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UniProtKB - Q763T4 (LAD_ASPOZ)
Protein
L-arabinitol 4-dehydrogenase
Gene
ladA
Organism
Aspergillus oryzae (Yellow koji mold)
Status
Functioni
Catalyzes the NAD-dependent oxidation of L-arabinitol to L-xylulose in the fungal L-arabinose catabolic pathway. L-arabinose catabolism is important for using plant material as a carbon source. Also active on ribitol and xylitol. Not active with NADP as cosubstrate.
1 PublicationCatalytic activityi
- EC:1.1.1.121 Publication
Cofactori
Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity
: L-arabinose degradation via L-arabinitol Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-xylulose 5-phosphate from L-arabinose (fungal route). This subpathway is part of the pathway L-arabinose degradation via L-arabinitol, which is itself part of Carbohydrate degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-xylulose 5-phosphate from L-arabinose (fungal route), the pathway L-arabinose degradation via L-arabinitol and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 55 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 80 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 81 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 110 | Zinc; structuralBy similarity | 1 | |
Metal bindingi | 113 | Zinc; structuralBy similarity | 1 | |
Metal bindingi | 116 | Zinc; structuralBy similarity | 1 | |
Metal bindingi | 124 | Zinc; structuralBy similarity | 1 | |
Metal bindingi | 165 | Zinc; catalyticBy similarity | 1 | |
Binding sitei | 213 | NADBy similarity | 1 | |
Binding sitei | 218 | NADBy similarity | 1 | |
Binding sitei | 293 | NAD; via carbonyl oxygenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 192 – 193 | NADBy similarity | 2 | |
Nucleotide bindingi | 317 – 319 | NADBy similarity | 3 |
GO - Molecular functioni
- L-arabinitol 4-dehydrogenase activity Source: UniProtKB-EC
- nucleotide binding Source: UniProtKB-KW
- oxidoreductase activity Source: AspGD
- zinc ion binding Source: InterPro
GO - Biological processi
- L-arabinose catabolic process to xylulose 5-phosphate Source: UniProtKB-UniPathway
- L-xylitol catabolic process to xylulose 5-phosphate Source: AspGD
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Arabinose catabolism, Carbohydrate metabolism |
Ligand | Metal-binding, NAD, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 1.1.1.12, 522 |
UniPathwayi | UPA00146;UER00575 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ladA Synonyms:xdhB |
Organismi | Aspergillus oryzae (Yellow koji mold) |
Taxonomic identifieri | 5062 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Circumdati |
Organism-specific databases
VEuPathDBi | FungiDB:AO090005001078 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000418406 | 1 – 382 | L-arabinitol 4-dehydrogenaseAdd BLAST | 382 |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
STRINGi | 5062.CADAORAP00002952 |
Family & Domainsi
Sequence similaritiesi
Belongs to the zinc-containing alcohol dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | KOG0024, Eukaryota |
Family and domain databases
CDDi | cd05285, sorbitol_DH, 1 hit |
InterProi | View protein in InterPro IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR045306, SDH-like |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q763T4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATATVLEKA NIGVYTNTNH DLWVAESKPT LEEVKSGESL KPGEVTVQVR
60 70 80 90 100
STGICGSDVH FWHAGCIGPM IVTGDHILGH ESAGEVIAVA SDVTHLKPGD
110 120 130 140 150
RVAVEPNIPC HACEPCLTGR YNGCEKVLFL STPPVDGLLR RYVNHPAVWC
160 170 180 190 200
HKIGDMSYED GALLEPLSVS LAAIERSGLR LGDPVLVTGA GPIGLITLLS
210 220 230 240 250
ARAAGATPIV ITDIDEGRLA FAKSLVPDVI TYKVQTNLSA EDNAAGIIDA
260 270 280 290 300
FNDGQGSAPD ALKPKLALEC TGVESSVASA IWSVKFGGKV FVIGVGKNEM
310 320 330 340 350
KIPFMRLSTQ EIDLQYQYRY CNTWPRAIRL VRNGVISLKK LVTHRFLLED
360 370 380
ALKAFETAAD PKTGAIKVQI MSNEEDVKGA SA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB116938 Genomic DNA Translation: BAC81768.1 |
Genome annotation databases
EnsemblFungii | BAE56054; BAE56054; AO090005001078 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB116938 Genomic DNA Translation: BAC81768.1 |
3D structure databases
SMRi | Q763T4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 5062.CADAORAP00002952 |
Genome annotation databases
EnsemblFungii | BAE56054; BAE56054; AO090005001078 |
Organism-specific databases
VEuPathDBi | FungiDB:AO090005001078 |
Phylogenomic databases
eggNOGi | KOG0024, Eukaryota |
Enzyme and pathway databases
UniPathwayi | UPA00146;UER00575 |
BRENDAi | 1.1.1.12, 522 |
Family and domain databases
CDDi | cd05285, sorbitol_DH, 1 hit |
InterProi | View protein in InterPro IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR045306, SDH-like |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LAD_ASPOZ | |
Accessioni | Q763T4Primary (citable) accession number: Q763T4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2012 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families