Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATPase WRNIP1

Gene

wrnip1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi240 – 246ATPBy similarity7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA replication
LigandATP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase WRNIP1By similarity (EC:3.6.1.3By similarity)
Alternative name(s):
Werner helicase-interacting protein 1 homolog
Gene namesi
Name:wrnip1By similarity
ORF Names:DDB_G0272158
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272158 wrnip1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003917901 – 876ATPase WRNIP1By similarityAdd BLAST876

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ75JU2

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0305118

Structurei

3D structure databases

ProteinModelPortaliQ75JU2
SMRiQ75JU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi65 – 72Poly-AsnSequence analysis8
Compositional biasi104 – 143Poly-AsnSequence analysisAdd BLAST40
Compositional biasi151 – 159Poly-ThrSequence analysis9
Compositional biasi161 – 176Poly-AsnSequence analysisAdd BLAST16
Compositional biasi624 – 713Gln-richPROSITE-ProRule annotationAdd BLAST90
Compositional biasi752 – 763Poly-AsnSequence analysisAdd BLAST12

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2028 Eukaryota
COG2256 LUCA
InParanoidiQ75JU2
KOiK07478

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR032423 AAA_assoc_2
IPR008921 DNA_pol3_clamp-load_cplx_C
IPR021886 MgsA_C
IPR027417 P-loop_NTPase
IPR008824 RuvB_N
PfamiView protein in Pfam
PF16193 AAA_assoc_2, 1 hit
PF12002 MgsA_C, 1 hit
PF05496 RuvB_N, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF48019 SSF48019, 1 hit
SSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q75JU2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKKTNINTN TKINNFFQTK TNNANVVNEK GYIEDDNEII DINDFEEDQN
60 70 80 90 100
LYKIQNKSNG NNSINNNNNN KNTPTKPNLN LTPTKSHTIS FPTRPKLPSF
110 120 130 140 150
TQPNNNNNNN NNNNNNNNIN NNNNNNNNNN NNNNNNNNNN NNNSSTNVKP
160 170 180 190 200
TTTTTTTTTI NNNNNNNNNN NINNNNIDLK NKYSFLTNFK KKSFAPLSEQ
210 220 230 240 250
MRPTELSDFI GQESLLVGDP IVKKLFQSPE LPSFILYGPP GCGKTTLAQI
260 270 280 290 300
VASKSNYNIN ALSAVGSGVK DIKEVIDKAR NTLQFGKKTI LFIDEIHRYN
310 320 330 340 350
KLQQDVLLPA IESGIIILIG ATTENPSFEL NGALLSRCKV FKMEKLTKEN
360 370 380 390 400
LETLIKRTLE VTPLLMDRRL IMDEDAIKSL AEIADGDARV AINVLDMAIK
410 420 430 440 450
ANKEEQTYKE RMEEKHSTSG IVRDIVLTKK QMGSLLQRTS LIYDKGGDAF
460 470 480 490 500
YELISALHKS VRGSDANATA YWVIRMLESG CEPLYIVRRM VRMASEDIGL
510 520 530 540 550
ADNSALPLAI AAYQAVHFVG MPECTNAILQ CAVYLANAAK SNSCDHWYAH
560 570 580 590 600
TREYLEKHEG PPVPIHLRNA PTKMMKDWGY GADYQYNHAF DDQSQVTQIY
610 620 630 640 650
LPEPIKNEKF FEYKLTCPSV KDRQQSQDQT QRSSQQQQQQ QTQPQQQTQP
660 670 680 690 700
QQQTQQQIQQ QLEQLKQIQQ QLEQQVQQQI QQQSSQSPSQ QSQLQELQQI
710 720 730 740 750
QQQLQQIQQT NSQINNKNND SNIIKKNVNN SLDLNPTLPK KQKMIIPSIL
760 770 780 790 800
DNSNNNNNNN NINKSPTPIK KANISHNQLD SSINTSAITI DDSSECDINF
810 820 830 840 850
DDDFDMASVS STTMISNIPV GANVAGATEA ETETKAISST DTKESVSIND
860 870
SDKDLTTTHK NEQDQNNPPD PISLDF
Length:876
Mass (Da):98,566
Last modified:July 5, 2004 - v1
Checksum:i8C234DD6154E3297
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000008 Genomic DNA Translation: EAL71231.1
RefSeqiXP_645251.1, XM_640159.1

Genome annotation databases

EnsemblProtistsiEAL71231; EAL71231; DDB_G0272158
GeneIDi8618418
KEGGiddi:DDB_G0272158

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000008 Genomic DNA Translation: EAL71231.1
RefSeqiXP_645251.1, XM_640159.1

3D structure databases

ProteinModelPortaliQ75JU2
SMRiQ75JU2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0305118

Proteomic databases

PaxDbiQ75JU2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL71231; EAL71231; DDB_G0272158
GeneIDi8618418
KEGGiddi:DDB_G0272158

Organism-specific databases

dictyBaseiDDB_G0272158 wrnip1

Phylogenomic databases

eggNOGiKOG2028 Eukaryota
COG2256 LUCA
InParanoidiQ75JU2
KOiK07478

Miscellaneous databases

PROiPR:Q75JU2

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR032423 AAA_assoc_2
IPR008921 DNA_pol3_clamp-load_cplx_C
IPR021886 MgsA_C
IPR027417 P-loop_NTPase
IPR008824 RuvB_N
PfamiView protein in Pfam
PF16193 AAA_assoc_2, 1 hit
PF12002 MgsA_C, 1 hit
PF05496 RuvB_N, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF48019 SSF48019, 1 hit
SSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWRIP1_DICDI
AccessioniPrimary (citable) accession number: Q75JU2
Secondary accession number(s): Q559T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again