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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179By similarity1
Active sitei381By similarity1
Active sitei445By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

ESTHERiashgo-q752m5 Carboxypeptidase_S10
MEROPSiS10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:AFR549W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome VI

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 512LumenalSequence analysisAdd BLAST493
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21
Topological domaini534 – 599CytoplasmicSequence analysisAdd BLAST66

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000041190120 – 599Pheromone-processing carboxypeptidase KEX1Add BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi442N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ752M5

Interactioni

Protein-protein interaction databases

STRINGi33169.AAS53920

Structurei

3D structure databases

ProteinModelPortaliQ752M5
SMRiQ752M5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879
InParanoidiQ752M5
KOiK01288
OMAiNEIYFAG
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q752M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVRKLTLIG AALARAALAL QQEDFVVNGE LLPGVREIDR AEVPEMHAGL
60 70 80 90 100
MPLEEDEDGR ALFFWRMGEQ CGKRCSNELI VWLNGGPGCS SMDGALMETG
110 120 130 140 150
AFRVAEDGKL YLNSGSWHTR GTMLFVDQPV GTGFSRPGRD GRLRTELSQL
160 170 180 190 200
ADDFLLFMER YYAVFPEDRR RTLVLAGESY AGQYLPYFAD AVVRRNAERA
210 220 230 240 250
PEERYKLQNV MIGNGWVDPD LQSLSYVPFV SSRGLFGPET RNFQDILRDQ
260 270 280 290 300
EACQNAINHG PAKGFSHPEC EGILPKLLSS IPGPDRPVQQ CINMYDIRLR
310 320 330 340 350
DVFPSCGMNW PADLPNVHKF FGTPGVLEAL HVDPQVAGPW VECKSAVSEA
360 370 380 390 400
LVNAHSRPSV HLIPGLIEAG VKFVFFNGDQ DVICNNMGVE MLIAELRWRG
410 420 430 440 450
HMGFSNATEN FDWYHSDADA KTLVAAGVVK RDGPVTFISV FNASHMVPFD
460 470 480 490 500
VPRISRGIID IERSATILGV KGDSRMLITV DTEEDVTLST NAERNQQIRH
510 520 530 540 550
NQLKRLNGDT RKFTIAVFGL TISSIIGVIV YFSMRLHYGA KIRAILTNPK
560 570 580 590
SGTSSADDFS MDDEYTGTVM GDFHHGTHKK GQYYAVPDTD ISSSELHSV
Length:599
Mass (Da):66,497
Last modified:July 5, 2004 - v1
Checksum:i64D09A52E115AF6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA Translation: AAS53920.1
RefSeqiNP_986096.1, NM_212232.1

Genome annotation databases

EnsemblFungiiAAS53920; AAS53920; AGOS_AFR549W
GeneIDi4622376
KEGGiago:AGOS_AFR549W

Similar proteinsi

Entry informationi

Entry nameiKEX1_ASHGO
AccessioniPrimary (citable) accession number: Q752M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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