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Protein

Mediator of DNA damage checkpoint protein 1

Gene

MDC1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, DNA damage, DNA repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of DNA damage checkpoint protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MDC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000963201 – 2042Mediator of DNA damage checkpoint protein 1Add BLAST2042

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4PhosphothreonineBy similarity1
Modified residuei146PhosphothreonineBy similarity1
Modified residuei168PhosphoserineBy similarity1
Modified residuei176PhosphoserineBy similarity1
Modified residuei291PhosphoserineBy similarity1
Modified residuei293PhosphothreonineBy similarity1
Modified residuei321PhosphoserineBy similarity1
Modified residuei323PhosphothreonineBy similarity1
Modified residuei364PhosphoserineBy similarity1
Modified residuei368PhosphoserineBy similarity1
Modified residuei370PhosphothreonineBy similarity1
Modified residuei386PhosphoserineBy similarity1
Modified residuei389PhosphoserineBy similarity1
Modified residuei394PhosphoserineBy similarity1
Modified residuei403PhosphoserineBy similarity1
Modified residuei447PhosphoserineBy similarity1
Modified residuei449PhosphothreonineBy similarity1
Modified residuei484PhosphoserineBy similarity1
Modified residuei494PhosphoserineBy similarity1
Modified residuei502PhosphoserineBy similarity1
Modified residuei512PhosphothreonineBy similarity1
Modified residuei580PhosphoserineBy similarity1
Modified residuei617PhosphoserineBy similarity1
Modified residuei619PhosphoserineBy similarity1
Modified residuei773PhosphoserineBy similarity1
Modified residuei786PhosphoserineBy similarity1
Modified residuei802N6-acetyllysineBy similarity1
Modified residuei945PhosphoserineBy similarity1
Modified residuei989PhosphoserineBy similarity1
Modified residuei1027PhosphoserineBy similarity1
Modified residuei1062PhosphoserineBy similarity1
Modified residuei1080PhosphoserineBy similarity1
Modified residuei1146PhosphothreonineBy similarity1
Modified residuei1187PhosphothreonineBy similarity1
Modified residuei1228PhosphothreonineBy similarity1
Modified residuei1269PhosphothreonineBy similarity1
Modified residuei1381PhosphoserineBy similarity1
Modified residuei1382PhosphoserineBy similarity1
Modified residuei1384N6-acetyllysineBy similarity1
Modified residuei1385PhosphothreonineBy similarity1
Modified residuei1399PhosphothreonineBy similarity1
Modified residuei1440PhosphothreonineBy similarity1
Modified residuei1507PhosphothreonineBy similarity1
Modified residuei1522PhosphothreonineBy similarity1
Modified residuei1538PhosphoserineBy similarity1
Modified residuei1541PhosphothreonineBy similarity1
Modified residuei1563PhosphothreonineBy similarity1
Modified residuei1575PhosphoserineBy similarity1
Modified residuei1579PhosphothreonineBy similarity1
Modified residuei1593PhosphothreonineBy similarity1
Modified residuei1634PhosphothreonineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1744Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1754PhosphothreonineBy similarity1
Modified residuei1774PhosphoserineBy similarity1
Modified residuei1896Omega-N-methylarginineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated upon exposure to ionizing radiation (IR), ultraviolet radiation (UV), and hydroxyurea (HU). Phosphorylation in response to IR requires ATM, NBN, and possibly CHEK2. Also phosphorylated during the G2/M phase of the cell cycle and during activation of the mitotic spindle checkpoint. Phosphorylation at Thr-4 by ATM stabilizes and enhances homodimerization via the FHA domain (By similarity).By similarity
Sumoylation by PIAS4 following DNA damage promotes ubiquitin-mediated degradation.By similarity
Ubiquitinated by RNF4, leading to proteasomal degradation; undergoes 'Lys-48'-linked polyubiquitination.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q767L8

PeptideAtlas

More...
PeptideAtlasi
Q767L8

PRoteomics IDEntifications database

More...
PRIDEi
Q767L8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with several proteins involved in the DNA damage response, although not all these interactions may be direct. Interacts with H2AFX, which requires phosphorylation of H2AFX. Interacts with the MRN complex, composed of MRE11, RAD50, and NBN. Interacts with CHEK2, which requires ATM-mediated phosphorylation within the FHA domain of CHEK2. Interacts constitutively with the BRCA1-BARD1 complex, SMC1A and TP53BP1. Interacts with ATM and FANCD2, and these interactions are reduced upon DNA damage. Also interacts with the PRKDC complex, composed of XRCC6/KU70, XRCC5/KU80 and PRKDC/XRCC7. This interaction may be required for PRKDC autophosphorylation, which is essential for DNA double strand break (DSB) repair. When phosphorylated by ATM, interacts with RNF8 (via FHA domain). Interacts with CEP164. When phosphorylated, interacts with APTX (via FHA-like domain) (By similarity).By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000001438

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q767L8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q767L8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 105FHAPROSITE-ProRule annotationAdd BLAST52
Domaini1845 – 1923BRCT 1PROSITE-ProRule annotationAdd BLAST79
Domaini1944 – 2035BRCT 2PROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 150Interaction with CHEK2By similarityAdd BLAST150
Regioni2 – 219Interaction with the MRN complexAdd BLAST218
Regioni145 – 557Required for nuclear localization (NLS1)By similarityAdd BLAST413
Regioni1137 – 1580Interaction with the PRKDC complexBy similarityAdd BLAST444
Regioni1661 – 2042Required for nuclear localization (NLS2)By similarityAdd BLAST382

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1016 – 1788Pro-richAdd BLAST773

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Tandemly repeated BRCT domains are characteristic of proteins involved in DNA damage signaling. In MDC1, these repeats are required for localization to chromatin which flanks sites of DNA damage marked by 'Ser-139' phosphorylation of H2AFX (By similarity).By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2043 Eukaryota
ENOG4111RPS LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113506

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080567

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q767L8

KEGG Orthology (KO)

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KOi
K20780

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00027 BRCT, 1 hit
cd00060 FHA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10190, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00498 FHA, 1 hit
PF16770 RTT107_BRCT_5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00240 FHA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879 SSF49879, 1 hit
SSF52113 SSF52113, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172 BRCT, 1 hit
PS50006 FHA_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q767L8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDTQVINWE AEEEEVEEGP SEPLGCNLQP VGQLRIFSSS YGPEKDFPLY
60 70 80 90 100
LGKNVVGRMP ECSVALPFSS ISKQHAVIEI LAWNKAPVLR DCGSLNGTQI
110 120 130 140 150
LRPPKVLGPG VSHRLRNREL ILFADLPCQY HRLDVPPPLV SRGPLTVEET
160 170 180 190 200
PRGQGGTQPH RLLLAEDSEE EVDSLSERCV VKGPKTSLTT VIPESDEEGP
210 220 230 240 250
SPAPDGPGPP FAFNLNSDTD EEESQQPGAG EAPSAAETEQ PKPVTTEIQL
260 270 280 290 300
IKDQCPVKEK HKDARVKRAA SNGVVPVGAI LERSQPAGED SDTDVDEGSG
310 320 330 340 350
LPRRPAGAHS ERAQPCGFID SDTDAEEEGI PATPAVVPVK KRQIFHEVGT
360 370 380 390 400
ESPQAPGVAH AQESPAGSDT DIEEGEAPRT VPLDSSRASM MIDSNMDDEE
410 420 430 440 450
EVSAALTLAR LRESQAVPWN RDAGAGDHRA QPVALLDQSQ ASAGRDSDTD
460 470 480 490 500
MEEEGLPLEK RGSLPKGPAD KAHPEKSQPP LRGSDVKVEE DERSPGVHPG
510 520 530 540 550
RSQASATVDA ITQVEEKAPP RPAVTLSEQH QVPVAWTPQT DVEAEGDPAK
560 570 580 590 600
LPVVHPAEAR PPPAGGHEPD VEKNTSLAAS AGADVRKSQL LAEGDAGTEW
610 620 630 640 650
AVAILAQDRA LGAGAQSVSA RAQVGQDLPL VSREHLADVA VDTGAPGEAT
660 670 680 690 700
QTQREGTQAL TERERELNVD RTIDSGDNRD DSEDLDLQAT QCFVEGENQS
710 720 730 740 750
PEAVPSMEDE PTQAFPSTLP QEPGPSCCSF QASGTLDEPW ELLATQPFCP
760 770 780 790 800
RESEASEIQP VDTHLEARGL CPSPPRAALP EQHPESPEPL GSQGGGRQTV
810 820 830 840 850
EKATGTPRET AEGPTPERGP LERATKEPPS EGERGGMGEE GLPRGTQDRE
860 870 880 890 900
EKQVLAGVTQ RQESDRTVKS TSTDGGLESL QVEIETPKEM QENEIEKQTL
910 920 930 940 950
ARDMLEREAE KPVAERESEA GGPEVKVPEA VQDRGPLRAE AEGTSQDQKG
960 970 980 990 1000
