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Protein

D-arabinono-1,4-lactone oxidase

Gene

ALO1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2.

Cofactori

FADBy similarity

Pathwayi: D-erythroascorbate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. D-arabinono-1,4-lactone oxidase (ALO1)
This subpathway is part of the pathway D-erythroascorbate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose, the pathway D-erythroascorbate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayi
UPA00771;UER00766

Names & Taxonomyi

Protein namesi
Recommended name:
D-arabinono-1,4-lactone oxidase (EC:1.1.3.37)
Short name:
ALO
Alternative name(s):
L-galactono-gamma-lactone oxidase
Gene namesi
Name:ALO1
Ordered Locus Names:AFR440C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome VI

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001281631 – 532D-arabinono-1,4-lactone oxidaseAdd BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62Pros-8alpha-FAD histidineBy similarity1

Interactioni

Protein-protein interaction databases

STRINGi33169.AAS53811

Structurei

3D structure databases

ProteinModelPortaliQ752Y3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 199FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST175

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000204635
InParanoidiQ752Y3
KOiK00107
OMAiFRFLWFP
OrthoDBiEOG092C14O7

Family and domain databases

Gene3Di3.30.43.10, 1 hit
InterProiView protein in InterPro
IPR007173 ALO
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR010031 FAD_lactone_oxidase
IPR006094 Oxid_FAD_bind_N
IPR006093 Oxy_OxRdtase_FAD_BS
IPR030654 Sugar_lactone_oxidase
PANTHERiPTHR43762 PTHR43762, 1 hit
PfamiView protein in Pfam
PF04030 ALO, 1 hit
PF01565 FAD_binding_4, 1 hit
PIRSFiPIRSF000136 LGO_GLO, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
TIGRFAMsiTIGR01678 FAD_lactone_ox, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit
PS00862 OX2_COVAL_FAD, 1 hit

Sequencei

Sequence statusi: Complete.

Q752Y3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVLAGVEAS GIARNYVFKN WAGIYSARPR LYFQPRSEDE VVAIVRAARE
60 70 80 90 100
QGRTIVTVGS GHSPSDMCAT DDWMVNLDRL NGVLELQEDE QGRYADVTVA
110 120 130 140 150
AGIRVYELHR YLSARGYALQ NLGSISEQSV GGIISTGTHG SSPYHGLVSS
160 170 180 190 200
QYVNLTLVNG RGELVFLDSE HEPEVFRAAM LSLGKLGIIV RATIRVVPAF
210 220 230 240 250
NIHSTQEVIN FETLLDNWET IWTSSEFIRC WWYPYVRKCV LWRGVKTSEP
260 270 280 290 300
AEKSRSSWWG TTLGRLVYES LLWLTVNVYP SLTPFVERFI FRQQYGKVET
310 320 330 340 350
FGNGDEAVQT SIDGLNMDCL FSQFVDEWAC PLNNGPEVLR SLDHSIAQAA
360 370 380 390 400
QNKEFFVHVP IEVRCSNTTL PHEYKCPEDR TVTAPGPVYG NLLRPYLDNT
410 420 430 440 450
PSHLRYAPLS DVTNSQLTLY INATIYRPFG TNTPIHKWFT LFEDTLGAAG
460 470 480 490 500
GKPHWAKNFL GSTATAAGPV KSSDEYQDYE MRGMATKIKE WYGDNLKQFQ
510 520 530
KVRREQDPHN VFIANKDWAV KNGIIDIDEL DS
Length:532
Mass (Da):59,965
Last modified:July 5, 2004 - v1
Checksum:i8B975E346283331C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA Translation: AAS53811.1
RefSeqiNP_985987.1, NM_211342.1

Genome annotation databases

EnsemblFungiiAAS53811; AAS53811; AGOS_AFR440C
GeneIDi4622264
KEGGiago:AGOS_AFR440C

Similar proteinsi

Entry informationi

Entry nameiALO_ASHGO
AccessioniPrimary (citable) accession number: Q752Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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