Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

A disintegrin and metalloproteinase with thrombospondin motifs 13

Gene

Adamts13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Zinc and calcium ions cooperatively modulate enzyme activity. The cleavage of the pro-domain is not required for protease activity. Dependence on calcium for proteolytic activity is mediated by the high affinity site (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi85CalciumBy similarity1
Metal bindingi175CalciumBy similarity1
Metal bindingi184Calcium; high affinityBy similarity1
Metal bindingi186Calcium; high affinityBy similarity1
Metal bindingi189Calcium; high affinityBy similarity1
Metal bindingi214Calcium; high affinityBy similarity1
Metal bindingi226Zinc; catalyticBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei227PROSITE-ProRule annotation1
Metal bindingi230Zinc; catalyticBy similarity1
Metal bindingi236Zinc; catalyticBy similarity1
Metal bindingi281CalciumBy similarity1
Metal bindingi289CalciumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processBlood coagulation, Hemostasis
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.24.87 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5173214 O-glycosylation of TSR domain-containing proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 13 (EC:3.4.24.871 Publication)
Short name:
ADAM-TS 13
Short name:
ADAM-TS13
Short name:
ADAMTS-13
Alternative name(s):
von Willebrand factor-cleaving protease
Short name:
vWF-CP
Short name:
vWF-cleaving protease
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adamts13
Synonyms:Gm710
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685556 Adamts13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000024751234 – 76By similarityAdd BLAST43
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024751377 – 1426A disintegrin and metalloproteinase with thrombospondin motifs 13Add BLAST1350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi157 ↔ 210By similarity
Disulfide bondi204 ↔ 286By similarity
Disulfide bondi246 ↔ 270By similarity
Disulfide bondi316 ↔ 342By similarity
Disulfide bondi327 ↔ 352By similarity
Disulfide bondi337 ↔ 371By similarity
Disulfide bondi365 ↔ 376By similarity
Disulfide bondi401 ↔ 438By similarity
Disulfide bondi405 ↔ 443By similarity
Disulfide bondi416 ↔ 428By similarity
Disulfide bondi488 ↔ 527By similarity
Disulfide bondi513 ↔ 532By similarity
Disulfide bondi537 ↔ 553By similarity
Disulfide bondi550 ↔ 560By similarity
Glycosylationi557N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi564N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi584N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi619N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi703O-linked (Fuc...) serineBy similarity1
Glycosylationi762O-linked (Fuc...) serineBy similarity1
Glycosylationi834N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi914O-linked (Fuc...) serineBy similarity1
Glycosylationi973O-linked (Fuc...) threonineBy similarity1
Glycosylationi1033O-linked (Fuc...) serineBy similarity1
Glycosylationi1057N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1093O-linked (Fuc...) serineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor is processed by a furin endopeptidase which cleaves off the pro-domain.By similarity
O-glycosylated (By similarity). O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS13. May also be C-glycosylated on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and also N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q769J6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q769J6

PRoteomics IDEntifications database

More...
PRIDEi
Q769J6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q769J6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q769J6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma. Expression is consistently high in liver, medium in lung and spleen, low in skeletal muscle and undetectable in heart, brain, kidney and testis.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Increases steadly with the age of embryo, reaching highest levels in embryonic tissues of 19 days of gestation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000014852 Expressed in 12 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q769J6 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099955

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q769J6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q769J6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini74 – 291Peptidase M12BPROSITE-ProRule annotationAdd BLAST218
Domaini295 – 388DisintegrinAdd BLAST94
Domaini389 – 444TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini687 – 746TSP type-1 2PROSITE-ProRule annotationAdd BLAST60
Domaini747 – 810TSP type-1 3PROSITE-ProRule annotationAdd BLAST64
Domaini808 – 871TSP type-1 4PROSITE-ProRule annotationAdd BLAST64
Domaini904 – 957TSP type-1 5PROSITE-ProRule annotationAdd BLAST54
Domaini958 – 1019TSP type-1 6PROSITE-ProRule annotationAdd BLAST62
Domaini1020 – 1078TSP type-1 7PROSITE-ProRule annotationAdd BLAST59
Domaini1079 – 1137TSP type-1 8PROSITE-ProRule annotationAdd BLAST59
Domaini1195 – 1302CUB 1Add BLAST108
Domaini1293 – 1426CUB 2Add BLAST134

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni445 – 561Cysteine-richAdd BLAST117
Regioni556 – 685SpacerAdd BLAST130

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi503 – 505Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency.By similarity
The globular cysteineless spacer domain adopts a jelly-roll topology, and is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction (By similarity).By similarity

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538 Eukaryota
ENOG410XPKZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158379

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231627

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080358

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q769J6

KEGG Orthology (KO)

More...
KOi
K08627

Database of Orthologous Groups

More...
OrthoDBi
EOG091G14M8

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q769J6

TreeFam database of animal gene trees

More...
TreeFami
TF313537

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 3 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006586 ADAM_Cys-rich
IPR013273 ADAMTS/ADAMTS-like
IPR039806 ADAMTS13
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR035914 Sperma_CUB_dom_sf
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13723:SF20 PTHR13723:SF20, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857 ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00608 ACR, 1 hit
SM00209 TSP1, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854 SSF49854, 2 hits
SSF82895 SSF82895, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50092 TSP1, 4 hits
PS00142 ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q769J6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQLCLWLTC QPCYAVSVRG ILTGAIFILG CWGLSDFQKS LLQDLEPKDV
60 70 80 90 100
SSYFGHHAAP FTGHPPSHLQ RLRRRRTLED ILHLELLVAV GPDVSRAHQE
110 120 130 140 150
DTERYVLTNL NIGSELLRNP SLGVQFQVHL VKLITLSDSE STPNITANIT
160 170 180 190 200
SSLMSVCEWS QTINPHDDRD PSHADLILYI TRFDLELPDG NQQVRGVTQL
210 220 230 240 250
GGACSLSWSC LITEDTGFDL GVTIAHEIGH SFGLDHDGAP GSGSTCKASG
260 270 280 290 300
HVMAADGATP TGGTLEWSAC SQRQLQHLLS TGQMHCFQDP PGLQSGLTRH
310 320 330 340 350
QLMAQPGLYY SADDQCRVAF GSGAVACTFS REGLDVCQAL SCHTDPLDQS
360 370 380 390 400
SCSRLLVPLL DGTECGVEKW CSKARCRSLA ELAPVAAVHG HWSSWGPHSP
410 420 430 440 450
CSRSCGGGVI TRRRWCNNPR PAFGGRACVG EDLQAKMCNT QACEKTQLEF
460 470 480 490 500
MSEQCAQTDR QPLQLSQGTA SFYHWDAAVQ YSQGDTLCRH MCWAVGESFI
510 520 530 540 550
VSRGDRFLDG TRCVPSGPQD DGTLSLCLLG SCRTFGCDGR MDSQKVWDAC
560 570 580 590 600
QVCGGDNSTC SSRNGSFTAG RAREYVTFLI VTPNMTNAHI VNRRPLFTHL
610 620 630 640 650
AVRIQGHYIV AGKTSISPNT TYPSLLEDYR VEYRVTLTED QLPHLEEIHI
660 670 680 690 700
RGPVRDDIEI QVYRRYGGEY GDLTHPDITF SYFQLKQQAA WVWTAKRGPC
710 720 730 740 750
SVSCGAGLRW VTYSCQDQAQ DKWVKNAQCQ GSPQPPAWQE PCVSAPCSPY
760 770 780 790 800
WVAGDFSPCS VSCGGGLRER SLRCVETQDG FLKTLPPARC RAVAQQPAAE
810 820 830 840 850
VENCNSQPCP TRWEVSDPGP CMSSACEAGL DSRNVTCVSR AGDPEKPETA
860 870 880 890 900
GPCRTDEMSA MLEPCSRSLC SPGLGQVDNT MSLGEEAPSP VGSDKPGAQA
910 920 930 940 950
EHVWTPLVGL CSISCGRGLK ELYFLCMDSV LKMPVQEELC GLASKPPSRW
960 970 980 990 1000
EVCRARPCPA RWETQVLAPC PVTCGGGRVP LSVRCVQLDR GHPISVPHSK
1010 1020 1030 1040 1050
CSPVPKPGSF EDCSPEPCPA RWKVLSLGPC SASCGLGTAT QMVACMQLDQ
1060 1070 1080 1090 1100
GHDNEVNETF CKALVRPQAS VPCLIADCAF RWHISAWTEC SVSCGDGIQR
1110 1120 1130 1140 1150
RHDTCLGPQA QVPVPANFCQ HLPKPMTVRG CWAGPCAGQE TSSSLPHKEA
1160 1170 1180 1190 1200
TLPSQTQAAA TVASLQWSQP RARTPTLFSA SQSLGLQENL EEHGACGRQY
1210 1220 1230 1240 1250
LEPTGTIHMR DQGRLDCVVA IGRPLGEVVT LQILESSLKC SAGEQLLLWG
1260 1270 1280 1290 1300
RFTWRKTCRK MPGMTFSTKT NTVVVKQHRV LPGGGVLLRY WSQPAPGTFY
1310 1320 1330 1340 1350
KECDRQLFGP RGEIVSPSLS PDGRKAGTCR VFISVAPQAR IAIRALASDM
1360 1370 1380 1390 1400
GTASEGTNAN YVSIRDIHSL RTTTFWGQQV LYWESEGSEA ELEFSPGFLE
1410 1420
AHASLQGEYW TISPRTSEQD DSLALS
Length:1,426
Mass (Da):155,357
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62E9F672B91F6772
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ALB3A2ALB3_MOUSE
A disintegrin and metalloproteinase...
Adamts13
1,037Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti354R → H in BAC55159 (PubMed:15136581).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Two variants (Adamts13L and Adamts13S) were isolated that differed in the insertion of an intracisternal A particle (IAP) retrotransposon including a premature stop at the position 1036. In Adamts13S the C-terminal two TSP type-1 and two CUB domains are replaced with a 16-amino acid sequence derived from the IAP, this variant exhibited vWF cleaving activities in vitro. The IAP insertion is strain-specific and is found in BALB/c, C3H/He, C57BL/6 and DBA/2 strains, but not in the 129/Sv strain.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti1022 – 1037WKVLS…SCGLG → ALVWEAAPTFAVTRWR in Adamts13S. Add BLAST16
Natural varianti1038 – 1426Missing in Adamts13S. Add BLAST389

