UniProtKB - Q756Z0 (NTE1_ASHGO)
Protein
Lysophospholipase NTE1
Gene
NTE1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Functioni
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity
Catalytic activityi
- EC:3.1.1.5
Activity regulationi
Inhibited by organophosphorus esters.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 1252 | NucleophilePROSITE-ProRule annotation | 1 | |
Active sitei | 1370 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 661 – 782 | cNMP 1Add BLAST | 122 | |
Nucleotide bindingi | 778 – 918 | cNMP 2Add BLAST | 141 |
GO - Molecular functioni
- lysophospholipase activity Source: GO_Central
- phosphatidyl phospholipase B activity Source: UniProtKB-EC
GO - Biological processi
- phosphatidylcholine catabolic process Source: EnsemblFungi
- regulation of phospholipid biosynthetic process Source: EnsemblFungi
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Lysophospholipase NTE1 (EC:3.1.1.5)Alternative name(s): Intracellular phospholipase B Neuropathy target esterase homolog |
Gene namesi | Name:NTE1 Ordered Locus Names:AER124W |
Organismi | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
Taxonomic identifieri | 284811 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium › |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 73 | LumenalBy similarityAdd BLAST | 73 | |
Transmembranei | 74 – 94 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 95 – 1522 | CytoplasmicBy similarityAdd BLAST | 1428 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000295308 | 1 – 1522 | Lysophospholipase NTE1Add BLAST | 1522 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1219 – 1383 | PNPLAPROSITE-ProRule annotationAdd BLAST | 165 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1223 – 1228 | GXGXXGPROSITE-ProRule annotation | 6 | |
Motifi | 1250 – 1254 | GXSXGPROSITE-ProRule annotation | 5 | |
Motifi | 1370 – 1372 | DGA/GPROSITE-ProRule annotation | 3 |
Sequence similaritiesi
Belongs to the NTE family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2968, Eukaryota |
HOGENOMi | CLU_000960_1_1_1 |
InParanoidi | Q756Z0 |
OMAi | YPKATAH |
Family and domain databases
CDDi | cd00038, CAP_ED, 2 hits |
Gene3Di | 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR016035, Acyl_Trfase/lysoPLipase IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR001423, LysoPLipase_patatin_CS IPR002641, PNPLA_dom IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 2 hits PF01734, Patatin, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 2 hits |
SUPFAMi | SSF51206, SSF51206, 3 hits SSF52151, SSF52151, 1 hit |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 2 hits PS51635, PNPLA, 1 hit PS01237, UPF0028, 1 hit |
i Sequence
Sequence statusi: Complete.
Q756Z0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVDGTYVNSS VEAISGEADT AAVAELANQM VMNFLYESSS WLAQSTGPFL
60 70 80 90 100
WKGFRFLFLR LPSSLLVYLI NGTVPFYLVV LGSVFTPIIV YLILRSRVLS
110 120 130 140 150
AYSRLKGDNE DEVIDKKKQL VNDSEAMLMG GPDGKRRSGF SSYLDEFLSA
160 170 180 190 200
IKIFGYLDKL VFHELTKSMR TQRLEQGEVM LLDDSVGFAI VVEGGLHIYH
210 220 230 240 250
KIAHSQGSTR ESMPLPEDRS FDSNEDDLTI NGERFQLLNK VKAGNPVSSL
260 270 280 290 300
VSILKLFTDN HTPTVVDSSK SSPKQSAQVP IRQLISPFLD GNVERNKATL
310 320 330 340 350
NMKQVPTAEY EIPSAERAGS NVSSFTQQLY ESMLPKDHAA EDVREPLPEI
360 370 380 390 400
