UniProtKB - Q751I6 (MED19_ASHGO)
Protein
Mediator of RNA polymerase II transcription subunit 19
Gene
ROX3
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Functioni
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity
GO - Molecular functioni
- transcription coactivator activity Source: EnsemblFungi
- transcription coregulator activity Source: GO_Central
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: EnsemblFungi
- positive regulation of transcription by RNA polymerase II Source: EnsemblFungi
- regulation of transcription by RNA polymerase II Source: GO_Central
- RNA polymerase II preinitiation complex assembly Source: EnsemblFungi
- transcription open complex formation at RNA polymerase II promoter Source: EnsemblFungi
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Mediator of RNA polymerase II transcription subunit 19Alternative name(s): Mediator complex subunit 19 |
Gene namesi | Name:ROX3 Synonyms:MED19 Ordered Locus Names:AGL280W |
Organismi | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
Taxonomic identifieri | 284811 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium › |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- core mediator complex Source: GO_Central
- mediator complex Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000304775 | 1 – 207 | Mediator of RNA polymerase II transcription subunit 19Add BLAST | 207 |
Interactioni
Subunit structurei
Component of the Mediator complex.
By similarityProtein-protein interaction databases
STRINGi | 33169.AAS54211 |
Family & Domainsi
Sequence similaritiesi
Belongs to the Mediator complex subunit 19 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QXG3, Eukaryota |
HOGENOMi | CLU_117719_0_0_1 |
InParanoidi | Q751I6 |
OMAi | SYPTEFQ |
Family and domain databases
InterProi | View protein in InterPro IPR013942, Mediator_Med19_fun |
PANTHERi | PTHR28270, PTHR28270, 1 hit |
Pfami | View protein in Pfam PF08633, Rox3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q751I6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTVHDDATM PSYYYYVDPA GPAYEPQQPN PIDDLISVYG LQDISRQVAR
60 70 80 90 100
TNADGTKAVK LRKSYKNQIQ DLSGKFSVIP TRENGKGGEI SPIVFQNTDG
110 120 130 140 150
DAVRERGMGP EEWRRAQVFR DQALFEAPTM DWDMCAEVIS QFERSYPGEF
160 170 180 190 200
KNQGFEVEDL AFDLDGSGAN GAALGGKAKK RKSRSNGSSM ATPNSDLQED
IKRRRLE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE016820 Genomic DNA Translation: AAS54211.1 |
RefSeqi | NP_986387.1, NM_211449.1 |
Genome annotation databases
EnsemblFungii | AAS54211; AAS54211; AGOS_AGL280W |
GeneIDi | 4622680 |
KEGGi | ago:AGOS_AGL280W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE016820 Genomic DNA Translation: AAS54211.1 |
RefSeqi | NP_986387.1, NM_211449.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 33169.AAS54211 |
Genome annotation databases
EnsemblFungii | AAS54211; AAS54211; AGOS_AGL280W |
GeneIDi | 4622680 |
KEGGi | ago:AGOS_AGL280W |
Phylogenomic databases
eggNOGi | ENOG502QXG3, Eukaryota |
HOGENOMi | CLU_117719_0_0_1 |
InParanoidi | Q751I6 |
OMAi | SYPTEFQ |
Family and domain databases
InterProi | View protein in InterPro IPR013942, Mediator_Med19_fun |
PANTHERi | PTHR28270, PTHR28270, 1 hit |
Pfami | View protein in Pfam PF08633, Rox3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MED19_ASHGO | |
Accessioni | Q751I6Primary (citable) accession number: Q751I6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families