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Entry version 135 (08 May 2019)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Integrase

Gene
N/A
Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi223 – 270Integrase-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingSAAS annotation, EndonucleaseSAAS annotation, Hydrolase, Multifunctional enzymeSAAS annotation, Nuclease, Nucleotidyltransferase, RNA-directed DNA polymeraseSAAS annotation, Transferase
Biological processDNA integrationSAAS annotation, DNA recombinationSAAS annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
IntegraseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman immunodeficiency virus 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11676 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2366505

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q76353, 25 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q76353

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q76353

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 44Integrase-typeInterPro annotationAdd BLAST42
Domaini54 – 204Integrase catalyticInterPro annotationAdd BLAST151
Domaini223 – 270Integrase-typeInterPro annotationAdd BLAST48

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.200, 1 hit
2.30.30.10, 1 hit
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017856 Integrase-like_N
IPR036862 Integrase_C_dom_sf_retrovir
IPR001037 Integrase_C_retrovir
IPR001584 Integrase_cat-core
IPR003308 Integrase_Zn-bd_dom_N
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00552 IN_DBD_C, 1 hit
PF02022 Integrase_Zn, 1 hit
PF00665 rve, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46919 SSF46919, 1 hit
SSF50122 SSF50122, 1 hit
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50994 INTEGRASE, 1 hit
PS51027 INTEGRASE_DBD, 1 hit
PS50876 ZF_INTEGRASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q76353-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
FLDGIDKAQE EHEKYHSNWR AMASDFNLPP VVAKEIVASC DKCQLKGEAM
60 70 80 90 100
HGQVDCSPGI WQLDCTHLEG KVILVAVHVA SGYIEAEVIP AETGQETAYF
110 120 130 140 150
LLKLAGRWPV KTVHTDNGSN FTSTTVKAAC WWAGIKQEFG IPYNPQSQGV
160 170 180 190 200
IESMNKELKK IIGQVRDQAE HLKTAVQMAV FIHNFKRKGG IGGYSAGERI
210 220 230 240 250
VDIIATDIQT KELQKQITKI QNFRVYYRDS RDPVWKGPAK LLWKGEGAVV
260 270 280
IQDNSDIKVV PRRKAKIIRD YGKQMAGDDC VASRQDED
Length:288
Mass (Da):32,199
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0680E5CD1E201580
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L21188 Unassigned RNA Translation: AAC37875.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21188 Unassigned RNA Translation: AAC37875.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HYVX-ray1.70A47-212[»]
1HYZX-ray2.30A47-212[»]
3LPTX-ray2.00A50-212[»]
3LPUX-ray1.95A50-212[»]
3ZCMX-ray1.80A/B56-212[»]
3ZSOX-ray1.75A/B56-212[»]
3ZSQX-ray1.70A/B56-212[»]
3ZSRX-ray1.70A/B56-212[»]
3ZSVX-ray1.75A/B56-212[»]
3ZSWX-ray1.80A/B56-212[»]
3ZSXX-ray1.95A/B56-212[»]
3ZSYX-ray2.20A/B56-212[»]
3ZSZX-ray2.00A/B56-212[»]
3ZT0X-ray1.95A/B56-212[»]
3ZT1X-ray1.75A/B56-212[»]
3ZT2X-ray1.70A/B56-212[»]
3ZT3X-ray1.95A/B56-212[»]
3ZT4X-ray2.20A/B56-212[»]
4CE9X-ray2.10A/B50-212[»]
4CEAX-ray1.80A/B50-212[»]
4CEBX-ray1.75A/B50-212[»]
4CECX-ray1.75A/B50-212[»]
4CEDX-ray1.75A/B50-212[»]
4CEEX-ray1.80A/B50-212[»]
4CEFX-ray1.70A/B50-212[»]
4CEOX-ray1.90A/B50-212[»]
4CEQX-ray1.70A/B50-212[»]
4CERX-ray1.70A/B50-212[»]
4CESX-ray1.85A/B50-212[»]
4CEZX-ray1.70A/B50-212[»]
4CF0X-ray1.85A/B50-212[»]
4CF1X-ray1.95A/B50-212[»]
4CF2X-ray1.95A/B50-212[»]
4CF8X-ray1.65A/B50-212[»]
4CF9X-ray2.10A/B50-212[»]
4CFAX-ray2.05A/B50-212[»]
4CFBX-ray1.95A/B50-212[»]
4CFCX-ray1.90A/B50-212[»]
4CFDX-ray2.15A/B50-212[»]
4CGDX-ray2.00A/B50-212[»]
4CGFX-ray1.70A/B50-212[»]
4CGGX-ray1.75A/B50-212[»]
4CGHX-ray1.76A/B50-212[»]
4CGIX-ray2.07A/B50-212[»]
4CGJX-ray2.15A/B50-212[»]
4CHNX-ray2.00A/B50-212[»]
4CHOX-ray1.70A/B50-212[»]
4CHPX-ray1.90A/B50-212[»]
4CHQX-ray1.95A/B50-212[»]
4CHYX-ray1.70A/B50-212[»]
4CHZX-ray1.80A/B50-212[»]
4CIEX-ray1.70A/B50-212[»]
4CIFX-ray1.80A/B50-212[»]
4CIGX-ray1.70A/B50-212[»]
4CJ3X-ray1.70A/B50-212[»]
4CJ4X-ray1.80A/B50-212[»]
4CJ5X-ray1.95A/B50-212[»]
4CJEX-ray1.90A/B50-212[»]
4CJFX-ray1.90A/B50-212[»]
4CJKX-ray1.75A/B50-212[»]
4CJLX-ray1.77A50-212[»]
4CJPX-ray2.00A/B50-212[»]
4CJQX-ray1.70A/B50-212[»]
4CJRX-ray1.80A/B50-212[»]
4CJSX-ray1.80A/B50-212[»]
4CJTX-ray1.71A/B50-212[»]
4CJUX-ray1.70A/B50-212[»]
4CJVX-ray1.95A/B50-212[»]
4CJWX-ray1.95A/B50-212[»]
4CK1X-ray1.75A/B50-212[»]
4CK2X-ray1.85A/B50-212[»]
4CK3X-ray1.79A/B50-212[»]
4LH4X-ray1.80A50-212[»]
4LH5X-ray2.19A50-212[»]
4OVLX-ray1.70A/B50-212[»]
4Y1CX-ray2.30A/B50-212[»]
4Y1DX-ray1.93A/B50-212[»]
5KGWX-ray2.34A50-212[»]
5KGXX-ray2.67A50-212[»]
5KRSX-ray1.70A57-207[»]
5KRTX-ray1.65A57-207[»]
5U1Celectron microscopy3.90A/B/C/D1-288[»]
SMRiQ76353
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ76353, 25 interactors

Chemistry databases

ChEMBLiCHEMBL2366505

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ76353

Family and domain databases

Gene3Di1.10.10.200, 1 hit
2.30.30.10, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR017856 Integrase-like_N
IPR036862 Integrase_C_dom_sf_retrovir
IPR001037 Integrase_C_retrovir
IPR001584 Integrase_cat-core
IPR003308 Integrase_Zn-bd_dom_N
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00552 IN_DBD_C, 1 hit
PF02022 Integrase_Zn, 1 hit
PF00665 rve, 1 hit
SUPFAMiSSF46919 SSF46919, 1 hit
SSF50122 SSF50122, 1 hit
SSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50994 INTEGRASE, 1 hit
PS51027 INTEGRASE_DBD, 1 hit
PS50876 ZF_INTEGRASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ76353_9HIV1
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q76353
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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