STX1A

Functionⁱ

GO - Molecular functionⁱ

ATP-dependent protein binding Source: Ensembl
calcium channel inhibitor activity Source: Ensembl
calcium-dependent protein binding Source: Ensembl
ion channel binding Source: Ensembl
myosin head/neck binding Source: Ensembl
protein-containing complex binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein N-terminus binding Source: Ensembl
SNAP receptor activity Source: InterPro
SNARE binding Source: Ensembl

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-ion regulated exocytosis Source: Ensembl
insulin secretion Source: Ensembl
intracellular protein transport Source: InterPro
positive regulation of calcium ion-dependent exocytosis Source: Ensembl
positive regulation of excitatory postsynaptic potential Source: Ensembl
positive regulation of neurotransmitter secretion Source: Ensembl
positive regulation of norepinephrine secretion Source: Ensembl
protein localization to membrane Source: Ensembl
regulation of synaptic vesicle priming Source: Ensembl
response to gravity Source: Ensembl
SNARE complex assembly Source: Ensembl
synaptic vesicle docking Source: Ensembl
synaptic vesicle fusion to presynaptic active zone membrane Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Neurotransmitter transportARBA annotation, Transport

Biological process

Neurotransmitter transportARBA annotation, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: STX1A proteinImported Submitted name: Syntaxin 1A (Brain), isoform CRA_eImported Submitted name: Syntaxin 1A isoform AImported Submitted name: cDNA, FLJ94630, Homo sapiens syntaxin 1A (brain) (STX1A), mRNAImported
Gene namesⁱ	Name:STX1AImported ORF Names:hCG_96107Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

VEuPathDBⁱ	HostDB:ENSG00000106089.11

VEuPathDBⁱ

HostDB:ENSG00000106089.11

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	266 – 287	HelicalSequence analysisAdd BLAST		22

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA36233

PharmGKBⁱ

PA36233

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000106089, Expressed in frontal cortex and 139 other tissues
ExpressionAtlasⁱ	Q75ME0, baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

ATP-dependent protein binding Source: Ensembl
calcium-dependent protein binding Source: Ensembl
ion channel binding Source: Ensembl
myosin head/neck binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein N-terminus binding Source: Ensembl
SNARE binding Source: Ensembl

Complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	Q75ME0
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	192 – 254	T-SNARE coiled-coil homologyInterPro annotationAdd BLAST		63

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	68 – 106	Sequence analysisAdd BLAST		39

Sequence similaritiesⁱ

Belongs to the syntaxin family.UniRule annotationARBA annotation

Keywords - Domainⁱ

Coiled coilPROSITE-ProRule annotationARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

HOGENOMⁱ	CLU_042423_2_2_1
OMAⁱ	GQIRKQQ
Database of Orthologous Groups More...OrthoDBⁱ	1033833at2759

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00179, SynN, 1 hit
InterProⁱ	View protein in InterPro IPR010989, SNARE IPR028669, STX1 IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom
PANTHERⁱ	PTHR19957:SF84, PTHR19957:SF84, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05739, SNARE, 1 hit PF00804, Syntaxin, 1 hit
SMARTⁱ	View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit
SUPFAMⁱ	SSF47661, SSF47661, 1 hit
PROSITEⁱ	View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q75ME0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKDRTQELRT AKDSDDDDDV AVTVDRDRFM DEFFEQVEEI RGFIDKIAEN 
        60         70         80         90        100
VEEVKRKHSA ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI 
       110        120        130        140        150
EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MSEYNATQSD YRERCKGRIQ 
       160        170        180        190        200
RQLEITGRTT TSEELEDMLE SGNPAIFASG IIMDSSISKQ ALSEIETRHS 
       210        220        230        240        250
EIIKLENSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHA VDYVERAVSD 
       260        270        280 
TKKAVKYQSK ARRKKIMIII CCVILGIVIA STVGGIFA