QASNLTPEPG AGVGYLQGLA SAPAAPRSQA GGGGEAPVSP RRQQRGDLNC
1010 1020 1030 1040 1050
KMPPAEKSGV RAAFSPSLPS PHGDQESPEA CLPPEPPEAS APLQNPLPSQ
1060 1070 1080 1090 1100
SPKHPAPQSR LSPPPPPLEQ STPRTRPPQS QESPEPPFSS ELDPPNPEPK
1110 1120 1130 1140 1150
VRPQGSPPLS PIPLEAHPTS PTDQAGSPEP TSRAARGGTH RSFEVTPMSV
1160 1170 1180 1190 1200
VPTALELQSS TSADQPVVPK PTLRAPWGRT HRSSVKTPEP NIPTAPELQP
1210 1220 1230 1240 1250
STPTDQPVAP EPLSRATRGR TPRASVKTSE PVVPAAPEPQ PSTPTDQPVV
1260 1270 1280 1290 1300
PKPTLRAPRG RTHRSSVKTP EPNIPTAPEL RPSTPTDQPV APEPLSRATR
1310 1320 1330 1340 1350
GRTPRASVKS PEQNVPTAPE HPQPSTPTDQ PVTPKPTSRA TRGRAHRSSV
1360 1370 1380 1390 1400
KTPAASEPLP SASTDQPITP KPTSRGRAHR SSAKTPELQP PTSTGQPVTP
1410 1420 1430 1440 1450
RPTSQATRGR THRSSIKTPE PVVPTDPEPQ PSTPTDQPIT PELTSAATRG
1460 1470 1480 1490 1500
RTRRSSVKTP EPVVPTDPEP QPSTPTDQPI TPKPTSWATR GQAHRSSVKT
1510 1520 1530 1540 1550
PEPHVPTDPE PQPSTPTDQP VTPKPTSRAT RGRARKSSVK TPEPAVPTAA
1560 1570 1580 1590 1600
EPQPSASTDQ PITPKPTSRG RAHRSSAKTP ELQPPTSTGQ PFTPRPTSGA
1610 1620 1630 1640 1650
TQGRTHRSSA KTSQAVEPTA PDLEPPSPIG QPVTPKVIAE GGQNRILRSS
1660 1670 1680 1690 1700
RVGAVPGPTP PELQCPVPTE QPVPPEPIPR ASCSRRPRAT RKRESLTAHV
1710 1720 1730 1740 1750
GPDPCSAPPE PNSRSSRTQS LSTTPEPTLP QLPEAPAHAP QIPKVEAAGR
1760 1770 1780 1790 1800
PGFTLEPQPK ATQKRKRPLA PADSPPLPKR LQRGEVPPKT VILEEEENPT
1810 1820 1830 1840 1850
ARPGREEDAV IPEPGKRKRD QTEEEPRGVP SRSLRRTKPA QESTAPRVLF
1860 1870 1880 1890 1900
TGVVDARGER AVLALGGSLA SSVAEASHLV TDRIRRTVKF LCALGRGIPI
1910 1920 1930 1940 1950
LSLDWLHQSR KAGCFLPPDE YVVTDPEQEK NFGFSLREAL SRARERKLLE
1960 1970 1980 1990 2000
GYEIHVTPGV QPPPPQMGEI ISCCGGTVLP SMPRSYKPQR VVITCSQDFP
2010 2020 2030 2040
RCSVPFRLGL PVLSPEFLLT GVLKQEAKPE AFVLSTLEMA SA
Length:2,042
Mass (Da):217,917
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i897310CC1674C549
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB113356 Genomic DNA Translation: BAD08434.1
AB113357 Genomic DNA Translation: BAD08445.1

NCBI Reference Sequences

More...
RefSeqi
NP_001116610.1, NM_001123138.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Ssc.63271
Ssc.70644

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
100144453

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:100144453

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB113356 Genomic DNA Translation: BAD08434.1
AB113357 Genomic DNA Translation: BAD08445.1
RefSeqiNP_001116610.1, NM_001123138.1
UniGeneiSsc.63271
Ssc.70644

3D structure databases

ProteinModelPortaliQ767L8
SMRiQ767L8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001438

Proteomic databases

PaxDbiQ767L8
PeptideAtlasiQ767L8
PRIDEiQ767L8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100144453
KEGGissc:100144453

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9656

Phylogenomic databases

eggNOGiKOG2043 Eukaryota
ENOG4111RPS LUCA
HOGENOMiHOG000113506
HOVERGENiHBG080567
InParanoidiQ767L8
KOiK20780

Family and domain databases

CDDicd00027 BRCT, 1 hit
cd00060 FHA, 1 hit
Gene3Di3.40.50.10190, 2 hits
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF16770 RTT107_BRCT_5, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52113 SSF52113, 2 hits
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS50006 FHA_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMDC1_PIG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q767L8
Secondary accession number(s): Q767K4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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