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Protein

UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter

Gene

Slc35d2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
Alternative name(s):
Solute carrier family 35 member D2
UDP-galactose transporter-related protein 8
Short name:
UGTrel8
Gene namesi
Name:Slc35d2
Synonyms:Ugtrel8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1917734 Slc35d2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15ExtracellularSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 41CytoplasmicSequence analysis5
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 130ExtracellularSequence analysisAdd BLAST68
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 155CytoplasmicSequence analysis4
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 189ExtracellularSequence analysisAdd BLAST13
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 225CytoplasmicSequence analysisAdd BLAST15
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 253ExtracellularSequence analysis7
Transmembranei254 – 276HelicalSequence analysisAdd BLAST23
Topological domaini277 – 280CytoplasmicSequence analysis4
Transmembranei281 – 303HelicalSequence analysisAdd BLAST23
Topological domaini304 – 326ExtracellularSequence analysisAdd BLAST23

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130811 – 326UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporterAdd BLAST326

Proteomic databases

PaxDbiQ762D5
PRIDEiQ762D5

Expressioni

Gene expression databases

CleanExiMM_SLC35D2

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097040

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1444 Eukaryota
COG5070 LUCA
HOGENOMiHOG000038339
HOVERGENiHBG054071
InParanoidiQ762D5
KOiK15281
PhylomeDBiQ762D5
TreeFamiTF313307

Family and domain databases

InterProiView protein in InterPro
IPR004853 Sugar_P_trans_dom
PfamiView protein in Pfam
PF03151 TPT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q762D5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEPNAAPLP SRLARLLSAL FYGTCSFLIV LVNKALLTTY GFPSPIVLGI
60 70 80 90 100
GQMATTIMIL YVFKLNKIIH FPDFDKKIPG KLFPLPLLYV GNHISGLSST
110 120 130 140 150
SKLSLPMFTV LRKFTIPFTL LLEAIILGTQ YSLNIILSVL AIVLGAFIAA
160 170 180 190 200
GSDLTFNLEG YVFVFLNDIF TAANGVYTKQ KMDPKELGKY GVLFYNACFM
210 220 230 240 250
LIPTVIISVS TGDFQQATEF RHWKNVLFII QFLLSCLLGF LLMYSTALCS
260 270 280 290 300
YYNSALTTAV VGAIKNVSVA YIGMLVGGDY IFSLLNFIGL NICMAGGLRY
310 320
SFLTLSSQLK PKQPVDEESI PLDLKS
Length:326
Mass (Da):35,896
Last modified:July 5, 2004 - v1
Checksum:iF469DC23D635DB2F
GO
Isoform 2 (identifier: Q762D5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-283: NVSVAYIGMLVGGDYIFS → HGRWFKIFLFNTQQPVET
     284-326: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):31,507
Checksum:i6FDBFEA463ECC858
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J181A0A0R4J181_MOUSE
UDP-N-acetylglucosamine/UDP-glucose...
Slc35d2
326Annotation score:
A0A1Y7VL74A0A1Y7VL74_MOUSE
UDP-N-acetylglucosamine/UDP-glucose...
Slc35d2
283Annotation score:
A0A1Y7VJT8A0A1Y7VJT8_MOUSE
UDP-N-acetylglucosamine/UDP-glucose...
Slc35d2
124Annotation score:
Q3KNM7Q3KNM7_MOUSE
Slc35d2 protein
Slc35d2
45Annotation score:
A0A1Y7VK47A0A1Y7VK47_MOUSE
UDP-N-acetylglucosamine/UDP-glucose...
Slc35d2
43Annotation score:
A0A1Y7VJS4A0A1Y7VJS4_MOUSE
UDP-N-acetylglucosamine/UDP-glucose...
Slc35d2
129Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti162V → I in BAE34855 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030007266 – 283NVSVA…DYIFS → HGRWFKIFLFNTQQPVET in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_030008284 – 326Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB117931 mRNA Translation: BAD18884.1
AB117932 mRNA Translation: BAD18885.1
AK154257 mRNA Translation: BAE32469.1
AK159148 mRNA Translation: BAE34855.1
BC046402 mRNA Translation: AAH46402.1
BC107211 mRNA Translation: AAI07212.1
CCDSiCCDS26595.1 [Q762D5-1]
RefSeqiNP_001001321.2, NM_001001321.3
UniGeneiMm.133731

Genome annotation databases

GeneIDi70484
KEGGimmu:70484
UCSCiuc007qyg.1 mouse [Q762D5-1]
uc007qyi.1 mouse [Q762D5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB117931 mRNA Translation: BAD18884.1
AB117932 mRNA Translation: BAD18885.1
AK154257 mRNA Translation: BAE32469.1
AK159148 mRNA Translation: BAE34855.1
BC046402 mRNA Translation: AAH46402.1
BC107211 mRNA Translation: AAI07212.1
CCDSiCCDS26595.1 [Q762D5-1]
RefSeqiNP_001001321.2, NM_001001321.3
UniGeneiMm.133731

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097040

Proteomic databases

PaxDbiQ762D5
PRIDEiQ762D5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi70484
KEGGimmu:70484
UCSCiuc007qyg.1 mouse [Q762D5-1]
uc007qyi.1 mouse [Q762D5-2]

Organism-specific databases

CTDi11046
MGIiMGI:1917734 Slc35d2

Phylogenomic databases

eggNOGiKOG1444 Eukaryota
COG5070 LUCA
HOGENOMiHOG000038339
HOVERGENiHBG054071
InParanoidiQ762D5
KOiK15281
PhylomeDBiQ762D5
TreeFamiTF313307

Miscellaneous databases

ChiTaRSiSlc35d2 mouse
PROiPR:Q762D5
SOURCEiSearch...

Gene expression databases

CleanExiMM_SLC35D2

Family and domain databases

InterProiView protein in InterPro
IPR004853 Sugar_P_trans_dom
PfamiView protein in Pfam
PF03151 TPT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS35D2_MOUSE
AccessioniPrimary (citable) accession number: Q762D5
Secondary accession number(s): Q3TXR0, Q762D4, Q811G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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