Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

5-aminolevulinate synthase, mitochondrial

Gene

HEM1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.By similarity

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.By similarity

Cofactori

pyridoxal 5'-phosphateBy similarity

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-aminolevulinate from glycine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. 5-aminolevulinate synthase, mitochondrial (HEM1)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from glycine, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105SubstrateBy similarity1
Binding sitei218SubstrateBy similarity1
Binding sitei237SubstrateBy similarity1
Binding sitei270Pyridoxal phosphateBy similarity1
Binding sitei298Pyridoxal phosphateBy similarity1
Binding sitei342Pyridoxal phosphateBy similarity1
Active sitei345By similarity1
Binding sitei374Pyridoxal phosphate; shared with dimeric partnerBy similarity1
Binding sitei375Pyridoxal phosphate; shared with dimeric partnerBy similarity1
Binding sitei460SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processHeme biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, mitochondrial (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:HEM1
Ordered Locus Names:ABL104C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome II

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionSequence analysisAdd BLAST46
ChainiPRO_000000123647 – 5565-aminolevulinate synthase, mitochondrialAdd BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei345N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiQ75DX7

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi33169.AAS50667

Structurei

3D structure databases

ProteinModelPortaliQ75DX7
SMRiQ75DX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000221020
InParanoidiQ75DX7
KOiK00643
OMAiKQDHTYR
OrthoDBiEOG092C1OK6

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR010961 4pyrrol_synth_NH2levulA_synth
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01821 5aminolev_synth, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q75DX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSLARQSAK ICPFVSRVTS SMQQVQVLHK TNMSAMAQQC PVMRRAMAAR
60 70 80 90 100
GYVTASPPAG AAAADVGEAR PITPVLERGT QERTFDYDGL FETELQKKRL
110 120 130 140 150
DSSYRFFNNI NRLAKEYPMA HRLEEEDKVT VWCSNDYLTY SRNEKVMETM
160 170 180 190 200
KRTIDKYGAG AGGTRNIAGH NRHAMRLEAE LAALHKKEGA LVFSSCFVAN
210 220 230 240 250
DAVLSLLGQK MPNMVIFSDE MNHASMIMGI KHANVQKHIF RHNDLQHLEE
260 270 280 290 300
LLAMYPKSQP KLIAFESVYS MSGSVADIRK ICDLAEKYGA LTFLDEVHSV
310 320 330 340 350
GLYGPHGAGV AEHLDFEAHR KAGLASPAQT TVLDRVDMIT ATLGKSFGSV
360 370 380 390 400
GGYLAASEKL VDFVRSYAPG FIFTSSLPPA VMAGSAAAVF DQRSSLHLRQ
410 420 430 440 450
LQQKHTSYVK TGLGDLGIPV QPNPSHIVPV LVGNPDLAKR ASDILMEKHR
460 470 480 490 500
IYVQAINFPT VPRGTERLRI TPTPGHTNDL SDVLLDAMDD VWKTLQLPRV
510 520 530 540 550
SDWAAHGGLL GVGEPDYVPE ANLWTEEQMS LTNDDLHPSV FSPVEKFLEV

SSGIKA
Length:556
Mass (Da):61,222
Last modified:July 5, 2004 - v1
Checksum:iDABDD7E6FEB4E764
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016815 Genomic DNA Translation: AAS50667.1
RefSeqiNP_982843.1, NM_208196.1

Genome annotation databases

EnsemblFungiiAAS50667; AAS50667; AGOS_ABL104C
GeneIDi4618923
KEGGiago:AGOS_ABL104C

Similar proteinsi

Entry informationi

Entry nameiHEM1_ASHGO
AccessioniPrimary (citable) accession number: Q75DX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health