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Protein

Urotensin-2B

Gene

UTS2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Potent vasoconstrictor.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Urotensin-2B
Alternative name(s):
Urotensin II-related peptide
Urotensin IIB
Short name:
U-IIB
Short name:
UIIB
Urotensin-2 domain-containing protein
Gene namesi
Name:UTS2B
Synonyms:URP, UTS2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000188958.9
HGNCiHGNC:30894 UTS2B
neXtProtiNX_Q765I0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi257313
OpenTargetsiENSG00000188958
PharmGKBiPA142670632

Polymorphism and mutation databases

BioMutaiUTS2B
DMDMi212287929

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
PropeptideiPRO_000003635729 – 109By similarityAdd BLAST81
PeptideiPRO_0000036358112 – 119Urotensin-2B8

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi113 ↔ 118By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ765I0
PeptideAtlasiQ765I0
PRIDEiQ765I0
ProteomicsDBi68658

PTM databases

PhosphoSitePlusiQ765I0

Expressioni

Gene expression databases

BgeeiENSG00000188958
CleanExiHS_UTS2D
ExpressionAtlasiQ765I0 baseline and differential
GenevisibleiQ765I0 HS

Organism-specific databases

HPAiHPA026992

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi129211, 1 interactor
STRINGi9606.ENSP00000340526

Structurei

3D structure databases

ProteinModelPortaliQ765I0
SMRiQ765I0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urotensin-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J14T Eukaryota
ENOG410XXYD LUCA
GeneTreeiENSGT00390000003511
HOGENOMiHOG000133099
HOVERGENiHBG063072
InParanoidiQ765I0
OrthoDBiEOG091G0VM1
PhylomeDBiQ765I0
TreeFamiTF338338

Family and domain databases

InterProiView protein in InterPro
IPR001483 Urotensin_II
PfamiView protein in Pfam
PF02083 Urotensin_II, 1 hit
PROSITEiView protein in PROSITE
PS00984 UROTENSIN_II, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q765I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKILSSTVC FGLLTLLSVL SFLQSVHGRP YLTQGNEIFP DKKYTNREEL
60 70 80 90 100
LLALLNKNFD FQRPFNTDLA LPNKLEELNQ LEKLKEQLVE EKDSETSYAV
110
DGLFSSHPSK RACFWKYCV
Length:119
Mass (Da):13,749
Last modified:July 22, 2008 - v2
Checksum:i389E27F6469DA596
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04451721S → I3 PublicationsCorresponds to variant dbSNP:rs6788319Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116021 mRNA Translation: BAC98929.1
AY321313 mRNA Translation: AAQ83883.1
AK090630 mRNA Translation: BAG52200.1
CH471052 Genomic DNA Translation: EAW78091.1
CH471052 Genomic DNA Translation: EAW78092.1
CH471052 Genomic DNA Translation: EAW78093.1
CH471052 Genomic DNA Translation: EAW78094.1
BC112166 mRNA Translation: AAI12167.1
CCDSiCCDS3300.1
RefSeqiNP_937795.2, NM_198152.3
XP_011510933.1, XM_011512631.1
UniGeneiHs.518492

Genome annotation databases

EnsembliENST00000340524; ENSP00000340526; ENSG00000188958
ENST00000427544; ENSP00000398761; ENSG00000188958
GeneIDi257313
KEGGihsa:257313
UCSCiuc003fsu.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUTS2B_HUMAN
AccessioniPrimary (citable) accession number: Q765I0
Secondary accession number(s): B3KQY8, D3DNW1, Q2M1Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 22, 2008
Last modified: June 20, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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