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Protein

Rab effector Noc2

Gene

Rph3al

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Regulates the exocytosis of dense-core vesicles in neuroendocrine cells through interaction with RAB27A. Acts as a potential RAB3B effector protein in epithelial cells.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri89 – 146FYVE-typePROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Rab effector Noc2
Alternative name(s):
No C2 domains protein
Rabphilin-3A-like protein
Gene namesi
Name:Rph3al
Synonyms:Gm1753, Noc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1923492 Rph3al

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi51 – 55ELEII → ALEIA: Loss of binding to RAB27A, remaining cytoplasmic. 1 Publication5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002782641 – 302Rab effector Noc2Add BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ768S4
PRIDEiQ768S4

PTM databases

iPTMnetiQ768S4
PhosphoSitePlusiQ768S4

Expressioni

Tissue specificityi

Highly expressed in pancreatic islets. High to moderate expression in adrenal gland, pituitary gland and ovary.1 Publication

Gene expression databases

BgeeiENSMUSG00000020847 Expressed in 165 organ(s), highest expression level in oocyte
CleanExiMM_RPH3AL
ExpressionAtlasiQ768S4 baseline and differential
GenevisibleiQ768S4 MM

Interactioni

Subunit structurei

Recruited to dense-core vesicles through specific interaction with RAB27A in endocrine cells. Interacts with RAB3A, RAB3B, RAB3C and RAB3D. Interacts with ZYX (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi237613, 8 interactors
IntActiQ768S4, 1 interactor
STRINGi10090.ENSMUSP00000064202

Structurei

3D structure databases

ProteinModelPortaliQ768S4
SMRiQ768S4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 158RabBDPROSITE-ProRule annotationAdd BLAST118

Domaini

The N-terminus of the RabBD domain is necessary and sufficient for interaction with RAB27A.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri89 – 146FYVE-typePROSITE-ProRule annotationAdd BLAST58

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1013 Eukaryota
ENOG410XQXA LUCA
GeneTreeiENSGT00440000034248
HOGENOMiHOG000126816
HOVERGENiHBG052990
InParanoidiQ768S4
KOiK19939
OMAiQRKSQCL
OrthoDBiEOG091G0FPP
PhylomeDBiQ768S4
TreeFamiTF342971

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR010911 Rab_BD
IPR030538 Rab_effect_Noc2
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10024:SF244 PTHR10024:SF244, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q768S4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADTIFSSGN DQWVCPNDRQ LALRAKLQTG WSVHTYQTEK QRRSQCLSPG
60 70 80 90 100
ELEIILQVIQ RAERLDILEQ QRIGRLVERL ETMQRNVMGN GLSQCLLCGE
110 120 130 140 150
VLGFLGSSSV FCKDCRKKVC TKCGIEASPG QKRPLWLCKI CSEQREVWKR
160 170 180 190 200
SGAWFYKGLP KYILPLKTPG RADDPHFRPL PVEPTETQPP SAETSRVYTW
210 220 230 240 250
ARGRVVSSDS DSDSDLSSSS LEDRPLPSGV KGTKGDKPRG DSGASMESPR
260 270 280 290 300
LGPARPPSHL SGSQSSLGSE AGTGATEPQG GTPAQPEPRV PGKRHTWATP

RY
Length:302
Mass (Da):33,259
Last modified:July 5, 2004 - v1
Checksum:i5AE4A68535653324
GO
Isoform 2 (identifier: Q768S4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-141: KVCTKCGIEASPGQKRPLWLCKIC → LGIRWLQHFLESLLILNRDLTCSL
     142-302: Missing.

Show »
Length:141
Mass (Da):16,166
Checksum:iF500312CD1913D1E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7FAU1B7FAU1_MOUSE
Rab effector Noc2
Rph3al RP23-78H4.4-004
99Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023245118 – 141KVCTK…LCKIC → LGIRWLQHFLESLLILNRDL TCSL in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_023246142 – 302Missing in isoform 2. 1 PublicationAdd BLAST161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB112925 mRNA Translation: BAD07030.1
AB158403 mRNA Translation: BAD18853.1
AK018335 mRNA Translation: BAB31169.1
AL731710 Genomic DNA Translation: CAI24681.1
AL731710, AL669897 Genomic DNA Translation: CAI24682.1
AL669897, AL731710 Genomic DNA Translation: CAI26031.1
BC127960 mRNA Translation: AAI27961.1
CCDSiCCDS25058.1 [Q768S4-1]
CCDS70243.1 [Q768S4-2]
RefSeqiNP_001278088.1, NM_001291159.1 [Q768S4-2]
NP_083824.1, NM_029548.4 [Q768S4-1]
XP_006533700.1, XM_006533637.1 [Q768S4-1]
XP_006533701.1, XM_006533638.3 [Q768S4-1]
XP_006533702.1, XM_006533639.3 [Q768S4-1]
XP_006533703.1, XM_006533640.3 [Q768S4-1]
XP_006533704.1, XM_006533641.3 [Q768S4-1]
XP_006533705.1, XM_006533642.3 [Q768S4-1]
XP_011247403.1, XM_011249101.1 [Q768S4-2]
XP_011247404.1, XM_011249102.1 [Q768S4-2]
UniGeneiMm.425697
Mm.488178

