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Entry version 114 (31 Jul 2019)
Sequence version 3 (09 Feb 2010)
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Protein

GRB2-associated and regulator of MAPK protein 2

Gene

GAREM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GRB2-associated and regulator of MAPK protein 2
Alternative name(s):
GRB2-associated and regulator of MAPK1-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GAREM2
Synonyms:FAM59B, GAREML, KIAA2038
ORF Names:HRIHFB2063
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27172 GAREM2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617999 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q75VX8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
150946

Open Targets

More...
OpenTargetsi
ENSG00000157833

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671865

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GAREM2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
288558847

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003402531 – 874GRB2-associated and regulator of MAPK protein 2Add BLAST874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei735PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q75VX8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q75VX8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q75VX8

PeptideAtlas

More...
PeptideAtlasi
Q75VX8

PRoteomics IDEntifications database

More...
PRIDEi
Q75VX8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
6266
68654 [Q75VX8-1]
68655 [Q75VX8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q75VX8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q75VX8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000157833 Expressed in 135 organ(s), highest expression level in medial globus pallidus

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q75VX8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA071575

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127333, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q75VX8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384593

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q75VX8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini807 – 871SAMAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni12 – 339CABITAdd BLAST328

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi179 – 205Gly-richAdd BLAST27
Compositional biasi383 – 759Pro-richAdd BLAST377

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GAREM family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II0U Eukaryota
ENOG410XSPW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063834

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000074085

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q75VX8

Identification of Orthologs from Complete Genome Data

More...
OMAi
PLFKPSH

Database of Orthologous Groups

More...
OrthoDBi
288834at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q75VX8

TreeFam database of animal gene trees

More...
TreeFami
TF329726

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025946 CABIT_dom
IPR013761 SAM/pointed_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12736 CABIT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q75VX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKLAAGLAG LRWSMGAFPL DLIVSRCRLP TLACLGPGEY AEGVSERDIL
60 70 80 90 100
LIHSCRQWTT VTAHTLEEGH YVIGPKIDIP LQYPGKFKLL EQARDVREPV
110 120 130 140 150
RYFSSVEEVA SVFPDRIFVM EAITFSVKVV SGEFSEDSEV YNFTLHAGDE
160 170 180 190 200
LTLMGQAEIL CAKTTKERSR FTTLLRKLGR AGALAGVGGG GPASAGAAGG
210 220 230 240 250
TGGGGARPVK GKMPCLICMN HRTNESLSLP FQCQGRFSTR SPLELQMQEG
260 270 280 290 300
EHTVRAIIER VRLPVNVLVP SRPPRNPYDL HPVREGHCYK LVSIISKTVV
310 320 330 340 350
LGLALRREGP APLHFLLLTD TPRFALPQGL LAGDPRVERL VRDSASYCRE
360 370 380 390 400
RFDPDEYSTA VREAPAELAE DCASPRRARL CLPAPRAPGL ARAPGPLAPA
410 420 430 440 450
PAGEGDQEYV SPDWAAAPEP AAPPAEIPYE ELWAHQGPEG LVRPPPGLDL
460 470 480 490 500
ISFGAAGPPR REPEAPPPPV PPKSEAVKEE CRLLNAPPVP PRGGNGSGRL
510 520 530 540 550
SSSPPVPPRF PKLQPVHSPS SSLSYYSSGL QDGAGSRSGS GSPSPDTYSL
560 570 580 590 600
YCYPCTWGDC KVGESSSRPA PGPLPSTTQP SQASRALTEP LSGRAASLLG
610 620 630 640 650
ADTPVKTYHS CPPLFKPSHP QKRFAPFGAL NPFSGPAYPS GPSAALSSGP
660 670 680 690 700
RTTSGPVATS GPAYSPGPAS PGQAYSAAPP SSCAPSSSSS SEWQEPVLEP
710 720 730 740 750
FDPFELGQGS SPEPELLRSQ EPRAVGTPGP GPRLSPLGPS KAFEPEGLVL
760 770 780 790 800
HQVPTPLSPA ALQGPEAGGA LFLTQGRLEG PPASPRDGAT GFGVRDASSW
810 820 830 840 850
QPPADLSALS LEEVSRSLRF IGLSEDVVSF FARERIDGSI FVQLSEDILA
860 870
DDFHLTKLQV KKIMQFIKGW RPKI
Length:874
Mass (Da):92,882
Last modified:February 9, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC5B7536971763523
GO
Isoform 2 (identifier: Q75VX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     562-694: Missing.

