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UniProtKB - Q769F9 (TMEDA_DICDI)
Protein
Transmembrane emp24 domain-containing protein A
Gene
empA
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Could have a role in the budding of coatomer-coated and other species of coated vesicles.
By similarityGO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- Golgi organization Source: GO_Central
- intracellular protein transport Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-DDI-6807878, COPI-mediated anterograde transport R-DDI-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane emp24 domain-containing protein A |
Gene namesi | Name:empA ORF Names:DDB_G0288053 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0288053, empA |
Subcellular locationi
Other locations
- Cytoplasmic vesicle membrane By similarity; Single-pass type I membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: GO_Central
Other locations
- COPII-coated ER to Golgi transport vesicle Source: GO_Central
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- endoplasmic reticulum-Golgi intermediate compartment Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 172 | LumenalSequence analysisAdd BLAST | 148 | |
Transmembranei | 173 – 193 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 194 – 205 | CytoplasmicSequence analysisAdd BLAST | 12 |
Keywords - Cellular componenti
Cytoplasmic vesicle, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000342022 | 25 – 205 | Transmembrane emp24 domain-containing protein AAdd BLAST | 181 |
Proteomic databases
PaxDbi | Q769F9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 116 | GOLDPROSITE-ProRule annotationAdd BLAST | 83 |
Sequence similaritiesi
Belongs to the EMP24/GP25L family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1692, Eukaryota |
HOGENOMi | CLU_066963_4_1_1 |
InParanoidi | Q769F9 |
OMAi | WNLFVIG |
PhylomeDBi | Q769F9 |
Family and domain databases
InterProi | View protein in InterPro IPR015720, Emp24-like IPR009038, GOLD_dom IPR036598, GOLD_dom_sf |
PANTHERi | PTHR22811, PTHR22811, 1 hit |
Pfami | View protein in Pfam PF01105, EMP24_GP25L, 1 hit |
SMARTi | View protein in SMART SM01190, EMP24_GP25L, 1 hit |
SUPFAMi | SSF101576, SSF101576, 1 hit |
PROSITEi | View protein in PROSITE PS50866, GOLD, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q769F9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMNNKLLLLV IALLCIASNS IVESFSFKVS AKVEECIYEE IGVDLSFTAM
60 70 80 90 100
FQVIQGGFND IDFTIISPDK RIVYSGQRES EGTKTLRSSF AGVYSFCFSN
110 120 130 140 150
KMSSLTDKTV SFILSVGESS PIREIAKKKD LTPIERSIMT LSDGVIAVKN
160 170 180 190 200
EQNYFKMREA AHRNTAESTN SRVLWWSVFE AFVLIALSIW QIYYLRRFFE
VKRAV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB112541 Genomic DNA Translation: BAD05160.1 AAFI02000107 Genomic DNA Translation: EAL63452.1 |
RefSeqi | XP_636960.1, XM_631868.1 |
Genome annotation databases
EnsemblProtistsi | EAL63452; EAL63452; DDB_G0288053 |
GeneIDi | 8626435 |
KEGGi | ddi:DDB_G0288053 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB112541 Genomic DNA Translation: BAD05160.1 AAFI02000107 Genomic DNA Translation: EAL63452.1 |
RefSeqi | XP_636960.1, XM_631868.1 |
3D structure databases
SMRi | Q769F9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0201636 |
Proteomic databases
PaxDbi | Q769F9 |
Genome annotation databases
EnsemblProtistsi | EAL63452; EAL63452; DDB_G0288053 |
GeneIDi | 8626435 |
KEGGi | ddi:DDB_G0288053 |
Organism-specific databases
dictyBasei | DDB_G0288053, empA |
Phylogenomic databases
eggNOGi | KOG1692, Eukaryota |
HOGENOMi | CLU_066963_4_1_1 |
InParanoidi | Q769F9 |
OMAi | WNLFVIG |
PhylomeDBi | Q769F9 |
Enzyme and pathway databases
Reactomei | R-DDI-6807878, COPI-mediated anterograde transport R-DDI-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Miscellaneous databases
PROi | PR:Q769F9 |
Family and domain databases
InterProi | View protein in InterPro IPR015720, Emp24-like IPR009038, GOLD_dom IPR036598, GOLD_dom_sf |
PANTHERi | PTHR22811, PTHR22811, 1 hit |
Pfami | View protein in Pfam PF01105, EMP24_GP25L, 1 hit |
SMARTi | View protein in SMART SM01190, EMP24_GP25L, 1 hit |
SUPFAMi | SSF101576, SSF101576, 1 hit |
PROSITEi | View protein in PROSITE PS50866, GOLD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TMEDA_DICDI | |
Accessioni | Q769F9Primary (citable) accession number: Q769F9 Secondary accession number(s): Q54JH1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - SIMILARITY comments
Index of protein domains and families