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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1252NucleophilePROSITE-ProRule annotation1
Active sitei1370Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi661 – 782cNMP 1Add BLAST122
Nucleotide bindingi778 – 918cNMP 2Add BLAST141

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lysophospholipase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NTE1
Ordered Locus Names:AER124W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284811 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000591 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 73LumenalBy similarityAdd BLAST73
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 1522CytoplasmicBy similarityAdd BLAST1428

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002953081 – 1522Lysophospholipase NTE1Add BLAST1522

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q756Z0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
33169.AAS52807

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q756Z0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q756Z0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1219 – 1383PNPLAPROSITE-ProRule annotationAdd BLAST165

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1223 – 1228GXGXXGPROSITE-ProRule annotation6
Motifi1250 – 1254GXSXGPROSITE-ProRule annotation5
Motifi1370 – 1372DGA/GPROSITE-ProRule annotation3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NTE family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000048680

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q756Z0

KEGG Orthology (KO)

More...
KOi
K14676

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCITQAD

Database of Orthologous Groups

More...
OrthoDBi
EOG092C0BAH

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00038 CAP_ED, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001423 LysoPLipase_patatin_CS
IPR002641 PNPLA_dom
IPR014710 RmlC-like_jellyroll

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00027 cNMP_binding, 2 hits
PF01734 Patatin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00100 cNMP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51206 SSF51206, 3 hits
SSF52151 SSF52151, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50042 CNMP_BINDING_3, 2 hits
PS51635 PNPLA, 1 hit
PS01237 UPF0028, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q756Z0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDGTYVNSS VEAISGEADT AAVAELANQM VMNFLYESSS WLAQSTGPFL
60 70 80 90 100
WKGFRFLFLR LPSSLLVYLI NGTVPFYLVV LGSVFTPIIV YLILRSRVLS
110 120 130 140 150
AYSRLKGDNE DEVIDKKKQL VNDSEAMLMG GPDGKRRSGF SSYLDEFLSA
160 170 180 190 200
IKIFGYLDKL VFHELTKSMR TQRLEQGEVM LLDDSVGFAI VVEGGLHIYH
210 220 230 240 250
KIAHSQGSTR ESMPLPEDRS FDSNEDDLTI NGERFQLLNK VKAGNPVSSL
260 270 280 290 300
VSILKLFTDN HTPTVVDSSK SSPKQSAQVP IRQLISPFLD GNVERNKATL
310 320 330 340 350
NMKQVPTAEY EIPSAERAGS NVSSFTQQLY ESMLPKDHAA EDVREPLPEI
360 370 380 390 400
VAYAASDCAI AVIPASSFKR LMVKYPRSAS QIIQVILTKL YRVTFQTAHS
410 420 430 440 450
YLGLTKEIMH TEVVLNNSTN FELPYYLQEA ILRKIKNGSK ESSVQESIHR
460 470 480 490 500
ATLRSKNVHA HNSPTPNKIS RHIALESRDQ YNPGDLLSNV PLSRKGSKTA
510 520 530 540 550
SSSSVSIPRI SSLRHQKEAA SSPLATLRRL EGNDSQNFAP LSSSSPMSVS
560 570 580 590 600
EKPSVVGGGA HDNISQISFS SALEETEESS WRMALVESMF GYLGITNESI
610 620 630 640 650
MPPTEDLLFL NNRASSGSSV CSVSSYSHPQ TINQDLFRCL SPELVRTKKK
660 670 680 690 700
APRQKYTEEM PINVDFNTAK EEFAEGLETL FIPSGATIVE QNGNNKGLYY
710 720 730 740 750
IVSGELLVCW KNEEDNIEYV LYTVKPGGIA GYLASLIGFK SFVSLRAKTD
760 770 780 790 800
LYVGFLPIEV LERLCDKYFM IYLKIAETLT KLLSPKILKL DYALEWIHLE
810 820 830 840 850
ASETLFNQND PANAIYVVLN GRLRQLHQKS KNEERLSRPT TQRKKRKDDN
860 870 880 890 900
QPNVQVVGEY SQGCSFGEVE VLTAMNRVST VVAVRDTELA RIPRTLFEVL
910 920 930 940 950
ALEHPSIMIR VSRLVAHKIL QRSSDIREPT KIVNSANGYR YDFNLTIPPS
960 970 980 990 1000
AGTSSWGNNS DGGSISYKTI TILPITYGLP VEEFANKLVS TFRQVGRSTI
1010 1020 1030 1040 1050
GLTQCTTLKH LGRHAFDKLA NLKQSGYFAE LEELYELVVY IADTPVKSSW
1060 1070 1080 1090 1100
TSTCISQGDC ILLLADASSD PEIGEFERLL INNRTTARTE LLLLHPERYV
1110 1120 1130 1140 1150
EPGLTHKWLR KRTWVHQHHH MQFVSSQNPS ERVDSKAPPI PGAPPNLIGR
1160 1170 1180 1190 1200
LKKRERLNQL TKRTQENFAR LLPDSIKLTV ENISMKYIQK KQKYYTPVSA
1210 1220 1230 1240 1250
HKNDFLRLAR ILSGQAIGLV LGGGGARGIS HLGILKAIEE HGIPIDMIGG
1260 1270 1280 1290 1300
TSIGSFVGGL YAKDYDLVPT YGRVKKFAGR IGSIWRMLSD LTWPVTSYTT
1310 1320 1330 1340 1350
GHEFNRGIWK AFGDIRIEDF WIQYYCNSTN ITESMQEIHT FGYAWRYVRA
1360 1370 1380 1390 1400
SMSLAGILPP ITDNGNMLLD GGYLDNLPVL EMKARGCKTI FAVDVGSVDD
1410 1420 1430 1440 1450
RTPMDYGDSL NGFWIVLNRW NPFSKHPNVP SMAEIQMRLG YVASVNALEK
1460 1470 1480 1490 1500
AKTTQGVVYF RPPIEDYATL DFAKFEEIYQ VGTAYGATFL HELEQNGKLP
1510 1520
RIPGNEPANG PGIHLLHRRN SI
Length:1,522
Mass (Da):170,071
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9013C45B4D219D27
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE016818 Genomic DNA Translation: AAS52807.1

NCBI Reference Sequences

More...
RefSeqi
NP_984983.1, NM_210337.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AAS52807; AAS52807; AGOS_AER124W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4621189

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ago:AGOS_AER124W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016818 Genomic DNA Translation: AAS52807.1
RefSeqiNP_984983.1, NM_210337.1

3D structure databases

ProteinModelPortaliQ756Z0
SMRiQ756Z0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi33169.AAS52807

Proteomic databases

PRIDEiQ756Z0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS52807; AAS52807; AGOS_AER124W
GeneIDi4621189
KEGGiago:AGOS_AER124W

Phylogenomic databases

HOGENOMiHOG000048680
InParanoidiQ756Z0
KOiK14676
OMAiTCITQAD
OrthoDBiEOG092C0BAH

Family and domain databases

CDDicd00038 CAP_ED, 2 hits
Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001423 LysoPLipase_patatin_CS
IPR002641 PNPLA_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 2 hits
PF01734 Patatin, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 2 hits
SUPFAMiSSF51206 SSF51206, 3 hits
SSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 2 hits
PS51635 PNPLA, 1 hit
PS01237 UPF0028, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTE1_ASHGO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q756Z0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: December 5, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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