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Entry version 116 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Serine-type D-Ala-D-Ala carboxypeptidase

Gene

pbp3

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.ARBA annotation EC:3.4.16.4

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei56Acyl-ester intermediateUniRule annotation1
Active sitei59Proton acceptorUniRule annotation1
Active sitei119UniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei239SubstrateUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidaseImportedARBA annotation, Hydrolase, Protease
Biological processCell shape, Cell wall biogenesis/degradationARBA annotation, Peptidoglycan synthesisARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00219

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S11.006

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine-type D-Ala-D-Ala carboxypeptidaseARBA annotation (EC:3.4.16.4ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pbp3Imported
ORF Names:A4260_08535Imported, AZJ70_09550Imported, ERS409062_01740Imported, GM536_07150Imported, GM539_04540Imported, GM545_04145Imported, SAMEA104035333_00721Imported, SAMEA104035469_01047Imported, SAMEA104154666_01915Imported, SAMEA2050264_01390Imported, SAMEA2052026_01110Imported, SAMEA2203388_01440Imported, SAMEA3207204_01845Imported, SAMEA4038883_00551Imported, SAMEA4388349_01154Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus pneumoniaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1313 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000312328 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000073219 Componenti: Unassembled WGS sequence
  • UP000313195 Componenti: Unassembled WGS sequence
  • UP000467349 Componenti: Unassembled WGS sequence
  • UP000320896 Componenti: Unassembled WGS sequence
  • UP000437160 Componenti: Unassembled WGS sequence
  • UP000093517 Componenti: Unassembled WGS sequence
  • UP000388566 Componenti: Unassembled WGS sequence
  • UP000310500 Componenti: Unassembled WGS sequence
  • UP000407764 Componenti: Unassembled WGS sequence
  • UP000364910 Componenti: Unassembled WGS sequence
  • UP000412169 Componenti: Unassembled WGS sequence
  • UP000310997 Componenti: Unassembled WGS sequence
  • UP000474228 Componenti: Unassembled WGS sequence
  • UP000377368 Componenti: Unassembled WGS sequence

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01163, Amdinocillin
DB00415, Ampicillin
DB08795, Azidocillin
DB00833, Cefaclor
DB01140, Cefadroxil
DB00456, Cefalotin
DB01330, Cefotetan
DB01331, Cefoxitin
DB00438, Ceftazidime
DB00567, Cephalexin
DB03313, Cephalosporin C
DB01000, Cyclacillin
DB00485, Dicloxacillin
DB00739, Hetacillin
DB00447, Loracarbef
DB01603, Meticillin
DB00948, Mezlocillin
DB00607, Nafcillin
DB00713, Oxacillin
DB00319, Piperacillin

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509863023 – 413Serine-type D-Ala-D-Ala carboxypeptidaseSequence analysisAdd BLAST391

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini293 – 394PBP5_CInterPro annotationAdd BLAST102

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S11 family.UniRule annotationARBA annotation

Keywords - Domaini

SignalSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.410.10, 1 hit
3.40.710.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012338, Beta-lactam/transpept-like
IPR015956, Peniciliin-bd_prot_C_sf
IPR018044, Peptidase_S11
IPR012907, Peptidase_S11_C
IPR037167, Peptidase_S11_C_sf
IPR001967, Peptidase_S11_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07943, PBP5_C, 1 hit
PF00768, Peptidase_S11, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00725, DADACBPTASE1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00936, PBP5_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56601, SSF56601, 1 hit
SSF69189, SSF69189, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q75Y35-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKIFLTLLT VSLLGGASTA VAQDFTIAAK HAIAVEANTG KILYEKDATQ
60 70 80 90 100
PVEIASITKL ITVYLVYEAL ENGSITLSTP VDISDYPYQL TTNSEASNIP
110 120 130 140 150
MEARNYTVEE LLEATLVSSA NSAAIALAEK IAGSEKDFVD MMRAKLLEWG
160 170 180 190 200
IQDATVVNTT GLNNETLGDN IYPGSKKDEE NKLSAYDVAI VARNLIKKYP
210 220 230 240 250
QVLEITKKPS STFAGMTITS TNYMLEGMPA YRGGFDGLKT GTTDKAGESF
260 270 280 290 300
VGTTVEKGMR VITVVLNADH QDNNPYARFT ATSSLMDYIS STFTLRKIVQ
310 320 330 340 350
QGDAYQDSKT PVQDGKEDTV TAVAPEDIYL IERVGNQSSQ SVQFTPDSKA
360 370 380 390 400
IPAPLEAGTV VGHLTYEDKD LIGQGYITTE RPSFEMVADK KIEKAFFLKV
410
WWNQFVRFVN EKL
Length:413
Mass (Da):45,210
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i403AE4A2AA3DA847
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ056818 Genomic DNA Translation: AAY56862.1
FJ441591 Genomic DNA Translation: ACM17687.1
FJ441595 Genomic DNA Translation: ACM17691.1
AB119956 Genomic DNA Translation: BAD00944.1
AB119961 Genomic DNA Translation: BAD00949.1
AB119971 Genomic DNA Translation: BAD00959.1
AB119975 Genomic DNA Translation: BAD00963.1
AB119976 Genomic DNA Translation: BAD00964.1
AB119986 Genomic DNA Translation: BAD00974.1
AB119992 Genomic DNA Translation: BAD00980.1
FDEV01000017 Genomic DNA Translation: CVS94934.1
WNHU01000015 Genomic DNA Translation: MTV42841.1
WNHJ01000012 Genomic DNA Translation: MTV62680.1
WNIA01000034 Genomic DNA Translation: MTV98862.1
LWGW01000054 Genomic DNA Translation: OCQ83167.1
VMWH01000128 Genomic DNA Translation: TVW83171.1
CAAKWD010000009 Genomic DNA Translation: VIT21330.1
CAALGS010000008 Genomic DNA Translation: VIZ65508.1
CAAMCP010000010 Genomic DNA Translation: VJM93990.1
CAAVND010000003 Genomic DNA Translation: VOV82919.1
CAAWLZ010000012 Genomic DNA Translation: VPJ36074.1
CAAYQF010000004 Genomic DNA Translation: VQN81903.1
CABCYJ010000012 Genomic DNA Translation: VSW94368.1
CABDLL010000003 Genomic DNA Translation: VTE36880.1
CABDOF010000005 Genomic DNA Translation: VTF82302.1

