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Protein

Putative microRNA 17 host gene protein

Gene

MIR17HG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Miscellaneous

The microRNAs that are encoded in a MIR17HG intron stimulate growth of cultured lung cancer cells.

Caution

Product of a dubious CDS prediction. The MIR17HG transcript shows predominant nuclear localization and may not be efficiently translated into protein.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Putative microRNA 17 host gene protein
Alternative name(s):
Putative microRNA host gene 1 protein
Gene namesi
Name:MIR17HG
Synonyms:C13orf25, MIRH1, MIRHG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:23564 MIR17HG
MIMi609415 gene
neXtProtiNX_Q75NE6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 43HelicalSequence analysisAdd BLAST23
Topological domaini44 – 70ExtracellularSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Feingold syndrome 2 (FGLDS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. Microdeletions encompassing the MIR17HG locus can be responsible of FGLDS2.
Disease descriptionA syndrome characterized by microcephaly, short stature, and digital abnormalities including brachydactyly, brachymesophalangy of the second and fifth fingers, hypoplastic thumbs of variable severity, and cutaneous syndactyly of the toes.
See also OMIM:614326

Organism-specific databases

DisGeNETi407975
MalaCardsiMIR17HG
MIMi614326 phenotype
Orphaneti391646 Feingold syndrome type 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002745111 – 70Putative microRNA 17 host gene proteinAdd BLAST70

Proteomic databases

PRIDEiQ75NE6
ProteomicsDBi68645
68646 [Q75NE6-2]

Expressioni

Tissue specificityi

Highly expressed in B-cell lymphoma and lung cancer.

Gene expression databases

CleanExiHS_MIRHG1

Structurei

3D structure databases

SMRiQ75NE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ75NE6

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q75NE6-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFCHVDVKIS SKRYTWTKLP LNVPKLVLIY LQSHFVLFFF SMCQSIWERP
60 70
AIGRATTSSA SWMVGYDCLL
Length:70
Mass (Da):8,163
Last modified:July 5, 2004 - v1
Checksum:i721AE2157D5735EB
GO
Isoform 2 (identifier: Q75NE6-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     14-32: YTWTKLPLNVPKLVLIYLQ → QTCLTTSQTWVFSCSLKTH
     33-70: Missing.

Show »
Length:32
Mass (Da):3,703
Checksum:i4136FA4EDC372052
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02277514 – 32YTWTK…LIYLQ → QTCLTTSQTWVFSCSLKTH in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_02277633 – 70Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB176707 mRNA Translation: BAD18386.1
AB176708 mRNA Translation: BAD18387.1
AL138714 Genomic DNA No translation available.
AL162375 Genomic DNA No translation available.
BC109082 mRNA Translation: AAI09083.1

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiMIRH1_HUMAN
AccessioniPrimary (citable) accession number: Q75NE6
Secondary accession number(s): A4QMU7, Q75NE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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