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Protein

Endothelin-3

Gene

EDN3

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Biological processi

Keywordsi

Molecular functionVasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-3
Short name:
ET-3
Alternative name(s):
Preproendothelin-3
Short name:
PPET3
Gene namesi
Name:EDN3
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000000810817 – 86By similarityAdd BLAST70
PeptideiPRO_000000810989 – 109Endothelin-3Add BLAST21
PropeptideiPRO_0000008110110 – 198By similarityAdd BLAST89

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 103By similarity
Disulfide bondi91 ↔ 99By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei109 – 110Cleavage; by KELBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ765Z4

Expressioni

Tissue specificityi

Expressed in which included heart, lung, liver, kidney, spleen, stomach, pancreas, duodenum, colon, uterus, ovary and testis.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000018044

Structurei

3D structure databases

SMRiQ765Z4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 164Endothelin-likeAdd BLAST15

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXXK Eukaryota
ENOG410YW48 LUCA
HOGENOMiHOG000231110
HOVERGENiHBG051442
InParanoidiQ765Z4
KOiK05227

Family and domain databases

InterProiView protein in InterPro
IPR020475 Endothelin
IPR019764 Endothelin_toxin_CS
IPR001928 Endothln-like_toxin
PfamiView protein in Pfam
PF00322 Endothelin, 1 hit
PRINTSiPR00365 ENDOTHELIN
SMARTiView protein in SMART
SM00272 END, 2 hits
PROSITEiView protein in PROSITE
PS00270 ENDOTHELIN, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q765Z4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGLWLLFG LTVTSAAGLV PCPQPGDAGK SGVPGTPPTA RSEGDIQEPV
60 70 80 90 100
AMTAVQGPSP RSPEQEQELG RFGEQASKGG PVHGRARRCT CFTYKDKECV
110 120 130 140 150
YYCHLDIIWI NTPEQTVPYG LSNYRGSFRG RRSTGLFPQS PQPSKWTQRC
160 170 180 190
ACVQSQDSAC LHFCTRTLAV SRNSRTATNP DKEEEPASRG NGGLRPTR
Length:198
Mass (Da):21,527
Last modified:July 5, 2004 - v1
Checksum:iBF60D73286A73B7A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1PNP0F1PNP0_CANLF
Endothelin-3
EDN3
209Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB115086 mRNA Translation: BAD07479.1
RefSeqiNP_001002942.1, NM_001002942.1
UniGeneiCfa.105

Genome annotation databases

GeneIDi403406
KEGGicfa:403406

Similar proteinsi

Entry informationi

Entry nameiEDN3_CANLF
AccessioniPrimary (citable) accession number: Q765Z4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: December 20, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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