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UniProtKB - Q75N62 (GIMA8_MOUSE)
Protein
GTPase IMAP family member 8
Gene
Gimap8
Organism
Mus musculus (Mouse)
Status
Functioni
Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 76 | GTPBy similarity | 1 | |
Binding sitei | 209 | GTPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 55 – 63 | GTPBy similarity | 9 | |
Nucleotide bindingi | 173 – 175 | GTPBy similarity | 3 |
GO - Molecular functioni
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- regulation of T cell apoptotic process Source: MGI
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: GTPase IMAP family member 8Short name: mGIMAP8 Alternative name(s): Immune-associated nucleotide-binding protein 9 Short name: IAN-9 Immunity-associated protein 8 |
Gene namesi | Name:Gimap8 Synonyms:Ian91 Publication, Imap8 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2685303, Gimap8 |
VEuPathDBi | HostDB:ENSMUSG00000064262 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Cytoplasm and Cytosol
- cytosol By similarity
Golgi apparatus
- Golgi apparatus 1 Publication
Cytosol
- cytosol Source: GO_Central
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Golgi apparatus, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000341971 | 1 – 688 | GTPase IMAP family member 8Add BLAST | 688 |
Proteomic databases
EPDi | Q75N62 |
MaxQBi | Q75N62 |
PaxDbi | Q75N62 |
PRIDEi | Q75N62 |
ProteomicsDBi | 267795 |
PTM databases
iPTMneti | Q75N62 |
PhosphoSitePlusi | Q75N62 |
Expressioni
Tissue specificityi
Abundantly expressed in the thymus (in thymocytes), spleen (in splenocytes), lymph node, followed by bone marrow and lung.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000064262, Expressed in mesenteric lymph node and 191 other tissues |
ExpressionAtlasi | Q75N62, baseline and differential |
Genevisiblei | Q75N62, MM |
Interactioni
Protein-protein interaction databases
IntActi | Q75N62, 1 interactor |
STRINGi | 10090.ENSMUSP00000077350 |
Miscellaneous databases
RNActi | Q75N62, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 247 | AIG1-type G 1PROSITE-ProRule annotationAdd BLAST | 202 | |
Domaini | 282 – 472 | AIG1-type G 2PROSITE-ProRule annotationAdd BLAST | 191 | |
Domaini | 473 – 677 | AIG1-type G 3PROSITE-ProRule annotationAdd BLAST | 205 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 42 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 55 – 62 | G1PROSITE-ProRule annotation | 8 | |
Regioni | 82 – 86 | G2PROSITE-ProRule annotation | 5 | |
Regioni | 103 – 106 | G3PROSITE-ProRule annotation | 4 | |
Regioni | 172 – 175 | G4PROSITE-ProRule annotation | 4 | |
Regioni | 208 – 210 | G5PROSITE-ProRule annotation | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 26 – 42 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502RB0C, Eukaryota |
GeneTreei | ENSGT00940000162462 |
HOGENOMi | CLU_010468_5_1_1 |
InParanoidi | Q75N62 |
OMAi | QHCLELS |
OrthoDBi | 1033397at2759 |
PhylomeDBi | Q75N62 |
TreeFami | TF330845 |
Family and domain databases
Gene3Di | 3.40.50.300, 3 hits |
InterProi | View protein in InterPro IPR006703, G_AIG1 IPR045058, GIMA/IAN/Toc IPR027417, P-loop_NTPase |
PANTHERi | PTHR10903, PTHR10903, 1 hit |
Pfami | View protein in Pfam PF04548, AIG1, 3 hits |
SUPFAMi | SSF52540, SSF52540, 3 hits |
PROSITEi | View protein in PROSITE PS51720, G_AIG1, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q75N62-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATSSHQGAA AGSQAEHRSC EASVGQGERP SASQGQEGNF KQNQGTSTLR
60 70 80 90 100
LLLLGKQGAG KSATGNTILG KAVFESKFSD HMVTDRCQSE SVSVRGKQVI
110 120 130 140 150
VIDTPDLFSS LSCSEVRQQN LKQCLELLAD DHCVLLLVTP IGHYTEEDRE
160 170 180 190 200
TIEGIWGKIG PKAYRHMIVV FTREDELDED SLWNYIESKE SLKELIKNIG
210 220 230 240 250