Note: No experimental confirmation available.
Show »
Length:741
Mass (Da):79,710
Checksum:iB674FD8A80F38FA9
GO
Isoform 3 (identifier: Q75VX8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     78-83: DIPLQY → MHRMPD
     562-694: Missing.

Note: No experimental confirmation available.
Show »
Length:664
Mass (Da):71,345
Checksum:i34DEF674129AF41D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC03435 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC99057 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti407Q → R in BAC03435 (Ref. 1) Curated1
Sequence conflicti473 – 475KSE → DAW in BAA88120 (PubMed:9853615).Curated3
Sequence conflicti733R → P in BAC03435 (Ref. 1) Curated1
Sequence conflicti819R → G in BAC03435 (Ref. 1) Curated1
Sequence conflicti864M → I in BAC03435 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0473211 – 77Missing in isoform 3. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_04732278 – 83DIPLQY → MHRMPD in isoform 3. 1 Publication6
Alternative sequenceiVSP_034201562 – 694Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST133

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB124552 mRNA Translation: BAC99057.1 Different initiation.
AC011742 Genomic DNA No translation available.
AK090454 mRNA Translation: BAC03435.1 Different initiation.
AB015349 mRNA Translation: BAA88120.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54336.1 [Q75VX8-1]
CCDS54337.1 [Q75VX8-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001161713.1, NM_001168241.1 [Q75VX8-1]
NP_001177962.1, NM_001191033.1 [Q75VX8-3]
XP_006712014.1, XM_006711951.3 [Q75VX8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000401533; ENSP00000384593; ENSG00000157833 [Q75VX8-1]
ENST00000407684; ENSP00000384581; ENSG00000157833 [Q75VX8-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
150946

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:150946

UCSC genome browser

More...
UCSCi
uc002rgw.2 human [Q75VX8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB124552 mRNA Translation: BAC99057.1 Different initiation.
AC011742 Genomic DNA No translation available.
AK090454 mRNA Translation: BAC03435.1 Different initiation.
AB015349 mRNA Translation: BAA88120.1
CCDSiCCDS54336.1 [Q75VX8-1]
CCDS54337.1 [Q75VX8-3]
RefSeqiNP_001161713.1, NM_001168241.1 [Q75VX8-1]
NP_001177962.1, NM_001191033.1 [Q75VX8-3]
XP_006712014.1, XM_006711951.3 [Q75VX8-2]

3D structure databases

SMRiQ75VX8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127333, 6 interactors
IntActiQ75VX8, 1 interactor
STRINGi9606.ENSP00000384593

PTM databases

iPTMnetiQ75VX8
PhosphoSitePlusiQ75VX8

Polymorphism and mutation databases

BioMutaiGAREM2
DMDMi288558847

Proteomic databases

EPDiQ75VX8
jPOSTiQ75VX8
PaxDbiQ75VX8
PeptideAtlasiQ75VX8
PRIDEiQ75VX8
ProteomicsDBi6266
68654 [Q75VX8-1]
68655 [Q75VX8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401533; ENSP00000384593; ENSG00000157833 [Q75VX8-1]
ENST00000407684; ENSP00000384581; ENSG00000157833 [Q75VX8-3]
GeneIDi150946
KEGGihsa:150946
UCSCiuc002rgw.2 human [Q75VX8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
150946
DisGeNETi150946

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GAREM2
HGNCiHGNC:27172 GAREM2
HPAiHPA071575
MIMi617999 gene
neXtProtiNX_Q75VX8
OpenTargetsiENSG00000157833
PharmGKBiPA142671865

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II0U Eukaryota
ENOG410XSPW LUCA
GeneTreeiENSGT00530000063834
HOGENOMiHOG000074085
InParanoidiQ75VX8
OMAiPLFKPSH
OrthoDBi288834at2759
PhylomeDBiQ75VX8
TreeFamiTF329726

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
150946

Protein Ontology

More...
PROi
PR:Q75VX8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000157833 Expressed in 135 organ(s), highest expression level in medial globus pallidus
GenevisibleiQ75VX8 HS

Family and domain databases

Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR025946 CABIT_dom
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF12736 CABIT, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGARE2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q75VX8
Secondary accession number(s): B5MC97
, B7WNK9, Q8NF27, Q9UIK8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 9, 2010
Last modified: July 31, 2019
This is version 114 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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