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Protein

Mitochondrial glycine transporter

Gene

AGR383W

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
Ordered Locus Names:AGR383W
ORF Names:AGOS_AGR383W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome VII

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 37Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei60 – 86Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei108 – 133Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei161 – 184Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei212 – 238Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei266 – 284Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789231 – 293Mitochondrial glycine transporterAdd BLAST293

Proteomic databases

PRIDEiQ74Z23

Structurei

3D structure databases

ProteinModelPortaliQ74Z23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 85Solcar 1UniRule annotationAdd BLAST80
Repeati102 – 186Solcar 2UniRule annotationAdd BLAST85
Repeati208 – 291Solcar 3UniRule annotationAdd BLAST84

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000006978
InParanoidiQ74Z23
KOiK15118
OMAiTVYEQMM
OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 1 hit
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q74Z23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKAGGVPA HLVSGFFGGL ASVCALQPLD LLKTRLQQAQ ASSLRSVLRE
60 70 80 90 100
VRTTRELWRG TLPSALRTSI GSALYLSLLN YSRSALARGS EARTRSSLLP
110 120 130 140 150
RLQSYQNLLT GALSRAAVGL VTMPITVIKV RYESTLYAYN GLAEATRHIW
160 170 180 190 200
RSEGARGFFK GAAATTLRDA PYAGLYVLLY EQAKEMLPRA LPATLLGADE
210 220 230 240 250
SGKLTAPASA MVNGVSAFLS ASLATTLTAP FDTIKTRMQL QSHPVGFVQT
260 270 280 290
LRHIVCEERA RTLFDGLSLR LCRKAMSACI AWGIYEELLK LLH
Length:293
Mass (Da):31,817
Last modified:July 5, 2004 - v1
Checksum:iA3626494BE773541
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016820 Genomic DNA Translation: AAS54873.1
RefSeqiNP_987049.1, NM_212111.1

Genome annotation databases

EnsemblFungiiAAS54873; AAS54873; AGOS_AGR383W
GeneIDi4623353
KEGGiago:AGOS_AGR383W

Similar proteinsi

Entry informationi

Entry nameiS2538_ASHGO
AccessioniPrimary (citable) accession number: Q74Z23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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