SRRCCTFNNK ADKKQRELQV FKLLDAIELL MMESPEPYFE PLKMESSGVQ
260 270 280 290 300
GCGNGVTYEG DTLCGSKKRQ PQITGPDCDP DMPELRVLLM GKRGVGKSAA
310 320 330 340 350
GNSILGKQVF KTQFSEKQRV TKAFASHSRV WQGKKVLIID SPEISSWKLD
360 370 380 390 400
ESAVKNHTFP GPHAFLLVTP LGSSLKSDDD VFSIIKRIFG EKFTKFTIVL
410 420 430 440 450
FTRKEDFEDQ ALDKVIKEND ALYNLTQKFG ERYAIFNYRA SVEEEQSQVG
460 470 480 490 500
KLLSQIEKMV QCHSNKPCVI REKELLNIIL LGRSGAGKSA TGNTILGRSA
510 520 530 540 550
FFSQLRAQPV TSSSQSGKRT LDWQDVVVVD TPSFIQTPGT EKDPSRLKEE
560 570 580 590 600
IHHCLSLCEE GMKIFVLVLQ LGRFTQEDEV VVEQLEASFE ENIMKYMIVL
610 620 630 640 650
FTRKEDLGDG DLHDYTNNTK NKALKKILKK CNGRVCAFNN KETGEDQETQ
660 670 680
VKGLLKIANS LKKNYDEHSN SWVGQLKSTL GQITMAFK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0R3P9C7 | A0A0R3P9C7_MOUSE | GTPase IMAP family member 8 | Gimap8 | 349 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 204 | C → Y in BAE22049 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ617674 mRNA Translation: CAE85147.1 AB178029 mRNA Translation: BAD16741.1 AK134199 mRNA Translation: BAE22049.1 BC137943 mRNA Translation: AAI37944.1 BC137944 mRNA Translation: AAI37945.1 |
CCDSi | CCDS20108.1 |
RefSeqi | NP_001070878.1, NM_001077410.1 NP_997651.1, NM_212486.2 |
Genome annotation databases
Ensembli | ENSMUST00000203083; ENSMUSP00000145286; ENSMUSG00000064262 ENSMUST00000203509; ENSMUSP00000145255; ENSMUSG00000064262 |
GeneIDi | 243374 |
KEGGi | mmu:243374 |
UCSCi | uc009bvf.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ617674 mRNA Translation: CAE85147.1 AB178029 mRNA Translation: BAD16741.1 AK134199 mRNA Translation: BAE22049.1 BC137943 mRNA Translation: AAI37944.1 BC137944 mRNA Translation: AAI37945.1 |
CCDSi | CCDS20108.1 |
RefSeqi | NP_001070878.1, NM_001077410.1 NP_997651.1, NM_212486.2 |
3D structure databases
AlphaFoldDBi | Q75N62 |
SMRi | Q75N62 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q75N62, 1 interactor |
STRINGi | 10090.ENSMUSP00000077350 |
PTM databases
iPTMneti | Q75N62 |
PhosphoSitePlusi | Q75N62 |
Proteomic databases
EPDi | Q75N62 |
MaxQBi | Q75N62 |
PaxDbi | Q75N62 |
PRIDEi | Q75N62 |
ProteomicsDBi | 267795 |
Protocols and materials databases
Antibodypediai | 2915, 126 antibodies from 20 providers |
DNASUi | 243374 |
Genome annotation databases
Ensembli | ENSMUST00000203083; ENSMUSP00000145286; ENSMUSG00000064262 ENSMUST00000203509; ENSMUSP00000145255; ENSMUSG00000064262 |
GeneIDi | 243374 |
KEGGi | mmu:243374 |
UCSCi | uc009bvf.1, mouse |
Organism-specific databases
CTDi | 155038 |
MGIi | MGI:2685303, Gimap8 |
VEuPathDBi | HostDB:ENSMUSG00000064262 |
Phylogenomic databases
eggNOGi | ENOG502RB0C, Eukaryota |
GeneTreei | ENSGT00940000162462 |
HOGENOMi | CLU_010468_5_1_1 |
InParanoidi | Q75N62 |
OMAi | QHCLELS |
OrthoDBi | 1033397at2759 |
PhylomeDBi | Q75N62 |
TreeFami | TF330845 |
Miscellaneous databases
BioGRID-ORCSi | 243374, 1 hit in 71 CRISPR screens |
PROi | PR:Q75N62 |
RNActi | Q75N62, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000064262, Expressed in mesenteric lymph node and 191 other tissues |
ExpressionAtlasi | Q75N62, baseline and differential |
Genevisiblei | Q75N62, MM |
Family and domain databases
Gene3Di | 3.40.50.300, 3 hits |
InterProi | View protein in InterPro IPR006703, G_AIG1 IPR045058, GIMA/IAN/Toc IPR027417, P-loop_NTPase |
PANTHERi | PTHR10903, PTHR10903, 1 hit |
Pfami | View protein in Pfam PF04548, AIG1, 3 hits |
SUPFAMi | SSF52540, SSF52540, 3 hits |
PROSITEi | View protein in PROSITE PS51720, G_AIG1, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | GIMA8_MOUSE | |
Accessioni | Q75N62Primary (citable) accession number: Q75N62 Secondary accession number(s): Q3UZ12 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 22, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families