NCBI Reference Sequences

More...
RefSeqi
WP_000719163.1, NZ_WNIA01000034.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CKH49359; CKH49359; ERS096107_00701
CVS89045; CVS89045; ERS409064_00700
CVY95557; CVY95557; ERS409327_02857
OCQ83167; OCQ83167; A4260_08535
VFH84639; VFH84639; SAMEA2434610_00829

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1313.6472.peg.1312

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ056818 Genomic DNA Translation: AAY56862.1
FJ441591 Genomic DNA Translation: ACM17687.1
FJ441595 Genomic DNA Translation: ACM17691.1
AB119956 Genomic DNA Translation: BAD00944.1
AB119961 Genomic DNA Translation: BAD00949.1
AB119971 Genomic DNA Translation: BAD00959.1
AB119975 Genomic DNA Translation: BAD00963.1
AB119976 Genomic DNA Translation: BAD00964.1
AB119986 Genomic DNA Translation: BAD00974.1
AB119992 Genomic DNA Translation: BAD00980.1
FDEV01000017 Genomic DNA Translation: CVS94934.1
WNHU01000015 Genomic DNA Translation: MTV42841.1
WNHJ01000012 Genomic DNA Translation: MTV62680.1
WNIA01000034 Genomic DNA Translation: MTV98862.1
LWGW01000054 Genomic DNA Translation: OCQ83167.1
VMWH01000128 Genomic DNA Translation: TVW83171.1
CAAKWD010000009 Genomic DNA Translation: VIT21330.1
CAALGS010000008 Genomic DNA Translation: VIZ65508.1
CAAMCP010000010 Genomic DNA Translation: VJM93990.1
CAAVND010000003 Genomic DNA Translation: VOV82919.1
CAAWLZ010000012 Genomic DNA Translation: VPJ36074.1
CAAYQF010000004 Genomic DNA Translation: VQN81903.1
CABCYJ010000012 Genomic DNA Translation: VSW94368.1
CABDLL010000003 Genomic DNA Translation: VTE36880.1
CABDOF010000005 Genomic DNA Translation: VTF82302.1
RefSeqiWP_000719163.1, NZ_WNIA01000034.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Chemistry databases

DrugBankiDB01163, Amdinocillin
DB00415, Ampicillin
DB08795, Azidocillin
DB00833, Cefaclor
DB01140, Cefadroxil
DB00456, Cefalotin
DB01330, Cefotetan
DB01331, Cefoxitin
DB00438, Ceftazidime
DB00567, Cephalexin
DB03313, Cephalosporin C
DB01000, Cyclacillin
DB00485, Dicloxacillin
DB00739, Hetacillin
DB00447, Loracarbef
DB01603, Meticillin
DB00948, Mezlocillin
DB00607, Nafcillin
DB00713, Oxacillin
DB00319, Piperacillin

Protein family/group databases

MEROPSiS11.006

Genome annotation databases

EnsemblBacteriaiCKH49359; CKH49359; ERS096107_00701
CVS89045; CVS89045; ERS409064_00700
CVY95557; CVY95557; ERS409327_02857
OCQ83167; OCQ83167; A4260_08535
VFH84639; VFH84639; SAMEA2434610_00829
PATRICifig|1313.6472.peg.1312

Enzyme and pathway databases

UniPathwayiUPA00219

Family and domain databases

Gene3Di2.60.410.10, 1 hit
3.40.710.10, 1 hit
InterProiView protein in InterPro
IPR012338, Beta-lactam/transpept-like
IPR015956, Peniciliin-bd_prot_C_sf
IPR018044, Peptidase_S11
IPR012907, Peptidase_S11_C
IPR037167, Peptidase_S11_C_sf
IPR001967, Peptidase_S11_N
PfamiView protein in Pfam
PF07943, PBP5_C, 1 hit
PF00768, Peptidase_S11, 1 hit
PRINTSiPR00725, DADACBPTASE1
SMARTiView protein in SMART
SM00936, PBP5_C, 1 hit
SUPFAMiSSF56601, SSF56601, 1 hit
SSF69189, SSF69189, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ75Y35_STREE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q75Y35
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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