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UniProtKB - Q75BB3 (LYS2_ASHGO)

Entry version 109 (12 Aug 2020)
Sequence version 2 (09 Jan 2013)
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Protein

L-2-aminoadipate reductase large subunit

Gene

LYS2

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-lysine biosynthesis via AAA pathway

This protein is involved in step 1 of the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (fungal route).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-2-aminoadipate reductase large subunit (LYS2)
  2. no protein annotated in this organism
  3. Saccharopine dehydrogenase [NAD(+), L-lysine-forming] (LYS1)
This subpathway is part of the pathway L-lysine biosynthesis via AAA pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (fungal route), the pathway L-lysine biosynthesis via AAA pathway and in Amino-acid biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Lysine biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00033;UER00032

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
L-2-aminoadipate reductase large subunit (EC:1.2.1.31By similarity, EC:1.2.1.95By similarity)
Alternative name(s):
Alpha-aminoadipate reductase
Short name:
Alpha-AR
L-aminoadipate-semialdehyde dehydrogenase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LYS2
Ordered Locus Names:ADL346W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284811 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000591 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001931481 – 1385L-2-aminoadipate reductase large subunitAdd BLAST1385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei880O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q75BB3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		33169.AAS51573

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini843 – 920CarrierPROSITE-ProRule annotationAdd BLAST78

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1178, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000022_19_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q75BB3

KEGG Orthology (KO)

More...KOi		K00143

Identification of Orthologs from Complete Genome Data

More...OMAi		ENDKFTM

Family and domain databases

Conserved Domains Database

More...CDDi		cd05235, SDR_e1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1200.10, 1 hit
3.40.50.12780, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR014397, Lys2
IPR013120, Male_sterile_NAD-bd
IPR036291, NAD(P)-bd_dom_sf
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR010080, Thioester_reductase-like_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00501, AMP-binding, 1 hit
PF07993, NAD_binding_4, 1 hit
PF00550, PP-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00823, PKS_PP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47336, SSF47336, 1 hit
SSF51735, SSF51735, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01733, AA-adenyl-dom, 1 hit
TIGR03443, alpha_am_amid, 1 hit
TIGR01746, Thioester-redct, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00455, AMP_BINDING, 1 hit
PS50075, CARRIER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q75BB3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCAVLEPSMI RWLSEVDNIV VSSLPSDYIP SGPAGVKAES CEVELPGSFG 
        60         70         80         90        100
VIDEEDSYIR LLSAFATLVC RMSGESDVAM YSKANRLLKL AVPPGVAFQQ 
       110        120        130        140        150
LRASVTEAVE GTLALPAVDF DELSALEREK KQLDYYPQYF KVGVVTAADK 
       160        170        180        190        200
TKLDQFRYHK FELLLRQVTS SRFEMVYDSE RFSPDRIGEL GEQLVQFLTL 
       210        220        230        240        250
VEAKDDADVY AISLVTSGAS RVLPDPTTDL GWGQFRGAIH DIFQHHAETR 
       260        270        280        290        300
PDRLCVVETG VGQVAARTFT YSAINCASNI VAHYLLARGI RRGDVVMIYS 
       310        320        330        340        350
TRGVDLLVSV LGVLKSGAVF SVIDPAYPPA RQNVYLGVAK PAGLIVIQAA 
       360        370        380        390        400
GQLDEAVEAF IRDNLSLKAR LPALALQTDG AILGGTLPDF HLDTLVPFAS 
       410        420        430        440        450
LKNTRTDVVV GPDSNPTLSF TSGSEGIPKG VLGRHFSLTY YFDWMAKRFG 
       460        470        480        490        500
LSEDDKFTML SGIAHDPIQR DMFTPIYLGA QLLVPQEDDI GTPGRLATWM 
       510        520        530        540        550
ATHGATVTHL TPAMGQVLTA DATTPFPSLK RAFFVGDVLT KRDCARLQSL 
       560        570        580        590        600
AENVAIVNMY GSTETQRAVS YFEVPSCSSN PSYLDNLKSI IPAGRGMHNV 
       610        620        630        640        650
QLLIVNRHDR TKLCGIGEVG EIYVRAGGLS EGYRGLPEIN KEKFIDNWFV 
       660        670        680        690        700
DAGHWGGLDL SGDEPWRNYW LGVRDRLYRT GDLGRYLPNG DCECCGRADD 
       710        720        730        740        750
QVKIRGFRIE LGEIDTNISQ YPLCRENITL LRKDQNGEST LISYLVPRSD 
       760        770        780        790        800
QKALASFISA VPESIATESI AGSLIKYHKL INDIRGFLKK RLAGYAIPTL 
       810        820        830        840        850
IMVMERLPLN PNGKIDKNKL QFPEPTELDR ASEHFASETL GLSSFSPLEQ 
       860        870        880        890        900
EIRKIWLDLL PTRPAITSSD ESFFDLGGTS ILATRMAIVL RNRLNISLAL 
       910        920        930        940        950
STIFRYPTVK ELAKEISRVR GTISDDKSSN SGTTEYYADA KHVSEAELAS 
       960        970        980        990       1000
KYESRLSLLP SGATSAPVYV FLTGVTGFLG CHILADLLNR SRKPYDITVY 
      1010       1020       1030       1040       1050
AHVRASDESS ALQRIKSVCT AYGLWKNAYA PRIKVVLGNL AEKQFGLPKK 
      1060       1070       1080       1090       1100
AWHDLQEGID VIIHNAALVH WVYPYSKLRE ANVLSTVNVL NLAAAGKAKY 
      1110       1120       1130       1140       1150
FTFVSSTSAL DTKHYLELSN AAIESGGSGV PEDDDLMGGS LGLKGGYGQS 
      1160       1170       1180       1190       1200
KWAAEFIIKR AGERGLRGCI LRPGYVTGSP STGASNADDF LLRFLRGCVQ 
      1210       1220       1230       1240       1250
LGKIPDIEGT VNMVPVDYVA RLATAASFSS SGNTHMMVVN VNAKPRISFR 
      1260       1270       1280       1290       1300
DYLLALKEYG YQVTSVPYDE WSKALESSSD EENPLYPLLY LVLDDLPKKL 
      1310       1320       1330       1340       1350
RSPELDTTNA KFVLEEDFAR TNIEPIIITS VSLEVVGSYI SFLHKLGFLE 
      1360       1370       1380 
EPAKGSRPLP NISLSDEQIS LIAAVATARS STAKP
Length:1,385
Mass (Da):151,953
Last modified:January 9, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE96D1018986F338
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE016817 Genomic DNA Translation: AAS51573.2