Length:288

Mass (Da):33,023

Last modified:May 10, 2005 - v1

Checksum:ⁱ8AC787EFCE65ACA1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC073846 Genomic DNA Translation: AAS07469.1 KJ534952 mRNA Translation: AHW56592.1 AK313980 mRNA Translation: BAG36694.1 CR457018 mRNA Translation: CAG33299.1 CH471200 Genomic DNA Translation: EAW69653.1 CH471200 Genomic DNA Translation: EAW69654.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004594.1, NM_004603.3

Genome annotation databases

GeneIDⁱ	6804
KEGGⁱ	hsa:6804
UCSC genome browser More...UCSCⁱ	uc003tyx.4, human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q75ME0	Syntaxin-1A		HUMAN		288	UniRef100_Q16623
t-SNARE coiled-coil homology domain-containing protein		PANTR		344
Syntaxin-1A		PONAB		259
Syntaxin-1A isoform 1 (Fragment)		MACMU		260
Syntaxin 1A		CALJA		288
+3

Protein	Similar proteins		Species	Score	Length	Source
Q75ME0	Syntaxin-1A		HUMAN		288	UniRef90_Q16623
Syntaxin-1A	)	RAT		288
t-SNARE coiled-coil homology domain-containing protein		PANTR		344
Syntaxin-1A		PONAB		259
Syntaxin-1A isoform 1 (Fragment)		MACMU		260
+8

Protein	Similar proteins		Species	Score	Length	Source
Q75ME0	Syntaxin-1A		HUMAN		288	UniRef50_Q16623
Syntaxin-1A	)	RAT		288
Syntaxin-1A		BOVIN		288
Syntaxin-1A		PONAB		288
Syntaxin-1A		DROME		291
+299

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC073846 Genomic DNA Translation: AAS07469.1 KJ534952 mRNA Translation: AHW56592.1 AK313980 mRNA Translation: BAG36694.1 CR457018 mRNA Translation: CAG33299.1 CH471200 Genomic DNA Translation: EAW69653.1 CH471200 Genomic DNA Translation: EAW69654.1
RefSeqⁱ	NP_004594.1, NM_004603.3

3D structure databases

SMRⁱ	Q75ME0
ModBaseⁱ	Search...

Protocols and materials databases

Antibodypediaⁱ	3644, 693 antibodies
The DNASU plasmid repository More...DNASUⁱ	6804

Genome annotation databases

GeneIDⁱ	6804
KEGGⁱ	hsa:6804
UCSCⁱ	uc003tyx.4, human

Organism-specific databases

CTDⁱ	6804
PharmGKBⁱ	PA36233
VEuPathDBⁱ	HostDB:ENSG00000106089.11

Phylogenomic databases

HOGENOMⁱ	CLU_042423_2_2_1
OMAⁱ	GQIRKQQ
OrthoDBⁱ	1033833at2759

Miscellaneous databases

BioGRID-ORCSⁱ	6804, 8 hits in 995 CRISPR screens
ChiTaRSⁱ	STX1A, human
GenomeRNAiⁱ	6804

Gene expression databases

Bgeeⁱ	ENSG00000106089, Expressed in frontal cortex and 139 other tissues
ExpressionAtlasⁱ	Q75ME0, baseline and differential

Family and domain databases

CDDⁱ	cd00179, SynN, 1 hit
InterProⁱ	View protein in InterPro IPR010989, SNARE IPR028669, STX1 IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom
PANTHERⁱ	PTHR19957:SF84, PTHR19957:SF84, 1 hit
Pfamⁱ	View protein in Pfam PF05739, SNARE, 1 hit PF00804, Syntaxin, 1 hit
SMARTⁱ	View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit
SUPFAMⁱ	SSF47661, SSF47661, 1 hit
PROSITEⁱ	View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q75ME0_HUMAN
Accessionⁱ	Q75ME0Primary (citable) accession number: Q75ME0
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	April 7, 2021
	This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q75ME0 (Q75ME0_HUMAN)

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STX1A protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