VAYAASDCAI AVIPASSFKR LMVKYPRSAS QIIQVILTKL YRVTFQTAHS
410 420 430 440 450
YLGLTKEIMH TEVVLNNSTN FELPYYLQEA ILRKIKNGSK ESSVQESIHR
460 470 480 490 500
ATLRSKNVHA HNSPTPNKIS RHIALESRDQ YNPGDLLSNV PLSRKGSKTA
510 520 530 540 550
SSSSVSIPRI SSLRHQKEAA SSPLATLRRL EGNDSQNFAP LSSSSPMSVS
560 570 580 590 600
EKPSVVGGGA HDNISQISFS SALEETEESS WRMALVESMF GYLGITNESI
610 620 630 640 650
MPPTEDLLFL NNRASSGSSV CSVSSYSHPQ TINQDLFRCL SPELVRTKKK
660 670 680 690 700
APRQKYTEEM PINVDFNTAK EEFAEGLETL FIPSGATIVE QNGNNKGLYY
710 720 730 740 750
IVSGELLVCW KNEEDNIEYV LYTVKPGGIA GYLASLIGFK SFVSLRAKTD
760 770 780 790 800
LYVGFLPIEV LERLCDKYFM IYLKIAETLT KLLSPKILKL DYALEWIHLE
810 820 830 840 850
ASETLFNQND PANAIYVVLN GRLRQLHQKS KNEERLSRPT TQRKKRKDDN
860 870 880 890 900
QPNVQVVGEY SQGCSFGEVE VLTAMNRVST VVAVRDTELA RIPRTLFEVL
910 920 930 940 950
ALEHPSIMIR VSRLVAHKIL QRSSDIREPT KIVNSANGYR YDFNLTIPPS
960 970 980 990 1000
AGTSSWGNNS DGGSISYKTI TILPITYGLP VEEFANKLVS TFRQVGRSTI
1010 1020 1030 1040 1050
GLTQCTTLKH LGRHAFDKLA NLKQSGYFAE LEELYELVVY IADTPVKSSW
1060 1070 1080 1090 1100
TSTCISQGDC ILLLADASSD PEIGEFERLL INNRTTARTE LLLLHPERYV
1110 1120 1130 1140 1150
EPGLTHKWLR KRTWVHQHHH MQFVSSQNPS ERVDSKAPPI PGAPPNLIGR
1160 1170 1180 1190 1200
LKKRERLNQL TKRTQENFAR LLPDSIKLTV ENISMKYIQK KQKYYTPVSA
1210 1220 1230 1240 1250
HKNDFLRLAR ILSGQAIGLV LGGGGARGIS HLGILKAIEE HGIPIDMIGG
1260 1270 1280 1290 1300
TSIGSFVGGL YAKDYDLVPT YGRVKKFAGR IGSIWRMLSD LTWPVTSYTT
1310 1320 1330 1340 1350
GHEFNRGIWK AFGDIRIEDF WIQYYCNSTN ITESMQEIHT FGYAWRYVRA
1360 1370 1380 1390 1400
SMSLAGILPP ITDNGNMLLD GGYLDNLPVL EMKARGCKTI FAVDVGSVDD
1410 1420 1430 1440 1450
RTPMDYGDSL NGFWIVLNRW NPFSKHPNVP SMAEIQMRLG YVASVNALEK
1460 1470 1480 1490 1500
AKTTQGVVYF RPPIEDYATL DFAKFEEIYQ VGTAYGATFL HELEQNGKLP
1510 1520
RIPGNEPANG PGIHLLHRRN SI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE016818 Genomic DNA Translation: AAS52807.1 |
RefSeqi | NP_984983.1, NM_210337.1 |
Genome annotation databases
EnsemblFungii | AAS52807; AAS52807; AGOS_AER124W |
GeneIDi | 4621189 |
KEGGi | ago:AGOS_AER124W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE016818 Genomic DNA Translation: AAS52807.1 |
RefSeqi | NP_984983.1, NM_210337.1 |
3D structure databases
SMRi | Q756Z0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 33169.AAS52807 |
Genome annotation databases
EnsemblFungii | AAS52807; AAS52807; AGOS_AER124W |
GeneIDi | 4621189 |
KEGGi | ago:AGOS_AER124W |
Phylogenomic databases
eggNOGi | KOG2968, Eukaryota |
HOGENOMi | CLU_000960_1_1_1 |
InParanoidi | Q756Z0 |
OMAi | YPKATAH |
Family and domain databases
CDDi | cd00038, CAP_ED, 2 hits |
Gene3Di | 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR016035, Acyl_Trfase/lysoPLipase IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR001423, LysoPLipase_patatin_CS IPR002641, PNPLA_dom IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 2 hits PF01734, Patatin, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 2 hits |
SUPFAMi | SSF51206, SSF51206, 3 hits SSF52151, SSF52151, 1 hit |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 2 hits PS51635, PNPLA, 1 hit PS01237, UPF0028, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NTE1_ASHGO | |
Accessioni | Q756Z0Primary (citable) accession number: Q756Z0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families