NCBI Reference Sequences

More...RefSeqi		NP_983749.2, NM_209102.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		AAS51573; AAS51573; AGOS_ADL346W

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4619884

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ago:AGOS_ADL346W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016817 Genomic DNA Translation: AAS51573.2
RefSeqiNP_983749.2, NM_209102.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi33169.AAS51573

Proteomic databases

PRIDEiQ75BB3

Genome annotation databases

EnsemblFungiiAAS51573; AAS51573; AGOS_ADL346W
GeneIDi4619884
KEGGiago:AGOS_ADL346W

Phylogenomic databases

eggNOGiKOG1178, Eukaryota
HOGENOMiCLU_000022_19_1_1
InParanoidiQ75BB3
KOiK00143
OMAiENDKFTM

Enzyme and pathway databases

UniPathwayiUPA00033;UER00032

Family and domain databases

CDDicd05235, SDR_e1, 1 hit
Gene3Di1.10.1200.10, 1 hit
3.40.50.12780, 1 hit
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR014397, Lys2
IPR013120, Male_sterile_NAD-bd
IPR036291, NAD(P)-bd_dom_sf
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR010080, Thioester_reductase-like_dom
PfamiView protein in Pfam
PF00501, AMP-binding, 1 hit
PF07993, NAD_binding_4, 1 hit
PF00550, PP-binding, 1 hit
SMARTiView protein in SMART
SM00823, PKS_PP, 1 hit
SUPFAMiSSF47336, SSF47336, 1 hit
SSF51735, SSF51735, 1 hit
TIGRFAMsiTIGR01733, AA-adenyl-dom, 1 hit
TIGR03443, alpha_am_amid, 1 hit
TIGR01746, Thioester-redct, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 1 hit
PS50075, CARRIER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLYS2_ASHGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q75BB3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 9, 2013
Last modified: August 12, 2020
This is version 109 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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