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UniProtKB - Q74ZH9 (GDE1_ASHGO)

Entry version 115 (23 Feb 2022)
Sequence version 2 (09 Jan 2013)
Previous versions | rss
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Protein

Glycerophosphocholine phosphodiesterase GDE1

Gene

GDE1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycerophosphocholine phosphodiesterase GDE1 (EC:3.1.4.2By similarity)
Alternative name(s):
Glycerophosphodiester phosphodiesterase GDE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GDE1
Ordered Locus Names:AGR223W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284811 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000591 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002330081 – 1321Glycerophosphocholine phosphodiesterase GDE1Add BLAST1321

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		33169.AAS54713

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q74ZH9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 209SPXPROSITE-ProRule annotationAdd BLAST209
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati417 – 446ANK 1Add BLAST30
Repeati463 – 495ANK 2Add BLAST33
Repeati497 – 524ANK 3Add BLAST28
Repeati529 – 558ANK 4Add BLAST30
Repeati563 – 592ANK 5Add BLAST30
Repeati596 – 626ANK 6Add BLAST31
Domaini972 – 1311GP-PDEAdd BLAST340

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni630 – 698DisorderedSequence analysisAdd BLAST69
Regioni868 – 893DisorderedSequence analysisAdd BLAST26
Regioni1056 – 1079DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi630 – 692Polar residuesSequence analysisAdd BLAST63
Compositional biasi872 – 893Polar residuesSequence analysisAdd BLAST22
Compositional biasi1056 – 1075Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GDE1 family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0504, Eukaryota
KOG1162, Eukaryota
KOG2421, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005444_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q74ZH9

Identification of Orthologs from Complete Genome Data

More...OMAi		HSTQLDT

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit
3.20.20.190, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR033506, Gde1
IPR030395, GP_PDE_dom
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR004331, SPX_dom

