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UniProtKB - Q767L0 (ABCF1_PIG)
Protein
ATP-binding cassette sub-family F member 1
Gene
ABCF1
Organism
Sus scrofa (Pig)
Status
Functioni
Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 298 – 305 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 620 – 627 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- ribosome binding Source: UniProtKB
- translation activator activity Source: UniProtKB
GO - Biological processi
- positive regulation of translation Source: UniProtKB
- translational initiation Source: UniProtKB
Keywordsi
Molecular function | Activator |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-binding cassette sub-family F member 1 |
Gene namesi | Name:ABCF1 |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Nucleus
- nucleoplasm By similarity
- Nucleus envelope By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- nuclear envelope Source: UniProtKB
- nucleoplasm Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- polysomal ribosome Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093321 | 1 – 807 | ATP-binding cassette sub-family F member 1Add BLAST | 807 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 22 | PhosphoserineBy similarity | 1 | |
Modified residuei | 106 | PhosphoserineBy similarity | 1 | |
Modified residuei | 110 | Phosphoserine; by CK2By similarity | 1 | |
Modified residuei | 141 | Phosphoserine; by CK2By similarity | 1 | |
Modified residuei | 167 | PhosphoserineBy similarity | 1 | |
Modified residuei | 557 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylated at phosphoserine and phosphothreonine. Phosphorylation on Ser-110 and Ser-141 by CK2; inhibits association of EIF2 with ribosomes (By similarity).By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q767L0 |
PeptideAtlasi | Q767L0 |
PRIDEi | Q767L0 |
Expressioni
Gene expression databases
Bgeei | ENSSSCG00000001346, Expressed in oocyte and 47 other tissues |
Genevisiblei | Q767L0, SS |
Interactioni
Subunit structurei
Interacts (via N-terminus) with EIF2S1; the interaction is independent of its phosphorylated status. Associates (via both ABC transporter domains) with the ribosomes (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9823.ENSSSCP00000001420 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 266 – 510 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 245 | |
Domaini | 587 – 802 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 216 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 227 | DisorderedSequence analysisAdd BLAST | 227 | |
Regioni | 521 – 564 | DisorderedSequence analysisAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 37 – 73 | Basic and acidic residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 83 – 121 | Basic and acidic residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 146 – 163 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 174 – 197 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 208 – 227 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0066, Eukaryota |
HOGENOMi | CLU_000604_36_5_1 |
InParanoidi | Q767L0 |
OMAi | MDKIVDH |
OrthoDBi | 580544at2759 |
TreeFami | TF105207 |
Family and domain databases
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q767L0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKGPKQQPP EPEWIGDGES TSPTDKVVKK GKKDKKTKKT FFEELAVEDR
60 70 80 90 100
QAGEEEKVLK EKEQQQQHQQ QQQKKKRDTR KGRRKKDVDD DDGEEKELME
110 120 130 140 150
RLKKLSVPAS DEEEEAPAPV PRGGKKNKGG NVFAALIQDQ SEEEEEEEKH
160 170 180 190 200
PPKPAKPEKN RINKAVSQEQ QPGPKGRKGK EEKSKGKAKP QNKFAALDDE
210 220 230 240 250
EEQDEEEIKE KEPPKQGKEK AKKAEQMEYE RQVASLKAAN AAENDFSVSQ
260 270 280 290 300
AEMSSRQAML ENASDIKLEK FSISAHGKEL FVNADLYIVA GRRYGLVGPN
310 320 330 340 350
GKGKTTLLKH IANRALSIPP NIDVLLCEQE VVADETPAVQ AVLRADTKRL
360 370 380 390 400
KLLEEERRLQ GQLEQGDDTA ADRLEKVYEE LRATGAAAAE AKARRILAGL
410 420 430 440 450
GFDPEMQNRP TQKFSGGWRM RVSLARALFM EPTLLMLDEP TNHLDLNAVI
460 470 480 490 500
WLNNYLQGWR KTLLIVSHDQ GFLDDVCTDI IHLDAQRLHY YRGNYMTFKK
510 520 530 540 550
MYQQKQKELL KQYEKQEKKL KELKAGGKST KQAEKQTKEA LTRKQQKCRR
560 570 580 590 600
KNQDEESQEA PELLKRPKEY TVRFTFPDPP PLSPPVLGLH GVTFGYEGQK
610 620 630 640 650
PLFKNLDFGI DMDSRICIVG PNGVGKSTLL LLLTGKLTPT RGEMRKNHRL
660 670 680 690 700
KIGFFNQQYA EQLRMEETPT EYLQRGFNLP YQDARKCLGR FGLESHAHTI
710 720 730 740 750
QICKLSGGQK ARVVFAELAC REPDVLILDE PTNNLDIESI DALGEAINEY
760 770 780 790 800
KGAVIVVSHD ARLITETNCQ LWVVEEQSVS QIDGDFDDYK REVLEALGEV
MVSRPRE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB113357 Genomic DNA Translation: BAD08439.1 |
RefSeqi | NP_001116541.1, NM_001123069.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB113357 Genomic DNA Translation: BAD08439.1 |
RefSeqi | NP_001116541.1, NM_001123069.1 |
3D structure databases
SMRi | Q767L0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000001420 |
Proteomic databases
PaxDbi | Q767L0 |
PeptideAtlasi | Q767L0 |
PRIDEi | Q767L0 |
Genome annotation databases
Organism-specific databases
CTDi | 23 |
Phylogenomic databases
eggNOGi | KOG0066, Eukaryota |
HOGENOMi | CLU_000604_36_5_1 |
InParanoidi | Q767L0 |
OMAi | MDKIVDH |
OrthoDBi | 580544at2759 |
TreeFami | TF105207 |
Gene expression databases
Bgeei | ENSSSCG00000001346, Expressed in oocyte and 47 other tissues |
Genevisiblei | Q767L0, SS |
Family and domain databases
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ABCF1_PIG | |
Accessioni | Q767L0Primary (citable) accession number: Q767L0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 7, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families