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UniProtKB - Q75DG6 (DCW1_ASHGO)
Protein
Mannan endo-1,6-alpha-mannosidase DCW1
Gene
DCW1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Functioni
Required for normal synthesis of the cell wall.
By similarityCatalytic activityi
- Random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans. EC:3.2.1.101
GO - Molecular functioni
- mannan endo-1,6-alpha-mannosidase activity Source: UniProtKB-EC
GO - Biological processi
- budding cell bud growth Source: GO_Central
- carbohydrate catabolic process Source: InterPro
- cell wall organization Source: UniProtKB-KW
- fungal-type cell wall biogenesis Source: GO_Central
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Biological process | Cell wall biogenesis/degradation |
Protein family/group databases
CAZyi | GH76, Glycoside Hydrolase Family 76 |
Names & Taxonomyi
Protein namesi | Recommended name: Mannan endo-1,6-alpha-mannosidase DCW1 (EC:3.2.1.101)Alternative name(s): Defective cell wall 1 Endo-alpha-1->6-D-mannanase DCW1 |
Gene namesi | Name:DCW1 Ordered Locus Names:ABR060W |
Organismi | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
Taxonomic identifieri | 284811 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; GPI-anchor By similarity
Cell wall
- cell wall By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Plasma Membrane
- anchored component of plasma membrane Source: EnsemblFungi
Keywords - Cellular componenti
Cell membrane, Cell wall, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000012121 | 22 – 427 | Mannan endo-1,6-alpha-mannosidase DCW1Add BLAST | 406 | |
PropeptideiPRO_0000012122 | 428 – 451 | Removed in mature formSequence analysisAdd BLAST | 24 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 84 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 109 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 203 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 242 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 267 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 291 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 427 | GPI-anchor amidated aspartateSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, GPI-anchor, LipoproteinFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 397 – 419 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 76 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QSWP, Eukaryota |
HOGENOMi | CLU_025694_1_2_1 |
InParanoidi | Q75DG6 |
OMAi | WQIFRFN |
Family and domain databases
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR005198, Glyco_hydro_76 IPR014480, Mannan-1_6-alpha_mannosidase |
PANTHERi | PTHR12145, PTHR12145, 1 hit |
Pfami | View protein in Pfam PF03663, Glyco_hydro_76, 1 hit |
PIRSFi | PIRSF016302, Man_a_manosd, 1 hit |
SUPFAMi | SSF48208, SSF48208, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q75DG6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLAVTFTAAA VLSLLAASGR TLNLDVDDLQ SIREATSLLA TGLMDYYHGH
60 70 80 90 100
DYGETVGKFS DPYYWWEAGG AWGSILDYWY YMENSTYNDL LTDSLLHQAG
110 120 130 140 150
EDLSYTPWNE TTTEGNDDQF FWGMAVMAAA ERNFPNPPAD QPQWLALAQA
160 170 180 190 200
VFNTMALRWD METCNGGLRW QIFRWNDGYH YKNSVSNGAL FHMAARLTRY
210 220 230 240 250
TGNATYLEWA ERVYDWMYGV GLISIVQPNW HVVYDGTDIN DNCTNLNKLQ
260 270 280 290 300
WTYNHGLIMA GCAFIYNHTQ DELWHQRTLR FLDSARIFLS NDTLYEAGCQ
310 320 330 340 350
GGDNCNIDQR SFKAYFSRFL GLTAQLVPES RETIVRWIRA SAQGAAASCS
360 370 380 390 400
GGRDGHTCGL NWLINGWDGK WGLGEQMAAL EIIQNLRCLE RPAPYTAMNG
410 420 430 440 450
GTSPGDPAAG TKTKAENLPP LDIKAGDRAG AGIITALIGS SFLACTLWLI
I
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE016815 Genomic DNA Translation: AAS50830.2 |
RefSeqi | NP_983006.2, NM_208359.2 |
Genome annotation databases
EnsemblFungii | AAS50830; AAS50830; AGOS_ABR060W |
GeneIDi | 4619110 |
KEGGi | ago:AGOS_ABR060W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE016815 Genomic DNA Translation: AAS50830.2 |
RefSeqi | NP_983006.2, NM_208359.2 |
3D structure databases
SMRi | Q75DG6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 33169.AAS50830 |
Protein family/group databases
CAZyi | GH76, Glycoside Hydrolase Family 76 |
Genome annotation databases
EnsemblFungii | AAS50830; AAS50830; AGOS_ABR060W |
GeneIDi | 4619110 |
KEGGi | ago:AGOS_ABR060W |
Phylogenomic databases
eggNOGi | ENOG502QSWP, Eukaryota |
HOGENOMi | CLU_025694_1_2_1 |
InParanoidi | Q75DG6 |
OMAi | WQIFRFN |
Family and domain databases
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR005198, Glyco_hydro_76 IPR014480, Mannan-1_6-alpha_mannosidase |
PANTHERi | PTHR12145, PTHR12145, 1 hit |
Pfami | View protein in Pfam PF03663, Glyco_hydro_76, 1 hit |
PIRSFi | PIRSF016302, Man_a_manosd, 1 hit |
SUPFAMi | SSF48208, SSF48208, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DCW1_ASHGO | |
Accessioni | Q75DG6Primary (citable) accession number: Q75DG6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | January 9, 2013 | |
Last modified: | February 23, 2022 | |
This is version 101 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - SIMILARITY comments
Index of protein domains and families