UniProtKB - Q75ME0 (Q75ME0_HUMAN)
Protein
Submitted name:
STX1A protein
Gene
STX1A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATP-dependent protein binding Source: Ensembl
- calcium channel inhibitor activity Source: Ensembl
- calcium-dependent protein binding Source: Ensembl
- ion channel binding Source: Ensembl
- myosin head/neck binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- protein N-terminus binding Source: Ensembl
- SNAP receptor activity Source: InterPro
- SNARE binding Source: Ensembl
GO - Biological processi
- calcium-ion regulated exocytosis Source: Ensembl
- insulin secretion Source: Ensembl
- intracellular protein transport Source: InterPro
- positive regulation of calcium ion-dependent exocytosis Source: Ensembl
- positive regulation of excitatory postsynaptic potential Source: Ensembl
- positive regulation of neurotransmitter secretion Source: Ensembl
- positive regulation of norepinephrine secretion Source: Ensembl
- protein localization to membrane Source: Ensembl
- regulation of synaptic vesicle priming Source: Ensembl
- response to gravity Source: Ensembl
- SNARE complex assembly Source: Ensembl
- synaptic vesicle docking Source: Ensembl
- synaptic vesicle fusion to presynaptic active zone membrane Source: Ensembl
Keywordsi
Biological process | Neurotransmitter transportARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: STX1A proteinImportedSubmitted name: Syntaxin 1A (Brain), isoform CRA_eImportedSubmitted name: Syntaxin 1A isoform AImportedSubmitted name: cDNA, FLJ94630, Homo sapiens syntaxin 1A (brain) (STX1A), mRNAImported |
Gene namesi | Name:STX1AImported ORF Names:hCG_96107Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000106089.11 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type IV membrane protein ARBA annotation
Cytoskeleton
- actomyosin Source: Ensembl
Nucleus
- nuclear membrane Source: Ensembl
Plasma Membrane
- integral component of presynaptic membrane Source: Ensembl
- presynaptic active zone membrane Source: Ensembl
- voltage-gated potassium channel complex Source: Ensembl
Other locations
- axon Source: Ensembl
- glutamatergic synapse Source: Ensembl
- integral component of synaptic vesicle membrane Source: Ensembl
- postsynaptic density Source: Ensembl
- secretory granule Source: Ensembl
- synaptobrevin 2-SNAP-25-syntaxin-1a complex Source: Ensembl
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex Source: Ensembl
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 266 – 287 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000106089, Expressed in frontal cortex and 139 other tissues |
ExpressionAtlasi | Q75ME0, baseline and differential |
Interactioni
GO - Molecular functioni
- ATP-dependent protein binding Source: Ensembl
- calcium-dependent protein binding Source: Ensembl
- ion channel binding Source: Ensembl
- myosin head/neck binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- protein N-terminus binding Source: Ensembl
- SNARE binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 192 – 254 | T-SNARE coiled-coil homologyInterPro annotationAdd BLAST | 63 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 68 – 106 | Sequence analysisAdd BLAST | 39 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPROSITE-ProRule annotationARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_042423_2_2_1 |
OMAi | GQIRKQQ |
OrthoDBi | 1033833at2759 |
Family and domain databases
CDDi | cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR028669, STX1 IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
PANTHERi | PTHR19957:SF84, PTHR19957:SF84, 1 hit |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF00804, Syntaxin, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q75ME0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDRTQELRT AKDSDDDDDV AVTVDRDRFM DEFFEQVEEI RGFIDKIAEN
60 70 80 90 100
VEEVKRKHSA ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI
110 120 130 140 150
EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MSEYNATQSD YRERCKGRIQ
160 170 180 190 200
RQLEITGRTT TSEELEDMLE SGNPAIFASG IIMDSSISKQ ALSEIETRHS
210 220 230 240 250
EIIKLENSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHA VDYVERAVSD
260 270 280
TKKAVKYQSK ARRKKIMIII CCVILGIVIA STVGGIFA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073846 Genomic DNA Translation: AAS07469.1 KJ534952 mRNA Translation: AHW56592.1 AK313980 mRNA Translation: BAG36694.1 CR457018 mRNA Translation: CAG33299.1 CH471200 Genomic DNA Translation: EAW69653.1 CH471200 Genomic DNA Translation: EAW69654.1 |
RefSeqi | NP_004594.1, NM_004603.3 |
Genome annotation databases
GeneIDi | 6804 |
KEGGi | hsa:6804 |
UCSCi | uc003tyx.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073846 Genomic DNA Translation: AAS07469.1 KJ534952 mRNA Translation: AHW56592.1 AK313980 mRNA Translation: BAG36694.1 CR457018 mRNA Translation: CAG33299.1 CH471200 Genomic DNA Translation: EAW69653.1 CH471200 Genomic DNA Translation: EAW69654.1 |
RefSeqi | NP_004594.1, NM_004603.3 |
3D structure databases
SMRi | Q75ME0 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 3644, 693 antibodies |
DNASUi | 6804 |
Genome annotation databases
GeneIDi | 6804 |
KEGGi | hsa:6804 |
UCSCi | uc003tyx.4, human |
Organism-specific databases
CTDi | 6804 |
PharmGKBi | PA36233 |
VEuPathDBi | HostDB:ENSG00000106089.11 |
Phylogenomic databases
HOGENOMi | CLU_042423_2_2_1 |
OMAi | GQIRKQQ |
OrthoDBi | 1033833at2759 |
Miscellaneous databases
BioGRID-ORCSi | 6804, 8 hits in 995 CRISPR screens |
ChiTaRSi | STX1A, human |
GenomeRNAii | 6804 |
Gene expression databases
Bgeei | ENSG00000106089, Expressed in frontal cortex and 139 other tissues |
ExpressionAtlasi | Q75ME0, baseline and differential |
Family and domain databases
CDDi | cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR028669, STX1 IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
PANTHERi | PTHR19957:SF84, PTHR19957:SF84, 1 hit |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF00804, Syntaxin, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q75ME0_HUMAN | |
Accessioni | Q75ME0Primary (citable) accession number: Q75ME0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |