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Entry version 101 (10 Apr 2019)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

D-alanyl-D-alanine carboxypeptidase

Gene

pbp3

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidaseImported, Hydrolase, Protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S11.006

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
D-alanyl-D-alanine carboxypeptidaseImported
Submitted name:
D-alanyl-D-alanine carboxypeptidase, penicillin-binding protein 3Imported (EC:3.4.16.4Imported)
Submitted name:
Penicillin-binding protein 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pbp3Imported
ORF Names:A4260_08535Imported, ERS019416_01786Imported, ERS096107_00701Imported, ERS409064_00700Imported, ERS409327_02857Imported, ERS558328_01093Imported, KK0981_28400Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus pneumoniaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1313 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000042802 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000043857 Componenti: Unassembled WGS sequence
  • UP000071938 Componenti: Unassembled WGS sequence
  • UP000218786 Componenti: Chromosome
  • UP000093517 Componenti: Unassembled WGS sequence
  • UP000249206 Componenti: Unassembled WGS sequence
  • UP000074995 Componenti: Unassembled WGS sequence

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01163 Amdinocillin
DB00415 Ampicillin
DB08795 Azidocillin
DB00833 Cefaclor
DB01140 Cefadroxil
DB00456 Cefalotin
DB01330 Cefotetan
DB01331 Cefoxitin
DB00438 Ceftazidime
DB00567 Cephalexin
DB03313 Cephalosporin C
DB01000 Cyclacillin
DB00485 Dicloxacillin
DB00739 Hetacillin
DB00447 Loracarbef
DB01603 Meticillin
DB00948 Mezlocillin
DB00607 Nafcillin
DB00713 Oxacillin
DB00319 Piperacillin

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509863023 – 413Sequence analysisAdd BLAST391

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini293 – 394PBP5_CInterPro annotationAdd BLAST102

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S11 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DZ1 Bacteria
COG1686 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.410.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR015956 Peniciliin-bd_prot_C_sf
IPR018044 Peptidase_S11
IPR012907 Peptidase_S11_C
IPR037167 Peptidase_S11_C_sf
IPR001967 Peptidase_S11_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07943 PBP5_C, 1 hit
PF00768 Peptidase_S11, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00725 DADACBPTASE1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00936 PBP5_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56601 SSF56601, 1 hit
SSF69189 SSF69189, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q75Y35-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKIFLTLLT VSLLGGASTA VAQDFTIAAK HAIAVEANTG KILYEKDATQ
60 70 80 90 100
PVEIASITKL ITVYLVYEAL ENGSITLSTP VDISDYPYQL TTNSEASNIP
110 120 130 140 150
MEARNYTVEE LLEATLVSSA NSAAIALAEK IAGSEKDFVD MMRAKLLEWG
160 170 180 190 200
IQDATVVNTT GLNNETLGDN IYPGSKKDEE NKLSAYDVAI VARNLIKKYP
210 220 230 240 250
QVLEITKKPS STFAGMTITS TNYMLEGMPA YRGGFDGLKT GTTDKAGESF
260 270 280 290 300
VGTTVEKGMR VITVVLNADH QDNNPYARFT ATSSLMDYIS STFTLRKIVQ
310 320 330 340 350
QGDAYQDSKT PVQDGKEDTV TAVAPEDIYL IERVGNQSSQ SVQFTPDSKA
360 370 380 390 400
IPAPLEAGTV VGHLTYEDKD LIGQGYITTE RPSFEMVADK KIEKAFFLKV
410
WWNQFVRFVN EKL
Length:413
Mass (Da):45,210
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i403AE4A2AA3DA847
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ056818 Genomic DNA Translation: AAY56862.1
FJ441591 Genomic DNA Translation: ACM17687.1
FJ441595 Genomic DNA Translation: ACM17691.1
AB119956 Genomic DNA Translation: BAD00944.1
AB119961 Genomic DNA Translation: BAD00949.1
AB119971 Genomic DNA Translation: BAD00959.1
AB119975 Genomic DNA Translation: BAD00963.1
AB119976 Genomic DNA Translation: BAD00964.1
AB119986 Genomic DNA Translation: BAD00974.1
AB119992 Genomic DNA Translation: BAD00980.1
AP017971 Genomic DNA Translation: BAW84334.1
CKOI01000027 Genomic DNA Translation: CIX15865.1
CMTS01000009 Genomic DNA Translation: CKH49359.1
FDEX01000004 Genomic DNA Translation: CVS89045.1
FDON01000028 Genomic DNA Translation: CVY95557.1
FHVI01000008 Genomic DNA Translation: CYO74085.1
LWGW01000054 Genomic DNA Translation: OCQ83167.1

