UniProtKB - Q75SZ9 (IL15_CAVPO)
Protein
Interleukin-15
Gene
IL15
Organism
Cavia porcellus (Guinea pig)
Status
Functioni
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity).By similarity
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- cytokine receptor binding Source: InterPro
GO - Biological processi
- cell maturation Source: Ensembl
- extrathymic T cell selection Source: Ensembl
- immune response Source: InterPro
- interleukin-15-mediated signaling pathway Source: UniProtKB
- lymph node development Source: Ensembl
- macrophage differentiation Source: Ensembl
- negative regulation of cold-induced thermogenesis Source: Ensembl
- neutrophil activation Source: UniProtKB
- NK T cell proliferation Source: Ensembl
- positive regulation of immune response Source: Ensembl
- positive regulation of interleukin-17 production Source: Ensembl
- positive regulation of natural killer cell differentiation Source: Ensembl
- positive regulation of natural killer cell proliferation Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of phagocytosis Source: UniProtKB
- positive regulation of protein O-linked glycosylation Source: Ensembl
- positive regulation of T cell proliferation Source: Ensembl
- regulation of defense response to virus by host Source: Ensembl
- regulation of T cell differentiation Source: Ensembl
- tyrosine phosphorylation of STAT protein Source: Ensembl
Keywordsi
Molecular function | Cytokine |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-15Short name: IL-15 |
Gene namesi | Name:IL15 |
Organismi | Cavia porcellus (Guinea pig) |
Taxonomic identifieri | 10141 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricomorpha › Caviidae › Cavia |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Cytosol
- cytosol Source: Ensembl
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Nucleus
- nuclear speck Source: Ensembl
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
PropeptideiPRO_0000358327 | 30 – 48 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5000051007 | 49 – 162 | Interleukin-15Add BLAST | 114 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 83 ↔ 133 | By similarity | ||
Disulfide bondi | 90 ↔ 136 | By similarity | ||
Glycosylationi | 119 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 127 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinExpressioni
Gene expression databases
Bgeei | ENSCPOG00000008232, Expressed in adult mammalian kidney and 5 other tissues |
Interactioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- cytokine receptor binding Source: InterPro
Protein-protein interaction databases
STRINGi | 10141.ENSCPOP00000007401 |
Family & Domainsi
Sequence similaritiesi
Belongs to the IL-15/IL-21 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SCMF, Eukaryota |
GeneTreei | ENSGT00390000016264 |
HOGENOMi | CLU_135111_0_0_1 |
InParanoidi | Q75SZ9 |
OMAi | ANWQDVI |
OrthoDBi | 1521691at2759 |
TreeFami | TF336199 |
Family and domain databases
Gene3Di | 1.20.1250.70, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR020439, IL-15 IPR003443, IL-15/IL-21_fam IPR038327, IL-15/IL-21_sf IPR020466, IL-15_mml |
PANTHERi | PTHR14356, PTHR14356, 1 hit |
Pfami | View protein in Pfam PF02372, IL15, 1 hit |
PRINTSi | PR01947, INTLKN15MAML PR01930, INTRLEUKIN15 |
SUPFAMi | SSF47266, SSF47266, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q75SZ9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRISKPSLRS TSIQCYLCFL LNSHLITEAG IHVFVWGCIS AGLPKTEASW
60 70 80 90 100
HDVIYDLKRI ENLIQSIHID ATLYTESDVH PNCKITAMKC FLLELRVILH
110 120 130 140 150
ESRNEDIHET ITNLIILANS SLNSNGNVTE SGCKECEELE EKSIAEFLQS
160
FVHIVQMFIN TS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB128160 mRNA Translation: BAD04908.1 |
RefSeqi | NP_001166300.1, NM_001172829.1 XP_013015503.1, XM_013160049.1 |
Genome annotation databases
Ensembli | ENSCPOT00000008307; ENSCPOP00000007401; ENSCPOG00000008232 |
GeneIDi | 100379533 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB128160 mRNA Translation: BAD04908.1 |
RefSeqi | NP_001166300.1, NM_001172829.1 XP_013015503.1, XM_013160049.1 |
3D structure databases
SMRi | Q75SZ9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10141.ENSCPOP00000007401 |
Genome annotation databases
Ensembli | ENSCPOT00000008307; ENSCPOP00000007401; ENSCPOG00000008232 |
GeneIDi | 100379533 |
Organism-specific databases
CTDi | 3600 |
Phylogenomic databases
eggNOGi | ENOG502SCMF, Eukaryota |
GeneTreei | ENSGT00390000016264 |
HOGENOMi | CLU_135111_0_0_1 |
InParanoidi | Q75SZ9 |
OMAi | ANWQDVI |
OrthoDBi | 1521691at2759 |
TreeFami | TF336199 |
Gene expression databases
Bgeei | ENSCPOG00000008232, Expressed in adult mammalian kidney and 5 other tissues |
Family and domain databases
Gene3Di | 1.20.1250.70, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR020439, IL-15 IPR003443, IL-15/IL-21_fam IPR038327, IL-15/IL-21_sf IPR020466, IL-15_mml |
PANTHERi | PTHR14356, PTHR14356, 1 hit |
Pfami | View protein in Pfam PF02372, IL15, 1 hit |
PRINTSi | PR01947, INTLKN15MAML PR01930, INTRLEUKIN15 |
SUPFAMi | SSF47266, SSF47266, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL15_CAVPO | |
Accessioni | Q75SZ9Primary (citable) accession number: Q75SZ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 16, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | August 12, 2020 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families