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UniProtKB - Q75K18 (SRP54_DICDI)

Entry version 116 (23 Feb 2022)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Signal recognition particle 54 kDa protein

Gene

srp54

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi108 – 115GTPBy similarity8
Nucleotide bindingi190 – 194GTPBy similarity5
Nucleotide bindingi248 – 251GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DDI-1799339, SRP-dependent cotranslational protein targeting to membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal recognition particle 54 kDa protein
Short name:
SRP54
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:srp54
ORF Names:DDB_G0275455
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...dictyBasei		DDB_G0275455, srp54

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Signal recognition particle

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003276781 – 542Signal recognition particle 54 kDa proteinAdd BLAST542

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q75K18

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Signal recognition particle consists of a 7S RNA molecule and six protein subunits: srp72, srp68, srp54, srp19, srp14 and srp9.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		44689.DDB0232373

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q75K18

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 295G-domainAdd BLAST295
Regioni296 – 542M-domainAdd BLAST247

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GTP-binding SRP family. SRP54 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0780, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009301_6_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q75K18

Identification of Orthologs from Complete Genome Data

More...OMAi		DTAGRHK

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q75K18

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.260.30, 1 hit
1.20.120.140, 1 hit
3.40.50.300, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00306, SRP54, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR027417, P-loop_NTPase
IPR036891, Signal_recog_part_SRP54_M_sf
IPR013822, Signal_recog_particl_SRP54_hlx
IPR004125, Signal_recog_particle_SRP54_M
IPR036225, SRP/SRP_N
IPR022941, SRP54
IPR006325, SRP54_euk
IPR000897, SRP54_GTPase_dom
IPR042101, SRP54_N_sf

The PANTHER Classification System

More...PANTHERi		PTHR11564, PTHR11564, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00448, SRP54, 1 hit
PF02881, SRP54_N, 1 hit
PF02978, SRP_SPB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 1 hit
SM00962, SRP54, 1 hit
SM00963, SRP54_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47364, SSF47364, 1 hit
SSF47446, SSF47446, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01425, SRP54_euk, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00300, SRP54, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q75K18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLADLGNQL SSALRSLNET TIVNEDTINQ LLKEVGNALS KSDVSMSLII 
        60         70         80         90        100
QMRKNIKDKI KLDQMAAGLN KRKIIKQVVF DELIRLLDPG VPLWKPTKGK 
       110        120        130        140        150
SNIVMFVGLQ GAGKTTSVTK LAYFYKKKGF STAIVCADTF RAGAFDQVRH 
       160        170        180        190        200
NAAKAKIHYY GSETEKDPVV VARTGVDIFK KDGTEIIIVD TSGRHKQDSE 
       210        220        230        240        250
LFEEMKQIET AVKPDNCIFV MDSSIGQAAY EQATAFRSSV KVGSIIITKM 
       260        270        280        290        300
DGNSMGGGAI SAVAATNTPI IFIGTGEHLT DLELFDPSTF VSKLLGYGDM 
       310        320        330        340        350
KGMLEKIKEV IPEDSTSLKE IAQGKFTLRS MQQQFQQIMQ LGPIDKLVQM 
       360        370        380        390        400
IPGMNQLPQL QGNEGGLKLK AYINILDSLS EKELDGKKPI TQKRIITIAQ 
       410        420        430        440        450
GSGRHPNEVV ELLEQHKTFE KLIGKGGPGG GLGSLMAGKG GPKNMEQAMK 
       460        470        480        490        500
QMNANGGMQG LMNSLKGMGG MGDLAKMFGG GGGGGGGMPS MGDLAKMMGG 
       510        520        530        540 
MGGGGRGGGG MPNMGDLAKM MGGMGGGAGK GGQNGFPNLD LD
Length:542
Mass (Da):57,610
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5AE74963AD00D20
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAFI02000013 Genomic DNA Translation: EAL69478.1

NCBI Reference Sequences

More...RefSeqi		XP_643640.1, XM_638548.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		EAL69478; EAL69478; DDB_G0275455

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8620227

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ddi:DDB_G0275455

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA Translation: EAL69478.1
RefSeqiXP_643640.1, XM_638548.1

3D structure databases

SMRiQ75K18
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0232373

Proteomic databases

PaxDbiQ75K18

Genome annotation databases

EnsemblProtistsiEAL69478; EAL69478; DDB_G0275455
GeneIDi8620227
KEGGiddi:DDB_G0275455

Organism-specific databases

dictyBaseiDDB_G0275455, srp54

Phylogenomic databases

eggNOGiKOG0780, Eukaryota
HOGENOMiCLU_009301_6_1_1
InParanoidiQ75K18
OMAiDTAGRHK
PhylomeDBiQ75K18

Enzyme and pathway databases

ReactomeiR-DDI-1799339, SRP-dependent cotranslational protein targeting to membrane

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q75K18

Family and domain databases

Gene3Di1.10.260.30, 1 hit
1.20.120.140, 1 hit
3.40.50.300, 1 hit
HAMAPiMF_00306, SRP54, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR027417, P-loop_NTPase
IPR036891, Signal_recog_part_SRP54_M_sf
IPR013822, Signal_recog_particl_SRP54_hlx
IPR004125, Signal_recog_particle_SRP54_M
IPR036225, SRP/SRP_N
IPR022941, SRP54
IPR006325, SRP54_euk
IPR000897, SRP54_GTPase_dom
IPR042101, SRP54_N_sf
PANTHERiPTHR11564, PTHR11564, 1 hit
PfamiView protein in Pfam
PF00448, SRP54, 1 hit
PF02881, SRP54_N, 1 hit
PF02978, SRP_SPB, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM00962, SRP54, 1 hit
SM00963, SRP54_N, 1 hit
SUPFAMiSSF47364, SSF47364, 1 hit
SSF47446, SSF47446, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR01425, SRP54_euk, 1 hit
PROSITEiView protein in PROSITE
PS00300, SRP54, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRP54_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q75K18
Secondary accession number(s): Q552P1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: February 23, 2022
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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