Genome annotation databases

EnsembliENSMUST00000021208; ENSMUSP00000021208; ENSMUSG00000020847 [Q768S4-2]
ENSMUST00000066504; ENSMUSP00000064202; ENSMUSG00000020847 [Q768S4-1]
ENSMUST00000108420; ENSMUSP00000104058; ENSMUSG00000020847 [Q768S4-2]
ENSMUST00000121287; ENSMUSP00000113869; ENSMUSG00000020847 [Q768S4-1]
GeneIDi380714
KEGGimmu:380714
UCSCiuc007kew.2 mouse [Q768S4-1]
uc007kex.2 mouse [Q768S4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB112925 mRNA Translation: BAD07030.1
AB158403 mRNA Translation: BAD18853.1
AK018335 mRNA Translation: BAB31169.1
AL731710 Genomic DNA Translation: CAI24681.1
AL731710, AL669897 Genomic DNA Translation: CAI24682.1
AL669897, AL731710 Genomic DNA Translation: CAI26031.1
BC127960 mRNA Translation: AAI27961.1
CCDSiCCDS25058.1 [Q768S4-1]
CCDS70243.1 [Q768S4-2]
RefSeqiNP_001278088.1, NM_001291159.1 [Q768S4-2]
NP_083824.1, NM_029548.4 [Q768S4-1]
XP_006533700.1, XM_006533637.1 [Q768S4-1]
XP_006533701.1, XM_006533638.3 [Q768S4-1]
XP_006533702.1, XM_006533639.3 [Q768S4-1]
XP_006533703.1, XM_006533640.3 [Q768S4-1]
XP_006533704.1, XM_006533641.3 [Q768S4-1]
XP_006533705.1, XM_006533642.3 [Q768S4-1]
XP_011247403.1, XM_011249101.1 [Q768S4-2]
XP_011247404.1, XM_011249102.1 [Q768S4-2]
UniGeneiMm.425697
Mm.488178

3D structure databases

ProteinModelPortaliQ768S4
SMRiQ768S4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237613, 8 interactors
IntActiQ768S4, 1 interactor
STRINGi10090.ENSMUSP00000064202

PTM databases

iPTMnetiQ768S4
PhosphoSitePlusiQ768S4

Proteomic databases

PaxDbiQ768S4
PRIDEiQ768S4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021208; ENSMUSP00000021208; ENSMUSG00000020847 [Q768S4-2]
ENSMUST00000066504; ENSMUSP00000064202; ENSMUSG00000020847 [Q768S4-1]
ENSMUST00000108420; ENSMUSP00000104058; ENSMUSG00000020847 [Q768S4-2]
ENSMUST00000121287; ENSMUSP00000113869; ENSMUSG00000020847 [Q768S4-1]
GeneIDi380714
KEGGimmu:380714
UCSCiuc007kew.2 mouse [Q768S4-1]
uc007kex.2 mouse [Q768S4-2]

Organism-specific databases

CTDi9501
MGIiMGI:1923492 Rph3al

Phylogenomic databases

eggNOGiKOG1013 Eukaryota
ENOG410XQXA LUCA
GeneTreeiENSGT00440000034248
HOGENOMiHOG000126816
HOVERGENiHBG052990
InParanoidiQ768S4
KOiK19939
OMAiQRKSQCL
OrthoDBiEOG091G0FPP
PhylomeDBiQ768S4
TreeFamiTF342971

Miscellaneous databases

PROiPR:Q768S4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020847 Expressed in 165 organ(s), highest expression level in oocyte
CleanExiMM_RPH3AL
ExpressionAtlasiQ768S4 baseline and differential
GenevisibleiQ768S4 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR010911 Rab_BD
IPR030538 Rab_effect_Noc2
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10024:SF244 PTHR10024:SF244, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPH3L_MOUSE
AccessioniPrimary (citable) accession number: Q768S4
Secondary accession number(s): Q9D353
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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