IL15

Functionⁱ

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity).By similarity

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
cytokine receptor binding Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell maturation Source: Ensembl
extrathymic T cell selection Source: Ensembl
immune response Source: InterPro
interleukin-15-mediated signaling pathway Source: UniProtKB
lymph node development Source: Ensembl
macrophage differentiation Source: Ensembl
negative regulation of cold-induced thermogenesis Source: Ensembl
neutrophil activation Source: UniProtKB
NK T cell proliferation Source: Ensembl
positive regulation of immune response Source: Ensembl
positive regulation of interleukin-17 production Source: Ensembl
positive regulation of natural killer cell differentiation Source: Ensembl
positive regulation of natural killer cell proliferation Source: Ensembl
positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
positive regulation of phagocytosis Source: UniProtKB
positive regulation of protein O-linked glycosylation Source: Ensembl
positive regulation of T cell proliferation Source: Ensembl
regulation of defense response to virus by host Source: Ensembl
regulation of T cell differentiation Source: Ensembl
tyrosine phosphorylation of STAT protein Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine

Molecular function

Cytokine

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-15 Short name: IL-15
Gene namesⁱ	Name:IL15
Organismⁱ	Cavia porcellus (Guinea pig)
Taxonomic identifierⁱ	10141 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Hystricomorpha › Caviidae › Cavia
Proteomesⁱ	UP000005447 Componentⁱ: Unassembled WGS sequence

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 29	Sequence analysisAdd BLAST	29
PropeptideⁱPRO_0000358327	30 – 48	Sequence analysisAdd BLAST	19
ChainⁱPRO_5000051007	49 – 162	Interleukin-15Add BLAST	114

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	83 ↔ 133	By similarity
Disulfide bondⁱ	90 ↔ 136	By similarity
Glycosylationⁱ	119	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	127	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSCPOG00000008232, Expressed in adult mammalian kidney and 5 other tissues

Bgeeⁱ

ENSCPOG00000008232, Expressed in adult mammalian kidney and 5 other tissues

Interactionⁱ

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
cytokine receptor binding Source: InterPro

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10141.ENSCPOP00000007401

STRINGⁱ

10141.ENSCPOP00000007401

Structureⁱ

3D structure databases

SMRⁱ	Q75SZ9
ModBaseⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IL-15/IL-21 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG502SCMF, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016264
HOGENOMⁱ	CLU_135111_0_0_1
InParanoidⁱ	Q75SZ9
OMAⁱ	ANWQDVI
Database of Orthologous Groups More...OrthoDBⁱ	1521691at2759
TreeFamⁱ	TF336199

Family and domain databases

Gene3Dⁱ	1.20.1250.70, 1 hit
InterProⁱ	View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR020439, IL-15 IPR003443, IL-15/IL-21_fam IPR038327, IL-15/IL-21_sf IPR020466, IL-15_mml
PANTHERⁱ	PTHR14356, PTHR14356, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02372, IL15, 1 hit
PRINTSⁱ	PR01947, INTLKN15MAML PR01930, INTRLEUKIN15
SUPFAMⁱ	SSF47266, SSF47266, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q75SZ9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRISKPSLRS TSIQCYLCFL LNSHLITEAG IHVFVWGCIS AGLPKTEASW 
        60         70         80         90        100
HDVIYDLKRI ENLIQSIHID ATLYTESDVH PNCKITAMKC FLLELRVILH 
       110        120        130        140        150
ESRNEDIHET ITNLIILANS SLNSNGNVTE SGCKECEELE EKSIAEFLQS 
       160 
FVHIVQMFIN TS

Length:162

Mass (Da):18,365

Last modified:July 5, 2004 - v1

Checksum:ⁱF9F0270F7305690E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB128160 mRNA Translation: BAD04908.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001166300.1, NM_001172829.1 XP_013015503.1, XM_013160049.1

Genome annotation databases

Ensemblⁱ	ENSCPOT00000008307; ENSCPOP00000007401; ENSCPOG00000008232
GeneIDⁱ	100379533

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q75SZ9	interleukin-15		OCTDE		169	UniRef90_Q75SZ9
+4

Protein	Similar proteins		Species	Score	Length	Source
Q75SZ9	Interleukin-15	)	HUMAN		162	UniRef50_P40933
Interleukin-15		MARMO		162
Interleukin-15		MARHI		162
Interleukin-15		RAT		162
Interleukin-15	)	MOUSE		162
+144

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB128160 mRNA Translation: BAD04908.1
RefSeqⁱ	NP_001166300.1, NM_001172829.1 XP_013015503.1, XM_013160049.1

3D structure databases

SMRⁱ	Q75SZ9
ModBaseⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10141.ENSCPOP00000007401

STRINGⁱ

10141.ENSCPOP00000007401

Genome annotation databases

Ensemblⁱ	ENSCPOT00000008307; ENSCPOP00000007401; ENSCPOG00000008232
GeneIDⁱ	100379533

Organism-specific databases

CTDⁱ	3600

CTDⁱ

3600

Phylogenomic databases

eggNOGⁱ	ENOG502SCMF, Eukaryota
GeneTreeⁱ	ENSGT00390000016264
HOGENOMⁱ	CLU_135111_0_0_1
InParanoidⁱ	Q75SZ9
OMAⁱ	ANWQDVI
OrthoDBⁱ	1521691at2759
TreeFamⁱ	TF336199

Gene expression databases

Bgeeⁱ	ENSCPOG00000008232, Expressed in adult mammalian kidney and 5 other tissues

Bgeeⁱ

ENSCPOG00000008232, Expressed in adult mammalian kidney and 5 other tissues

Family and domain databases

Gene3Dⁱ	1.20.1250.70, 1 hit
InterProⁱ	View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR020439, IL-15 IPR003443, IL-15/IL-21_fam IPR038327, IL-15/IL-21_sf IPR020466, IL-15_mml
PANTHERⁱ	PTHR14356, PTHR14356, 1 hit
Pfamⁱ	View protein in Pfam PF02372, IL15, 1 hit
PRINTSⁱ	PR01947, INTLKN15MAML PR01930, INTRLEUKIN15
SUPFAMⁱ	SSF47266, SSF47266, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL15_CAVPO
Accessionⁱ	Q75SZ9Primary (citable) accession number: Q75SZ9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
	Last sequence update:	July 5, 2004
	Last modified:	August 12, 2020
	This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Supporting data

UniProtKB - Q75SZ9 (IL15_CAVPO)

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Interleukin-15

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Cytosol

Extracellular region or secreted

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