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UniProtKB - Q74ZH9 (GDE1_ASHGO)
Protein
Glycerophosphocholine phosphodiesterase GDE1
Gene
GDE1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Functioni
Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source.
By similarityCatalytic activityi
GO - Molecular functioni
- glycerophosphocholine phosphodiesterase activity Source: GO_Central
GO - Biological processi
- glycerophospholipid catabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Names & Taxonomyi
Protein namesi | Recommended name: Glycerophosphocholine phosphodiesterase GDE1 (EC:3.1.4.2By similarity)Alternative name(s): Glycerophosphodiester phosphodiesterase GDE1 |
Gene namesi | Name:GDE1 Ordered Locus Names:AGR223W |
Organismi | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
Taxonomic identifieri | 284811 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233008 | 1 – 1321 | Glycerophosphocholine phosphodiesterase GDE1Add BLAST | 1321 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 209 | SPXPROSITE-ProRule annotationAdd BLAST | 209 | |
Repeati | 417 – 446 | ANK 1Add BLAST | 30 | |
Repeati | 463 – 495 | ANK 2Add BLAST | 33 | |
Repeati | 497 – 524 | ANK 3Add BLAST | 28 | |
Repeati | 529 – 558 | ANK 4Add BLAST | 30 | |
Repeati | 563 – 592 | ANK 5Add BLAST | 30 | |
Repeati | 596 – 626 | ANK 6Add BLAST | 31 | |
Domaini | 972 – 1311 | GP-PDEAdd BLAST | 340 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 630 – 698 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 868 – 893 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 1056 – 1079 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 630 – 692 | Polar residuesSequence analysisAdd BLAST | 63 | |
Compositional biasi | 872 – 893 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1056 – 1075 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the GDE1 family.Curated
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0504, Eukaryota KOG1162, Eukaryota KOG2421, Eukaryota |
HOGENOMi | CLU_005444_1_0_1 |
InParanoidi | Q74ZH9 |
OMAi | HSTQLDT |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR033506, Gde1 IPR030395, GP_PDE_dom IPR017946, PLC-like_Pdiesterase_TIM-brl IPR004331, SPX_dom |
PANTHERi | PTHR22958:SF1, PTHR22958:SF1, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF03009, GDPD, 1 hit PF03105, SPX, 2 hits |
SMARTi | View protein in SMART SM00248, ANK, 7 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS51704, GP_PDE, 1 hit PS51382, SPX, 1 hit |
i Sequence
Sequence statusi: Complete.
Q74ZH9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKFGKTFPNH QVPEWAHKYV NYKGLKKQIK EITLVQDALF RQEQGAASQD
60 70 80 90 100
GPARRRGRES KEQYLGHPEV KKLLAAFFFA LDRDIEKVDG FYNMQFMEYD
110 120 130 140 150
RRLRKLLSSA QLADITSVQR GATGYLHAPL PQYIAYGERE RDGLPERYVP
160 170 180 190 200
PHATDMSEDL AEVLTILLEL RSHFRNLKWY GELNKRAFTK IMKKLDKKVG
210 220 230 240 250
TNQQHSYFQA RIKPLEFADD TPIVKALATI NEILDRISPC VKDLQDKLRG
260 270 280 290 300
EDRRLLQGSS SPIDVASQLV TKDDGAGLIN ELISMYRSVV LIPTRTLVTL
310 320 330 340 350