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB071302 mRNA Translation: BAC55159.2
AB095445 Genomic DNA Translation: BAD04062.1
AB112362 mRNA Translation: BAD18090.1
AL773563, AL845266 Genomic DNA Translation: CAM23711.1
AL845266, AL773563 Genomic DNA Translation: CAM24664.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15820.1

NCBI Reference Sequences

More...
RefSeqi
NP_001001322.1, NM_001001322.2
NP_001277392.1, NM_001290463.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.330084

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000102891; ENSMUSP00000099955; ENSMUSG00000014852

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
279028

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:279028

UCSC genome browser

More...
UCSCi
uc008iwp.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071302 mRNA Translation: BAC55159.2
AB095445 Genomic DNA Translation: BAD04062.1
AB112362 mRNA Translation: BAD18090.1
AL773563, AL845266 Genomic DNA Translation: CAM23711.1
AL845266, AL773563 Genomic DNA Translation: CAM24664.1
CCDSiCCDS15820.1
RefSeqiNP_001001322.1, NM_001001322.2
NP_001277392.1, NM_001290463.1
UniGeneiMm.330084

3D structure databases

ProteinModelPortaliQ769J6
SMRiQ769J6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099955

PTM databases

iPTMnetiQ769J6
PhosphoSitePlusiQ769J6

Proteomic databases

MaxQBiQ769J6
PaxDbiQ769J6
PRIDEiQ769J6

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
279028
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102891; ENSMUSP00000099955; ENSMUSG00000014852
GeneIDi279028
KEGGimmu:279028
UCSCiuc008iwp.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11093
MGIiMGI:2685556 Adamts13

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410XPKZ LUCA
GeneTreeiENSGT00940000158379
HOGENOMiHOG000231627
HOVERGENiHBG080358
InParanoidiQ769J6
KOiK08627
OrthoDBiEOG091G14M8
PhylomeDBiQ769J6
TreeFamiTF313537

Enzyme and pathway databases

BRENDAi3.4.24.87 3474
ReactomeiR-MMU-5173214 O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q769J6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000014852 Expressed in 12 organ(s), highest expression level in liver
ExpressionAtlasiQ769J6 baseline and differential

Family and domain databases

Gene3Di2.20.100.10, 3 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR006586 ADAM_Cys-rich
IPR013273 ADAMTS/ADAMTS-like
IPR039806 ADAMTS13
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR035914 Sperma_CUB_dom_sf
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PANTHERiPTHR13723:SF20 PTHR13723:SF20, 3 hits
PfamiView protein in Pfam
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 3 hits
PRINTSiPR01857 ADAMTSFAMILY
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00209 TSP1, 6 hits
SUPFAMiSSF49854 SSF49854, 2 hits
SSF82895 SSF82895, 4 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50092 TSP1, 4 hits
PS00142 ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATS13_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q769J6
Secondary accession number(s): A2ALB4, Q76LW1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 19, 2004
Last modified: December 5, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again