The PANTHER Classification System

More...PANTHERi		PTHR22958:SF1, PTHR22958:SF1, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 1 hit
PF03009, GDPD, 1 hit
PF03105, SPX, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit
SSF51695, SSF51695, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS51704, GP_PDE, 1 hit
PS51382, SPX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q74ZH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFGKTFPNH QVPEWAHKYV NYKGLKKQIK EITLVQDALF RQEQGAASQD 
        60         70         80         90        100
GPARRRGRES KEQYLGHPEV KKLLAAFFFA LDRDIEKVDG FYNMQFMEYD 
       110        120        130        140        150
RRLRKLLSSA QLADITSVQR GATGYLHAPL PQYIAYGERE RDGLPERYVP 
       160        170        180        190        200
PHATDMSEDL AEVLTILLEL RSHFRNLKWY GELNKRAFTK IMKKLDKKVG 
       210        220        230        240        250
TNQQHSYFQA RIKPLEFADD TPIVKALATI NEILDRISPC VKDLQDKLRG 
       260        270        280        290        300
EDRRLLQGSS SPIDVASQLV TKDDGAGLIN ELISMYRSVV LIPTRTLVTL 
       310        320        330        340        350
LNKSALSRSF SCVDEILGII PTLGDPSDIN GRNFFHHHVI ALGKKRTKSL 
       360        370        380        390        400
EERDNINSLL SDSLDLEAAI PPEPNTRLVG AFGPDGVNSD DSPAPLSHIL 
       410        420        430        440        450
QQLPAHLRPS LLQRDNYKRT PLHYSAQYGL CEVTRIILQA LSEWDAWNAD 
       460        470        480        490        500
VAIDDIDVWG DSENLTPLHL AVIGTHPLTV STLLSFMNPE KSLNSPRLLH 
       510        520        530        540        550
LATRLNSPSL LNSLLSAKGF DIDYQEPENL ETALYVACKL DIYEAAEYLV 
       560        570        580        590        600
KQGANMELGE KLFGWTPIFA AATEGYARIV QLLVDHGAKY DLFDESGWTP 
       610        620        630        640        650
MEHAALRGHL DISQLIRITD NKAITRPKFA TDWNKSTRPT ETTNGLLSAL 
       660        670        680        690        700
TPSESGSTTT GSENKSSSLT PSTSNEMYAL PARSSTSIDK ISEPNKGNHR 
       710        720        730        740        750
KVLKSQLSHG KVQTIKDTQL PQQPIKSFGH SFLQKDESVI LLTLGTNDNR 
       760        770        780        790        800
STIPAVSLNK VPVAKASSTE LDTALSLLVT CMDNLDAEPV MLDLPLHENL 
       810        820        830        840        850
DSVTFKVPYK KDSSYTIFFD IVPTYGYSMA NMNRENSSGM HSNVGNSTGP 
       860        870        880        890        900
AYLDAQVGQC GSRLHYDQLG RDTPNTYDQR SRHQASQQKE QIATKKQSKI 
       910        920        930        940        950
LGRAVALLDS APTSVGPNRR SIAEAITIPI IGSDTLEVLG IIRFDFLVVT 
       960        970        980        990       1000
PFVHKNLSVG PAETYWKSLV STRVIGHRGL GKNMNTNKSL QLGENTVESF 
      1010       1020       1030       1040       1050
IAAASLGASY VEFDVQLTKD NIPVVYHDFL VAESGVDIPM HELTLEQFLD 
      1060       1070       1080       1090       1100
LNGERQRHQD AREAHRNHRS PNGRRLSMDD SSAELIKRSL MMRGDEDRTA 
      1110       1120       1130       1140       1150
RDLNTIYGDR MRLTRTFKKN AFKANSRGHA IASSFVTLKE LFKKIPQNVG 
      1160       1170       1180       1190       1200
FNIECKYPMV DEAEEEDIGP IAVEMNHWID TVLEVVYDNV EGRDVIFSSF 
      1210       1220       1230       1240       1250
QPDVCLMLSL KQPSFPILFL TEGGTAKRCD IRAASLQNAI RFAHRWNLLG 
      1260       1270       1280       1290       1300
IVSAAAPIVI APRLAQIVKS SGLVCVTYGV ENNDPEIARV EMDAGVDAVI 
      1310       1320 
VDSVLAVRKG LTREAQDADT L
Length:1,321
Mass (Da):147,076
Last modified:January 9, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95CF4D85909CC556
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE016820 Genomic DNA Translation: AAS54713.2

NCBI Reference Sequences

More...RefSeqi		NP_986889.2, NM_211951.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		AAS54713; AAS54713; AGOS_AGR223W

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4623191

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ago:AGOS_AGR223W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016820 Genomic DNA Translation: AAS54713.2
RefSeqiNP_986889.2, NM_211951.2

3D structure databases

SMRiQ74ZH9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi33169.AAS54713

Genome annotation databases

EnsemblFungiiAAS54713; AAS54713; AGOS_AGR223W
GeneIDi4623191
KEGGiago:AGOS_AGR223W

Phylogenomic databases

eggNOGiKOG0504, Eukaryota
KOG1162, Eukaryota
KOG2421, Eukaryota
HOGENOMiCLU_005444_1_0_1
InParanoidiQ74ZH9
OMAiHSTQLDT

Family and domain databases

Gene3Di1.25.40.20, 1 hit
3.20.20.190, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR033506, Gde1
IPR030395, GP_PDE_dom
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR004331, SPX_dom
PANTHERiPTHR22958:SF1, PTHR22958:SF1, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF03009, GDPD, 1 hit
PF03105, SPX, 2 hits
SMARTiView protein in SMART
SM00248, ANK, 7 hits
SUPFAMiSSF48403, SSF48403, 1 hit
SSF51695, SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS51704, GP_PDE, 1 hit
PS51382, SPX, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGDE1_ASHGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q74ZH9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 9, 2013
Last modified: February 23, 2022
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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