NCBI Reference Sequences

More...
RefSeqi
WP_000719163.1, NZ_UHHG01000005.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CIX15865; CIX15865; ERS019416_01786
CVM68216; CVM68216; ERS367628_01073
CVO43389; CVO43389; ERS408893_00763
CVO79460; CVO79460; ERS367764_00507
CVS89045; CVS89045; ERS409064_00700
CYO74085; CYO74085; ERS558328_01093
OCQ83167; OCQ83167; A4260_08535

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1313.6472.peg.1312

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ056818 Genomic DNA Translation: AAY56862.1
FJ441591 Genomic DNA Translation: ACM17687.1
FJ441595 Genomic DNA Translation: ACM17691.1
AB119956 Genomic DNA Translation: BAD00944.1
AB119961 Genomic DNA Translation: BAD00949.1
AB119971 Genomic DNA Translation: BAD00959.1
AB119975 Genomic DNA Translation: BAD00963.1
AB119976 Genomic DNA Translation: BAD00964.1
AB119986 Genomic DNA Translation: BAD00974.1
AB119992 Genomic DNA Translation: BAD00980.1
AP017971 Genomic DNA Translation: BAW84334.1
CKOI01000027 Genomic DNA Translation: CIX15865.1
CMTS01000009 Genomic DNA Translation: CKH49359.1
FDEX01000004 Genomic DNA Translation: CVS89045.1
FDON01000028 Genomic DNA Translation: CVY95557.1
FHVI01000008 Genomic DNA Translation: CYO74085.1
LWGW01000054 Genomic DNA Translation: OCQ83167.1
RefSeqiWP_000719163.1, NZ_UHHG01000005.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Chemistry databases

DrugBankiDB01163 Amdinocillin
DB00415 Ampicillin
DB08795 Azidocillin
DB00833 Cefaclor
DB01140 Cefadroxil
DB00456 Cefalotin
DB01330 Cefotetan
DB01331 Cefoxitin
DB00438 Ceftazidime
DB00567 Cephalexin
DB03313 Cephalosporin C
DB01000 Cyclacillin
DB00485 Dicloxacillin
DB00739 Hetacillin
DB00447 Loracarbef
DB01603 Meticillin
DB00948 Mezlocillin
DB00607 Nafcillin
DB00713 Oxacillin
DB00319 Piperacillin

Protein family/group databases

MEROPSiS11.006

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCIX15865; CIX15865; ERS019416_01786
CVM68216; CVM68216; ERS367628_01073
CVO43389; CVO43389; ERS408893_00763
CVO79460; CVO79460; ERS367764_00507
CVS89045; CVS89045; ERS409064_00700
CYO74085; CYO74085; ERS558328_01093
OCQ83167; OCQ83167; A4260_08535
PATRICifig|1313.6472.peg.1312

Phylogenomic databases

eggNOGiENOG4105DZ1 Bacteria
COG1686 LUCA

Family and domain databases

Gene3Di2.60.410.10, 1 hit
InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR015956 Peniciliin-bd_prot_C_sf
IPR018044 Peptidase_S11
IPR012907 Peptidase_S11_C
IPR037167 Peptidase_S11_C_sf
IPR001967 Peptidase_S11_N
PfamiView protein in Pfam
PF07943 PBP5_C, 1 hit
PF00768 Peptidase_S11, 1 hit
PRINTSiPR00725 DADACBPTASE1
SMARTiView protein in SMART
SM00936 PBP5_C, 1 hit
SUPFAMiSSF56601 SSF56601, 1 hit
SSF69189 SSF69189, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ75Y35_STREE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q75Y35
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 10, 2019
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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