LNKSALSRSF SCVDEILGII PTLGDPSDIN GRNFFHHHVI ALGKKRTKSL
360 370 380 390 400
EERDNINSLL SDSLDLEAAI PPEPNTRLVG AFGPDGVNSD DSPAPLSHIL
410 420 430 440 450
QQLPAHLRPS LLQRDNYKRT PLHYSAQYGL CEVTRIILQA LSEWDAWNAD
460 470 480 490 500
VAIDDIDVWG DSENLTPLHL AVIGTHPLTV STLLSFMNPE KSLNSPRLLH
510 520 530 540 550
LATRLNSPSL LNSLLSAKGF DIDYQEPENL ETALYVACKL DIYEAAEYLV
560 570 580 590 600
KQGANMELGE KLFGWTPIFA AATEGYARIV QLLVDHGAKY DLFDESGWTP
610 620 630 640 650
MEHAALRGHL DISQLIRITD NKAITRPKFA TDWNKSTRPT ETTNGLLSAL
660 670 680 690 700
TPSESGSTTT GSENKSSSLT PSTSNEMYAL PARSSTSIDK ISEPNKGNHR
710 720 730 740 750
KVLKSQLSHG KVQTIKDTQL PQQPIKSFGH SFLQKDESVI LLTLGTNDNR
760 770 780 790 800
STIPAVSLNK VPVAKASSTE LDTALSLLVT CMDNLDAEPV MLDLPLHENL
810 820 830 840 850
DSVTFKVPYK KDSSYTIFFD IVPTYGYSMA NMNRENSSGM HSNVGNSTGP
860 870 880 890 900
AYLDAQVGQC GSRLHYDQLG RDTPNTYDQR SRHQASQQKE QIATKKQSKI
910 920 930 940 950
LGRAVALLDS APTSVGPNRR SIAEAITIPI IGSDTLEVLG IIRFDFLVVT
960 970 980 990 1000
PFVHKNLSVG PAETYWKSLV STRVIGHRGL GKNMNTNKSL QLGENTVESF
1010 1020 1030 1040 1050
IAAASLGASY VEFDVQLTKD NIPVVYHDFL VAESGVDIPM HELTLEQFLD
1060 1070 1080 1090 1100
LNGERQRHQD AREAHRNHRS PNGRRLSMDD SSAELIKRSL MMRGDEDRTA
1110 1120 1130 1140 1150
RDLNTIYGDR MRLTRTFKKN AFKANSRGHA IASSFVTLKE LFKKIPQNVG
1160 1170 1180 1190 1200
FNIECKYPMV DEAEEEDIGP IAVEMNHWID TVLEVVYDNV EGRDVIFSSF
1210 1220 1230 1240 1250
QPDVCLMLSL KQPSFPILFL TEGGTAKRCD IRAASLQNAI RFAHRWNLLG
1260 1270 1280 1290 1300
IVSAAAPIVI APRLAQIVKS SGLVCVTYGV ENNDPEIARV EMDAGVDAVI
1310 1320
VDSVLAVRKG LTREAQDADT L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE016820 Genomic DNA Translation: AAS54713.2 |
RefSeqi | NP_986889.2, NM_211951.2 |
Genome annotation databases
EnsemblFungii | AAS54713; AAS54713; AGOS_AGR223W |
GeneIDi | 4623191 |
KEGGi | ago:AGOS_AGR223W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE016820 Genomic DNA Translation: AAS54713.2 |
RefSeqi | NP_986889.2, NM_211951.2 |
3D structure databases
SMRi | Q74ZH9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 33169.AAS54713 |
Genome annotation databases
EnsemblFungii | AAS54713; AAS54713; AGOS_AGR223W |
GeneIDi | 4623191 |
KEGGi | ago:AGOS_AGR223W |
Phylogenomic databases
eggNOGi | KOG0504, Eukaryota KOG1162, Eukaryota KOG2421, Eukaryota |
HOGENOMi | CLU_005444_1_0_1 |
InParanoidi | Q74ZH9 |
OMAi | HSTQLDT |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR033506, Gde1 IPR030395, GP_PDE_dom IPR017946, PLC-like_Pdiesterase_TIM-brl IPR004331, SPX_dom |
PANTHERi | PTHR22958:SF1, PTHR22958:SF1, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF03009, GDPD, 1 hit PF03105, SPX, 2 hits |
SMARTi | View protein in SMART SM00248, ANK, 7 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS51704, GP_PDE, 1 hit PS51382, SPX, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GDE1_ASHGO | |
Accessioni | Q74ZH9Primary (citable) accession number: Q74ZH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | January 9, 2013 | |
Last modified: | February 23, 2022 | |
This is version 115 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families