed:16710414).Curated | 1 | |
Sequence conflicti | 534 | L → F in AAD09521 (PubMed:16710414).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055545 | 1 – 40 | MIWRS…SDQHA → MPQAPSTGSSLIRDPSIAHR NTQILWTEAGRDLAQDTRYT in isoform 2. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_055546 | 41 – 142 | Missing in isoform 2. 1 PublicationAdd BLAST | 102 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB111893 mRNA Translation: BAD04066.1 AK123024 mRNA Translation: BAG53853.1 AK294365 mRNA Translation: BAH11746.1 AL354771 Genomic DNA No translation available. AL365402 Genomic DNA No translation available. AL391645 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91222.1 BC105052 mRNA Translation: AAI05053.1 BC105054 mRNA Translation: AAI05055.1 U67037 mRNA Translation: AAD09521.1 |
CCDSi | CCDS1373.1 [Q76B58-1] |
RefSeqi | NP_001304117.1, NM_001317188.1 [Q76B58-2] NP_950252.1, NM_199051.2 [Q76B58-1] XP_011507778.1, XM_011509476.2 [Q76B58-2] XP_016856614.1, XM_017001125.1 [Q76B58-1] XP_016856615.1, XM_017001126.1 [Q76B58-1] XP_016856618.1, XM_017001129.1 [Q76B58-2] XP_016856619.1, XM_017001130.1 [Q76B58-2] |
Genome annotation databases
Ensembli | ENST00000367462; ENSP00000356432; ENSG00000162670 [Q76B58-1] |
GeneIDi | 339479 |
KEGGi | hsa:339479 |
UCSCi | uc001gse.2, human [Q76B58-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB111893 mRNA Translation: BAD04066.1 AK123024 mRNA Translation: BAG53853.1 AK294365 mRNA Translation: BAH11746.1 AL354771 Genomic DNA No translation available. AL365402 Genomic DNA No translation available. AL391645 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91222.1 BC105052 mRNA Translation: AAI05053.1 BC105054 mRNA Translation: AAI05055.1 U67037 mRNA Translation: AAD09521.1 |
CCDSi | CCDS1373.1 [Q76B58-1] |
RefSeqi | NP_001304117.1, NM_001317188.1 [Q76B58-2] NP_950252.1, NM_199051.2 [Q76B58-1] XP_011507778.1, XM_011509476.2 [Q76B58-2] XP_016856614.1, XM_017001125.1 [Q76B58-1] XP_016856615.1, XM_017001126.1 [Q76B58-1] XP_016856618.1, XM_017001129.1 [Q76B58-2] XP_016856619.1, XM_017001130.1 [Q76B58-2] |
3D structure databases
SMRi | Q76B58 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130891, 20 interactors |
IntActi | Q76B58, 16 interactors |
STRINGi | 9606.ENSP00000356432 |
PTM databases
GlyGeni | Q76B58, 6 sites |
iPTMneti | Q76B58 |
PhosphoSitePlusi | Q76B58 |
Polymorphism and mutation databases
BioMutai | BRINP3 |
DMDMi | 74749831 |
Proteomic databases
jPOSTi | Q76B58 |
MassIVEi | Q76B58 |
MaxQBi | Q76B58 |
PaxDbi | Q76B58 |
PeptideAtlasi | Q76B58 |
PRIDEi | Q76B58 |
ProteomicsDBi | 6410 68662 [Q76B58-1] |
Protocols and materials databases
Antibodypediai | 55879, 82 antibodies |
Genome annotation databases
Ensembli | ENST00000367462; ENSP00000356432; ENSG00000162670 [Q76B58-1] |
GeneIDi | 339479 |
KEGGi | hsa:339479 |
UCSCi | uc001gse.2, human [Q76B58-1] |
Organism-specific databases
CTDi | 339479 |
DisGeNETi | 339479 |
EuPathDBi | HostDB:ENSG00000162670.10 |
GeneCardsi | BRINP3 |
HGNCi | HGNC:22393, BRINP3 |
HPAi | ENSG00000162670, Tissue enhanced (brain, intestine) |
MIMi | 618390, gene |
neXtProti | NX_Q76B58 |
OpenTargetsi | ENSG00000162670 |
PharmGKBi | PA142671896 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQZS, Eukaryota |
GeneTreei | ENSGT00940000156099 |
HOGENOMi | CLU_018347_0_0_1 |
InParanoidi | Q76B58 |
OMAi | EKNRQGF |
OrthoDBi | 157712at2759 |
PhylomeDBi | Q76B58 |
TreeFami | TF331600 |
Enzyme and pathway databases
PathwayCommonsi | Q76B58 |
Miscellaneous databases
BioGRID-ORCSi | 339479, 3 hits in 829 CRISPR screens |
ChiTaRSi | BRINP3, human |
GenomeRNAii | 339479 |
Pharosi | Q76B58, Tbio |
PROi | PR:Q76B58 |
RNActi | Q76B58, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162670, Expressed in corpus callosum and 137 other tissues |
ExpressionAtlasi | Q76B58, baseline and differential |
Genevisiblei | Q76B58, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033237, BRINP IPR009030, Growth_fac_rcpt_cys_sf IPR020864, MACPF |
PANTHERi | PTHR15564, PTHR15564, 1 hit |
Pfami | View protein in Pfam PF19052, BRINP, 1 hit PF01823, MACPF, 1 hit |
SMARTi | View protein in SMART SM00457, MACPF, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BRNP3_HUMAN | |
Accessioni | Q76B58Primary (citable) accession number: Q76B58 Secondary accession number(s): B3KVP1 Q2M330 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM