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Entry version 110 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

TrkA domain protein

Gene

GSU0527

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei46GlucoseCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi183Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi183Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi183Calcium 3; via carbonyl oxygenCombined sources1
Metal bindingi210Calcium 1Combined sources1
Metal bindingi210Calcium 2Combined sources1
Metal bindingi210Calcium 3Combined sources1
Metal bindingi210Calcium 4Combined sources1
Metal bindingi214Calcium 1Combined sources1
Metal bindingi214Calcium 2Combined sources1
Metal bindingi214Calcium 4Combined sources1
Binding sitei249GlucoseCombined sources1
Metal bindingi359Zinc; via tele nitrogenCombined sources1
Binding sitei361NADCombined sources1
Metal bindingi364ZincCombined sources1
Binding sitei372GlucoseCombined sources1
Binding sitei377GlucoseCombined sources1
Binding sitei381AMPCombined sources1
Metal bindingi388ZincCombined sources1
Metal bindingi391Zinc; via pros nitrogenCombined sources1
Binding sitei406GlucoseCombined sources1
Binding sitei411GlucoseCombined sources1
Binding sitei418ADP; via carbonyl oxygenCombined sources1
Binding sitei420AMPCombined sources1
Binding sitei420NAD; via amide nitrogenCombined sources1
Binding sitei444ADPCombined sources1
Binding sitei444AMPCombined sources1
Binding sitei444NADCombined sources1
Metal bindingi449Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi449Calcium 5; via carbonyl oxygenCombined sources1
Metal bindingi450Calcium 1Combined sources1
Metal bindingi450Calcium 4Combined sources1
Metal bindingi450Calcium 5Combined sources1
Metal bindingi450Calcium 6Combined sources1
Metal bindingi453Calcium 1Combined sources1
Metal bindingi453Calcium 5Combined sources1
Metal bindingi453Calcium 6Combined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi226 – 228NADCombined sources3
Nucleotide bindingi247 – 249NADCombined sources3
Nucleotide bindingi360 – 363ADPCombined sources4
Nucleotide bindingi361 – 363AMPCombined sources3
Nucleotide bindingi381 – 383ADPCombined sources3
Nucleotide bindingi381 – 383NADCombined sources3
Nucleotide bindingi397 – 399NADCombined sources3
Nucleotide bindingi397 – 398ADPCombined sources2
Nucleotide bindingi397 – 398AMPCombined sources2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transportARBA annotation, Transport
LigandCalciumCombined sources, Metal-bindingCombined sources, NADCombined sources, Nucleotide-bindingCombined sources, ZincCombined sources

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TrkA domain proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:GSU0527Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243231 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000577 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 41HelicalSequence analysisAdd BLAST22
Transmembranei53 – 71HelicalSequence analysisAdd BLAST19
Transmembranei83 – 110HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
243231.GSU0527

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q74FS9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini132 – 253RCK N-terminalInterPro annotationAdd BLAST122
Domaini263 – 347RCK C-terminalInterPro annotationAdd BLAST85
Domaini353 – 471RCK N-terminalInterPro annotationAdd BLAST119
Domaini477 – 563RCK C-terminalInterPro annotationAdd BLAST87

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0569, Bacteria
COG1226, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_035216_0_0_7

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q74FS9

Identification of Orthologs from Complete Genome Data

More...
OMAi
IACQVAY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.1450, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013099, K_chnl_dom
IPR036291, NAD(P)-bd_dom_sf
IPR006037, RCK_C
IPR036721, RCK_C_sf
IPR003148, RCK_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07885, Ion_trans_2, 1 hit
PF02080, TrkA_C, 2 hits
PF02254, TrkA_N, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF116726, SSF116726, 2 hits
SSF51735, SSF51735, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51202, RCK_C, 2 hits
PS51201, RCK_N, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q74FS9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVLASELAY FLRGRARQNL KVLLLYCAFL LVMLLAYASI FRYLMWHLEG
60 70 80 90 100
REYSFMAGIY WTITVMTTLG FGDITFQSDA GYLFASIVTV SGVIFLLIIL
110 120 130 140 150
PFGFVSMFLA PWIERRLRYH PTIELPDDTR GHILIFGIDP ITRTLIRKLE
160 170 180 190 200
SRNHLFVVVT DNYDQALHLE EQEGFKVVYG SPTDAHVLAG LRVAAARSII
210 220 230 240 250
ANLSDPDNAN LCLTVRSLCQ TPIIAVVKEP VHGELLRLAG ANQVVPLTRI
260 270 280 290 300
LGRYLGIRAT TCGALAHILD SFGNLQIAEL PVHGTPFAGK TIGESGIRQR
310 320 330 340 350
TGLSIIGVWE RGSLTTPQRE TVLTEQSLLV LAGTKSQLAA LEYLIGEAPE
360 370 380 390 400
DELIFIIGHG RIGCAAAAFL DRKPVPFILI DRQESPVCND HVVVYGDATV
410 420 430 440 450
GQTLRQAGID RASGIIVTTN DDSTNIFLTL ACRHLHSHIR IVARANGEEN
460 470 480 490 500
VDQLYAAGAD FVVSNASVGA NILGNLLEHK ESAFLSEGMA VFRRPLPPAM
510 520 530 540 550
AGKTIAETRL RPLTGCSIVA IEAPDRADIL ISPPPETILA EGARLILIGT
560
SEQEKTFDQT IAAR
Length:564
Mass (Da):61,669
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E56CAD82B1157D6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE017180 Genomic DNA Translation: AAR33858.1

NCBI Reference Sequences

More...
RefSeqi
NP_951585.1, NC_002939.5
WP_010941195.1, NC_002939.5

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAR33858; AAR33858; GSU0527

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gsu:GSU0527

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|243231.5.peg.528

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA Translation: AAR33858.1
RefSeqiNP_951585.1, NC_002939.5
WP_010941195.1, NC_002939.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GVLX-ray3.00A/B/C/D107-564[»]
4GX0X-ray2.60A/B/C/D9-564[»]
4GX1X-ray2.80A/B/C/D9-564[»]
4GX2X-ray3.20A/B/C/D9-564[»]
4GX5X-ray3.70A/B/C/D9-564[»]
SMRiQ74FS9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi243231.GSU0527

Genome annotation databases

EnsemblBacteriaiAAR33858; AAR33858; GSU0527
KEGGigsu:GSU0527
PATRICifig|243231.5.peg.528

Phylogenomic databases

eggNOGiCOG0569, Bacteria
COG1226, Bacteria
HOGENOMiCLU_035216_0_0_7
InParanoidiQ74FS9
OMAiIACQVAY

Family and domain databases

Gene3Di3.30.70.1450, 2 hits
InterProiView protein in InterPro
IPR013099, K_chnl_dom
IPR036291, NAD(P)-bd_dom_sf
IPR006037, RCK_C
IPR036721, RCK_C_sf
IPR003148, RCK_N
PfamiView protein in Pfam
PF07885, Ion_trans_2, 1 hit
PF02080, TrkA_C, 2 hits
PF02254, TrkA_N, 2 hits
SUPFAMiSSF116726, SSF116726, 2 hits
SSF51735, SSF51735, 2 hits
PROSITEiView protein in PROSITE
PS51202, RCK_C, 2 hits
PS51201, RCK_N, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ74FS9_GEOSL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q74FS9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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