Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

5-hydroxytryptamine receptor 2A

Gene

HTR2A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei229Hydrophobic barrier that decreases the speed of ligand binding and dissociationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBehavior

Enzyme and pathway databases

ReactomeiR-BTA-390666 Serotonin receptors
R-BTA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 2A
Short name:
5-HT-2
Short name:
5-HT-2A
Alternative name(s):
Serotonin receptor 2A
Gene namesi
Name:HTR2A
Synonyms:5HTR2A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:29996 HTR2A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 75ExtracellularBy similarityAdd BLAST75
Transmembranei76 – 99Helical; Name=1By similarityAdd BLAST24
Topological domaini100 – 110CytoplasmicBy similarityAdd BLAST11
Transmembranei111 – 133Helical; Name=2By similarityAdd BLAST23
Topological domaini134 – 148ExtracellularBy similarityAdd BLAST15
Transmembranei149 – 171Helical; Name=3By similarityAdd BLAST23
Topological domaini172 – 191CytoplasmicBy similarityAdd BLAST20
Transmembranei192 – 215Helical; Name=4By similarityAdd BLAST24
Topological domaini216 – 233ExtracellularBy similarityAdd BLAST18
Transmembranei234 – 254Helical; Name=5By similarityAdd BLAST21
Topological domaini255 – 323CytoplasmicBy similarityAdd BLAST69
Transmembranei324 – 345Helical; Name=6By similarityAdd BLAST22
Topological domaini346 – 361ExtracellularBy similarityAdd BLAST16
Transmembranei362 – 383Helical; Name=7By similarityAdd BLAST22
Topological domaini384 – 470CytoplasmicBy similarityAdd BLAST87

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3446

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689421 – 4705-hydroxytryptamine receptor 2AAdd BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi148 ↔ 227PROSITE-ProRule annotation
Modified residuei280PhosphoserineBy similarity1
Disulfide bondi348 ↔ 352PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ75Z89
PRIDEiQ75Z89

Expressioni

Gene expression databases

BgeeiENSBTAG00000013498 Expressed in 8 organ(s), highest expression level in brain

Interactioni

Subunit structurei

Interacts (via C-terminus) with MPDZ and PATJ. May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2. Interacts with GRM2 and DRD2; this may affect signaling.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017943

Chemistry databases

BindingDBiQ75Z89

Structurei

3D structure databases

ProteinModelPortaliQ75Z89
SMRiQ75Z89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni155 – 160Agonist bindingBy similarity6
Regioni335 – 339Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi172 – 174DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi375 – 379NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5
Motifi468 – 470PDZ-bindingBy similarity3

Domaini

The PDZ domain-binding motif is involved in the interaction with PATJ, CASK, APBA1, DLG1 and DLG4.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000240378
HOVERGENiHBG107487
InParanoidiQ75Z89
KOiK04157
OMAiAGRRTMQ
OrthoDBiEOG091G06VI
TreeFamiTF316350

Family and domain databases

InterProiView protein in InterPro
IPR000455 5HT2A_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF30 PTHR24247:SF30, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00516 5HT2ARECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q75Z89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDILCEENTS LSSTTNSLMQ LHADTRLYST DFNSGEGNTS NAFNWTVDSE
60 70 80 90 100
NRTNLSCEGC LSPPCFSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS
110 120 130 140 150
LEKKLQNATN YFLMSLAIAD MLLGFLVMPV STLTILYGYR WPLPSKLCAV
160 170 180 190 200
WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW
210 220 230 240 250
TISVGISMPI PVFGLQDDSK VFKEGSCLLA DENFVLIGSF VAFFIPLTIM
260 270 280 290 300
VITYFLTIKS LQKEATLCVS DPGTRTKLAS FSFLPQSSLS SEKLFQRSIH
310 320 330 340 350
REPGSYGRRT MQSISNEQKA CKVLGIVFFL FVVMWCPFFI TNIMAVICKE
360 370 380 390 400
SCNRDVIEAL LNVFVWIGYL SSAVNPLVYT LFNKTYRSAF SRYIQCQYKE
410 420 430 440 450
NKKPLQLILV NTIPALAYKS SQLQMGPKKN SKKDDKTTDN DCTMVALGKE
460 470
HPEDAPADSS NTVNEKVSCV
Length:470
Mass (Da):52,571
Last modified:July 5, 2004 - v1
Checksum:i85414E50CA9A91F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB119637 mRNA Translation: BAD12238.1
RefSeqiNP_001001157.1, NM_001001157.1
UniGeneiBt.27990

Genome annotation databases

EnsembliENSBTAT00000017943; ENSBTAP00000017943; ENSBTAG00000013498
GeneIDi407230
KEGGibta:407230

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB119637 mRNA Translation: BAD12238.1
RefSeqiNP_001001157.1, NM_001001157.1
UniGeneiBt.27990

3D structure databases

ProteinModelPortaliQ75Z89
SMRiQ75Z89
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017943

Chemistry databases

BindingDBiQ75Z89
ChEMBLiCHEMBL3446

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ75Z89
PRIDEiQ75Z89

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017943; ENSBTAP00000017943; ENSBTAG00000013498
GeneIDi407230
KEGGibta:407230

Organism-specific databases

CTDi3356
VGNCiVGNC:29996 HTR2A

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000240378
HOVERGENiHBG107487
InParanoidiQ75Z89
KOiK04157
OMAiAGRRTMQ
OrthoDBiEOG091G06VI
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-BTA-390666 Serotonin receptors
R-BTA-416476 G alpha (q) signalling events

Gene expression databases

BgeeiENSBTAG00000013498 Expressed in 8 organ(s), highest expression level in brain

Family and domain databases

InterProiView protein in InterPro
IPR000455 5HT2A_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF30 PTHR24247:SF30, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00516 5HT2ARECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei5HT2A_BOVIN
AccessioniPrimary (citable) accession number: Q75Z89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again